GREMLIN Database
INSI3 - Transposase InsI for insertion sequence element IS30C
UniProt: P0CF89 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG40009
Length: 383 (317)
Sequences: 1239 (973)
Seq/√Len: 54.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
316_D322_Q4.8951.00
78_R88_P4.8161.00
255_S374_I4.4791.00
337_F354_V4.4611.00
110_N114_N4.4541.00
71_L95_V4.1081.00
256_R365_T3.9391.00
84_L91_I3.8761.00
63_E86_R3.8001.00
146_E364_K3.4191.00
219_H316_D3.2301.00
230_S233_H3.2131.00
323_R326_N3.1721.00
68_R106_A3.1591.00
348_Q352_D2.9361.00
150_G368_F2.9171.00
151_W373_E2.7911.00
265_G270_S2.6671.00
236_G292_W2.6271.00
219_H322_Q2.6251.00
260_I355_A2.4601.00
98_N116_M2.4081.00
260_I333_I2.3691.00
369_K377_R2.2071.00
190_R335_Q2.1791.00
66_E70_G2.1541.00
77_I92_S2.1291.00
300_R303_E2.0421.00
59_L90_T1.9791.00
214_N302_L1.9711.00
88_P92_S1.9491.00
336_Y357_Q1.9461.00
247_I337_F1.9351.00
79_A82_T1.9141.00
343_L346_Y1.8830.99
325_T329_T1.8810.99
77_I95_V1.8610.99
247_I351_L1.8530.99
142_K357_Q1.8510.99
369_K374_I1.8410.99
262_R348_Q1.8330.99
267_D270_S1.8250.99
256_R325_T1.8050.99
70_G83_A1.7570.99
228_R256_R1.7540.99
75_M79_A1.7510.99
254_K378_G1.7480.99
261_L274_A1.7370.99
146_E368_F1.7350.99
75_M83_A1.7160.99
58_H113_A1.6740.99
234_W252_D1.6730.99
89_S93_R1.6550.99
141_M357_Q1.6550.99
70_G75_M1.6460.99
134_L138_K1.6380.99
259_I278_K1.6230.98
315_C323_R1.6170.98
228_R325_T1.6160.98
81_A88_P1.6130.98
167_E171_K1.6130.98
225_I289_S1.6060.98
92_S96_Q1.5820.98
301_H305_T1.5770.98
248_A261_L1.5760.98
151_W155_T1.5680.98
117_A120_P1.5460.98
231_L252_D1.5440.98
191_R331_G1.5400.98
215_G294_R1.5320.98
335_Q361_R1.5300.98
356_A360_N1.5250.98
251_V258_T1.5050.97
154_R369_K1.4920.97
251_V325_T1.4900.97
240_S266_K1.4880.97
337_F343_L1.4740.97
77_I88_P1.4530.97
225_I252_D1.4420.97
236_G250_L1.4380.97
258_T329_T1.4340.97
78_R82_T1.4250.96
251_V329_T1.4050.96
112_R116_M1.3780.96
70_G95_V1.3720.96
79_A83_A1.3640.95
332_L361_R1.3620.95
217_P316_D1.3570.95
213_V299_A1.3360.95
275_L304_F1.3350.95
223_R226_D1.3330.95
59_L67_I1.3280.95
256_R366_L1.3180.94
138_K143_W1.3130.94
145_P169_I1.2990.94
292_W323_R1.2870.94
247_I260_I1.2850.94
147_Q190_R1.2830.94
352_D355_A1.2730.93
153_R163_R1.2560.93
224_N230_S1.2550.93
333_I354_V1.2500.93
65_E69_A1.2270.92
235_E253_R1.2220.92
77_I81_A1.2170.92
364_K368_F1.2170.92
326_N330_N1.2130.92
87_S92_S1.2110.92
95_V99_R1.2110.92
212_I301_H1.2060.91
348_Q355_A1.1750.90
98_N109_A1.1670.90
76_S79_A1.1620.90
98_N112_R1.1620.90
366_L371_P1.1520.89
250_L271_V1.1490.89
257_Y372_K1.1460.89
248_A263_L1.1420.89
360_N372_K1.1390.89
60_T86_R1.1380.89
89_S92_S1.1360.89
179_E182_H1.1190.88
61_L65_E1.0990.87
228_R253_R1.0930.87
86_R91_I1.0910.87
221_R291_T1.0810.86
78_R92_S1.0800.86
87_S93_R1.0750.86
147_Q335_Q1.0740.86
154_R367_K1.0700.86
260_I354_V1.0640.85
233_H288_K1.0600.85
369_K373_E1.0540.85
64_R94_E1.0510.85
350_E353_L1.0450.84
258_T358_L1.0430.84
230_S288_K1.0420.84
233_H289_S1.0420.84
319_S322_Q1.0270.83
337_F346_Y1.0190.83
240_S244_N1.0090.82
71_L99_R1.0070.82
316_D319_S0.9970.81
113_A120_P0.9950.81
66_E69_A0.9860.81
109_A112_R0.9830.80
261_L278_K0.9790.80
147_Q361_R0.9770.80
143_W370_T0.9700.79
108_D112_R0.9690.79
268_S299_A0.9590.79
250_L275_L0.9540.78
135_V169_I0.9410.77
142_K188_H0.9360.77
67_I84_L0.9350.77
328_N332_L0.9330.77
328_N331_G0.9320.77
292_W312_V0.9270.76
134_L151_W0.9270.76
246_H266_K0.9240.76
81_A92_S0.9240.76
253_R256_R0.9230.76
216_T305_T0.9220.76
146_E166_P0.9140.75
315_C326_N0.9130.75
342_C345_Q0.9130.75
70_G84_L0.9080.75
138_K141_M0.9070.75
352_D356_A0.9070.75
84_L88_P0.9040.74
268_S272_N0.9040.74
294_R318_Q0.9030.74
238_L246_H0.8990.74
292_W298_L0.8980.74
63_E66_E0.8980.74
245_S262_R0.8960.74
185_N192_S0.8940.74
233_H252_D0.8840.73
247_I333_I0.8760.72
142_K336_Y0.8730.72
278_K352_D0.8700.72
94_E104_Y0.8700.72
149_S169_I0.8690.71
292_W326_N0.8670.71
139_L148_I0.8650.71
304_F308_T0.8630.71
248_A271_V0.8630.71
236_G312_V0.8570.70
130_P159_Q0.8560.70
217_P294_R0.8480.70
227_N254_K0.8440.69
63_E84_L0.8420.69
266_K272_N0.8400.69
100_G105_K0.8360.68
236_G323_R0.8350.68
263_L274_A0.8300.68
222_S228_R0.8280.68
145_P173_L0.8280.68
269_V303_E0.8250.67
305_T311_K0.8240.67
241_G339_K0.8190.67
216_T311_K0.8120.66
70_G73_A0.8100.66
333_I337_F0.8100.66
276_T307_S0.8080.66
239_V260_I0.8060.66
272_N300_R0.8060.66
241_G323_R0.8050.66
333_I343_L0.8010.65
151_W370_T0.8000.65
117_A121_K0.7980.65
77_I84_L0.7970.65
272_N303_E0.7970.65
358_L361_R0.7960.65
190_R361_R0.7950.65
71_L77_I0.7950.65
263_L266_K0.7940.64
231_L254_K0.7930.64
320_P358_L0.7930.64
159_Q162_L0.7910.64
276_T304_F0.7900.64
249_T326_N0.7840.63
353_L357_Q0.7820.63
287_R310_V0.7790.63
346_Y350_E0.7780.63
370_T373_E0.7760.63
333_I355_A0.7690.62
258_T333_I0.7680.62
304_F312_V0.7670.62
239_V258_T0.7650.62
358_L371_P0.7630.61
68_R105_K0.7570.61
266_K271_V0.7570.61
294_R298_L0.7560.61
273_Q276_T0.7520.60
151_W154_R0.7500.60
351_L354_V0.7500.60
149_S164_I0.7490.60
115_R118_K0.7480.60
261_L275_L0.7480.60
111_N115_R0.7460.60
64_R104_Y0.7430.59
82_T88_P0.7420.59
294_R320_P0.7400.59
60_T63_E0.7390.59
138_K151_W0.7370.59
197_H203_R0.7340.58
145_P148_I0.7320.58
146_E150_G0.7300.58
125_L320_P0.7280.58
263_L271_V0.7270.58
218_I255_S0.7240.57
78_R87_S0.7220.57
341_T346_Y0.7190.57
87_S90_T0.7190.57
109_A116_M0.7170.57
165_S317_P0.7120.56
132_R136_L0.7120.56
366_L374_I0.7110.56
207_R242_T0.7080.56
134_L373_E0.7060.55
139_L145_P0.7060.55
80_I95_V0.7030.55
236_G326_N0.7010.55
76_S82_T0.7010.55
84_L87_S0.7010.55
142_K335_Q0.6980.55
167_E174_Y0.6980.55
67_I87_S0.6970.54
247_I354_V0.6960.54
289_S311_K0.6950.54
212_I266_K0.6940.54
218_I221_R0.6930.54
332_L335_Q0.6930.54
272_N304_F0.6890.54
210_I296_M0.6870.53
250_L355_A0.6860.53
190_R332_L0.6860.53
279_F283_P0.6850.53
245_S344_A0.6820.53
221_R253_R0.6810.53
221_R233_H0.6800.53
224_N233_H0.6780.52
347_T350_E0.6740.52
270_S273_Q0.6740.52
366_L370_T0.6720.52
62_S65_E0.6710.52
253_R324_G0.6700.52
248_A275_L0.6690.51
77_I93_R0.6650.51
246_H263_L0.6650.51
69_A106_A0.6650.51
146_E149_S0.6610.51
228_R234_W0.6610.51
76_S88_P0.6600.51
65_E105_K0.6590.50
64_R109_A0.6570.50
248_A298_L0.6530.50
247_I355_A0.6520.50
56_V87_S0.6520.50
67_I80_I0.6520.50
135_V173_L0.6500.49
262_R346_Y0.6500.49
343_L351_L0.6500.49
329_T358_L0.6490.49
143_W148_I0.6490.49
280_L311_K0.6470.49
73_A83_A0.6470.49
240_S243_K0.6430.49
221_R289_S0.6430.49
183_H187_Q0.6420.49
222_S324_G0.6410.48
135_V148_I0.6400.48
310_V351_L0.6390.48
221_R235_E0.6340.48
76_S92_S0.6330.48
241_G250_L0.6310.47
195_L198_G0.6300.47
275_L292_W0.6290.47
167_E193_H0.6270.47
218_I222_S0.6260.47
224_N228_R0.6260.47
216_T315_C0.6260.47
66_E83_A0.6250.47
81_A89_S0.6250.47
65_E68_R0.6210.46
349_H356_A0.6200.46
336_Y361_R0.6200.46
135_V139_L0.6190.46
252_D289_S0.6180.46
258_T355_A0.6160.46
262_R351_L0.6150.46
120_P238_L0.6140.46
221_R252_D0.6140.46
326_N331_G0.6120.45
91_I100_G0.6110.45
245_S342_C0.6110.45
221_R228_R0.6100.45
231_L375_I0.6100.45
134_L155_T0.6090.45
120_P123_C0.6050.45
141_M360_N0.6050.45
148_I152_L0.6050.45
251_V326_N0.6040.45
257_Y355_A0.6040.45
89_S190_R0.6030.44
279_F375_I0.6000.44
238_L263_L0.5990.44
216_T301_H0.5990.44
77_I86_R0.5980.44
246_H265_G0.5980.44
216_T220_E0.5980.44
77_I89_S0.5970.44
116_M367_K0.5950.44
94_E109_A0.5940.43
113_A117_A0.5930.43
134_L143_W0.5920.43
81_A90_T0.5890.43
112_R115_R0.5880.43
329_T371_P0.5860.43
232_G252_D0.5840.42
242_T342_C0.5840.42
143_W366_L0.5830.42
92_S249_T0.5820.42
152_L163_R0.5820.42
358_L363_R0.5810.42
279_F287_R0.5810.42
248_A278_K0.5810.42
348_Q351_L0.5800.42
96_Q99_R0.5790.42
238_L266_K0.5790.42
193_H292_W0.5790.42
269_V356_A0.5760.42
354_V357_Q0.5760.42
202_T207_R0.5750.41
172_T294_R0.5740.41
253_R291_T0.5740.41
140_E319_S0.5730.41
250_L290_L0.5700.41
256_R324_G0.5690.41
134_L137_E0.5690.41
266_K313_Y0.5680.41
241_G271_V0.5670.41
137_E140_E0.5670.41
359_N363_R0.5660.41
269_V273_Q0.5640.40
71_L80_I0.5640.40
178_R182_H0.5630.40
174_Y287_R0.5620.40
142_K366_L0.5620.40
99_R102_R0.5610.40
278_K320_P0.5610.40
233_H291_T0.5600.40
165_S168_T0.5580.40
69_A72_S0.5580.40
211_N214_N0.5580.40
315_C330_N0.5580.40
222_S321_W0.5570.40
257_Y299_A0.5560.40
232_G291_T0.5540.39
68_R72_S0.5540.39
187_Q343_L0.5540.39
100_G112_R0.5530.39
168_T171_K0.5520.39
369_K372_K0.5510.39
208_G212_I0.5490.39
59_L86_R0.5490.39
60_T140_E0.5480.39
72_S282_L0.5480.39
337_F351_L0.5470.39
346_Y351_L0.5460.39
263_L270_S0.5430.38
142_K242_T0.5430.38
222_S225_I0.5430.38
290_L298_L0.5430.38
313_Y333_I0.5410.38
178_R183_H0.5400.38
325_T365_T0.5380.38
182_H347_T0.5380.38
150_G364_K0.5370.38
100_G103_Y0.5370.38
174_Y185_N0.5370.38
239_V247_I0.5360.37
147_Q286_L0.5360.37
236_G266_K0.5350.37
61_L110_N0.5350.37
76_S91_I0.5330.37
234_W259_I0.5320.37
174_Y189_L0.5310.37
211_N296_M0.5310.37
236_G275_L0.5300.37
91_I267_D0.5300.37
306_V309_G0.5290.37
208_G296_M0.5270.37
261_L277_D0.5270.37
222_S291_T0.5270.37
314_F366_L0.5260.36
74_K79_A0.5260.36
259_I355_A0.5260.36
301_H314_F0.5230.36
139_L147_Q0.5230.36
192_S335_Q0.5220.36
212_I305_T0.5220.36
150_G256_R0.5200.36
58_H267_D0.5190.36
78_R122_P0.5190.36
263_L272_N0.5180.36
271_V274_A0.5170.36
196_R283_P0.5160.36
234_W256_R0.5150.35
193_H342_C0.5150.35
290_L310_V0.5150.35
349_H353_L0.5130.35
248_A294_R0.5110.35
249_T371_P0.5100.35
370_T374_I0.5100.35
75_M319_S0.5100.35
336_Y358_L0.5090.35
283_P287_R0.5090.35
82_T342_C0.5080.35
246_H268_S0.5080.35
258_T325_T0.5080.35
56_V93_R0.5060.35
58_H298_L0.5060.35
250_L363_R0.5060.35
62_S91_I0.5060.35
281_S349_H0.5060.35
239_V245_S0.5040.34
101_R111_N0.5030.34
194_S306_V0.5030.34
58_H69_A0.5030.34
276_T309_G0.5020.34
185_N188_H0.5010.34
257_Y375_I0.5000.34
86_R321_W0.5000.34
255_S379_V0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fcyA 4 0.7572 100 0.771 Contact Map
4pa1A 2 0.389 99.9 0.818 Contact Map
3kksA 2 0.3864 99.9 0.83 Contact Map
4cf8A 2 0.3812 99.9 0.832 Contact Map
3l3uA 2 0.3916 99.9 0.835 Contact Map
1ex4A 5 0.389 99.9 0.836 Contact Map
1c6vA 4 0.3708 99.9 0.837 Contact Map
3f9kA 5 0.5352 99.8 0.844 Contact Map
1k6yA 4 0.4909 99.8 0.847 Contact Map
4fw1A 2 0.4099 99.8 0.848 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0103 seconds.