GREMLIN Database
INSD8 - Putative transposase InsD for insertion element IS2E
UniProt: P0CF60 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG40004
Length: 218 (193)
Sequences: 8231 (5537)
Seq/√Len: 398.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_L128_F2.8131.00
196_R204_Q2.7941.00
65_F154_V2.6541.00
186_E199_R2.6391.00
41_E44_Q2.5841.00
43_N46_W2.4891.00
73_E199_R2.4821.00
182_E186_E2.4511.00
78_A95_G2.4201.00
47_C150_A2.2921.00
155_K159_R2.1471.00
40_K44_Q2.0891.00
48_S114_T2.0721.00
169_D172_T1.9751.00
5_N8_R1.9661.00
197_S200_E1.9441.00
73_E202_L1.9441.00
167_K176_N1.9271.00
196_R201_Y1.8821.00
168_P172_T1.8161.00
69_C149_I1.8131.00
48_S112_W1.8121.00
52_E60_R1.8061.00
47_C69_C1.7981.00
78_A91_D1.7881.00
140_A146_S1.7841.00
161_Y176_N1.7101.00
126_R136_P1.6791.00
51_F158_K1.6771.00
160_D188_H1.6651.00
48_S120_Y1.6601.00
65_F150_A1.6481.00
41_E110_V1.5751.00
86_S90_Q1.5401.00
129_A136_P1.5361.00
46_W96_A1.5281.00
129_A134_L1.5251.00
44_Q110_V1.4971.00
46_W66_A1.4971.00
39_V45_R1.4761.00
84_F119_C1.4691.00
74_A153_F1.4581.00
74_A185_N1.4181.00
152_S156_T1.4171.00
76_H92_V1.4111.00
116_N138_N1.4091.00
10_Y14_R1.4091.00
63_V157_I1.3991.00
64_T120_Y1.3971.00
152_S155_K1.3911.00
157_I177_L1.3811.00
81_T170_G1.3811.00
199_R203_R1.3791.00
90_Q128_F1.3751.00
8_R11_R1.3531.00
113_L137_K1.3491.00
12_I16_N1.3491.00
61_L170_G1.3461.00
50_G119_C1.3431.00
43_N100_R1.3311.00
128_F132_L1.3161.00
72_R190_H1.3091.00
64_T92_V1.2921.00
71_D202_L1.2851.00
161_Y167_K1.2821.00
47_C149_I1.2761.00
114_T136_P1.2681.00
39_V44_Q1.2651.00
139_T147_N1.2601.00
173_A177_L1.2591.00
116_N141_V1.2581.00
54_C60_R1.2531.00
48_S66_A1.2371.00
97_V132_L1.2351.00
193_L201_Y1.2321.00
182_E187_W1.2011.00
97_V134_L1.1951.00
110_V134_L1.1911.00
174_A178_A1.1821.00
170_G174_A1.1791.00
176_N179_E1.1791.00
31_R34_T1.1761.00
145_E148_G1.1701.00
74_A181_F1.1631.00
7_K10_Y1.1521.00
80_T88_T1.1491.00
55_C58_G1.1451.00
86_S122_A1.1391.00
85_N88_T1.1341.00
86_S124_E1.1311.00
197_S201_Y1.1181.00
42_S70_C1.1091.00
66_A92_V1.1081.00
127_Q131_M1.1061.00
172_T176_N1.0881.00
52_E62_R1.0831.00
90_Q124_E1.0631.00
42_S71_D1.0561.00
8_R12_I1.0521.00
66_A96_A1.0521.00
140_A143_S1.0491.00
113_L146_S1.0461.00
123_N127_Q1.0421.00
178_A182_E1.0321.00
191_S195_Y1.0311.00
45_R111_E1.0221.00
193_L197_S1.0131.00
121_R138_N1.0081.00
67_L74_A1.0051.00
165_M176_N1.0051.00
196_R200_E1.0001.00
150_A154_V1.0001.00
63_V77_W0.9921.00
61_L173_A0.9911.00
64_T88_T0.9911.00
83_G88_T0.9861.00
72_R192_A0.9771.00
41_E70_C0.9761.00
84_F118_S0.9691.00
112_W134_L0.9651.00
72_R149_I0.9631.00
112_W125_T0.9421.00
45_R69_C0.9361.00
6_A10_Y0.9311.00
118_S122_A0.9301.00
67_L149_I0.9291.00
114_T138_N0.9251.00
139_T146_S0.9151.00
79_V174_A0.9141.00
111_E137_K0.9141.00
50_G84_F0.9091.00
7_K11_R0.9051.00
56_D166_P0.9051.00
90_Q94_L0.9031.00
43_N202_L0.9021.00
77_W178_A0.8991.00
87_E124_E0.8981.00
73_E100_R0.8951.00
67_L150_A0.8941.00
183_H187_W0.8911.00
65_F153_F0.8911.00
118_S121_R0.8871.00
63_V79_V0.8821.00
153_F157_I0.8741.00
111_E135_E0.8721.00
87_E91_D0.8711.00
76_H95_G0.8651.00
189_P195_Y0.8501.00
126_R130_R0.8351.00
29_S136_P0.8321.00
46_W110_V0.8301.00
200_E203_R0.8271.00
13_M18_L0.8171.00
93_M112_W0.8161.00
71_D201_Y0.8121.00
80_T85_N0.8091.00
48_S64_T0.8011.00
116_N121_R0.7931.00
12_I15_Q0.7881.00
5_N11_R0.7861.00
46_W109_P0.7851.00
190_H193_L0.7811.00
100_R202_L0.7781.00
89_V125_T0.7701.00
119_C122_A0.7691.00
16_N19_L0.7681.00
200_E204_Q0.7661.00
106_P109_P0.7631.00
161_Y180_A0.7531.00
201_Y204_Q0.7501.00
128_F131_M0.7481.00
39_V70_C0.7471.00
30_K34_T0.7471.00
95_G99_R0.7411.00
32_A135_E0.7411.00
52_E84_F0.7401.00
14_R19_L0.7401.00
94_L98_E0.7391.00
160_D180_A0.7381.00
76_H96_A0.7371.00
45_R113_L0.7331.00
153_F184_Y0.7291.00
172_T175_K0.7281.00
11_R15_Q0.7201.00
124_E128_F0.7201.00
75_L96_A0.7151.00
36_R45_R0.7141.00
33_H45_R0.7101.00
64_T89_V0.7071.00
153_F181_F0.7071.00
125_T129_A0.7071.00
122_A125_T0.7041.00
39_V69_C0.7031.00
10_Y19_L0.7021.00
167_K173_A0.7021.00
113_L139_T0.6971.00
21_E25_A0.6941.00
29_S32_A0.6901.00
53_F177_L0.6891.00
127_Q130_R0.6881.00
47_C147_N0.6850.99
67_L72_R0.6840.99
181_F185_N0.6820.99
50_G62_R0.6820.99
156_T180_A0.6780.99
50_G64_T0.6750.99
94_L132_L0.6660.99
77_W181_F0.6640.99
19_L22_R0.6620.99
92_V96_A0.6610.99
161_Y177_L0.6590.99
53_F162_I0.6570.99
156_T190_H0.6550.99
100_R107_S0.6510.99
143_S146_S0.6470.99
124_E127_Q0.6390.99
20_L23_K0.6380.99
57_N170_G0.6370.99
56_D168_P0.6320.99
139_T142_R0.6310.99
80_T84_F0.6270.99
78_A92_V0.6240.99
53_F173_A0.6180.99
84_F88_T0.6180.99
65_F74_A0.6150.99
112_W129_A0.6130.99
87_E90_Q0.6120.99
114_T125_T0.6070.99
46_W75_L0.6010.99
55_C61_L0.6010.99
93_M125_T0.6010.99
46_W100_R0.6000.99
23_K159_R0.5940.99
62_R84_F0.5940.99
93_M129_A0.5940.99
53_F63_V0.5870.98
177_L181_F0.5860.98
125_T136_P0.5860.98
55_C170_G0.5780.98
67_L153_F0.5760.98
78_A88_T0.5760.98
28_P31_R0.5740.98
84_F89_V0.5740.98
21_E164_I0.5730.98
63_V177_L0.5720.98
47_C113_L0.5710.98
184_Y190_H0.5690.98
154_V180_A0.5670.98
43_N96_A0.5640.98
156_T184_Y0.5630.98
51_F154_V0.5620.98
137_K146_S0.5610.98
5_N10_Y0.5600.98
184_Y188_H0.5590.98
73_E186_E0.5550.98
30_K33_H0.5510.98
79_V177_L0.5500.98
91_D94_L0.5470.98
73_E99_R0.5460.98
162_I167_K0.5440.97
78_A174_A0.5430.97
113_L147_N0.5420.97
126_R138_N0.5410.97
62_R119_C0.5360.97
150_A153_F0.5360.97
97_V108_S0.5360.97
171_L174_A0.5340.97
50_G89_V0.5310.97
12_I18_L0.5310.97
93_M134_L0.5300.97
86_S118_S0.5290.97
193_L196_R0.5250.97
31_R37_V0.5250.97
80_T174_A0.5240.97
186_E203_R0.5240.97
141_V144_P0.5210.97
123_N126_R0.5200.97
159_R163_S0.5190.97
13_M20_L0.5180.97
144_P154_V0.5130.96
47_C67_L0.5130.96
112_W136_P0.5110.96
55_C173_A0.5110.96
144_P148_G0.5090.96
93_M128_F0.5050.96
10_Y20_L0.5050.96
35_G145_E0.5030.96
69_C72_R0.5030.96
158_K163_S0.5000.96
89_V112_W0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1bcoA 1 0.7936 100 0.399 Contact Map
4fcyA 4 0.922 100 0.401 Contact Map
3oymA 3 0.9312 100 0.414 Contact Map
4cf8A 2 0.6835 100 0.424 Contact Map
3kksA 2 0.6972 100 0.424 Contact Map
3f9kA 5 0.8257 100 0.431 Contact Map
1k6yA 4 0.7661 100 0.431 Contact Map
1c6vA 4 0.6835 100 0.433 Contact Map
3l3uA 2 0.7018 100 0.433 Contact Map
1ex4A 5 0.7248 100 0.438 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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