GREMLIN Database
INSB3 - Insertion element IS1 3 protein InsB
UniProt: P0CF27 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG40002
Length: 167 (133)
Sequences: 190 (147)
Seq/√Len: 12.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_E65_R3.5870.99
134_Q144_L3.3070.98
65_R124_R3.0480.97
137_A144_L2.9160.96
135_H160_Y2.7420.94
49_Y88_S2.6660.93
149_S152_Q2.6000.92
48_G153_H2.4710.90
58_W62_A2.2140.84
134_Q137_A2.1470.82
98_W110_L2.1180.81
49_Y85_R2.0280.78
127_R131_N1.8640.72
134_Q145_S1.8180.70
57_R154_D1.8100.69
63_Y128_H1.7120.65
46_Q59_L1.6980.64
61_Y129_N1.6720.63
127_R130_L1.6650.62
58_W86_L1.6150.60
43_M100_T1.6140.60
130_L144_L1.6100.60
48_G127_R1.5950.59
80_M108_S1.5940.59
49_Y60_F1.5630.57
139_L144_L1.5610.57
74_V82_T1.5510.57
157_I161_L1.5380.56
128_H134_Q1.5380.56
68_K128_H1.5240.55
125_I139_L1.5080.55
140_G146_F1.4900.54
42_E124_R1.4640.52
122_T138_R1.4620.52
49_Y66_L1.4480.52
83_L109_R1.4330.51
105_L118_S1.4160.50
130_L140_G1.3850.48
58_W143_S1.3530.47
130_L134_Q1.3280.45
65_R159_H1.3270.45
50_V153_H1.3220.45
63_Y68_K1.3050.44
80_M84_G1.2760.43
63_Y67_R1.2420.41
125_I159_H1.2280.40
64_D146_F1.2160.40
61_Y155_K1.2140.40
131_N135_H1.2090.39
44_D138_R1.1930.39
42_E122_T1.1920.38
64_D145_S1.1910.38
47_W164_K1.1710.37
101_D126_E1.1660.37
47_W122_T1.1470.36
39_V49_Y1.1410.36
50_V147_S1.1350.36
130_L137_A1.1290.35
47_W146_F1.1180.35
59_L93_F1.1160.35
139_L157_I1.0990.34
74_V150_V1.0940.34
61_Y115_H1.0930.34
131_N160_Y1.0900.34
72_A86_L1.0750.33
106_Y126_E1.0550.32
57_R150_V1.0400.31
134_Q140_G1.0310.31
128_H144_L1.0190.30
47_W86_L1.0140.30
146_F153_H1.0110.30
89_L93_F1.0060.30
136_L149_S0.9950.29
80_M145_S0.9940.29
59_L158_G0.9930.29
93_F123_Q0.9660.28
43_M161_L0.9650.28
87_M162_N0.9540.28
80_M104_P0.9490.27
33_P36_D0.9470.27
126_E133_R0.9460.27
67_R92_P0.9440.27
97_I116_V0.9280.27
34_G37_V0.9070.26
66_L161_L0.9030.26
137_A145_S0.9000.25
135_H153_H0.8970.25
128_H136_L0.8950.25
70_V143_S0.8910.25
84_G117_I0.8850.25
63_Y82_T0.8700.24
63_Y124_R0.8650.24
43_M152_Q0.8620.24
37_V125_I0.8550.24
90_L156_V0.8470.23
50_V117_I0.8440.23
93_F158_G0.8440.23
62_A147_S0.8420.23
46_Q132_L0.8330.23
63_Y165_H0.8280.23
63_Y100_T0.8050.22
92_P108_S0.7970.22
84_G108_S0.7940.22
82_T157_I0.7900.21
149_S156_V0.7810.21
42_E103_W0.7790.21
51_G71_V0.7750.21
131_N164_K0.7710.21
50_V57_R0.7710.21
57_R110_L0.7690.21
67_R165_H0.7650.21
158_G163_I0.7600.20
152_Q156_V0.7590.20
42_E119_K0.7390.20
45_E53_K0.7360.20
123_Q127_R0.7340.20
40_C121_Y0.7260.19
43_M120_R0.7190.19
137_A140_G0.7160.19
77_E82_T0.7120.19
54_S85_R0.7100.19
92_P125_I0.7060.19
74_V86_L0.7050.19
71_V85_R0.6960.18
138_R147_S0.6950.18
73_H159_H0.6950.18
61_Y125_I0.6930.18
50_V103_W0.6900.18
46_Q123_Q0.6830.18
48_G131_N0.6800.18
147_S153_H0.6790.18
110_L154_D0.6780.18
101_D106_Y0.6700.18
134_Q139_L0.6690.17
160_Y164_K0.6580.17
57_R70_V0.6440.17
68_K130_L0.6420.17
59_L75_F0.6420.17
121_Y142_K0.6370.17
41_A165_H0.6330.16
77_E81_A0.6300.16
88_S100_T0.6300.16
68_K124_R0.6290.16
99_M151_E0.6240.16
56_Q89_L0.6200.16
79_T87_M0.6140.16
101_D138_R0.6110.16
86_L142_K0.6090.16
62_A70_V0.6070.16
99_M110_L0.6050.16
123_Q158_G0.6030.16
38_I73_H0.6000.16
58_W105_L0.6000.16
52_A64_D0.5990.16
63_Y164_K0.5970.15
38_I102_G0.5920.15
54_S99_M0.5900.15
100_T125_I0.5870.15
51_G107_E0.5830.15
90_L137_A0.5800.15
99_M136_L0.5800.15
70_V76_G0.5760.15
91_S96_V0.5760.15
51_G81_A0.5750.15
106_Y127_R0.5740.15
40_C65_R0.5650.15
67_R128_H0.5620.15
98_W150_V0.5610.15
62_A138_R0.5610.15
127_R164_K0.5590.14
68_K134_Q0.5590.14
43_M52_A0.5580.14
106_Y143_S0.5580.14
132_L136_L0.5560.14
91_S155_K0.5560.14
83_L165_H0.5530.14
95_V130_L0.5490.14
75_F78_R0.5430.14
99_M164_K0.5410.14
70_V131_N0.5350.14
49_Y74_V0.5330.14
85_R105_L0.5310.14
77_E91_S0.5290.14
50_V100_T0.5280.14
60_F133_R0.5260.14
68_K164_K0.5250.14
128_H165_H0.5220.14
59_L90_L0.5150.13
53_K106_Y0.5140.13
87_M110_L0.5120.13
109_R115_H0.5120.13
66_L151_E0.5110.13
71_V78_R0.5110.13
135_H164_K0.5080.13
105_L120_R0.5070.13
153_H158_G0.5060.13
54_S88_S0.5040.13
60_F161_L0.5020.13
43_M163_I0.5010.13
160_Y163_I0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fcyA 4 0.982 97.8 0.865 Contact Map
1bcoA 1 0.8024 97.5 0.871 Contact Map
4fw1A 2 0.8024 97.5 0.873 Contact Map
3l3uA 2 0.7066 97.3 0.875 Contact Map
1cxqA 2 0.7665 97.2 0.878 Contact Map
4mq3A 1 0.7006 97.2 0.879 Contact Map
4cf8A 2 0.7066 97 0.882 Contact Map
1c6vA 4 0.6647 96.9 0.883 Contact Map
2x78A 2 0.7365 96.6 0.887 Contact Map
4pa1A 2 0.7066 96.6 0.887 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0069 seconds.