GREMLIN Database
INSI1 - Transposase InsI for insertion sequence element IS30A
UniProt: P0CF88 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG40009
Length: 383 (317)
Sequences: 1242 (976)
Seq/√Len: 54.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
316_D322_Q4.9711.00
78_R88_P4.8221.00
255_S374_I4.5081.00
110_N114_N4.4901.00
337_F354_V4.4751.00
71_L95_V4.1861.00
256_R365_T3.9931.00
84_L91_I3.8601.00
63_E86_R3.8291.00
146_E364_K3.4131.00
219_H316_D3.2481.00
230_S233_H3.2191.00
68_R106_A3.1851.00
323_R326_N3.1591.00
348_Q352_D2.9481.00
150_G368_F2.9041.00
151_W373_E2.8241.00
219_H322_Q2.6951.00
265_G270_S2.6791.00
236_G292_W2.6141.00
260_I355_A2.4811.00
98_N116_M2.4521.00
260_I333_I2.3971.00
190_R335_Q2.2271.00
369_K377_R2.1971.00
66_E70_G2.1571.00
77_I92_S2.1321.00
300_R303_E2.0401.00
59_L90_T2.0041.00
336_Y357_Q1.9731.00
214_N302_L1.9681.00
247_I337_F1.9531.00
88_P92_S1.9441.00
247_I351_L1.8901.00
343_L346_Y1.8800.99
325_T329_T1.8780.99
79_A82_T1.8620.99
77_I95_V1.8620.99
369_K374_I1.8540.99
262_R348_Q1.8300.99
142_K357_Q1.8240.99
267_D270_S1.8180.99
256_R325_T1.8050.99
228_R256_R1.7650.99
70_G83_A1.7490.99
146_E368_F1.7440.99
234_W252_D1.7370.99
75_M79_A1.7360.99
261_V274_A1.7240.99
75_M83_A1.7080.99
225_I289_S1.7070.99
254_K378_G1.6680.99
70_G75_M1.6640.99
134_L138_K1.6620.99
89_S93_R1.6470.99
141_M357_Q1.6340.99
58_H113_A1.6290.99
315_C323_R1.6290.99
231_L252_D1.6230.98
259_I278_K1.6050.98
117_A120_P1.5950.98
167_E171_K1.5900.98
228_R325_T1.5900.98
81_A88_P1.5890.98
248_A261_V1.5770.98
251_V258_T1.5680.98
191_R331_G1.5660.98
215_G294_R1.5550.98
92_S96_Q1.5460.98
301_H305_T1.5440.98
335_Q361_R1.5430.98
240_S266_K1.5230.98
356_A360_N1.5080.98
251_V325_T1.4930.97
337_F343_L1.4920.97
151_W155_T1.4770.97
236_G250_L1.4620.97
154_R369_K1.4520.97
258_T329_T1.4460.97
77_I88_P1.4450.97
251_V329_T1.4340.97
225_I252_D1.4330.97
78_R82_T1.4250.96
332_L361_R1.3970.96
223_R226_D1.3890.96
217_P316_D1.3630.95
70_G95_V1.3600.95
112_R116_M1.3500.95
256_R366_L1.3450.95
79_A83_A1.3390.95
275_L304_F1.3280.95
247_I260_I1.3270.95
59_L67_I1.3080.94
145_P169_I1.2940.94
147_Q190_R1.2920.94
213_V299_A1.2850.94
292_W323_R1.2740.93
352_D355_A1.2740.93
65_E69_A1.2500.93
224_N230_S1.2460.93
153_R163_R1.2440.93
138_K143_W1.2370.92
333_I354_V1.2320.92
235_E253_R1.2210.92
364_K368_F1.2120.92
77_I81_A1.2120.92
76_S79_A1.2070.91
326_N330_N1.2060.91
87_S92_S1.1990.91
248_A263_L1.1890.91
250_L271_V1.1880.91
212_I301_H1.1760.90
98_N109_A1.1720.90
348_Q355_A1.1700.90
98_N112_R1.1670.90
366_L371_P1.1500.89
89_S92_S1.1480.89
95_V99_R1.1420.89
78_R92_S1.1270.88
154_R367_K1.1260.88
60_T86_R1.1150.88
179_E182_H1.1140.88
257_Y372_K1.1130.88
61_L65_E1.1110.88
228_R253_R1.1020.87
360_N372_K1.0970.87
64_R94_E1.0920.87
86_R91_I1.0870.87
221_R291_T1.0800.86
260_I354_V1.0720.86
147_Q335_Q1.0720.86
87_S93_R1.0500.85
319_S322_Q1.0480.84
350_E353_L1.0400.84
233_H289_S1.0360.84
369_K373_E1.0220.83
240_S244_N1.0200.83
316_D319_S1.0190.83
109_A112_R1.0180.83
230_S288_K1.0160.83
66_E69_A1.0140.82
71_L99_R1.0110.82
337_F346_Y1.0110.82
233_H288_K1.0090.82
258_T358_L1.0090.82
108_D112_R0.9890.81
261_V278_K0.9860.81
135_V169_I0.9770.80
147_Q361_R0.9570.79
134_L151_W0.9540.78
268_S299_A0.9540.78
315_C326_N0.9510.78
67_I84_L0.9480.78
113_A120_P0.9480.78
142_K188_H0.9470.78
328_N332_L0.9380.77
216_T305_T0.9370.77
138_K141_M0.9340.77
250_L275_L0.9310.77
328_N331_G0.9300.77
238_L246_H0.9270.76
294_R318_Q0.9210.76
253_R256_R0.9210.76
352_D356_A0.9170.76
63_E66_E0.9170.76
143_W370_T0.9140.75
139_L148_I0.9140.75
142_K336_Y0.9140.75
130_P159_Q0.9130.75
146_E166_P0.9090.75
81_A92_S0.9080.75
247_I333_I0.9070.75
292_W312_V0.9040.75
342_C345_Q0.9010.74
246_H266_K0.9000.74
292_W298_L0.9000.74
94_E104_Y0.8930.74
70_G84_L0.8920.74
84_L88_P0.8920.74
233_H252_D0.8900.73
149_S169_I0.8840.73
217_P294_R0.8740.72
278_K352_D0.8700.72
268_S272_N0.8680.71
245_S262_R0.8660.71
248_A271_V0.8610.71
185_N192_S0.8550.70
239_V260_I0.8510.70
227_N254_K0.8480.70
292_W326_N0.8470.70
272_N303_E0.8450.69
241_G339_K0.8400.69
117_A121_K0.8380.69
231_L254_K0.8370.69
241_G323_R0.8310.68
276_T307_S0.8310.68
63_E84_L0.8310.68
346_Y350_E0.8290.68
236_G323_R0.8270.68
266_K272_N0.8260.68
222_S228_R0.8260.68
305_T311_K0.8260.68
145_P173_L0.8180.67
263_L274_A0.8170.67
190_R361_R0.8170.67
333_I355_A0.8120.66
236_G312_V0.8110.66
70_G73_A0.8050.66
272_N300_R0.7990.65
304_F308_T0.7980.65
64_R104_Y0.7980.65
358_L361_R0.7960.65
216_T311_K0.7960.65
77_I84_L0.7950.65
149_S164_I0.7860.64
276_T304_F0.7850.64
273_Q276_T0.7840.64
151_W370_T0.7810.63
333_I343_L0.7810.63
78_R87_S0.7770.63
111_N115_R0.7760.63
333_I337_F0.7760.63
239_V258_T0.7760.63
249_T326_N0.7750.63
263_L266_K0.7730.63
258_T333_I0.7730.63
294_R320_P0.7720.62
287_R310_V0.7700.62
261_V275_L0.7660.62
82_T88_P0.7660.62
100_G105_K0.7660.62
266_K271_V0.7630.62
269_V303_E0.7610.61
71_L77_I0.7590.61
304_F312_V0.7590.61
294_R298_L0.7520.60
159_Q162_L0.7510.60
134_L373_E0.7500.60
353_L357_Q0.7490.60
145_P148_I0.7490.60
358_L371_P0.7480.60
370_T373_E0.7440.60
351_L354_V0.7440.60
60_T63_E0.7420.59
151_W154_R0.7410.59
68_R105_K0.7380.59
115_R118_K0.7290.58
221_R253_R0.7280.58
366_L374_I0.7270.58
138_K151_W0.7270.58
332_L335_Q0.7260.58
272_N304_F0.7250.58
221_R233_H0.7240.57
146_E150_G0.7190.57
224_N233_H0.7180.57
347_T350_E0.7180.57
190_R332_L0.7160.57
341_T346_Y0.7160.57
139_L145_P0.7160.57
320_P358_L0.7130.56
218_I221_R0.7120.56
80_I95_V0.7100.56
210_I296_M0.7050.55
197_H203_R0.7050.55
132_R136_L0.7040.55
289_S311_K0.7030.55
64_R109_A0.7010.55
195_L198_G0.7000.55
142_K335_Q0.6990.55
250_L355_A0.6960.55
247_I354_V0.6960.55
76_S82_T0.6920.54
263_L271_V0.6920.54
87_S90_T0.6880.54
236_G326_N0.6850.53
279_F283_P0.6820.53
67_I87_S0.6810.53
253_R324_G0.6800.53
167_E174_Y0.6800.53
231_L375_I0.6720.52
109_A116_M0.6710.52
62_S65_E0.6670.51
125_L320_P0.6670.51
84_L87_S0.6660.51
56_V87_S0.6650.51
218_I255_S0.6600.51
212_I266_K0.6600.51
120_P238_L0.6590.51
245_S344_A0.6570.50
222_S324_G0.6570.50
207_R242_T0.6570.50
165_S317_P0.6540.50
202_T207_R0.6540.50
76_S88_P0.6510.50
248_A298_L0.6500.50
65_E105_K0.6490.49
77_I93_R0.6460.49
221_R289_S0.6460.49
241_G250_L0.6460.49
143_W148_I0.6460.49
216_T315_C0.6450.49
248_A275_L0.6400.49
258_T355_A0.6390.48
221_R235_E0.6370.48
270_S273_Q0.6360.48
135_V139_L0.6350.48
81_A89_S0.6340.48
228_R234_W0.6340.48
146_E149_S0.6330.48
310_V351_L0.6330.48
240_S243_K0.6320.48
366_L370_T0.6300.47
275_L292_W0.6290.47
280_L311_K0.6290.47
329_T358_L0.6290.47
94_E109_A0.6280.47
246_H263_L0.6270.47
66_E83_A0.6240.47
140_E319_S0.6220.47
73_A83_A0.6220.47
247_I355_A0.6210.46
224_N228_R0.6200.46
113_A117_A0.6190.46
67_I80_I0.6190.46
246_H265_G0.6170.46
221_R228_R0.6160.46
69_A106_A0.6140.46
262_R346_Y0.6130.46
245_S342_C0.6120.46
135_V173_L0.6120.46
343_L351_L0.6090.45
348_Q351_L0.6080.45
262_R351_L0.6080.45
238_L263_L0.6080.45
65_E68_R0.6080.45
208_G296_M0.6080.45
76_S92_S0.6080.45
221_R252_D0.6040.45
183_H187_Q0.6040.45
329_T371_P0.6030.45
77_I86_R0.6020.44
150_G364_K0.6020.44
326_N331_G0.6000.44
251_V326_N0.5990.44
91_I100_G0.5990.44
77_I89_S0.5990.44
112_R115_R0.5980.44
336_Y361_R0.5980.44
279_F375_I0.5970.44
135_V148_I0.5960.44
120_P123_C0.5940.44
216_T220_E0.5930.43
167_E193_H0.5920.43
207_R210_I0.5910.43
248_A278_K0.5910.43
216_T301_H0.5900.43
148_I152_L0.5890.43
125_L132_R0.5870.43
89_S190_R0.5860.43
152_L163_R0.5860.43
346_Y351_L0.5850.43
172_T294_R0.5850.43
279_F287_R0.5850.43
354_V357_Q0.5840.43
100_G103_Y0.5830.42
142_K366_L0.5820.42
143_W366_L0.5820.42
252_D289_S0.5800.42
187_Q343_L0.5790.42
253_R291_T0.5780.42
242_T342_C0.5780.42
256_R324_G0.5770.42
195_L199_R0.5760.42
222_S225_I0.5740.42
193_H292_W0.5730.41
134_L155_T0.5730.41
336_Y358_L0.5710.41
178_R182_H0.5700.41
68_R72_S0.5700.41
232_G252_D0.5690.41
174_Y189_L0.5690.41
257_Y299_A0.5690.41
257_Y355_A0.5680.41
91_I267_D0.5660.41
349_H356_A0.5660.41
141_M360_N0.5650.41
337_F351_L0.5640.40
71_L80_I0.5640.40
137_E140_E0.5630.40
234_W259_I0.5630.40
241_G271_V0.5600.40
233_H291_T0.5600.40
97_R104_Y0.5590.40
301_H314_F0.5580.40
246_H268_S0.5580.40
290_L298_L0.5570.40
232_G291_T0.5570.40
238_L266_K0.5560.40
222_S321_W0.5550.40
116_M367_K0.5550.40
314_F366_L0.5540.39
218_I222_S0.5540.39
99_R102_R0.5530.39
290_L310_V0.5530.39
59_L86_R0.5510.39
150_G256_R0.5500.39
349_H353_L0.5490.39
263_L270_S0.5480.39
369_K372_K0.5480.39
269_V273_Q0.5460.39
269_V356_A0.5460.39
250_L290_L0.5440.38
69_A72_S0.5440.38
61_L110_N0.5430.38
147_Q286_L0.5420.38
325_T365_T0.5410.38
81_A90_T0.5400.38
74_K79_A0.5380.38
266_K313_Y0.5380.38
249_T371_P0.5360.38
134_L137_E0.5360.38
174_Y185_N0.5350.38
222_S291_T0.5340.37
142_K242_T0.5330.37
101_R111_N0.5290.37
78_R122_P0.5280.37
306_V309_G0.5280.37
211_N214_N0.5260.37
229_R254_K0.5260.37
56_V93_R0.5250.37
134_L143_W0.5220.36
239_V247_I0.5220.36
236_G266_K0.5220.36
255_S378_G0.5210.36
359_N363_R0.5210.36
239_V246_H0.5200.36
358_L363_R0.5190.36
98_N121_K0.5190.36
82_T342_C0.5190.36
278_K320_P0.5180.36
168_T171_K0.5170.36
178_R183_H0.5170.36
196_R283_P0.5170.36
174_Y287_R0.5160.36
314_F361_R0.5160.36
76_S91_I0.5150.36
248_A294_R0.5150.36
370_T374_I0.5140.35
136_L173_L0.5140.35
125_L165_S0.5140.35
208_G212_I0.5130.35
64_R80_I0.5120.35
263_L272_N0.5110.35
92_S249_T0.5110.35
139_L147_Q0.5110.35
259_I355_A0.5110.35
271_V274_A0.5100.35
236_G275_L0.5090.35
283_P287_R0.5090.35
165_S168_T0.5080.35
313_Y333_I0.5080.35
282_L375_I0.5080.35
194_S306_V0.5070.35
234_W256_R0.5070.35
185_N188_H0.5070.35
132_R135_V0.5050.35
94_E97_R0.5050.35
193_H342_C0.5050.35
258_T325_T0.5040.34
212_I296_M0.5030.34
315_C330_N0.5030.34
268_S279_F0.5020.34
239_V346_Y0.5010.34
279_F309_G0.5010.34
58_H298_L0.5010.34
241_G326_N0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fcyA 4 0.7572 100 0.772 Contact Map
4pa1A 2 0.389 99.9 0.816 Contact Map
3kksA 2 0.389 99.9 0.83 Contact Map
4cf8A 2 0.3812 99.9 0.831 Contact Map
3l3uA 2 0.3916 99.9 0.833 Contact Map
1ex4A 5 0.389 99.9 0.835 Contact Map
1c6vA 4 0.3708 99.9 0.836 Contact Map
3f9kA 5 0.5326 99.8 0.844 Contact Map
4fw1A 2 0.4099 99.8 0.846 Contact Map
1k6yA 4 0.4909 99.8 0.846 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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