GREMLIN Database
INSF4 - Transposase InsF for insertion sequence IS3D
UniProt: P0CF82 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG40006
Length: 288 (251)
Sequences: 10928 (8038)
Seq/√Len: 507.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
150_V234_F2.9011.00
163_S179_M2.5611.00
127_G130_Q2.5281.00
178_Q208_Q2.4411.00
129_N132_W2.4241.00
235_H239_V2.4101.00
158_A280_E2.3721.00
134_G194_T2.2651.00
262_E267_R2.2201.00
50_D92_Q2.1891.00
267_R280_E2.1801.00
133_A230_V2.1601.00
277_L282_F2.1451.00
220_A226_D2.1261.00
70_T74_R2.0941.00
232_S235_H2.0431.00
133_A154_L2.0341.00
126_S130_Q2.0221.00
209_L214_L2.0111.00
150_V230_V2.0041.00
154_L229_C1.9441.00
137_T238_K1.9281.00
196_R218_M1.9001.00
52_V55_A1.8691.00
219_S227_N1.7921.00
278_S281_Q1.7771.00
71_D276_G1.7771.00
75_A281_Q1.7761.00
168_M199_Q1.7731.00
249_S252_I1.7721.00
209_L216_G1.7631.00
167_R172_L1.7561.00
194_T216_G1.7521.00
248_I252_I1.7351.00
163_S175_D1.7231.00
52_V76_Q1.7191.00
46_R84_T1.7161.00
134_G192_V1.7001.00
247_F256_T1.6921.00
130_Q188_R1.6881.00
206_Q216_G1.6761.00
50_D91_R1.6611.00
131_K191_I1.6371.00
158_A283_E1.6291.00
81_N84_T1.6091.00
159_V266_N1.6001.00
25_A28_G1.5931.00
136_I199_Q1.5691.00
19_C29_W1.5591.00
132_W180_A1.5411.00
170_A174_C1.5291.00
159_V233_F1.5261.00
72_E76_Q1.5211.00
237_L257_V1.5171.00
134_G200_Y1.5141.00
196_R221_K1.5071.00
72_E270_R1.4771.00
241_C256_T1.4751.00
230_V234_F1.4721.00
174_C208_Q1.4651.00
232_S236_S1.4541.00
208_Q212_H1.4161.00
86_A90_R1.3981.00
66_A86_A1.3921.00
64_Y68_R1.3781.00
132_W151_V1.3621.00
157_R271_H1.3561.00
148_L237_L1.3531.00
157_R229_C1.3431.00
138_Y147_Y1.3331.00
169_T172_L1.3321.00
240_E269_R1.3281.00
236_S265_Y1.3231.00
156_S282_F1.3201.00
174_C204_D1.3191.00
70_T85_V1.3171.00
138_Y145_W1.3051.00
151_V180_A1.2881.00
54_L58_T1.2731.00
53_V69_L1.2661.00
140_R145_W1.2521.00
149_A200_Y1.2441.00
201_C218_M1.2391.00
68_R240_E1.2291.00
262_E268_W1.2251.00
50_D54_L1.2201.00
193_H217_S1.2191.00
134_G151_V1.2181.00
151_V176_A1.2101.00
274_C282_F1.2091.00
225_Y228_A1.2051.00
265_Y271_H1.2031.00
254_R258_F1.2021.00
159_V261_I1.1961.00
191_I217_S1.1901.00
223_C226_D1.1881.00
277_L281_Q1.1851.00
149_A176_A1.1831.00
70_T82_V1.1701.00
125_A131_K1.1691.00
133_A229_C1.1681.00
50_D88_S1.1671.00
220_A223_C1.1561.00
253_M257_V1.1451.00
27_S30_Y1.1421.00
51_S55_A1.1401.00
128_P156_S1.1361.00
157_R273_W1.1351.00
146_L253_M1.1331.00
207_A211_R1.1301.00
219_S226_D1.1281.00
170_A204_D1.1261.00
161_G176_A1.1241.00
75_A270_R1.1231.00
131_K154_L1.1221.00
156_S283_E1.1181.00
181_L214_L1.1171.00
125_A130_Q1.1011.00
58_T62_Q1.0971.00
148_L162_W1.0971.00
52_V78_Y1.0961.00
133_A227_N1.0921.00
146_L250_R1.0871.00
84_T87_A1.0871.00
72_E75_A1.0861.00
52_V56_A1.0841.00
66_A82_V1.0831.00
274_C278_S1.0771.00
162_W261_I1.0741.00
199_Q202_S1.0731.00
241_C247_F1.0711.00
127_G155_W1.0601.00
83_K86_A1.0521.00
193_H226_D1.0471.00
166_P250_R1.0471.00
171_Q204_D1.0431.00
131_K193_H1.0331.00
198_G201_C1.0291.00
27_S31_T1.0271.00
82_V86_A1.0241.00
152_I230_V1.0231.00
26_R30_Y1.0231.00
137_T234_F1.0231.00
261_I266_N1.0171.00
160_I183_R1.0161.00
54_L92_Q1.0161.00
272_S276_G1.0131.00
56_A72_E1.0131.00
136_I168_M1.0061.00
49_C52_V0.9981.00
47_Q51_S0.9971.00
252_I256_T0.9831.00
127_G188_R0.9821.00
161_G179_M0.9781.00
270_R274_C0.9691.00
278_S282_F0.9681.00
250_R254_R0.9631.00
181_L212_H0.9621.00
205_Y209_L0.9621.00
271_H274_C0.9581.00
165_S172_L0.9571.00
128_P155_W0.9561.00
170_A202_S0.9521.00
46_R49_C0.9501.00
256_T259_N0.9391.00
28_G32_W0.9331.00
173_A205_Y0.9311.00
164_M254_R0.9211.00
194_T218_M0.9211.00
83_K87_A0.9171.00
49_C80_F0.9141.00
152_I229_C0.9031.00
198_G202_S0.9001.00
274_C277_L0.8951.00
192_V205_Y0.8921.00
171_Q175_D0.8871.00
152_I159_V0.8861.00
136_I173_A0.8831.00
48_H52_V0.8811.00
129_N283_E0.8811.00
45_F49_C0.8791.00
245_E256_T0.8761.00
88_S92_Q0.8751.00
92_Q95_R0.8721.00
149_A172_L0.8691.00
241_C260_Y0.8691.00
150_V233_F0.8631.00
24_V29_W0.8621.00
233_F237_L0.8621.00
45_F84_T0.8601.00
57_F62_Q0.8541.00
53_V88_S0.8541.00
227_N230_V0.8501.00
182_W185_K0.8481.00
258_F262_E0.8431.00
29_W33_C0.8431.00
206_Q210_K0.8411.00
28_G31_T0.8311.00
55_A59_R0.8311.00
27_S34_Q0.8311.00
192_V214_L0.8291.00
174_C178_Q0.8231.00
133_A228_A0.8191.00
207_A210_K0.8151.00
39_I47_Q0.8151.00
57_F94_L0.8151.00
203_A207_A0.8131.00
233_F265_Y0.8091.00
125_A154_L0.8091.00
191_I215_R0.8091.00
134_G149_A0.7941.00
141_T144_G0.7931.00
263_C268_W0.7931.00
56_A69_L0.7911.00
64_Y72_E0.7911.00
141_T146_L0.7881.00
122_D131_K0.7851.00
24_V28_G0.7811.00
168_M198_G0.7811.00
47_Q50_D0.7811.00
136_I147_Y0.7791.00
84_T88_S0.7761.00
31_T35_R0.7741.00
18_M22_L0.7721.00
177_L192_V0.7711.00
160_I180_A0.7681.00
136_I149_A0.7671.00
68_R72_E0.7621.00
202_S205_Y0.7621.00
148_L257_V0.7621.00
132_W160_I0.7621.00
125_A155_W0.7611.00
193_H219_S0.7591.00
59_R268_W0.7571.00
217_S226_D0.7531.00
66_A70_T0.7471.00
69_L89_L0.7431.00
205_Y216_G0.7411.00
152_I157_R0.7411.00
152_I233_F0.7401.00
240_E260_Y0.7391.00
71_D270_R0.7361.00
139_L242_I0.7331.00
81_N85_V0.7321.00
165_S169_T0.7291.00
137_T148_L0.7281.00
197_G200_Y0.7261.00
67_P272_S0.7251.00
80_F85_V0.7211.00
129_N184_R0.7201.00
80_F84_T0.7191.00
164_M257_V0.7191.00
30_Y34_Q0.7161.00
66_A69_L0.7151.00
268_W280_E0.7151.00
196_R201_C0.7111.00
133_A193_H0.7111.00
119_L131_K0.7051.00
147_Y168_M0.7031.00
162_W258_F0.7021.00
181_L186_R0.6981.00
137_T237_L0.6941.00
149_A173_A0.6931.00
252_I255_A0.6921.00
176_A179_M0.6891.00
54_L57_F0.6891.00
60_S63_R0.6881.00
70_T81_N0.6851.00
160_I261_I0.6841.00
161_G180_A0.6771.00
129_N180_A0.6701.00
73_L85_V0.6651.00
33_C36_R0.6641.00
204_D207_A0.6641.00
162_W257_V0.6531.00
74_R79_P0.6521.00
69_L73_L0.6451.00
68_R272_S0.6451.00
158_A266_N0.6401.00
88_S91_R0.6401.00
40_S43_Q0.6391.00
257_V261_I0.6361.00
24_V32_W0.6341.00
192_V216_G0.6341.00
40_S44_Q0.6331.00
44_Q50_D0.6331.00
31_T34_Q0.6331.00
236_S271_H0.6321.00
32_W36_R0.6321.00
168_M172_L0.6311.00
259_N263_C0.6301.00
18_M21_V0.6281.00
174_C205_Y0.6281.00
81_N87_A0.6271.00
179_M183_R0.6261.00
65_G68_R0.6231.00
148_L164_M0.6211.00
53_V85_V0.6201.00
46_R50_D0.6191.00
46_R87_A0.6191.00
55_A76_Q0.6151.00
158_A184_R0.6121.00
175_D178_Q0.6111.00
138_Y168_M0.6081.00
134_G177_L0.6071.00
45_F48_H0.6060.99
204_D208_Q0.6050.99
161_G261_I0.6040.99
219_S222_G0.6040.99
142_D246_H0.6030.99
192_V209_L0.6010.99
194_T205_Y0.5960.99
172_L175_D0.5940.99
251_E254_R0.5940.99
224_C234_F0.5910.99
206_Q218_M0.5910.99
233_F261_I0.5910.99
139_L148_L0.5900.99
184_R283_E0.5870.99
142_D248_I0.5850.99
241_C257_V0.5840.99
270_R277_L0.5810.99
232_S239_V0.5790.99
19_C30_Y0.5770.99
236_S260_Y0.5760.99
165_S168_M0.5760.99
234_F237_L0.5750.99
154_L228_A0.5740.99
139_L253_M0.5720.99
42_R46_R0.5710.99
178_Q182_W0.5700.99
219_S223_C0.5680.99
103_S106_S0.5660.99
49_C57_F0.5640.99
163_S176_A0.5610.99
165_S175_D0.5610.99
22_L29_W0.5590.99
185_K188_R0.5590.99
42_R45_F0.5570.99
74_R82_V0.5570.99
19_C26_R0.5550.99
93_G97_K0.5530.99
205_Y208_Q0.5520.99
203_A206_Q0.5520.99
168_M173_A0.5520.99
95_R98_A0.5520.99
173_A199_Q0.5510.99
144_G166_P0.5510.99
63_R240_E0.5500.99
163_S254_R0.5450.99
61_K245_E0.5450.99
193_H227_N0.5410.99
157_R274_C0.5400.99
61_K64_Y0.5350.99
160_I266_N0.5330.99
162_W179_M0.5310.99
21_V27_S0.5290.99
118_L215_R0.5280.99
260_Y265_Y0.5270.99
177_L205_Y0.5250.99
141_T253_M0.5240.99
175_D179_M0.5240.99
147_Y199_Q0.5210.98
51_S54_L0.5200.98
78_Y84_T0.5180.98
247_F253_M0.5180.98
133_A152_I0.5140.98
176_A180_A0.5100.98
66_A85_V0.5090.98
146_L164_M0.5080.98
45_F50_D0.5070.98
48_H78_Y0.5070.98
44_Q47_Q0.5070.98
54_L94_L0.5020.98
263_C267_R0.5010.98
128_P153_D0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fcyA 4 0.9271 100 0.374 Contact Map
3oymA 3 0.9167 100 0.407 Contact Map
4fw2A 2 0.5312 100 0.481 Contact Map
1k6yA 4 0.6493 100 0.482 Contact Map
3f9kA 5 0.7118 100 0.485 Contact Map
3hphA 3 0.6806 100 0.489 Contact Map
4cf8A 2 0.5035 100 0.491 Contact Map
4u7bA 2 0.9479 100 0.496 Contact Map
1ex4A 5 0.5139 100 0.503 Contact Map
1bcoA 1 0.5625 100 0.503 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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