GREMLIN Database
INSD4 - Transposase InsD for insertion element IS2H
UniProt: P0CF56 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG40004
Length: 301 (254)
Sequences: 11404 (8534)
Seq/√Len: 535.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
148_F237_V2.8741.00
223_A229_S2.7941.00
279_R287_Q2.7301.00
269_E282_R2.5011.00
131_S197_T2.4911.00
156_E282_R2.4351.00
265_E269_E2.3731.00
124_E127_Q2.3601.00
177_L211_F2.3571.00
72_W76_R2.2251.00
126_N129_W2.2161.00
53_L99_N2.1331.00
238_K242_R2.1111.00
161_A178_G2.0921.00
148_F233_A2.0851.00
130_C233_A2.0341.00
130_C152_C1.9911.00
212_A217_L1.9701.00
280_S283_E1.9651.00
235_S238_K1.9581.00
156_E285_L1.9331.00
123_K127_Q1.8981.00
57_H61_G1.8981.00
152_C232_I1.8821.00
55_R58_H1.8761.00
128_R194_E1.8101.00
18_S28_L1.8081.00
199_N221_N1.7981.00
88_N91_R1.7951.00
134_F241_K1.7701.00
279_R284_Y1.7691.00
251_P255_T1.7661.00
155_R275_A1.7541.00
127_Q190_S1.7461.00
77_R283_E1.7241.00
165_G168_N1.7051.00
53_L98_Q1.6741.00
197_T219_P1.6651.00
154_D284_Y1.6501.00
212_A219_P1.6391.00
49_D91_R1.6331.00
157_A236_F1.6211.00
55_R78_Q1.6201.00
222_T230_N1.6201.00
159_H264_F1.6091.00
252_D255_T1.5921.00
74_L78_Q1.5921.00
73_A278_Y1.5851.00
250_K259_N1.5761.00
199_N224_V1.5541.00
168_N171_T1.5521.00
24_S27_Q1.5501.00
133_G202_C1.5421.00
235_S239_T1.5221.00
68_Y93_Y1.4801.00
240_I260_L1.4791.00
146_V240_I1.4751.00
157_A268_N1.4611.00
282_R286_R1.4591.00
155_R273_H1.4541.00
135_E145_R1.4461.00
244_Y259_N1.4381.00
161_A174_D1.4351.00
169_S173_Q1.4331.00
72_W92_V1.4221.00
131_S203_Y1.4151.00
56_I71_V1.4101.00
135_E143_R1.4061.00
209_R219_P1.3991.00
211_F215_L1.3911.00
55_R59_V1.3531.00
173_Q211_F1.3481.00
131_S195_W1.3451.00
129_W179_A1.3431.00
129_W149_A1.3371.00
53_L95_I1.3331.00
62_E270_W1.3311.00
91_R94_R1.3071.00
74_L272_P1.3061.00
25_R29_H1.3001.00
167_F202_C1.2991.00
243_D271_H1.2851.00
157_A264_F1.2771.00
131_S149_A1.2651.00
53_L57_H1.2641.00
230_N233_A1.2641.00
204_R221_N1.2611.00
147_T203_Y1.2611.00
244_Y263_A1.2561.00
58_H62_E1.2551.00
226_S229_S1.2551.00
16_L20_C1.2521.00
149_A179_A1.2381.00
66_Y70_R1.2381.00
228_E231_G1.2321.00
93_Y97_R1.2231.00
223_A226_S1.2171.00
72_W89_A1.2121.00
137_C143_R1.2071.00
74_L77_R1.2061.00
253_G257_A1.1961.00
194_E220_K1.1881.00
89_A93_Y1.1801.00
49_D52_V1.1741.00
147_T175_V1.1721.00
173_Q207_E1.1691.00
70_R243_D1.1641.00
257_A261_A1.1611.00
77_R272_P1.1591.00
149_A175_V1.1531.00
233_A237_V1.1451.00
150_L232_I1.1261.00
26_A29_H1.1211.00
154_D285_L1.1191.00
128_R152_C1.1161.00
90_K94_R1.1111.00
155_R232_I1.1101.00
54_L58_H1.1011.00
276_L284_Y1.0971.00
23_V28_L1.0961.00
159_H175_V1.0921.00
122_V127_Q1.0881.00
26_A30_V1.0811.00
124_E153_C1.0801.00
130_C232_I1.0701.00
69_R274_S1.0691.00
165_G171_T1.0661.00
134_F237_V1.0621.00
256_A260_L1.0551.00
169_S207_E1.0531.00
259_N262_E1.0531.00
124_E190_S1.0491.00
196_L220_K1.0471.00
144_L253_G1.0381.00
173_Q177_L1.0371.00
210_Q214_M1.0321.00
208_T212_A1.0321.00
90_K93_Y1.0301.00
122_V128_R1.0281.00
128_R196_L1.0271.00
150_L233_A1.0251.00
160_W178_G1.0201.00
68_Y89_A1.0061.00
164_T253_G1.0051.00
117_T120_V1.0051.00
50_T54_L1.0011.00
222_T229_S0.9991.00
16_L19_R0.9951.00
144_L256_A0.9951.00
244_Y250_K0.9911.00
57_H99_N0.9891.00
27_Q31_I0.9881.00
130_C230_N0.9871.00
283_E286_R0.9871.00
148_F236_F0.9791.00
248_M259_N0.9731.00
196_L229_S0.9721.00
261_A265_E0.9631.00
126_N285_L0.9611.00
29_H33_R0.9561.00
59_V74_L0.9551.00
265_E270_W0.9471.00
183_R285_L0.9441.00
56_I95_I0.9431.00
264_F268_N0.9401.00
150_L157_A0.9341.00
126_N183_R0.9341.00
180_V215_L0.9261.00
163_T171_T0.9221.00
236_F240_I0.9131.00
170_E207_E0.9031.00
158_L179_A0.9031.00
52_V87_I0.9001.00
133_G145_R0.8961.00
169_S205_A0.8911.00
87_I91_R0.8871.00
280_S284_Y0.8861.00
23_V27_Q0.8841.00
273_H276_L0.8771.00
48_D52_V0.8761.00
279_R283_E0.8761.00
262_E266_H0.8751.00
180_V217_L0.8741.00
210_Q213_R0.8671.00
176_M195_W0.8641.00
206_N210_Q0.8641.00
32_L36_D0.8631.00
201_S204_R0.8621.00
30_V34_R0.8601.00
150_L236_F0.8581.00
202_C205_A0.8551.00
197_T221_N0.8521.00
50_T53_L0.8511.00
274_S278_Y0.8501.00
267_Y273_H0.8501.00
239_T267_Y0.8441.00
177_L181_E0.8431.00
255_T259_N0.8351.00
205_A208_T0.8331.00
125_S154_D0.8331.00
112_S115_A0.8331.00
243_D263_A0.8311.00
63_L266_H0.8271.00
159_H178_G0.8251.00
70_R74_L0.8201.00
48_D91_R0.8171.00
27_Q30_V0.8171.00
276_L280_S0.8151.00
18_S25_R0.8141.00
172_V208_T0.8101.00
26_A33_R0.8071.00
194_E218_E0.8051.00
79_A85_P0.8041.00
266_H270_W0.7951.00
284_Y287_Q0.7941.00
170_E174_D0.7931.00
57_H60_I0.7931.00
272_P276_L0.7921.00
133_G147_T0.7901.00
146_V160_W0.7891.00
207_E210_Q0.7881.00
52_V55_R0.7871.00
201_S205_A0.7861.00
17_V21_L0.7831.00
125_S153_C0.7831.00
59_V71_V0.7791.00
133_G172_V0.7791.00
158_L182_R0.7771.00
162_V257_A0.7771.00
136_F245_I0.7751.00
147_T172_V0.7741.00
113_K116_H0.7631.00
21_L28_L0.7631.00
95_I98_Q0.7571.00
158_L264_F0.7571.00
49_D53_L0.7521.00
167_F201_S0.7511.00
146_V260_L0.7471.00
160_W261_A0.7461.00
130_C231_G0.7441.00
68_Y71_V0.7421.00
196_L222_T0.7371.00
75_L92_V0.7361.00
88_N94_R0.7341.00
164_T171_T0.7311.00
76_R86_A0.7301.00
195_W217_L0.7281.00
133_G167_F0.7241.00
155_R276_L0.7231.00
60_I64_P0.7211.00
209_R213_R0.7211.00
56_I92_V0.7191.00
147_T171_T0.7171.00
122_V153_C0.7111.00
134_F146_V0.7071.00
70_R274_S0.7071.00
145_R167_F0.7051.00
130_C196_L0.7051.00
44_S47_T0.7051.00
95_I99_N0.7031.00
278_Y284_Y0.7031.00
51_D55_R0.7021.00
60_I101_L0.6991.00
111_P114_R0.6981.00
131_S147_T0.6971.00
136_F256_A0.6961.00
195_W208_T0.6921.00
174_D177_L0.6901.00
129_W158_L0.6881.00
68_Y96_M0.6871.00
195_W219_P0.6841.00
119_R128_R0.6811.00
66_Y74_L0.6781.00
71_V96_M0.6781.00
30_V33_R0.6741.00
69_R89_A0.6721.00
260_L264_F0.6701.00
177_L215_L0.6671.00
91_R95_I0.6621.00
57_H101_L0.6601.00
87_I92_V0.6521.00
126_N179_A0.6441.00
239_T273_H0.6431.00
55_R85_P0.6381.00
67_G70_R0.6371.00
122_V152_C0.6371.00
17_V20_C0.6361.00
235_S242_R0.6361.00
156_E183_R0.6321.00
138_C141_G0.6291.00
34_R37_D0.6271.00
171_T174_D0.6261.00
48_D51_D0.6261.00
47_T53_L0.6231.00
150_L155_R0.6221.00
156_E269_E0.6211.00
167_F171_T0.6191.00
51_D54_L0.6151.00
237_V240_I0.6141.00
28_L32_L0.6141.00
68_Y72_W0.6141.00
196_L230_N0.6091.00
180_V188_L0.6081.00
239_T242_R0.6081.00
43_R47_T0.6061.00
56_I60_I0.6051.00
111_P115_A0.6021.00
211_F214_M0.6021.00
178_G182_R0.6011.00
33_R37_D0.6011.00
104_E108_A0.5981.00
159_H179_A0.5951.00
73_A272_P0.5951.00
146_V159_H0.5941.00
175_V179_A0.5941.00
207_E211_F0.5941.00
134_F240_I0.5931.00
164_T168_N0.5931.00
139_D249_P0.5921.00
18_S29_H0.5901.00
174_D178_G0.5890.99
59_V78_Q0.5890.99
220_K229_S0.5880.99
167_F172_V0.5870.99
32_L35_T0.5860.99
117_T121_A0.5820.99
254_L257_A0.5820.99
88_N92_V0.5790.99
72_W88_N0.5740.99
23_V31_I0.5730.99
197_T203_Y0.5720.99
99_N102_L0.5700.99
75_L79_A0.5680.99
176_M197_T0.5660.99
181_E184_F0.5650.99
85_P91_R0.5640.99
110_P113_K0.5630.99
49_D94_R0.5630.99
138_C144_L0.5620.99
136_F260_L0.5610.99
261_A264_F0.5600.99
179_A184_F0.5530.99
255_T258_K0.5500.99
69_R72_W0.5490.99
146_V162_V0.5460.99
66_Y71_V0.5440.99
149_A176_M0.5440.99
222_T225_R0.5420.99
29_H32_L0.5410.99
145_R202_C0.5370.99
31_I35_T0.5370.99
163_T167_F0.5350.99
106_K110_P0.5330.99
242_R246_S0.5330.99
254_L258_K0.5300.99
276_L279_R0.5290.99
160_W175_V0.5280.99
110_P114_R0.5270.99
190_S218_E0.5270.99
71_V75_L0.5240.99
244_Y260_L0.5230.99
162_V260_L0.5210.99
270_W282_R0.5210.99
236_F267_Y0.5200.99
120_V123_K0.5180.99
208_T219_P0.5170.99
63_L74_L0.5170.99
133_G200_G0.5160.99
188_L215_L0.5160.99
173_Q208_T0.5150.99
266_H269_E0.5120.99
52_V60_I0.5090.99
117_T123_K0.5080.99
200_G203_Y0.5050.98
76_R89_A0.5050.98
31_I34_R0.5030.98
147_T160_W0.5030.98
60_I63_L0.5030.98
236_F264_F0.5020.98
53_L56_I0.5020.98
163_T168_N0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fcyA 4 0.9369 100 0.36 Contact Map
3oymA 3 0.9037 100 0.423 Contact Map
3f9kA 5 0.6877 100 0.492 Contact Map
4fw2A 2 0.5382 100 0.496 Contact Map
1k6yA 4 0.6445 100 0.496 Contact Map
4u7bA 2 0.9136 100 0.502 Contact Map
4cf8A 2 0.495 100 0.515 Contact Map
1bcoA 1 0.5781 100 0.515 Contact Map
3hphA 3 0.6811 100 0.518 Contact Map
2x78A 2 0.5415 100 0.519 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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