GREMLIN Database
INSA4 - Insertion element IS1 4 protein InsA
UniProt: P0CF10 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG40001
Length: 91 (73)
Sequences: 360 (324)
Seq/√Len: 37.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_C11_C7.5531.00
7_S11_C5.0261.00
20_N24_T3.2631.00
14_T42_Q3.1121.00
6_I11_C2.2610.99
59_M62_N2.0630.99
46_T49_Q1.7550.97
21_G36_R1.7240.97
35_C48_S1.6420.95
19_R22_K1.5680.94
48_S52_T1.5510.94
57_I62_N1.4500.91
74_G78_N1.3770.89
21_G49_Q1.3640.88
20_N35_C1.3370.87
7_S12_S1.3130.86
32_C48_S1.2900.85
74_G77_L1.2810.85
30_Y46_T1.2630.84
37_K50_P1.2280.82
63_G66_C1.2030.81
62_N66_C1.1970.81
58_D71_R1.1950.81
43_F47_A1.1620.79
20_N32_C1.1120.76
24_T35_C1.1060.75
26_G29_R1.0720.73
32_C52_T1.0650.72
60_A76_G1.0330.70
45_Y48_S1.0240.69
27_H43_F1.0100.68
22_K27_H0.9990.67
14_T68_A0.9860.66
62_N75_V0.9620.65
64_V68_A0.9340.62
19_R30_Y0.9290.62
38_T58_D0.9160.61
31_L38_T0.9130.60
57_I66_C0.9060.60
24_T29_R0.9040.60
30_Y38_T0.9030.60
62_N65_G0.8970.59
65_G70_A0.8970.59
69_T72_I0.8920.59
9_P12_S0.8840.58
31_L36_R0.8810.58
26_G40_Q0.8770.57
42_Q46_T0.8570.56
59_M66_C0.8200.52
7_S10_S0.8170.52
9_P13_A0.8120.52
33_S60_A0.8060.51
72_I76_G0.7970.50
33_S69_T0.7930.50
33_S39_W0.7910.50
67_R70_A0.7790.49
73_M77_L0.7720.48
56_I65_G0.7430.45
72_I75_V0.7310.44
23_S44_T0.7280.44
37_K56_I0.7270.44
22_K26_G0.7200.43
66_C75_V0.7190.43
25_A53_H0.7010.42
63_G76_G0.6740.39
30_Y51_G0.6730.39
55_K61_M0.6710.39
41_L46_T0.6620.38
15_D44_T0.6620.38
40_Q54_Q0.6600.38
28_Q31_L0.6520.38
66_C71_R0.6470.37
53_H71_R0.6460.37
8_C12_S0.6430.37
6_I10_S0.6430.37
70_A78_N0.6210.35
66_C78_N0.6130.34
6_I9_P0.6100.34
64_V75_V0.6090.34
38_T64_V0.6040.34
19_R44_T0.6000.33
53_H58_D0.6000.33
41_L47_A0.5980.33
17_V26_G0.5900.32
38_T55_K0.5870.32
46_T50_P0.5860.32
16_G44_T0.5740.31
19_R25_A0.5720.31
17_V20_N0.5650.31
28_Q54_Q0.5650.31
72_I77_L0.5480.29
13_A27_H0.5460.29
22_K29_R0.5460.29
6_I21_G0.5410.29
44_T47_A0.5400.29
39_W52_T0.5400.29
28_Q34_H0.5310.28
70_A74_G0.5280.28
11_C20_N0.5270.28
14_T32_C0.5270.28
24_T27_H0.5250.28
15_D40_Q0.5150.27
25_A29_R0.5130.27
34_H69_T0.5120.27
16_G42_Q0.5120.27
18_V44_T0.5080.26
24_T48_S0.5070.26
63_G67_R0.5060.26
20_N29_R0.5060.26
55_K65_G0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3w5kB 1 0.9121 99.2 0.423 Contact Map
2m9aA 1 0.9121 99.1 0.432 Contact Map
2i13A 1 0.8681 99.1 0.435 Contact Map
2rsjA 1 0.9231 99.1 0.441 Contact Map
1ej6B 7 0.8242 99.1 0.445 Contact Map
2dmdA 1 0.967 99.1 0.449 Contact Map
4x9jA 1 0.8681 99 0.455 Contact Map
2ee8A 1 0.978 99 0.458 Contact Map
2ma7A 1 0.6484 99 0.461 Contact Map
2jp9A 1 0.8681 99 0.462 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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