GREMLIN Database
INSB6 - Insertion element IS1 6 protein InsB
UniProt: P0CF29 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG40002
Length: 167 (134)
Sequences: 188 (147)
Seq/√Len: 12.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_E65_S3.3320.98
134_Q144_L3.1780.97
65_S124_R3.0220.96
137_A144_L2.9380.96
135_H160_Y2.6820.93
149_S152_L2.5210.91
49_Y88_S2.3510.87
48_G153_H2.3300.87
134_Q137_A2.1750.83
98_W110_L2.1110.81
58_W62_A1.9430.75
49_Y85_R1.8900.72
127_R131_N1.8600.71
57_R154_D1.7750.67
58_W86_L1.7180.65
134_Q145_S1.6790.63
127_R130_L1.6750.63
43_M100_T1.6700.63
61_Y129_N1.6070.59
74_V82_T1.6040.59
125_I139_L1.5920.59
80_M108_S1.5790.58
48_G127_R1.5730.58
130_L144_L1.5610.57
63_Y128_H1.5400.56
139_L144_L1.5360.56
49_Y66_L1.5240.55
49_Y60_F1.5060.54
105_L118_S1.5060.54
122_T138_R1.4690.52
157_I161_L1.4290.50
128_H134_Q1.4110.49
50_V153_H1.4010.49
46_Q59_L1.3850.48
68_K128_H1.3830.48
83_L109_R1.3720.47
63_Y68_K1.3560.47
65_S159_H1.3560.47
58_W143_S1.3380.46
161_L166_Y1.3270.45
42_E124_R1.3240.45
72_A86_L1.3230.45
130_L140_G1.3180.45
130_L134_Q1.2850.43
61_Y115_H1.2650.42
33_P36_D1.2610.42
61_Y155_K1.2120.39
125_I159_H1.2010.39
97_I116_V1.1880.38
64_D145_S1.1620.37
44_D138_R1.1460.36
101_D126_E1.1420.36
130_L137_A1.1330.36
140_G146_F1.1310.35
137_A145_S1.1280.35
47_W122_T1.0910.34
74_V150_V1.0760.33
39_V49_Y1.0760.33
128_H136_L1.0700.33
134_Q140_G1.0680.33
59_L93_F1.0600.32
106_Y126_E1.0570.32
131_N160_Y1.0500.32
66_L161_L1.0490.32
146_F153_H1.0470.32
57_R150_V1.0450.31
80_M84_G1.0410.31
131_N135_H1.0310.31
146_F166_Y1.0290.31
50_V147_S1.0290.31
63_Y67_R1.0140.30
87_M162_N1.0110.30
139_L157_I1.0040.30
136_L149_S0.9930.29
43_M161_L0.9860.29
57_R70_V0.9750.28
59_L75_F0.9730.28
70_V143_S0.9710.28
158_G163_I0.9700.28
67_R92_P0.9610.28
126_E133_R0.9550.28
47_W146_F0.9440.27
50_V117_I0.9380.27
111_K117_I0.9290.27
47_W164_K0.9250.26
47_W86_L0.9100.26
63_Y100_T0.9090.26
63_Y82_T0.9080.26
62_A70_V0.9070.26
42_E103_W0.9050.26
74_V86_L0.9030.26
128_H144_L0.8990.25
34_G37_V0.8970.25
89_L93_F0.8870.25
135_H153_H0.8800.25
80_M145_S0.8720.24
40_C121_Y0.8590.24
93_F123_Q0.8560.24
59_L158_G0.8560.24
43_M120_R0.8510.24
91_S96_V0.8320.23
52_A64_D0.8290.23
42_E122_T0.8240.23
147_S153_H0.8150.22
73_H159_H0.8120.22
93_F158_G0.8060.22
92_P108_S0.7940.21
84_G108_S0.7900.21
137_A140_G0.7850.21
37_V125_I0.7810.21
92_P125_I0.7660.21
42_E64_D0.7620.20
82_T157_I0.7610.20
95_V130_L0.7540.20
38_I73_H0.7530.20
67_R165_H0.7520.20
80_M104_P0.7360.20
99_M151_E0.7340.19
121_Y142_K0.7320.19
80_M166_Y0.7300.19
62_A147_S0.7290.19
77_E82_T0.7270.19
63_Y165_H0.7240.19
134_Q139_L0.7190.19
108_S166_Y0.7170.19
123_Q127_R0.7090.19
57_R110_L0.7080.19
81_A111_K0.7060.19
106_Y143_S0.7050.19
59_L157_I0.7010.18
52_A77_E0.7010.18
64_D146_F0.6910.18
90_L156_V0.6860.18
84_G117_I0.6830.18
51_G81_A0.6830.18
88_S100_T0.6820.18
160_Y164_K0.6800.18
45_E53_K0.6780.18
63_Y124_R0.6770.18
75_F78_R0.6760.18
50_V57_R0.6750.18
149_S156_V0.6740.18
86_L142_K0.6740.18
140_G166_Y0.6730.18
152_L156_V0.6720.18
56_Q89_L0.6690.17
47_W78_R0.6690.17
70_V131_N0.6690.17
79_T87_M0.6690.17
46_Q123_Q0.6680.17
49_Y74_V0.6650.17
100_T125_I0.6610.17
132_L136_L0.6560.17
110_L113_K0.6520.17
101_D106_Y0.6490.17
58_W105_L0.6450.17
138_R147_S0.6410.17
52_A98_W0.6390.17
128_H166_Y0.6340.16
51_G71_V0.6330.16
50_V103_W0.6240.16
43_M152_L0.6230.16
43_M163_I0.6210.16
110_L154_D0.6170.16
101_D138_R0.6150.16
98_W150_V0.6140.16
61_Y125_I0.6100.16
99_M136_L0.6090.16
41_A165_H0.6080.16
51_G151_E0.6060.16
38_I102_G0.6010.16
66_L151_E0.5980.15
50_V100_T0.5960.15
160_Y163_I0.5920.15
41_A64_D0.5860.15
46_Q132_L0.5810.15
90_L137_A0.5780.15
60_F133_R0.5770.15
50_V135_H0.5750.15
85_R105_L0.5650.15
83_L165_H0.5630.15
70_V76_G0.5620.14
54_S88_S0.5620.14
81_A84_G0.5600.14
54_S85_R0.5520.14
123_Q158_G0.5490.14
125_I153_H0.5490.14
116_V121_Y0.5450.14
153_H158_G0.5410.14
77_E81_A0.5380.14
48_G131_N0.5320.14
118_S157_I0.5280.14
71_V85_R0.5260.14
40_C151_E0.5180.13
53_K106_Y0.5170.13
40_C103_W0.5160.13
131_N164_K0.5140.13
46_Q75_F0.5130.13
127_R164_K0.5040.13
63_Y164_K0.5040.13
62_A138_R0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fcyA 4 0.976 97.5 0.87 Contact Map
4fw1A 2 0.8024 97.5 0.871 Contact Map
1bcoA 1 0.8024 97.5 0.871 Contact Map
3l3uA 2 0.7066 97.4 0.874 Contact Map
4mq3A 1 0.7006 97.2 0.877 Contact Map
1cxqA 2 0.7665 97.2 0.878 Contact Map
1c6vA 4 0.6647 97 0.881 Contact Map
4cf8A 2 0.7066 97 0.882 Contact Map
2x78A 2 0.7365 96.8 0.884 Contact Map
4pa1A 2 0.7066 96.6 0.886 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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