GREMLIN Database
INSC2 - Transposase InsC for insertion element IS2D
UniProt: P0CF41 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG40003
Length: 121 (113)
Sequences: 115 (70)
Seq/√Len: 6.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
110_I114_P2.5420.68
109_W114_P2.1510.55
76_A80_I2.1140.54
65_E71_S2.1000.53
84_Q89_K2.0390.51
14_T17_E2.0230.50
91_T96_L2.0040.49
73_L76_A1.9960.49
76_A111_A1.9670.48
110_I115_L1.9490.47
60_A67_V1.9280.47
96_L100_A1.9030.46
95_E100_A1.8450.44
53_Y57_S1.8200.43
94_N101_V1.7620.41
26_F57_S1.6690.37
95_E99_E1.6270.36
65_E69_P1.5450.33
14_T72_E1.5330.33
25_S50_R1.5300.33
91_T100_A1.5010.32
44_S50_R1.4670.31
79_Q84_Q1.4360.30
30_M38_Q1.4230.29
61_V74_A1.4150.29
47_F70_A1.4140.29
79_Q89_K1.3520.27
91_T99_E1.3440.27
43_A59_T1.3220.26
23_Q52_Q1.3170.26
38_Q106_A1.3140.26
8_E20_A1.2980.26
91_T95_E1.2650.25
25_S38_Q1.2630.25
7_P45_Q1.2630.25
26_F50_R1.2550.24
109_W115_L1.2520.24
109_W116_L1.2460.24
96_L99_E1.2420.24
37_R56_G1.2260.24
82_E89_K1.2260.24
107_K112_H1.2200.23
111_A115_L1.2120.23
21_I42_A1.2110.23
31_T80_I1.2090.23
64_G76_A1.1840.22
97_L100_A1.1750.22
7_P20_A1.1700.22
51_K77_M1.1700.22
8_E12_R1.1680.22
91_T97_L1.1450.21
25_S31_T1.1350.21
93_E100_A1.1340.21
55_E66_Q1.1190.21
23_Q62_A1.1070.21
109_W113_A1.1020.20
32_V68_V1.0960.20
112_H116_L1.0910.20
33_S87_L1.0770.20
93_E97_L1.0730.20
19_I52_Q1.0730.20
13_R45_Q1.0430.19
111_A114_P1.0330.19
36_A87_L1.0300.19
56_G83_L1.0280.19
21_I103_Y1.0260.19
4_V20_A1.0080.18
11_R22_V1.0070.18
92_M99_E1.0010.18
53_Y61_V0.9950.18
37_R49_W0.9940.18
45_Q48_L0.9870.18
58_L69_P0.9800.18
82_E85_R0.9560.17
54_Q92_M0.9500.17
80_I92_M0.9380.17
20_A84_Q0.9310.17
34_L38_Q0.9260.17
101_V104_G0.9260.17
30_M44_S0.9150.16
106_A110_I0.9130.16
105_R114_P0.9070.16
37_R83_L0.8960.16
110_I116_L0.8960.16
57_S69_P0.8940.16
22_V34_L0.8900.16
24_Q43_A0.8880.16
73_L80_I0.8680.15
7_P31_T0.8620.15
23_Q73_L0.8610.15
26_F41_V0.8610.15
93_E96_L0.8490.15
33_S49_W0.8480.15
69_P84_Q0.8370.15
29_G32_V0.8340.15
11_R40_G0.8290.15
10_R18_K0.8280.15
55_E61_V0.8250.15
23_Q77_M0.8240.15
64_G79_Q0.8180.14
11_R107_K0.8080.14
74_A77_M0.8070.14
70_A89_K0.8060.14
40_G61_V0.7990.14
96_L102_E0.7940.14
23_Q81_K0.7930.14
6_G25_S0.7850.14
52_Q60_A0.7840.14
4_V51_K0.7820.14
27_E109_W0.7740.14
27_E50_R0.7640.13
37_R100_A0.7410.13
41_V47_F0.7380.13
13_R46_L0.7320.13
41_V114_P0.7320.13
19_I75_A0.7300.13
30_M42_A0.7280.13
12_R47_F0.7270.13
33_S36_A0.7200.13
73_L84_Q0.7130.13
68_V71_S0.7090.13
82_E86_L0.7080.13
13_R31_T0.7000.12
4_V7_P0.6880.12
26_F78_K0.6850.12
101_V114_P0.6770.12
77_M107_K0.6750.12
91_T102_E0.6720.12
39_H98_K0.6660.12
54_Q66_Q0.6660.12
27_E73_L0.6630.12
86_L92_M0.6570.12
44_S85_R0.6530.12
68_V92_M0.6520.12
23_Q55_E0.6520.12
113_A116_L0.6500.12
57_S64_G0.6460.12
23_Q27_E0.6440.12
8_E14_T0.6430.12
56_G71_S0.6270.11
5_L98_K0.6270.11
63_A92_M0.6050.11
92_M97_L0.6040.11
74_A80_I0.6000.11
19_I82_E0.5930.11
109_W112_H0.5930.11
31_T39_H0.5920.11
41_V107_K0.5890.11
36_A46_L0.5870.11
48_L81_K0.5860.11
24_Q99_E0.5760.11
39_H58_L0.5760.11
52_Q104_G0.5690.10
108_K115_L0.5590.10
26_F86_L0.5580.10
83_L100_A0.5560.10
42_A73_L0.5510.10
40_G108_K0.5450.10
57_S65_E0.5450.10
34_L75_A0.5430.10
65_E116_L0.5410.10
99_E105_R0.5390.10
77_M80_I0.5260.10
64_G84_Q0.5250.10
42_A81_K0.5240.10
57_S77_M0.5140.10
24_Q52_Q0.5130.10
57_S101_V0.5080.10
53_Y76_A0.5040.10
22_V102_E0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jrtA 1 0.6198 99.6 0.723 Contact Map
2oa4A 1 0.6612 99.5 0.726 Contact Map
2rn7A 1 0.8347 99.3 0.76 Contact Map
2jn6A 1 0.7934 98.8 0.804 Contact Map
2elhA 1 0.6364 98 0.845 Contact Map
2gloA 1 0.4628 97.9 0.851 Contact Map
1hlvA 1 0.9256 97.6 0.859 Contact Map
2ao9A 7 0.7521 97.3 0.867 Contact Map
4dyqA 5 0.8017 96.5 0.88 Contact Map
1k78A 1 0.9256 96.5 0.881 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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