INH11 - ECOLI - GREMLIN Contacts

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INH11 - Transposase InsH for insertion sequence element IS5T

UniProt:	P0CE58	Sequences: MFVIWSHRTGFIMSHQLTFADSEFSSKRRQTRKEIFLSRMEQILPWQNMVEVIEPFYPKAGNGRRPYPLETMLRIHCMQHWYNLSDGAMEDALYEIASMRLFARLSLDSALPDRTTIMNFRHLLEQHQLARQLFKTINRWLAEAGVMMTQGTLVDATIIEAPSSTKNKEQQRDPEMHQTKKGNQWHFGMKAHIGVDAKSGLTHSLVTTAANEHDLNQLGNLLHGEEQFVSADAGYQGAPQREELAEVDVDWLIAERPGKVRTLKQHPRKNKTAINIEYMKASIRARVEHPFRIIKRQFGFVKARYKGLLKNDNQLAMLFTLANLFRADQMIRQWERSH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG40008
Length:	338 (304)
Sequences:	1974 (1465)
Seq/√Len:	84.0

ECOLI - INSH1 INSH2 INSH3 INSH4 INSH7 INSH8 INSH9 INH10 INH11 INSH6 INSH5
HALSA - TH11 Q9HPK7 Q7LYM0 Q9HSX5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
247_V	253_I	4.068	1.00
87_G	114_R	3.918	1.00
244_L	253_I	3.828	1.00
167_N	170_Q	3.734	1.00
92_A	96_I	3.696	1.00
205_L	316_A	3.637	1.00
195_V	287_V	3.601	1.00
75_I	93_L	3.364	1.00
192_H	208_T	3.320	1.00
244_L	247_V	3.319	1.00
202_T	319_F	3.164	1.00
204_S	224_G	3.008	1.00
79_Q	89_M	2.788	1.00
240_Q	243_E	2.722	1.00
70_E	74_R	2.598	1.00
58_P	62_N	2.561	1.00
248_D	253_I	2.502	1.00
93_L	103_A	2.346	1.00
205_L	319_F	2.343	1.00
191_A	315_L	2.241	1.00
136_T	139_R	2.150	1.00
95_E	98_S	2.111	1.00
86_D	121_R	2.040	1.00
154_V	194_G	2.031	1.00
201_L	326_R	1.994	1.00
307_G	310_K	1.978	1.00
141_L	327_A	1.972	1.00
74_R	103_A	1.897	1.00
157_T	295_K	1.864	1.00
90_E	114_R	1.858	1.00
52_V	132_Q	1.842	1.00
240_Q	253_I	1.803	1.00
192_H	235_Y	1.780	1.00
41_E	104_R	1.764	1.00
305_Y	310_K	1.722	1.00
206_V	312_D	1.717	1.00
156_A	190_K	1.715	1.00
75_I	117_I	1.689	1.00
17_L	20_A	1.675	1.00
294_I	318_L	1.674	1.00
22_S	25_S	1.667	1.00
115_T	118_M	1.657	1.00
57_Y	123_L	1.654	1.00
115_T	119_N	1.652	1.00
72_M	120_F	1.651	1.00
134_F	319_F	1.631	1.00
80_H	314_Q	1.627	1.00
156_A	214_D	1.621	1.00
208_T	217_Q	1.620	1.00
152_T	203_H	1.618	1.00
71_T	105_L	1.606	1.00
296_R	301_V	1.597	1.00
152_T	194_G	1.585	1.00
78_M	99_M	1.584	1.00
139_R	143_E	1.582	1.00
193_I	291_F	1.569	1.00
39_R	43_I	1.548	1.00
239_P	253_I	1.546	1.00
202_T	323_N	1.544	1.00
268_R	271_K	1.528	1.00
277_E	284_R	1.528	1.00
31_T	38_S	1.520	1.00
50_V	68_P	1.500	0.99
273_A	276_I	1.482	0.99
303_A	311_N	1.482	0.99
141_L	201_L	1.466	0.99
256_R	259_K	1.454	0.99
176_M	189_M	1.453	0.99
48_N	136_T	1.446	0.99
151_G	228_F	1.443	0.99
45_P	48_N	1.433	0.99
287_V	290_P	1.417	0.99
160_E	302_K	1.416	0.99
212_E	217_Q	1.410	0.99
195_V	290_P	1.405	0.99
281_A	284_R	1.388	0.99
207_T	312_D	1.387	0.99
90_E	113_D	1.384	0.99
196_D	199_S	1.381	0.99
300_F	318_L	1.377	0.99
131_R	135_K	1.375	0.99
231_A	234_G	1.367	0.99
204_S	221_L	1.355	0.99
50_V	70_E	1.354	0.99
193_I	290_P	1.349	0.99
49_M	53_I	1.342	0.99
88_A	92_A	1.339	0.99
179_T	190_K	1.330	0.99
239_P	247_V	1.329	0.99
251_W	254_A	1.327	0.99
244_L	249_V	1.306	0.98
125_E	313_N	1.302	0.98
41_E	74_R	1.298	0.98
179_T	210_A	1.293	0.98
92_A	99_M	1.288	0.98
182_G	186_H	1.285	0.98
298_F	322_A	1.281	0.98
274_I	277_E	1.267	0.98
241_R	254_A	1.261	0.98
244_L	252_L	1.255	0.98
248_D	252_L	1.241	0.98
218_L	222_L	1.240	0.98
262_T	266_H	1.238	0.98
217_Q	221_L	1.229	0.98
303_A	314_Q	1.223	0.98
45_P	74_R	1.218	0.98
153_L	197_A	1.210	0.97
194_G	204_S	1.195	0.97
243_E	247_V	1.187	0.97
130_A	316_A	1.184	0.97
82_Y	99_M	1.168	0.97
201_L	327_A	1.166	0.97
177_H	209_A	1.152	0.97
238_A	244_L	1.141	0.96
35_I	95_E	1.138	0.96
84_L	116_T	1.135	0.96
90_E	111_L	1.133	0.96
126_Q	309_L	1.132	0.96
217_Q	220_N	1.129	0.96
256_R	262_T	1.127	0.96
213_H	216_N	1.125	0.96
53_I	58_P	1.123	0.96
267_P	271_K	1.122	0.96
52_V	136_T	1.101	0.96
89_M	117_I	1.097	0.96
160_E	186_H	1.093	0.95
75_I	89_M	1.092	0.95
67_Y	71_T	1.084	0.95
105_L	109_S	1.084	0.95
242_E	246_E	1.080	0.95
192_H	221_L	1.079	0.95
90_E	117_I	1.074	0.95
75_I	112_P	1.073	0.95
194_G	225_E	1.072	0.95
54_E	58_P	1.072	0.95
263_L	266_H	1.059	0.95
153_L	286_R	1.057	0.95
244_L	254_A	1.057	0.95
25_S	38_S	1.056	0.94
305_Y	314_Q	1.053	0.94
244_L	248_D	1.049	0.94
133_L	320_T	1.032	0.94
47_Q	50_V	1.026	0.94
154_V	231_A	1.026	0.94
292_R	297_Q	1.023	0.94
254_A	257_P	1.021	0.93
237_G	240_Q	1.020	0.93
192_H	214_D	1.016	0.93
150_Q	227_Q	1.012	0.93
32_R	35_I	1.002	0.93
262_T	265_Q	0.999	0.93
219_G	243_E	0.999	0.93
203_H	225_E	0.999	0.93
294_I	300_F	0.994	0.93
105_L	111_L	0.993	0.92
182_G	185_W	0.991	0.92
247_V	252_L	0.991	0.92
282_S	285_A	0.990	0.92
156_A	192_H	0.990	0.92
158_I	179_T	0.987	0.92
157_T	191_A	0.984	0.92
52_V	55_P	0.982	0.92
206_V	217_Q	0.982	0.92
36_F	40_M	0.975	0.92
241_R	253_I	0.971	0.92
180_K	185_W	0.969	0.92
294_I	322_A	0.968	0.91
239_P	244_L	0.968	0.91
323_N	326_R	0.967	0.91
285_A	289_H	0.964	0.91
249_V	253_I	0.961	0.91
247_V	254_A	0.956	0.91
259_K	262_T	0.953	0.91
72_M	116_T	0.952	0.91
293_I	325_F	0.940	0.90
207_T	315_L	0.931	0.90
183_N	310_K	0.931	0.90
315_L	319_F	0.930	0.90
154_V	218_L	0.927	0.90
234_G	237_G	0.920	0.89
321_L	325_F	0.918	0.89
141_L	173_D	0.917	0.89
322_A	326_R	0.916	0.89
21_D	25_S	0.911	0.89
75_I	103_A	0.909	0.89
292_R	296_R	0.906	0.89
220_N	223_H	0.905	0.88
258_G	261_R	0.901	0.88
218_L	231_A	0.898	0.88
228_F	252_L	0.897	0.88
293_I	322_A	0.893	0.88
244_L	255_E	0.892	0.88
77_C	81_W	0.892	0.88
102_F	187_F	0.891	0.88
157_T	291_F	0.889	0.88
178_Q	185_W	0.887	0.87
257_P	261_R	0.886	0.87
173_D	189_M	0.882	0.87
137_I	320_T	0.882	0.87
96_I	99_M	0.875	0.87
215_L	237_G	0.862	0.86
312_D	316_A	0.861	0.86
90_E	94_Y	0.859	0.86
251_W	258_G	0.855	0.85
253_I	256_R	0.854	0.85
158_I	214_D	0.853	0.85
179_T	188_G	0.852	0.85
21_D	29_R	0.851	0.85
38_S	101_L	0.850	0.85
151_G	230_S	0.850	0.85
162_P	306_K	0.849	0.85
218_L	240_Q	0.847	0.85
18_T	21_D	0.844	0.85
279_M	284_R	0.844	0.85
175_E	308_L	0.843	0.85
67_Y	109_S	0.842	0.85
326_R	330_M	0.840	0.84
293_I	298_F	0.838	0.84
192_H	217_Q	0.837	0.84
314_Q	318_L	0.836	0.84
114_R	118_M	0.829	0.84
62_N	65_R	0.826	0.83
58_P	61_G	0.823	0.83
260_V	264_K	0.819	0.83
193_I	202_T	0.817	0.83
54_E	59_K	0.816	0.83
245_A	271_K	0.815	0.83
246_E	249_V	0.814	0.83
156_A	179_T	0.812	0.82
250_D	253_I	0.807	0.82
241_R	247_V	0.805	0.82
90_E	118_M	0.801	0.82
200_G	293_I	0.797	0.81
290_P	322_A	0.797	0.81
189_M	311_N	0.785	0.80
208_T	221_L	0.784	0.80
259_K	265_Q	0.783	0.80
303_A	315_L	0.780	0.80
182_G	234_G	0.777	0.80
134_F	316_A	0.776	0.79
173_D	177_H	0.774	0.79
194_G	221_L	0.770	0.79
81_W	321_L	0.770	0.79
223_H	226_E	0.769	0.79
239_P	248_D	0.769	0.79
283_I	286_R	0.768	0.79
78_M	82_Y	0.764	0.78
176_M	187_F	0.762	0.78
138_N	141_L	0.760	0.78
202_T	322_A	0.759	0.78
251_W	256_R	0.759	0.78
190_K	214_D	0.755	0.78
37_L	102_F	0.754	0.77
247_V	250_D	0.754	0.77
130_A	313_N	0.753	0.77
178_Q	187_F	0.749	0.77
20_A	23_E	0.746	0.77
230_S	283_I	0.744	0.77
165_T	187_F	0.740	0.76
272_T	277_E	0.739	0.76
200_G	322_A	0.735	0.76
294_I	319_F	0.735	0.76
191_A	319_F	0.733	0.75
119_N	133_L	0.733	0.75
276_I	279_M	0.733	0.75
137_I	324_L	0.732	0.75
205_L	315_L	0.732	0.75
122_H	310_K	0.731	0.75
304_R	314_Q	0.729	0.75
137_I	141_L	0.725	0.75
19_F	24_F	0.720	0.74
131_R	224_G	0.718	0.74
244_L	250_D	0.716	0.74
241_R	251_W	0.715	0.74
164_S	172_R	0.711	0.73
291_F	295_K	0.707	0.73
166_K	182_G	0.706	0.73
93_L	111_L	0.705	0.73
321_L	328_D	0.704	0.73
69_L	163_S	0.700	0.72
200_G	290_P	0.698	0.72
46_W	49_M	0.698	0.72
100_R	111_L	0.697	0.72
51_E	54_E	0.694	0.71
305_Y	311_N	0.692	0.71
194_G	229_V	0.692	0.71
48_N	143_E	0.691	0.71
44_L	74_R	0.690	0.71
181_K	186_H	0.689	0.71
326_R	329_Q	0.683	0.70
51_E	143_E	0.678	0.70
97_A	100_R	0.676	0.69
206_V	221_L	0.674	0.69
238_A	242_E	0.673	0.69
327_A	330_M	0.672	0.69
231_A	236_Q	0.668	0.69
295_K	300_F	0.665	0.68
156_A	291_F	0.662	0.68
25_S	42_Q	0.661	0.68
72_M	117_I	0.657	0.67
74_R	102_F	0.656	0.67
67_Y	75_I	0.654	0.67
249_V	254_A	0.654	0.67
286_R	289_H	0.654	0.67
35_I	72_M	0.653	0.67
96_I	133_L	0.653	0.67
166_K	178_Q	0.651	0.67
264_K	268_R	0.650	0.66
51_E	132_Q	0.649	0.66
133_L	145_G	0.649	0.66
206_V	220_N	0.649	0.66
218_L	229_V	0.646	0.66
59_K	62_N	0.645	0.66
37_L	46_W	0.645	0.66
273_A	277_E	0.644	0.66
35_I	98_S	0.644	0.66
56_F	59_K	0.642	0.65
321_L	326_R	0.640	0.65
89_M	202_T	0.640	0.65
150_Q	198_K	0.638	0.65
192_H	210_A	0.637	0.65
82_Y	95_E	0.637	0.65
277_E	280_K	0.634	0.65
23_E	29_R	0.634	0.65
166_K	200_G	0.633	0.64
37_L	78_M	0.633	0.64
245_A	248_D	0.632	0.64
247_V	251_W	0.632	0.64
308_L	312_D	0.631	0.64
51_E	227_Q	0.627	0.64
241_R	256_R	0.626	0.64
67_Y	120_F	0.624	0.63
163_S	172_R	0.624	0.63
205_L	320_T	0.624	0.63
179_T	186_H	0.624	0.63
257_P	260_V	0.624	0.63
280_K	284_R	0.623	0.63
57_Y	66_P	0.620	0.63
192_H	212_E	0.619	0.63
134_F	325_F	0.617	0.62
35_I	161_A	0.616	0.62
158_I	210_A	0.616	0.62
69_L	121_R	0.615	0.62
241_R	244_L	0.613	0.62
131_R	312_D	0.612	0.62
240_Q	247_V	0.612	0.62
208_T	212_E	0.611	0.62
86_D	120_F	0.611	0.62
250_D	255_E	0.611	0.62
200_G	326_R	0.610	0.62
256_R	260_V	0.609	0.61
276_I	280_K	0.608	0.61
243_E	248_D	0.605	0.61
94_Y	100_R	0.605	0.61
166_K	188_G	0.604	0.61
256_R	261_R	0.603	0.61
246_E	261_R	0.603	0.61
213_H	237_G	0.603	0.61
19_F	30_Q	0.601	0.60
163_S	187_F	0.601	0.60
318_L	321_L	0.598	0.60
48_N	52_V	0.598	0.60
187_F	295_K	0.596	0.60
313_N	317_M	0.595	0.60
159_I	191_A	0.592	0.59
47_Q	102_F	0.590	0.59
84_L	92_A	0.590	0.59
39_R	42_Q	0.584	0.58
193_I	287_V	0.583	0.58
37_L	82_Y	0.581	0.58
24_F	97_A	0.580	0.58
118_M	122_H	0.579	0.58
150_Q	228_F	0.579	0.58
241_R	255_E	0.579	0.58
41_E	102_F	0.577	0.57
207_T	311_N	0.577	0.57
250_D	261_R	0.577	0.57
159_I	303_A	0.574	0.57
189_M	308_L	0.574	0.57
299_G	314_Q	0.573	0.57
69_L	72_M	0.573	0.57
67_Y	119_N	0.570	0.56
91_D	95_E	0.568	0.56
35_I	101_L	0.568	0.56
84_L	138_N	0.568	0.56
293_I	297_Q	0.568	0.56
85_S	231_A	0.567	0.56
44_L	324_L	0.567	0.56
147_M	199_S	0.567	0.56
81_W	325_F	0.564	0.56
51_E	55_P	0.563	0.55
45_P	70_E	0.562	0.55
32_R	36_F	0.562	0.55
249_V	252_L	0.561	0.55
65_R	202_T	0.561	0.55
141_L	176_M	0.560	0.55
153_L	195_V	0.560	0.55
41_E	101_L	0.559	0.55
180_K	186_H	0.557	0.55
91_D	205_L	0.555	0.54
173_D	176_M	0.550	0.54
68_P	320_T	0.550	0.54
221_L	224_G	0.550	0.54
137_I	140_W	0.550	0.54
238_A	255_E	0.549	0.54
277_E	281_A	0.548	0.54
324_L	328_D	0.547	0.53
76_H	89_M	0.545	0.53
102_F	115_T	0.544	0.53
45_P	50_V	0.542	0.53
73_L	117_I	0.540	0.52
215_L	234_G	0.539	0.52
254_A	263_L	0.538	0.52
149_T	196_D	0.538	0.52
200_G	286_R	0.538	0.52
282_S	286_R	0.537	0.52
69_L	87_G	0.536	0.52
131_R	204_S	0.536	0.52
227_Q	278_Y	0.535	0.52
40_M	45_P	0.535	0.52
228_F	250_D	0.535	0.52
190_K	221_L	0.535	0.52
219_G	223_H	0.533	0.52
71_T	104_R	0.531	0.51
112_P	196_D	0.530	0.51
134_F	205_L	0.530	0.51
59_K	65_R	0.530	0.51
206_V	224_G	0.529	0.51
254_A	259_K	0.528	0.51
286_R	292_R	0.525	0.50
153_L	289_H	0.525	0.50
222_L	272_T	0.524	0.50
188_G	284_R	0.523	0.50
140_W	144_A	0.522	0.50
181_K	235_Y	0.521	0.50
119_N	122_H	0.521	0.50
73_L	130_A	0.521	0.50
111_L	119_N	0.518	0.50
164_S	214_D	0.517	0.49
259_K	263_L	0.516	0.49
311_N	320_T	0.516	0.49
126_Q	136_T	0.515	0.49
73_L	317_M	0.515	0.49
87_G	118_M	0.513	0.49
182_G	200_G	0.510	0.48
19_F	34_E	0.508	0.48
289_H	292_R	0.506	0.48
121_R	323_N	0.505	0.48
35_I	38_S	0.505	0.48
317_M	326_R	0.505	0.48
254_A	258_G	0.505	0.48
161_A	164_S	0.503	0.48
271_K	274_I	0.502	0.47
171_Q	178_Q	0.502	0.47
200_G	289_H	0.502	0.47
156_A	235_Y	0.500	0.47

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1musA	2	0.7692	98.3	0.887	Contact Map
4u7bA	2	0.8166	75.7	0.948	Contact Map
4dyqA	5	0.3698	45.6	0.957	Contact Map
1bcoA	1	0.4645	32.1	0.961	Contact Map
1c6vA	4	0.3757	31.2	0.961	Contact Map
4mq3A	1	0.3609	28.7	0.962	Contact Map
1jkoC	1	0.1331	27.4	0.962	Contact Map
3kksA	2	0.3964	18.3	0.965	Contact Map
4fw1A	2	0.426	17.6	0.965	Contact Map
2m8eA	1	0.1657	16.5	0.966	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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