INSL2 - ECOLI - GREMLIN Contacts

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INSL2 - Putative transposase InsL for insertion sequence element IS186B

UniProt:	P0CF92	Sequences: MNYSHDNWSAILAHIGKPEELDTSARNAGALTRRREIRDAATLLRLGLAYGPGGMSLREVTAWAQLHDVATLSDVALLKRLRNAADWFGILAAQTLAVRAAVTGCTSGKRLRLVDGTAISAPGGGSAEWRLHMGYDPHTCQFTDFELTDSRDAERLDRFAQTADEIRIADRGFGSRPECIRSLAFGEADYIVRVHWRGLRWLTAEGMRFDMMGFLRGLDCGKNGETTVMIGNSGNKKAGAPFPARLIAVSLPPEKALISKTRLLSENRRKGRVVQAETLEAAGHVLLLTSLPEDEYSAEQVADCYRLRWQIELAFKRLKSLLHLDALRAKEPELAKAWIFANLLAAFLIDDIIQPSLDFPPRSAGSEKKN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG40012
Length:	370 (309)
Sequences:	1032 (849)
Seq/√Len:	48.3

ECOLI - INSL1 INSL2 INSL3 INSG
HALSA - O51972 O54648 O52023 Q9HI34 O51966 Q9HI01 O54644

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
116_G	154_E	4.554	1.00
189_D	290_S	4.544	1.00
329_A	334_L	4.364	1.00
168_I	304_C	3.969	1.00
76_A	79_K	3.616	1.00
75_V	79_K	3.579	1.00
132_H	173_F	3.364	1.00
291_L	296_Y	3.271	1.00
80_R	83_N	3.258	1.00
113_L	137_P	3.238	1.00
73_S	76_A	3.124	1.00
328_R	338_W	2.685	1.00
190_Y	271_G	2.662	1.00
162_T	165_E	2.653	1.00
128_E	150_S	2.572	1.00
210_D	214_F	2.454	1.00
92_A	343_L	2.453	1.00
276_A	302_A	2.395	1.00
316_K	320_S	2.280	1.00
190_Y	290_S	2.256	1.00
303_D	306_R	2.241	1.00
183_L	188_A	2.222	1.00
132_H	148_T	2.216	1.00
93_A	144_D	2.191	1.00
112_R	165_E	2.162	1.00
211_M	214_F	2.155	1.00
166_I	291_L	2.139	1.00
169_A	192_V	2.137	1.00
110_R	165_E	2.063	1.00
313_L	316_K	2.024	1.00
229_M	232_N	2.011	0.99
46_L	49_A	2.009	0.99
81_L	337_A	2.007	0.99
194_V	198_G	1.997	0.99
89_G	336_K	1.991	0.99
29_G	32_T	1.978	0.99
311_I	315_F	1.935	0.99
109_K	189_D	1.915	0.99
85_A	336_K	1.864	0.99
112_R	143_T	1.863	0.99
279_L	282_A	1.858	0.99
27_N	90_I	1.853	0.99
38_R	41_A	1.793	0.99
117_T	131_L	1.768	0.99
248_A	270_K	1.734	0.98
46_L	341_A	1.731	0.98
182_S	186_G	1.723	0.98
171_R	192_V	1.702	0.98
117_T	319_K	1.699	0.98
51_G	83_N	1.688	0.98
89_G	93_A	1.682	0.98
316_K	321_L	1.677	0.98
350_D	353_I	1.670	0.98
176_R	198_G	1.660	0.98
184_A	290_S	1.650	0.98
211_M	215_L	1.642	0.98
180_I	192_V	1.637	0.98
109_K	166_I	1.626	0.98
114_V	134_G	1.624	0.98
312_E	319_K	1.605	0.97
148_T	152_D	1.591	0.97
133_M	315_F	1.588	0.97
56_S	301_V	1.586	0.97
145_F	343_L	1.543	0.97
82_R	331_E	1.527	0.97
39_D	87_W	1.522	0.96
118_A	130_R	1.488	0.96
60_V	65_Q	1.455	0.95
37_I	45_R	1.441	0.95
111_L	304_C	1.419	0.95
170_D	319_K	1.399	0.94
174_G	198_G	1.386	0.94
297_S	300_Q	1.386	0.94
171_R	193_R	1.385	0.94
95_T	347_F	1.379	0.94
192_V	288_L	1.372	0.94
56_S	60_V	1.355	0.93
144_D	160_A	1.338	0.93
166_I	191_I	1.335	0.93
212_M	215_L	1.319	0.92
332_P	336_K	1.314	0.92
308_R	312_E	1.300	0.92
211_M	216_R	1.295	0.92
163_A	187_E	1.291	0.92
21_L	24_S	1.284	0.91
213_G	216_R	1.273	0.91
147_L	336_K	1.272	0.91
296_Y	301_V	1.266	0.91
57_L	60_V	1.259	0.91
40_A	44_L	1.256	0.90
15_I	43_L	1.255	0.90
134_G	143_T	1.249	0.90
320_S	348_L	1.232	0.90
309_W	312_E	1.229	0.89
32_T	35_R	1.227	0.89
130_R	150_S	1.224	0.89
126_S	150_S	1.224	0.89
122_P	338_W	1.217	0.89
305_Y	319_K	1.216	0.89
276_A	285_V	1.212	0.89
191_I	304_C	1.209	0.89
275_Q	284_H	1.204	0.88
42_T	81_L	1.199	0.88
30_A	39_D	1.196	0.88
125_G	146_E	1.193	0.88
115_D	170_D	1.191	0.88
287_L	301_V	1.175	0.87
107_S	300_Q	1.175	0.87
112_R	134_G	1.174	0.87
11_I	14_H	1.165	0.87
129_W	339_I	1.163	0.87
88_F	337_A	1.154	0.86
106_T	111_L	1.142	0.86
21_L	25_A	1.141	0.86
214_F	274_V	1.141	0.86
277_E	282_A	1.132	0.85
170_D	305_Y	1.128	0.85
92_A	96_L	1.122	0.85
172_G	195_H	1.120	0.84
41_A	141_Q	1.120	0.84
317_R	350_D	1.118	0.84
19_E	23_T	1.116	0.84
337_A	341_A	1.109	0.84
210_D	213_G	1.109	0.84
122_P	335_A	1.099	0.83
196_W	335_A	1.097	0.83
12_L	15_I	1.094	0.83
115_D	312_E	1.090	0.83
305_Y	312_E	1.089	0.83
210_D	217_G	1.079	0.82
61_T	77_L	1.066	0.81
154_E	170_D	1.065	0.81
155_R	195_H	1.052	0.81
90_I	94_Q	1.042	0.80
46_L	329_A	1.032	0.79
317_R	321_L	1.022	0.79
142_F	347_F	1.021	0.79
142_F	295_E	1.021	0.79
247_I	297_S	1.021	0.79
301_V	315_F	1.015	0.78
72_L	199_L	1.009	0.78
81_L	338_W	1.001	0.77
130_R	290_S	0.998	0.77
96_L	347_F	0.993	0.77
91_L	297_S	0.989	0.76
329_A	338_W	0.986	0.76
20_E	24_S	0.981	0.76
322_L	349_I	0.980	0.76
272_R	276_A	0.977	0.75
142_F	314_A	0.972	0.75
246_L	250_S	0.967	0.75
91_L	344_L	0.965	0.74
161_Q	167_R	0.960	0.74
285_V	302_A	0.957	0.74
124_G	127_A	0.950	0.73
184_A	190_Y	0.942	0.73
191_I	301_V	0.942	0.73
57_L	78_L	0.941	0.73
187_E	282_A	0.940	0.72
181_R	185_F	0.935	0.72
42_T	83_N	0.932	0.72
140_C	156_L	0.931	0.72
169_A	183_L	0.931	0.72
348_L	352_I	0.930	0.72
106_T	304_C	0.929	0.72
20_E	94_Q	0.928	0.72
127_A	338_W	0.927	0.71
31_L	39_D	0.927	0.71
12_L	44_L	0.926	0.71
214_F	217_G	0.923	0.71
133_M	142_F	0.918	0.71
193_R	312_E	0.917	0.71
161_Q	300_Q	0.916	0.71
132_H	316_K	0.913	0.70
314_A	322_L	0.911	0.70
312_E	315_F	0.910	0.70
110_R	171_R	0.907	0.70
170_D	312_E	0.906	0.70
97_A	184_A	0.906	0.70
213_G	217_G	0.902	0.69
112_R	154_E	0.897	0.69
59_E	62_A	0.896	0.69
50_Y	341_A	0.894	0.69
85_A	333_E	0.892	0.68
112_R	167_R	0.890	0.68
15_I	18_P	0.883	0.68
136_D	139_T	0.882	0.68
317_R	346_A	0.876	0.67
42_T	80_R	0.874	0.67
85_A	339_I	0.870	0.67
292_P	296_Y	0.867	0.66
316_K	319_K	0.865	0.66
74_D	79_K	0.861	0.66
301_V	346_A	0.860	0.66
42_T	78_L	0.859	0.66
20_E	98_V	0.859	0.66
183_L	200_R	0.858	0.65
157_D	179_C	0.856	0.65
92_A	346_A	0.855	0.65
88_F	333_E	0.854	0.65
247_I	250_S	0.853	0.65
130_R	153_A	0.853	0.65
13_A	355_P	0.847	0.64
47_G	62_A	0.846	0.64
81_L	329_A	0.844	0.64
43_L	341_A	0.843	0.64
127_A	337_A	0.834	0.63
197_R	295_E	0.828	0.63
17_K	20_E	0.827	0.63
114_V	150_S	0.826	0.62
110_R	136_D	0.823	0.62
307_L	310_Q	0.821	0.62
105_C	264_L	0.817	0.62
87_W	133_M	0.814	0.61
135_Y	340_F	0.814	0.61
132_H	338_W	0.813	0.61
110_R	162_T	0.809	0.61
193_R	309_W	0.808	0.61
49_A	77_L	0.807	0.61
305_Y	311_I	0.807	0.61
115_D	308_R	0.804	0.60
144_D	354_Q	0.803	0.60
216_R	221_G	0.801	0.60
276_A	287_L	0.796	0.60
42_T	45_R	0.795	0.60
169_A	172_G	0.794	0.59
37_I	77_L	0.794	0.59
47_G	341_A	0.792	0.59
153_A	171_R	0.790	0.59
72_L	121_A	0.786	0.59
117_T	355_P	0.786	0.59
18_P	40_A	0.785	0.59
169_A	287_L	0.785	0.59
195_H	339_I	0.784	0.58
125_G	151_R	0.779	0.58
118_A	195_H	0.779	0.58
64_A	186_G	0.776	0.58
52_P	318_L	0.776	0.58
131_L	251_L	0.772	0.57
115_D	193_R	0.771	0.57
131_L	339_I	0.770	0.57
19_E	22_D	0.770	0.57
43_L	88_F	0.766	0.57
35_R	83_N	0.761	0.56
86_D	289_T	0.761	0.56
86_D	89_G	0.757	0.56
338_W	347_F	0.756	0.56
128_E	154_E	0.755	0.56
50_Y	317_R	0.753	0.55
154_E	172_G	0.753	0.55
115_D	172_G	0.752	0.55
67_H	117_T	0.744	0.54
147_L	339_I	0.739	0.54
75_V	120_S	0.738	0.54
341_A	348_L	0.738	0.54
43_L	48_L	0.738	0.54
18_P	22_D	0.737	0.54
106_T	109_K	0.737	0.54
121_A	327_L	0.735	0.54
124_G	298_A	0.734	0.53
18_P	21_L	0.733	0.53
172_G	313_L	0.732	0.53
75_V	176_R	0.730	0.53
59_E	63_W	0.729	0.53
119_I	131_L	0.728	0.53
311_I	343_L	0.727	0.53
89_G	158_R	0.726	0.53
297_S	332_P	0.725	0.53
310_Q	313_L	0.724	0.52
28_A	31_L	0.724	0.52
278_T	281_A	0.720	0.52
36_E	41_A	0.720	0.52
180_I	190_Y	0.718	0.52
352_I	356_S	0.714	0.51
111_L	161_Q	0.713	0.51
148_T	335_A	0.712	0.51
174_G	341_A	0.712	0.51
61_T	316_K	0.711	0.51
136_D	171_R	0.710	0.51
275_Q	286_L	0.710	0.51
88_F	341_A	0.708	0.51
302_A	322_L	0.707	0.51
137_P	304_C	0.706	0.51
85_A	89_G	0.705	0.51
80_R	108_G	0.705	0.51
97_A	101_A	0.702	0.50
86_D	185_F	0.701	0.50
24_S	27_N	0.701	0.50
42_T	126_S	0.697	0.50
214_F	221_G	0.696	0.50
60_V	64_A	0.696	0.50
315_F	344_L	0.696	0.50
171_R	195_H	0.696	0.50
97_A	274_V	0.694	0.49
75_V	345_A	0.692	0.49
39_D	83_N	0.691	0.49
48_L	114_V	0.691	0.49
29_G	91_L	0.690	0.49
75_V	78_L	0.689	0.49
127_A	174_G	0.688	0.49
121_A	247_I	0.685	0.49
134_G	167_R	0.684	0.48
75_V	172_G	0.683	0.48
69_V	149_D	0.683	0.48
15_I	311_I	0.683	0.48
179_C	287_L	0.682	0.48
84_A	188_A	0.681	0.48
31_L	34_R	0.680	0.48
10_A	14_H	0.679	0.48
21_L	67_H	0.678	0.48
274_V	289_T	0.674	0.47
78_L	334_L	0.674	0.47
138_H	307_L	0.673	0.47
200_R	210_D	0.672	0.47
19_E	24_S	0.671	0.47
210_D	215_L	0.670	0.47
133_M	346_A	0.670	0.47
170_D	309_W	0.667	0.47
20_E	23_T	0.667	0.47
21_L	38_R	0.664	0.46
102_V	152_D	0.663	0.46
81_L	126_S	0.663	0.46
13_A	344_L	0.662	0.46
15_I	23_T	0.661	0.46
115_D	319_K	0.660	0.46
23_T	26_R	0.659	0.46
289_T	301_V	0.659	0.46
293_E	297_S	0.658	0.46
29_G	297_S	0.655	0.46
47_G	345_A	0.653	0.45
217_G	221_G	0.652	0.45
45_R	57_L	0.652	0.45
65_Q	135_Y	0.644	0.44
305_Y	308_R	0.640	0.44
17_K	22_D	0.639	0.44
193_R	305_Y	0.639	0.44
133_M	354_Q	0.638	0.44
331_E	334_L	0.636	0.44
98_V	298_A	0.635	0.44
57_L	77_L	0.630	0.43
26_R	29_G	0.629	0.43
94_Q	97_A	0.629	0.43
211_M	273_V	0.628	0.43
134_G	179_C	0.627	0.43
248_A	251_L	0.627	0.43
49_A	337_A	0.625	0.43
80_R	334_L	0.624	0.42
11_I	99_R	0.624	0.42
56_S	199_L	0.623	0.42
115_D	289_T	0.623	0.42
103_T	107_S	0.622	0.42
39_D	42_T	0.620	0.42
154_E	315_F	0.619	0.42
187_E	297_S	0.618	0.42
54_G	59_E	0.617	0.42
74_D	346_A	0.613	0.41
37_I	41_A	0.613	0.41
196_W	294_D	0.613	0.41
26_R	47_G	0.612	0.41
200_R	247_I	0.611	0.41
12_L	47_G	0.611	0.41
92_A	338_W	0.609	0.41
120_S	128_E	0.608	0.41
102_V	163_A	0.607	0.41
134_G	306_R	0.607	0.41
221_G	230_I	0.606	0.41
147_L	199_L	0.606	0.41
88_F	344_L	0.604	0.40
72_L	76_A	0.602	0.40
141_Q	351_D	0.599	0.40
317_R	335_A	0.599	0.40
126_S	338_W	0.598	0.40
30_A	87_W	0.596	0.40
60_V	145_F	0.596	0.40
316_K	322_L	0.596	0.40
180_I	200_R	0.595	0.40
293_E	311_I	0.591	0.39
84_A	113_L	0.589	0.39
246_L	251_L	0.585	0.39
50_Y	338_W	0.585	0.39
128_E	338_W	0.583	0.38
163_A	304_C	0.579	0.38
22_D	26_R	0.579	0.38
95_T	344_L	0.577	0.38
24_S	28_A	0.577	0.38
37_I	70_A	0.573	0.38
103_T	109_K	0.572	0.37
143_T	335_A	0.572	0.37
180_I	198_G	0.571	0.37
146_E	270_K	0.570	0.37
114_V	138_H	0.569	0.37
149_D	172_G	0.569	0.37
184_A	307_L	0.569	0.37
50_Y	334_L	0.568	0.37
101_A	104_G	0.566	0.37
314_A	318_L	0.563	0.37
166_I	194_V	0.563	0.37
17_K	91_L	0.560	0.36
196_W	288_L	0.560	0.36
299_E	303_D	0.559	0.36
77_L	316_K	0.558	0.36
159_F	339_I	0.557	0.36
25_A	28_A	0.555	0.36
82_R	216_R	0.555	0.36
93_A	355_P	0.552	0.36
328_R	347_F	0.552	0.36
337_A	340_F	0.552	0.36
155_R	179_C	0.551	0.35
156_L	349_I	0.551	0.35
212_M	216_R	0.549	0.35
11_I	352_I	0.547	0.35
28_A	144_D	0.546	0.35
22_D	147_L	0.546	0.35
188_A	340_F	0.545	0.35
133_M	339_I	0.545	0.35
75_V	92_A	0.545	0.35
284_H	335_A	0.544	0.35
53_G	130_R	0.542	0.35
173_F	313_L	0.541	0.35
130_R	142_F	0.540	0.34
111_L	160_A	0.540	0.34
74_D	331_E	0.538	0.34
324_L	342_N	0.537	0.34
116_G	128_E	0.536	0.34
36_E	71_T	0.535	0.34
134_G	161_Q	0.534	0.34
136_D	193_R	0.534	0.34
23_T	297_S	0.534	0.34
31_L	35_R	0.533	0.34
311_I	319_K	0.533	0.34
79_K	129_W	0.532	0.34
105_C	311_I	0.530	0.34
221_G	247_I	0.530	0.34
22_D	40_A	0.530	0.34
289_T	345_A	0.529	0.33
329_A	335_A	0.527	0.33
60_V	121_A	0.525	0.33
171_R	198_G	0.523	0.33
144_D	159_F	0.522	0.33
54_G	58_R	0.522	0.33
13_A	304_C	0.520	0.33
189_D	291_L	0.520	0.33
293_E	296_Y	0.520	0.33
172_G	194_V	0.518	0.32
35_R	91_L	0.517	0.32
330_K	335_A	0.517	0.32
121_A	129_W	0.516	0.32
26_R	51_G	0.516	0.32
28_A	87_W	0.515	0.32
75_V	314_A	0.515	0.32
309_W	319_K	0.515	0.32
305_Y	309_W	0.512	0.32
180_I	194_V	0.511	0.32
97_A	103_T	0.509	0.32
99_R	164_D	0.508	0.32
331_E	340_F	0.507	0.32
88_F	163_A	0.506	0.31
34_R	269_R	0.506	0.31
112_R	162_T	0.504	0.31
103_T	216_R	0.503	0.31
221_G	310_Q	0.503	0.31
11_I	91_L	0.502	0.31
78_L	344_L	0.501	0.31
107_S	339_I	0.500	0.31

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1musA	2	0.8351	100	0.668	Contact Map
1pdnC	1	0.2054	8.8	0.969	Contact Map
2opoA	2	0.2243	8.3	0.969	Contact Map
3frwA	2	0.2486	4.5	0.973	Contact Map
1k78A	1	0.2162	4.5	0.973	Contact Map
4rxxA	1	0.2324	4.4	0.973	Contact Map
3dlmA	1	0.5243	4.3	0.973	Contact Map
2ga1A	2	0.2459	4.2	0.973	Contact Map
4hs2A	2	0.1703	3.6	0.974	Contact Map
3oqcA	1	0.4054	3.6	0.974	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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