GREMLIN Database
INSH8 - Transposase InsH for insertion sequence element IS5K
UniProt: P0CE55 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG40008
Length: 338 (304)
Sequences: 1974 (1465)
Seq/√Len: 84.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
247_V253_I4.0681.00
87_G114_R3.9181.00
244_L253_I3.8281.00
167_N170_Q3.7341.00
92_A96_I3.6961.00
205_L316_A3.6371.00
195_V287_V3.6011.00
75_I93_L3.3641.00
192_H208_T3.3201.00
244_L247_V3.3191.00
202_T319_F3.1641.00
204_S224_G3.0081.00
79_Q89_M2.7881.00
240_Q243_E2.7221.00
70_E74_R2.5981.00
58_P62_N2.5611.00
248_D253_I2.5021.00
93_L103_A2.3461.00
205_L319_F2.3431.00
191_A315_L2.2411.00
136_T139_R2.1501.00
95_E98_S2.1111.00
86_D121_R2.0401.00
154_V194_G2.0311.00
201_L326_R1.9941.00
307_G310_K1.9781.00
141_L327_A1.9721.00
74_R103_A1.8971.00
157_T295_K1.8641.00
90_E114_R1.8581.00
52_V132_Q1.8421.00
240_Q253_I1.8031.00
192_H235_Y1.7801.00
41_E104_R1.7641.00
305_Y310_K1.7221.00
206_V312_D1.7171.00
156_A190_K1.7151.00
75_I117_I1.6891.00
17_L20_A1.6751.00
294_I318_L1.6741.00
22_S25_S1.6671.00
115_T118_M1.6571.00
57_Y123_L1.6541.00
115_T119_N1.6521.00
72_M120_F1.6511.00
134_F319_F1.6311.00
80_H314_Q1.6271.00
156_A214_D1.6211.00
208_T217_Q1.6201.00
152_T203_H1.6181.00
71_T105_L1.6061.00
296_R301_V1.5971.00
152_T194_G1.5851.00
78_M99_M1.5841.00
139_R143_E1.5821.00
193_I291_F1.5691.00
39_R43_I1.5481.00
239_P253_I1.5461.00
202_T323_N1.5441.00
268_R271_K1.5281.00
277_E284_R1.5281.00
31_T38_S1.5201.00
50_V68_P1.5000.99
273_A276_I1.4820.99
303_A311_N1.4820.99
141_L201_L1.4660.99
256_R259_K1.4540.99
176_M189_M1.4530.99
48_N136_T1.4460.99
151_G228_F1.4430.99
45_P48_N1.4330.99
287_V290_P1.4170.99
160_E302_K1.4160.99
212_E217_Q1.4100.99
195_V290_P1.4050.99
281_A284_R1.3880.99
207_T312_D1.3870.99
90_E113_D1.3840.99
196_D199_S1.3810.99
300_F318_L1.3770.99
131_R135_K1.3750.99
231_A234_G1.3670.99
204_S221_L1.3550.99
50_V70_E1.3540.99
193_I290_P1.3490.99
49_M53_I1.3420.99
88_A92_A1.3390.99
179_T190_K1.3300.99
239_P247_V1.3290.99
251_W254_A1.3270.99
244_L249_V1.3060.98
125_E313_N1.3020.98
41_E74_R1.2980.98
179_T210_A1.2930.98
92_A99_M1.2880.98
182_G186_H1.2850.98
298_F322_A1.2810.98
274_I277_E1.2670.98
241_R254_A1.2610.98
244_L252_L1.2550.98
248_D252_L1.2410.98
218_L222_L1.2400.98
262_T266_H1.2380.98
217_Q221_L1.2290.98
303_A314_Q1.2230.98
45_P74_R1.2180.98
153_L197_A1.2100.97
194_G204_S1.1950.97
243_E247_V1.1870.97
130_A316_A1.1840.97
82_Y99_M1.1680.97
201_L327_A1.1660.97
177_H209_A1.1520.97
238_A244_L1.1410.96
35_I95_E1.1380.96
84_L116_T1.1350.96
90_E111_L1.1330.96
126_Q309_L1.1320.96
217_Q220_N1.1290.96
256_R262_T1.1270.96
213_H216_N1.1250.96
53_I58_P1.1230.96
267_P271_K1.1220.96
52_V136_T1.1010.96
89_M117_I1.0970.96
160_E186_H1.0930.95
75_I89_M1.0920.95
67_Y71_T1.0840.95
105_L109_S1.0840.95
242_E246_E1.0800.95
192_H221_L1.0790.95
90_E117_I1.0740.95
75_I112_P1.0730.95
194_G225_E1.0720.95
54_E58_P1.0720.95
263_L266_H1.0590.95
153_L286_R1.0570.95
244_L254_A1.0570.95
25_S38_S1.0560.94
305_Y314_Q1.0530.94
244_L248_D1.0490.94
133_L320_T1.0320.94
47_Q50_V1.0260.94
154_V231_A1.0260.94
292_R297_Q1.0230.94
254_A257_P1.0210.93
237_G240_Q1.0200.93
192_H214_D1.0160.93
150_Q227_Q1.0120.93
32_R35_I1.0020.93
262_T265_Q0.9990.93
219_G243_E0.9990.93
203_H225_E0.9990.93
294_I300_F0.9940.93
105_L111_L0.9930.92
182_G185_W0.9910.92
247_V252_L0.9910.92
282_S285_A0.9900.92
156_A192_H0.9900.92
158_I179_T0.9870.92
157_T191_A0.9840.92
52_V55_P0.9820.92
206_V217_Q0.9820.92
36_F40_M0.9750.92
241_R253_I0.9710.92
180_K185_W0.9690.92
294_I322_A0.9680.91
239_P244_L0.9680.91
323_N326_R0.9670.91
285_A289_H0.9640.91
249_V253_I0.9610.91
247_V254_A0.9560.91
259_K262_T0.9530.91
72_M116_T0.9520.91
293_I325_F0.9400.90
207_T315_L0.9310.90
183_N310_K0.9310.90
315_L319_F0.9300.90
154_V218_L0.9270.90
234_G237_G0.9200.89
321_L325_F0.9180.89
141_L173_D0.9170.89
322_A326_R0.9160.89
21_D25_S0.9110.89
75_I103_A0.9090.89
292_R296_R0.9060.89
220_N223_H0.9050.88
258_G261_R0.9010.88
218_L231_A0.8980.88
228_F252_L0.8970.88
293_I322_A0.8930.88
244_L255_E0.8920.88
77_C81_W0.8920.88
102_F187_F0.8910.88
157_T291_F0.8890.88
178_Q185_W0.8870.87
257_P261_R0.8860.87
173_D189_M0.8820.87
137_I320_T0.8820.87
96_I99_M0.8750.87
215_L237_G0.8620.86
312_D316_A0.8610.86
90_E94_Y0.8590.86
251_W258_G0.8550.85
253_I256_R0.8540.85
158_I214_D0.8530.85
179_T188_G0.8520.85
21_D29_R0.8510.85
38_S101_L0.8500.85
151_G230_S0.8500.85
162_P306_K0.8490.85
218_L240_Q0.8470.85
18_T21_D0.8440.85
279_M284_R0.8440.85
175_E308_L0.8430.85
67_Y109_S0.8420.85
326_R330_M0.8400.84
293_I298_F0.8380.84
192_H217_Q0.8370.84
314_Q318_L0.8360.84
114_R118_M0.8290.84
62_N65_R0.8260.83
58_P61_G0.8230.83
260_V264_K0.8190.83
193_I202_T0.8170.83
54_E59_K0.8160.83
245_A271_K0.8150.83
246_E249_V0.8140.83
156_A179_T0.8120.82
250_D253_I0.8070.82
241_R247_V0.8050.82
90_E118_M0.8010.82
200_G293_I0.7970.81
290_P322_A0.7970.81
189_M311_N0.7850.80
208_T221_L0.7840.80
259_K265_Q0.7830.80
303_A315_L0.7800.80
182_G234_G0.7770.80
134_F316_A0.7760.79
173_D177_H0.7740.79
194_G221_L0.7700.79
81_W321_L0.7700.79
223_H226_E0.7690.79
239_P248_D0.7690.79
283_I286_R0.7680.79
78_M82_Y0.7640.78
176_M187_F0.7620.78
138_N141_L0.7600.78
202_T322_A0.7590.78
251_W256_R0.7590.78
190_K214_D0.7550.78
37_L102_F0.7540.77
247_V250_D0.7540.77
130_A313_N0.7530.77
178_Q187_F0.7490.77
20_A23_E0.7460.77
230_S283_I0.7440.77
165_T187_F0.7400.76
272_T277_E0.7390.76
200_G322_A0.7350.76
294_I319_F0.7350.76
191_A319_F0.7330.75
119_N133_L0.7330.75
276_I279_M0.7330.75
137_I324_L0.7320.75
205_L315_L0.7320.75
122_H310_K0.7310.75
304_R314_Q0.7290.75
137_I141_L0.7250.75
19_F24_F0.7200.74
131_R224_G0.7180.74
244_L250_D0.7160.74
241_R251_W0.7150.74
164_S172_R0.7110.73
291_F295_K0.7070.73
166_K182_G0.7060.73
93_L111_L0.7050.73
321_L328_D0.7040.73
69_L163_S0.7000.72
200_G290_P0.6980.72
46_W49_M0.6980.72
100_R111_L0.6970.72
51_E54_E0.6940.71
305_Y311_N0.6920.71
194_G229_V0.6920.71
48_N143_E0.6910.71
44_L74_R0.6900.71
181_K186_H0.6890.71
326_R329_Q0.6830.70
51_E143_E0.6780.70
97_A100_R0.6760.69
206_V221_L0.6740.69
238_A242_E0.6730.69
327_A330_M0.6720.69
231_A236_Q0.6680.69
295_K300_F0.6650.68
156_A291_F0.6620.68
25_S42_Q0.6610.68
72_M117_I0.6570.67
74_R102_F0.6560.67
67_Y75_I0.6540.67
249_V254_A0.6540.67
286_R289_H0.6540.67
35_I72_M0.6530.67
96_I133_L0.6530.67
166_K178_Q0.6510.67
264_K268_R0.6500.66
51_E132_Q0.6490.66
133_L145_G0.6490.66
206_V220_N0.6490.66
218_L229_V0.6460.66
59_K62_N0.6450.66
37_L46_W0.6450.66
273_A277_E0.6440.66
35_I98_S0.6440.66
56_F59_K0.6420.65
321_L326_R0.6400.65
89_M202_T0.6400.65
150_Q198_K0.6380.65
192_H210_A0.6370.65
82_Y95_E0.6370.65
277_E280_K0.6340.65
23_E29_R0.6340.65
166_K200_G0.6330.64
37_L78_M0.6330.64
245_A248_D0.6320.64
247_V251_W0.6320.64
308_L312_D0.6310.64
51_E227_Q0.6270.64
241_R256_R0.6260.64
67_Y120_F0.6240.63
163_S172_R0.6240.63
205_L320_T0.6240.63
179_T186_H0.6240.63
257_P260_V0.6240.63
280_K284_R0.6230.63
57_Y66_P0.6200.63
192_H212_E0.6190.63
134_F325_F0.6170.62
35_I161_A0.6160.62
158_I210_A0.6160.62
69_L121_R0.6150.62
241_R244_L0.6130.62
131_R312_D0.6120.62
240_Q247_V0.6120.62
208_T212_E0.6110.62
86_D120_F0.6110.62
250_D255_E0.6110.62
200_G326_R0.6100.62
256_R260_V0.6090.61
276_I280_K0.6080.61
243_E248_D0.6050.61
94_Y100_R0.6050.61
166_K188_G0.6040.61
256_R261_R0.6030.61
246_E261_R0.6030.61
213_H237_G0.6030.61
19_F30_Q0.6010.60
163_S187_F0.6010.60
318_L321_L0.5980.60
48_N52_V0.5980.60
187_F295_K0.5960.60
313_N317_M0.5950.60
159_I191_A0.5920.59
47_Q102_F0.5900.59
84_L92_A0.5900.59
39_R42_Q0.5840.58
193_I287_V0.5830.58
37_L82_Y0.5810.58
24_F97_A0.5800.58
118_M122_H0.5790.58
150_Q228_F0.5790.58
241_R255_E0.5790.58
41_E102_F0.5770.57
207_T311_N0.5770.57
250_D261_R0.5770.57
159_I303_A0.5740.57
189_M308_L0.5740.57
299_G314_Q0.5730.57
69_L72_M0.5730.57
67_Y119_N0.5700.56
91_D95_E0.5680.56
35_I101_L0.5680.56
84_L138_N0.5680.56
293_I297_Q0.5680.56
85_S231_A0.5670.56
44_L324_L0.5670.56
147_M199_S0.5670.56
81_W325_F0.5640.56
51_E55_P0.5630.55
45_P70_E0.5620.55
32_R36_F0.5620.55
249_V252_L0.5610.55
65_R202_T0.5610.55
141_L176_M0.5600.55
153_L195_V0.5600.55
41_E101_L0.5590.55
180_K186_H0.5570.55
91_D205_L0.5550.54
173_D176_M0.5500.54
68_P320_T0.5500.54
221_L224_G0.5500.54
137_I140_W0.5500.54
238_A255_E0.5490.54
277_E281_A0.5480.54
324_L328_D0.5470.53
76_H89_M0.5450.53
102_F115_T0.5440.53
45_P50_V0.5420.53
73_L117_I0.5400.52
215_L234_G0.5390.52
254_A263_L0.5380.52
149_T196_D0.5380.52
200_G286_R0.5380.52
282_S286_R0.5370.52
69_L87_G0.5360.52
131_R204_S0.5360.52
227_Q278_Y0.5350.52
40_M45_P0.5350.52
228_F250_D0.5350.52
190_K221_L0.5350.52
219_G223_H0.5330.52
71_T104_R0.5310.51
112_P196_D0.5300.51
134_F205_L0.5300.51
59_K65_R0.5300.51
206_V224_G0.5290.51
254_A259_K0.5280.51
286_R292_R0.5250.50
153_L289_H0.5250.50
222_L272_T0.5240.50
188_G284_R0.5230.50
140_W144_A0.5220.50
181_K235_Y0.5210.50
119_N122_H0.5210.50
73_L130_A0.5210.50
111_L119_N0.5180.50
164_S214_D0.5170.49
259_K263_L0.5160.49
311_N320_T0.5160.49
126_Q136_T0.5150.49
73_L317_M0.5150.49
87_G118_M0.5130.49
182_G200_G0.5100.48
19_F34_E0.5080.48
289_H292_R0.5060.48
121_R323_N0.5050.48
35_I38_S0.5050.48
317_M326_R0.5050.48
254_A258_G0.5050.48
161_A164_S0.5030.48
271_K274_I0.5020.47
171_Q178_Q0.5020.47
200_G289_H0.5020.47
156_A235_Y0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.7692 98.3 0.887 Contact Map
4u7bA 2 0.8166 75.7 0.948 Contact Map
4dyqA 5 0.3698 45.6 0.957 Contact Map
1bcoA 1 0.4645 32.1 0.961 Contact Map
1c6vA 4 0.3757 31.2 0.961 Contact Map
4mq3A 1 0.3609 28.7 0.962 Contact Map
1jkoC 1 0.1331 27.4 0.962 Contact Map
3kksA 2 0.3964 18.3 0.965 Contact Map
4fw1A 2 0.426 17.6 0.965 Contact Map
2m8eA 1 0.1657 16.5 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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