GREMLIN Database
INSA1 - Insertion element IS1 1 protein InsA
UniProt: P0CF07 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG40001
Length: 91 (73)
Sequences: 306 (275)
Seq/√Len: 32.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_N24_T4.6421.00
8_C11_C3.8701.00
48_S52_T2.4010.99
21_G36_R2.3360.99
74_G78_N2.1300.98
7_S12_S1.9890.98
43_F47_A1.9840.98
37_K50_P1.8270.96
11_C20_N1.7840.95
11_C32_C1.7780.95
59_M62_N1.6960.94
31_L47_A1.6240.92
35_C48_S1.5780.91
25_A29_R1.5090.89
43_F50_P1.4920.89
17_V48_S1.4890.89
8_C13_A1.4640.88
33_S39_W1.4240.86
22_K29_R1.3750.84
28_Q31_L1.3060.81
46_T53_H1.3020.81
45_Y52_T1.2860.80
21_G49_Q1.2810.80
45_Y48_S1.2470.78
28_Q46_T1.2250.76
55_K66_C1.2200.76
19_R22_K1.2000.75
75_V78_N1.1940.75
19_R53_H1.1430.71
32_C48_S1.1270.70
11_C24_T1.1090.69
17_V20_N1.1030.68
44_T47_A1.0980.68
17_V24_T1.0750.66
63_G69_T1.0420.64
21_G33_S1.0240.63
49_Q54_Q1.0200.62
67_R77_L1.0170.62
13_A45_Y1.0050.61
25_A30_Y0.9940.60
15_D38_T0.9940.60
60_A67_R0.9910.60
14_T42_Q0.9850.60
44_T55_K0.9670.58
62_N73_M0.9310.55
15_D26_G0.9280.55
11_C35_C0.9240.55
61_M76_G0.9210.54
18_V22_K0.8690.50
33_S40_Q0.8400.48
15_D51_G0.8400.48
34_H52_T0.8100.45
62_N67_R0.8060.45
24_T32_C0.8060.45
67_R74_G0.7980.44
55_K63_G0.7970.44
26_G29_R0.7950.44
22_K48_S0.7910.44
34_H69_T0.7890.44
58_D70_A0.7740.42
13_A19_R0.7530.41
20_N45_Y0.7530.41
7_S10_S0.7460.40
29_R43_F0.7420.40
22_K27_H0.7250.39
40_Q43_F0.6940.36
50_P72_I0.6930.36
50_P54_Q0.6910.36
72_I77_L0.6890.36
10_S42_Q0.6720.34
13_A39_W0.6720.34
71_R78_N0.6720.34
16_G19_R0.6690.34
23_S40_Q0.6520.33
16_G42_Q0.6430.32
68_A73_M0.6400.32
49_Q64_V0.6330.32
58_D69_T0.6320.32
29_R38_T0.6250.31
41_L46_T0.6240.31
46_T51_G0.6190.31
67_R73_M0.6180.31
42_Q46_T0.6180.31
10_S41_L0.6050.30
14_T68_A0.5970.29
66_C72_I0.5960.29
68_A77_L0.5920.29
21_G70_A0.5710.27
30_Y46_T0.5670.27
47_A68_A0.5660.27
14_T25_A0.5660.27
69_T77_L0.5620.27
40_Q47_A0.5620.27
27_H43_F0.5600.27
6_I13_A0.5580.27
21_G39_W0.5550.26
22_K26_G0.5510.26
24_T29_R0.5470.26
56_I67_R0.5450.26
19_R29_R0.5340.25
6_I23_S0.5260.25
23_S62_N0.5260.25
28_Q58_D0.5220.24
26_G40_Q0.5190.24
49_Q65_G0.5150.24
55_K72_I0.5080.23
53_H65_G0.5040.23
23_S37_K0.5030.23
8_C12_S0.5010.23
57_I70_A0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i13A 1 0.5714 99.2 0.395 Contact Map
2lceA 1 0.6374 99.1 0.41 Contact Map
2lv2A 1 0.6264 99.1 0.415 Contact Map
1x6eA 1 0.6484 99.1 0.416 Contact Map
2cotA 1 0.6593 99.1 0.42 Contact Map
2ma7A 1 0.6484 99.1 0.421 Contact Map
4x9jA 1 0.8681 99.1 0.428 Contact Map
2gqjA 1 0.8022 99.1 0.429 Contact Map
3uk3C 1 0.5275 99 0.432 Contact Map
2n25A 1 0.2747 99 0.432 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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