GREMLIN Database
RNPH - Inactive ribonuclease PH
UniProt: P0CG19 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10863
Length: 228 (197)
Sequences: 7198 (3182)
Seq/√Len: 226.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_C132_G3.6311.00
18_R139_D3.6041.00
15_T31_E3.2881.00
31_E36_K3.1561.00
41_A136_A3.0621.00
166_I213_E2.9601.00
173_C224_E2.7111.00
189_V221_A2.7051.00
210_T213_E2.5681.00
39_C114_L2.5231.00
157_G194_D2.5201.00
17_T31_E2.4841.00
16_L30_V2.4001.00
134_C158_M2.3991.00
25_E68_R2.3471.00
157_G193_E2.3281.00
19_N139_D2.3071.00
22_K34_D2.3011.00
16_L135_V2.2781.00
165_G175_L2.2621.00
176_E179_E2.1731.00
211_H215_L2.0081.00
171_A216_I1.9881.00
98_L133_A1.9841.00
166_I184_E1.9581.00
165_G183_A1.9191.00
16_L131_T1.9111.00
37_V118_V1.9011.00
78_A83_Q1.8661.00
21_T40_T1.7861.00
38_L119_L1.7401.00
191_M225_S1.7221.00
69_S74_N1.7031.00
30_V128_A1.6991.00
168_N182_A1.6991.00
29_L36_K1.6341.00
211_H222_R1.6321.00
57_G95_A1.6131.00
171_A220_L1.5891.00
14_V32_F1.5701.00
11_V173_C1.5641.00
166_I171_A1.5571.00
141_L153_N1.5391.00
219_A223_G1.5331.00
167_V172_V1.5061.00
157_G192_T1.4351.00
173_C220_L1.4261.00
97_A199_E1.4011.00
213_E216_I1.3801.00
64_G87_T1.3791.00
21_T24_A1.3631.00
189_V218_L1.3511.00
74_N77_E1.3261.00
138_V155_M1.3171.00
25_E141_L1.3061.00
74_N84_G1.3031.00
130_I161_A1.2941.00
160_A225_S1.2851.00
28_V135_V1.2841.00
48_P54_Q1.2771.00
114_L133_A1.2671.00
95_A99_R1.2621.00
178_V182_A1.2551.00
98_L137_L1.2451.00
215_L219_A1.2311.00
32_F128_A1.2261.00
14_V131_T1.2221.00
116_C129_S1.2191.00
163_S186_D1.2121.00
30_V132_G1.2041.00
212_E216_I1.2001.00
43_I110_F1.1981.00
41_A114_L1.1941.00
161_A190_V1.1591.00
122_D178_V1.1361.00
171_A217_L1.1331.00
56_Q105_K1.1071.00
127_T161_A1.1011.00
169_G184_E1.0981.00
41_A140_A1.0901.00
25_E42_S1.0861.00
97_A190_V1.0781.00
102_V137_L1.0551.00
172_V179_E1.0541.00
73_R76_R1.0311.00
35_T123_G1.0241.00
164_V173_C1.0161.00
164_V221_A1.0161.00
39_C133_A1.0101.00
64_G83_Q1.0061.00
138_V153_N1.0061.00
51_L56_Q0.9931.00
30_V131_T0.9901.00
130_I159_V0.9891.00
45_E110_F0.9861.00
167_V182_A0.9821.00
134_C155_M0.9771.00
24_A42_S0.9771.00
162_V173_C0.9731.00
71_H74_N0.9671.00
211_H219_A0.9651.00
120_Q123_G0.9521.00
167_V170_E0.9521.00
101_A192_T0.9491.00
134_C138_V0.9371.00
191_M222_R0.9371.00
48_P53_G0.9331.00
101_A157_G0.9271.00
84_G88_M0.9201.00
63_Y125_T0.9161.00
44_E48_P0.9140.99
164_V220_L0.9060.99
101_A134_C0.9040.99
184_E207_E0.9000.99
164_V171_A0.8960.99
18_R135_V0.8900.99
83_Q88_M0.8860.99
107_L154_P0.8830.99
43_I106_A0.8830.99
33_G120_Q0.8810.99
26_G136_A0.8810.99
219_A222_R0.8800.99
192_T198_I0.8760.99
84_G87_T0.8730.99
26_G41_A0.8670.99
25_E43_I0.8630.99
56_Q104_L0.8510.99
190_V199_E0.8490.99
24_A40_T0.8460.99
78_A84_G0.8450.99
90_I124_G0.8430.99
77_E84_G0.8380.99
77_E87_T0.8360.99
61_A94_I0.8340.99
126_R163_S0.8320.99
197_I218_L0.8290.99
43_I141_L0.8280.99
12_R174_D0.8270.99
171_A213_E0.8210.99
119_L123_G0.8170.99
17_T20_Y0.8110.99
131_T160_A0.8100.99
43_I140_A0.8070.99
204_A208_P0.8050.99
57_G104_L0.7950.99
37_V129_S0.7940.99
92_R99_R0.7910.99
164_V187_M0.7900.99
54_Q57_G0.7830.98
131_T161_A0.7790.98
162_V224_E0.7770.98
155_M158_M0.7760.98
50_F56_Q0.7680.98
112_I141_L0.7630.98
94_I116_C0.7620.98
63_Y129_S0.7610.98
185_T209_F0.7590.98
88_M91_Q0.7560.98
103_D106_A0.7500.98
19_N26_G0.7500.98
31_E34_D0.7490.98
138_V158_M0.7450.98
216_I219_A0.7420.98
64_G115_D0.7370.98
170_E179_E0.7320.98
220_L224_E0.7310.98
215_L222_R0.7310.98
118_V123_G0.7300.98
44_E113_T0.7300.98
62_E115_D0.7290.98
102_V112_I0.7270.97
18_R28_V0.7260.97
57_G107_L0.7250.97
28_V139_D0.7210.97
21_T38_L0.7190.97
101_A159_V0.7170.97
20_Y36_K0.7060.97
126_R188_N0.7030.97
204_A207_E0.7000.97
90_I126_R0.6980.97
34_D122_D0.6970.97
21_T28_V0.6960.97
24_A27_S0.6960.97
27_S40_T0.6930.97
74_N78_A0.6910.97
112_I137_L0.6900.97
134_C157_G0.6880.97
178_V181_S0.6850.96
17_T29_L0.6850.96
163_S188_N0.6850.96
180_D186_D0.6840.96
141_L155_M0.6820.96
43_I108_G0.6820.96
164_V189_V0.6800.96
37_V128_A0.6800.96
27_S38_L0.6780.96
32_F131_T0.6780.96
209_F213_E0.6760.96
131_T135_V0.6750.96
57_G110_F0.6740.96
10_Q13_P0.6700.96
32_F123_G0.6690.96
67_P76_R0.6630.96
158_M193_E0.6620.96
15_T29_L0.6570.95
59_I102_V0.6520.95
92_R96_R0.6510.95
42_S113_T0.6510.95
70_T121_A0.6440.95
43_I153_N0.6430.95
26_G139_D0.6420.95
32_F162_V0.6410.95
39_C116_C0.6410.95
92_R95_A0.6400.95
57_G112_I0.6390.95
170_E216_I0.6340.95
37_V132_G0.6320.94
104_L107_L0.6320.94
53_G56_Q0.6300.94
116_C133_A0.6290.94
30_V37_V0.6280.94
185_T204_A0.6200.94
32_F127_T0.6200.94
216_I220_L0.6140.94
184_E213_E0.6120.93
58_W99_R0.6110.93
187_M202_G0.6100.93
162_V225_S0.6090.93
168_N184_E0.6080.93
164_V217_L0.6060.93
127_T188_N0.6050.93
29_L117_D0.6030.93
64_G67_P0.6010.93
75_A113_T0.6000.93
44_E110_F0.5960.93
60_T113_T0.5960.93
28_V132_G0.5950.92
124_G180_D0.5950.92
54_Q107_L0.5880.92
127_T130_I0.5880.92
209_F214_L0.5880.92
170_E212_E0.5870.92
212_E215_L0.5830.92
76_R83_Q0.5810.92
23_H34_D0.5790.91
195_G219_A0.5750.91
45_E108_G0.5740.91
51_L55_G0.5740.91
98_L114_L0.5710.91
86_R90_I0.5710.91
63_Y90_I0.5690.91
195_G200_V0.5670.91
20_Y29_L0.5630.90
159_V198_I0.5620.90
34_D120_Q0.5610.90
121_A177_Y0.5610.90
63_Y87_T0.5610.90
218_L221_A0.5590.90
46_G110_F0.5560.90
73_R77_E0.5560.90
42_S115_D0.5480.89
46_G111_T0.5470.89
138_V141_L0.5470.89
103_D156_K0.5440.89
119_L125_T0.5410.88
187_M197_I0.5390.88
189_V200_V0.5380.88
52_K55_G0.5370.88
64_G74_N0.5360.88
101_A156_K0.5360.88
43_I112_I0.5350.88
177_Y180_D0.5330.88
55_G109_E0.5300.87
94_I130_I0.5290.87
107_L141_L0.5280.87
75_A83_Q0.5250.87
116_C121_A0.5240.87
33_G123_G0.5220.87
57_G108_G0.5210.87
195_G222_R0.5180.86
40_T117_D0.5170.86
11_V162_V0.5170.86
134_C159_V0.5140.86
35_T128_A0.5130.86
121_A125_T0.5110.85
110_F153_N0.5100.85
65_M69_S0.5090.85
64_G78_A0.5090.85
221_A224_E0.5090.85
222_R225_S0.5060.85
61_A129_S0.5030.85
11_V14_V0.5020.84
86_R126_R0.5010.84
200_V222_R0.5010.84
176_E182_A0.5010.84
41_A137_L0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1udnA 5 0.9956 100 0.135 Contact Map
3dd6A 3 0.9912 100 0.144 Contact Map
2po1B 1 0.9693 100 0.145 Contact Map
1oysA 2 0.8947 100 0.148 Contact Map
2wnrA 1 0.9693 100 0.149 Contact Map
2je6A 3 0.9605 100 0.151 Contact Map
3b4tA 3 0.9912 100 0.152 Contact Map
1r6lA 3 0.9868 100 0.153 Contact Map
2nn6E 1 0.9693 100 0.16 Contact Map
3m7nG 1 0.9693 100 0.162 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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