GREMLIN Database
INSL3 - Putative transposase InsL for insertion sequence element IS186C
UniProt: P0CF93 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG40012
Length: 370 (309)
Sequences: 1032 (849)
Seq/√Len: 48.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
116_G154_E4.5541.00
189_D290_S4.5441.00
329_A334_L4.3641.00
168_I304_C3.9691.00
76_A79_K3.6161.00
75_V79_K3.5791.00
132_H173_F3.3641.00
291_L296_Y3.2711.00
80_R83_N3.2581.00
113_L137_P3.2381.00
73_S76_A3.1241.00
328_R338_W2.6851.00
190_Y271_G2.6621.00
162_T165_E2.6531.00
128_E150_S2.5721.00
210_D214_F2.4541.00
92_A343_L2.4531.00
276_A302_A2.3951.00
316_K320_S2.2801.00
190_Y290_S2.2561.00
303_D306_R2.2411.00
183_L188_A2.2221.00
132_H148_T2.2161.00
93_A144_D2.1911.00
112_R165_E2.1621.00
211_M214_F2.1551.00
166_I291_L2.1391.00
169_A192_V2.1371.00
110_R165_E2.0631.00
313_L316_K2.0241.00
229_M232_N2.0110.99
46_L49_A2.0090.99
81_L337_A2.0070.99
194_V198_G1.9970.99
89_G336_K1.9910.99
29_G32_T1.9780.99
311_I315_F1.9350.99
109_K189_D1.9150.99
85_A336_K1.8640.99
112_R143_T1.8630.99
279_L282_A1.8580.99
27_N90_I1.8530.99
38_R41_A1.7930.99
117_T131_L1.7680.99
248_A270_K1.7340.98
46_L341_A1.7310.98
182_S186_G1.7230.98
171_R192_V1.7020.98
117_T319_K1.6990.98
51_G83_N1.6880.98
89_G93_A1.6820.98
316_K321_L1.6770.98
350_D353_I1.6700.98
176_R198_G1.6600.98
184_A290_S1.6500.98
211_M215_L1.6420.98
180_I192_V1.6370.98
109_K166_I1.6260.98
114_V134_G1.6240.98
312_E319_K1.6050.97
148_T152_D1.5910.97
133_M315_F1.5880.97
56_S301_V1.5860.97
145_F343_L1.5430.97
82_R331_E1.5270.97
39_D87_W1.5220.96
118_A130_R1.4880.96
60_V65_Q1.4550.95
37_I45_R1.4410.95
111_L304_C1.4190.95
170_D319_K1.3990.94
174_G198_G1.3860.94
297_S300_Q1.3860.94
171_R193_R1.3850.94
95_T347_F1.3790.94
192_V288_L1.3720.94
56_S60_V1.3550.93
144_D160_A1.3380.93
166_I191_I1.3350.93
212_M215_L1.3190.92
332_P336_K1.3140.92
308_R312_E1.3000.92
211_M216_R1.2950.92
163_A187_E1.2910.92
21_L24_S1.2840.91
213_G216_R1.2730.91
147_L336_K1.2720.91
296_Y301_V1.2660.91
57_L60_V1.2590.91
40_A44_L1.2560.90
15_I43_L1.2550.90
134_G143_T1.2490.90
320_S348_L1.2320.90
309_W312_E1.2290.89
32_T35_R1.2270.89
130_R150_S1.2240.89
126_S150_S1.2240.89
122_P338_W1.2170.89
305_Y319_K1.2160.89
276_A285_V1.2120.89
191_I304_C1.2090.89
275_Q284_H1.2040.88
42_T81_L1.1990.88
30_A39_D1.1960.88
125_G146_E1.1930.88
115_D170_D1.1910.88
287_L301_V1.1750.87
107_S300_Q1.1750.87
112_R134_G1.1740.87
11_I14_H1.1650.87
129_W339_I1.1630.87
88_F337_A1.1540.86
106_T111_L1.1420.86
21_L25_A1.1410.86
214_F274_V1.1410.86
277_E282_A1.1320.85
170_D305_Y1.1280.85
92_A96_L1.1220.85
172_G195_H1.1200.84
41_A141_Q1.1200.84
317_R350_D1.1180.84
19_E23_T1.1160.84
337_A341_A1.1090.84
210_D213_G1.1090.84
122_P335_A1.0990.83
196_W335_A1.0970.83
12_L15_I1.0940.83
115_D312_E1.0900.83
305_Y312_E1.0890.83
210_D217_G1.0790.82
61_T77_L1.0660.81
154_E170_D1.0650.81
155_R195_H1.0520.81
90_I94_Q1.0420.80
46_L329_A1.0320.79
317_R321_L1.0220.79
142_F347_F1.0210.79
142_F295_E1.0210.79
247_I297_S1.0210.79
301_V315_F1.0150.78
72_L199_L1.0090.78
81_L338_W1.0010.77
130_R290_S0.9980.77
96_L347_F0.9930.77
91_L297_S0.9890.76
329_A338_W0.9860.76
20_E24_S0.9810.76
322_L349_I0.9800.76
272_R276_A0.9770.75
142_F314_A0.9720.75
246_L250_S0.9670.75
91_L344_L0.9650.74
161_Q167_R0.9600.74
285_V302_A0.9570.74
124_G127_A0.9500.73
184_A190_Y0.9420.73
191_I301_V0.9420.73
57_L78_L0.9410.73
187_E282_A0.9400.72
181_R185_F0.9350.72
42_T83_N0.9320.72
140_C156_L0.9310.72
169_A183_L0.9310.72
348_L352_I0.9300.72
106_T304_C0.9290.72
20_E94_Q0.9280.72
127_A338_W0.9270.71
31_L39_D0.9270.71
12_L44_L0.9260.71
214_F217_G0.9230.71
133_M142_F0.9180.71
193_R312_E0.9170.71
161_Q300_Q0.9160.71
132_H316_K0.9130.70
314_A322_L0.9110.70
312_E315_F0.9100.70
110_R171_R0.9070.70
170_D312_E0.9060.70
97_A184_A0.9060.70
213_G217_G0.9020.69
112_R154_E0.8970.69
59_E62_A0.8960.69
50_Y341_A0.8940.69
85_A333_E0.8920.68
112_R167_R0.8900.68
15_I18_P0.8830.68
136_D139_T0.8820.68
317_R346_A0.8760.67
42_T80_R0.8740.67
85_A339_I0.8700.67
292_P296_Y0.8670.66
316_K319_K0.8650.66
74_D79_K0.8610.66
301_V346_A0.8600.66
42_T78_L0.8590.66
20_E98_V0.8590.66
183_L200_R0.8580.65
157_D179_C0.8560.65
92_A346_A0.8550.65
88_F333_E0.8540.65
247_I250_S0.8530.65
130_R153_A0.8530.65
13_A355_P0.8470.64
47_G62_A0.8460.64
81_L329_A0.8440.64
43_L341_A0.8430.64
127_A337_A0.8340.63
197_R295_E0.8280.63
17_K20_E0.8270.63
114_V150_S0.8260.62
110_R136_D0.8230.62
307_L310_Q0.8210.62
105_C264_L0.8170.62
87_W133_M0.8140.61
135_Y340_F0.8140.61
132_H338_W0.8130.61
110_R162_T0.8090.61
193_R309_W0.8080.61
49_A77_L0.8070.61
305_Y311_I0.8070.61
115_D308_R0.8040.60
144_D354_Q0.8030.60
216_R221_G0.8010.60
276_A287_L0.7960.60
42_T45_R0.7950.60
169_A172_G0.7940.59
37_I77_L0.7940.59
47_G341_A0.7920.59
153_A171_R0.7900.59
72_L121_A0.7860.59
117_T355_P0.7860.59
18_P40_A0.7850.59
169_A287_L0.7850.59
195_H339_I0.7840.58
125_G151_R0.7790.58
118_A195_H0.7790.58
64_A186_G0.7760.58
52_P318_L0.7760.58
131_L251_L0.7720.57
115_D193_R0.7710.57
131_L339_I0.7700.57
19_E22_D0.7700.57
43_L88_F0.7660.57
35_R83_N0.7610.56
86_D289_T0.7610.56
86_D89_G0.7570.56
338_W347_F0.7560.56
128_E154_E0.7550.56
50_Y317_R0.7530.55
154_E172_G0.7530.55
115_D172_G0.7520.55
67_H117_T0.7440.54
147_L339_I0.7390.54
75_V120_S0.7380.54
341_A348_L0.7380.54
43_L48_L0.7380.54
18_P22_D0.7370.54
106_T109_K0.7370.54
121_A327_L0.7350.54
124_G298_A0.7340.53
18_P21_L0.7330.53
172_G313_L0.7320.53
75_V176_R0.7300.53
59_E63_W0.7290.53
119_I131_L0.7280.53
311_I343_L0.7270.53
89_G158_R0.7260.53
297_S332_P0.7250.53
310_Q313_L0.7240.52
28_A31_L0.7240.52
278_T281_A0.7200.52
36_E41_A0.7200.52
180_I190_Y0.7180.52
352_I356_S0.7140.51
111_L161_Q0.7130.51
148_T335_A0.7120.51
174_G341_A0.7120.51
61_T316_K0.7110.51
136_D171_R0.7100.51
275_Q286_L0.7100.51
88_F341_A0.7080.51
302_A322_L0.7070.51
137_P304_C0.7060.51
85_A89_G0.7050.51
80_R108_G0.7050.51
97_A101_A0.7020.50
86_D185_F0.7010.50
24_S27_N0.7010.50
42_T126_S0.6970.50
214_F221_G0.6960.50
60_V64_A0.6960.50
315_F344_L0.6960.50
171_R195_H0.6960.50
97_A274_V0.6940.49
75_V345_A0.6920.49
39_D83_N0.6910.49
48_L114_V0.6910.49
29_G91_L0.6900.49
75_V78_L0.6890.49
127_A174_G0.6880.49
121_A247_I0.6850.49
134_G167_R0.6840.48
75_V172_G0.6830.48
69_V149_D0.6830.48
15_I311_I0.6830.48
179_C287_L0.6820.48
84_A188_A0.6810.48
31_L34_R0.6800.48
10_A14_H0.6790.48
21_L67_H0.6780.48
274_V289_T0.6740.47
78_L334_L0.6740.47
138_H307_L0.6730.47
200_R210_D0.6720.47
19_E24_S0.6710.47
210_D215_L0.6700.47
133_M346_A0.6700.47
170_D309_W0.6670.47
20_E23_T0.6670.47
21_L38_R0.6640.46
102_V152_D0.6630.46
81_L126_S0.6630.46
13_A344_L0.6620.46
15_I23_T0.6610.46
115_D319_K0.6600.46
23_T26_R0.6590.46
289_T301_V0.6590.46
293_E297_S0.6580.46
29_G297_S0.6550.46
47_G345_A0.6530.45
217_G221_G0.6520.45
45_R57_L0.6520.45
65_Q135_Y0.6440.44
305_Y308_R0.6400.44
17_K22_D0.6390.44
193_R305_Y0.6390.44
133_M354_Q0.6380.44
331_E334_L0.6360.44
98_V298_A0.6350.44
57_L77_L0.6300.43
26_R29_G0.6290.43
94_Q97_A0.6290.43
211_M273_V0.6280.43
134_G179_C0.6270.43
248_A251_L0.6270.43
49_A337_A0.6250.43
80_R334_L0.6240.42
11_I99_R0.6240.42
56_S199_L0.6230.42
115_D289_T0.6230.42
103_T107_S0.6220.42
39_D42_T0.6200.42
154_E315_F0.6190.42
187_E297_S0.6180.42
54_G59_E0.6170.42
74_D346_A0.6130.41
37_I41_A0.6130.41
196_W294_D0.6130.41
26_R47_G0.6120.41
200_R247_I0.6110.41
12_L47_G0.6110.41
92_A338_W0.6090.41
120_S128_E0.6080.41
102_V163_A0.6070.41
134_G306_R0.6070.41
221_G230_I0.6060.41
147_L199_L0.6060.41
88_F344_L0.6040.40
72_L76_A0.6020.40
141_Q351_D0.5990.40
317_R335_A0.5990.40
126_S338_W0.5980.40
30_A87_W0.5960.40
60_V145_F0.5960.40
316_K322_L0.5960.40
180_I200_R0.5950.40
293_E311_I0.5910.39
84_A113_L0.5890.39
246_L251_L0.5850.39
50_Y338_W0.5850.39
128_E338_W0.5830.38
163_A304_C0.5790.38
22_D26_R0.5790.38
95_T344_L0.5770.38
24_S28_A0.5770.38
37_I70_A0.5730.38
103_T109_K0.5720.37
143_T335_A0.5720.37
180_I198_G0.5710.37
146_E270_K0.5700.37
114_V138_H0.5690.37
149_D172_G0.5690.37
184_A307_L0.5690.37
50_Y334_L0.5680.37
101_A104_G0.5660.37
314_A318_L0.5630.37
166_I194_V0.5630.37
17_K91_L0.5600.36
196_W288_L0.5600.36
299_E303_D0.5590.36
77_L316_K0.5580.36
159_F339_I0.5570.36
25_A28_A0.5550.36
82_R216_R0.5550.36
93_A355_P0.5520.36
328_R347_F0.5520.36
337_A340_F0.5520.36
155_R179_C0.5510.35
156_L349_I0.5510.35
212_M216_R0.5490.35
11_I352_I0.5470.35
28_A144_D0.5460.35
22_D147_L0.5460.35
188_A340_F0.5450.35
133_M339_I0.5450.35
75_V92_A0.5450.35
284_H335_A0.5440.35
53_G130_R0.5420.35
173_F313_L0.5410.35
130_R142_F0.5400.34
111_L160_A0.5400.34
74_D331_E0.5380.34
324_L342_N0.5370.34
116_G128_E0.5360.34
36_E71_T0.5350.34
134_G161_Q0.5340.34
136_D193_R0.5340.34
23_T297_S0.5340.34
31_L35_R0.5330.34
311_I319_K0.5330.34
79_K129_W0.5320.34
105_C311_I0.5300.34
221_G247_I0.5300.34
22_D40_A0.5300.34
289_T345_A0.5290.33
329_A335_A0.5270.33
60_V121_A0.5250.33
171_R198_G0.5230.33
144_D159_F0.5220.33
54_G58_R0.5220.33
13_A304_C0.5200.33
189_D291_L0.5200.33
293_E296_Y0.5200.33
172_G194_V0.5180.32
35_R91_L0.5170.32
330_K335_A0.5170.32
121_A129_W0.5160.32
26_R51_G0.5160.32
28_A87_W0.5150.32
75_V314_A0.5150.32
309_W319_K0.5150.32
305_Y309_W0.5120.32
180_I194_V0.5110.32
97_A103_T0.5090.32
99_R164_D0.5080.32
331_E340_F0.5070.32
88_F163_A0.5060.31
34_R269_R0.5060.31
112_R162_T0.5040.31
103_T216_R0.5030.31
221_G310_Q0.5030.31
11_I91_L0.5020.31
78_L344_L0.5010.31
107_S339_I0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.8351 100 0.668 Contact Map
1pdnC 1 0.2054 8.8 0.969 Contact Map
2opoA 2 0.2243 8.3 0.969 Contact Map
3frwA 2 0.2486 4.5 0.973 Contact Map
1k78A 1 0.2162 4.5 0.973 Contact Map
4rxxA 1 0.2324 4.4 0.973 Contact Map
3dlmA 1 0.5243 4.3 0.973 Contact Map
2ga1A 2 0.2459 4.2 0.973 Contact Map
4hs2A 2 0.1703 3.6 0.974 Contact Map
3oqcA 1 0.4054 3.6 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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