INSH6 - ECOLI - GREMLIN Contacts

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INSH6 - Transposase InsH for insertion sequence element IS5H

UniProt:	P0CE53	Sequences: MFVIWSHGTGFIMSHQLTFADSEFSSKRRQTRKEIFLSRMEQILPWQNMVEVIEPFYPKAGNGRRPYPLETMLRIHCMQHWYNLSDGAMEDALYEIASMRLFARLSLDSALPDRTTIMNFRHLLEQHQLARQLFKTINRWLAEAGVMMTQGTLVDATIIEAPSSTKNKEQQRDPEMHQTKKGNQWHFGMKAHIGVDAKSGLTHSLVTTAANEHDLNQLGNLLHGEEQFVSADAGYQGAPQREELAEVDVDWLIAERPGKVRTLKQHPRKNKTAINIEYMKASIRAKVEHPFRIIKRQFGFVKARYKGLLKNDNQLAMLFTLANLFRADQMIRQWERSH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG40008
Length:	338 (304)
Sequences:	1949 (1449)
Seq/√Len:	83.1

ECOLI - INSH6 INSH1 INSH2 INSH3 INSH4 INSH7 INSH8 INSH9 INH10 INH11 INSH5
HALSA - TH11 Q9HPK7 Q7LYM0 Q9HSX5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
87_G	114_R	3.930	1.00
92_A	96_I	3.886	1.00
247_V	253_I	3.799	1.00
195_V	287_V	3.700	1.00
244_L	253_I	3.650	1.00
205_L	316_A	3.586	1.00
244_L	247_V	3.475	1.00
75_I	93_L	3.405	1.00
202_T	319_F	3.311	1.00
192_H	208_T	3.237	1.00
248_D	253_I	3.060	1.00
204_S	224_G	2.973	1.00
79_Q	89_M	2.792	1.00
167_N	170_Q	2.760	1.00
58_P	62_N	2.664	1.00
240_Q	243_E	2.664	1.00
70_E	74_R	2.660	1.00
205_L	319_F	2.468	1.00
93_L	103_A	2.428	1.00
191_A	315_L	2.284	1.00
95_E	98_S	2.283	1.00
136_T	139_R	2.201	1.00
52_V	132_Q	2.117	1.00
86_D	121_R	2.086	1.00
74_R	103_A	2.007	1.00
141_L	327_A	2.002	1.00
201_L	326_R	1.979	1.00
157_T	295_K	1.972	1.00
154_V	194_G	1.933	1.00
17_L	20_A	1.918	1.00
307_G	310_K	1.883	1.00
192_H	235_Y	1.833	1.00
305_Y	310_K	1.831	1.00
115_T	118_M	1.792	1.00
193_I	291_F	1.785	1.00
90_E	114_R	1.779	1.00
41_E	104_R	1.766	1.00
31_T	38_S	1.745	1.00
294_I	318_L	1.733	1.00
75_I	117_I	1.727	1.00
152_T	194_G	1.701	1.00
206_V	312_D	1.692	1.00
265_Q	268_R	1.689	1.00
156_A	190_K	1.680	1.00
139_R	143_E	1.656	1.00
71_T	105_L	1.635	1.00
80_H	314_Q	1.626	1.00
303_A	311_N	1.624	1.00
72_M	120_F	1.593	1.00
152_T	203_H	1.578	1.00
39_R	43_I	1.575	1.00
134_F	319_F	1.568	1.00
263_L	267_P	1.563	1.00
244_L	249_V	1.553	1.00
156_A	214_D	1.549	1.00
266_H	269_K	1.547	1.00
57_Y	123_L	1.542	1.00
78_M	99_M	1.538	1.00
141_L	201_L	1.531	1.00
208_T	217_Q	1.529	1.00
115_T	119_N	1.525	0.99
273_A	276_I	1.505	0.99
212_E	217_Q	1.505	0.99
207_T	312_D	1.504	0.99
195_V	290_P	1.498	0.99
131_R	135_K	1.489	0.99
176_M	189_M	1.483	0.99
160_E	302_K	1.461	0.99
281_A	284_R	1.459	0.99
125_E	313_N	1.456	0.99
296_R	301_V	1.453	0.99
90_E	113_D	1.452	0.99
50_V	70_E	1.450	0.99
239_P	253_I	1.447	0.99
202_T	323_N	1.434	0.99
179_T	190_K	1.389	0.99
50_V	68_P	1.389	0.99
196_D	199_S	1.383	0.99
240_Q	253_I	1.383	0.99
264_K	269_K	1.374	0.99
218_L	222_L	1.360	0.99
49_M	53_I	1.358	0.99
277_E	284_R	1.356	0.99
151_G	228_F	1.343	0.99
265_Q	269_K	1.337	0.99
267_P	271_K	1.320	0.99
48_N	136_T	1.320	0.99
45_P	74_R	1.318	0.99
231_A	234_G	1.313	0.98
239_P	247_V	1.312	0.98
88_A	92_A	1.298	0.98
193_I	290_P	1.287	0.98
45_P	48_N	1.270	0.98
287_V	290_P	1.260	0.98
201_L	327_A	1.252	0.98
153_L	197_A	1.250	0.98
263_L	266_H	1.249	0.98
194_G	204_S	1.249	0.98
256_R	259_K	1.248	0.98
130_A	316_A	1.237	0.98
177_H	209_A	1.230	0.98
217_Q	220_N	1.229	0.98
217_Q	221_L	1.227	0.98
203_H	225_E	1.217	0.97
274_I	277_E	1.215	0.97
303_A	314_Q	1.212	0.97
41_E	74_R	1.210	0.97
300_F	318_L	1.208	0.97
251_W	254_A	1.208	0.97
150_Q	227_Q	1.204	0.97
35_I	95_E	1.194	0.97
32_R	35_I	1.191	0.97
75_I	112_P	1.188	0.97
179_T	210_A	1.173	0.97
204_S	221_L	1.168	0.97
298_F	322_A	1.163	0.97
154_V	218_L	1.160	0.97
133_L	320_T	1.160	0.97
90_E	111_L	1.156	0.97
160_E	186_H	1.154	0.97
192_H	221_L	1.145	0.96
292_R	297_Q	1.144	0.96
256_R	262_T	1.130	0.96
75_I	89_M	1.119	0.96
52_V	136_T	1.117	0.96
22_S	25_S	1.112	0.96
92_A	99_M	1.110	0.96
67_Y	71_T	1.109	0.96
89_M	117_I	1.097	0.95
244_L	252_L	1.097	0.95
153_L	286_K	1.091	0.95
322_A	326_R	1.090	0.95
84_L	116_T	1.089	0.95
105_L	109_S	1.074	0.95
82_Y	99_M	1.071	0.95
257_P	260_V	1.070	0.95
90_E	94_Y	1.070	0.95
285_A	289_H	1.062	0.94
282_S	285_A	1.054	0.94
206_V	217_Q	1.053	0.94
193_I	202_T	1.047	0.94
36_F	40_M	1.046	0.94
305_Y	314_Q	1.042	0.94
253_I	256_R	1.041	0.94
126_Q	309_L	1.037	0.94
154_V	231_A	1.036	0.94
90_E	117_I	1.036	0.94
207_T	315_L	1.035	0.94
157_T	191_A	1.033	0.94
47_Q	50_V	1.029	0.94
262_T	265_Q	1.025	0.93
243_E	247_V	1.016	0.93
194_G	225_E	1.013	0.93
158_I	179_T	1.013	0.93
263_L	269_K	1.013	0.93
264_K	267_P	1.006	0.93
156_A	192_H	1.000	0.93
192_H	214_D	0.998	0.92
200_G	322_A	0.991	0.92
293_I	298_F	0.987	0.92
294_I	300_F	0.983	0.92
38_S	101_L	0.965	0.91
105_L	111_L	0.964	0.91
293_I	322_A	0.962	0.91
223_H	226_E	0.961	0.91
248_D	252_L	0.960	0.91
294_I	322_A	0.948	0.90
220_N	223_H	0.944	0.90
151_G	230_S	0.941	0.90
244_L	248_D	0.934	0.90
102_F	187_F	0.930	0.90
293_I	325_F	0.927	0.89
247_V	252_L	0.926	0.89
213_H	216_N	0.921	0.89
315_L	319_F	0.919	0.89
178_Q	185_W	0.916	0.89
180_K	185_W	0.915	0.89
89_M	202_T	0.912	0.89
237_G	240_Q	0.911	0.89
218_L	240_Q	0.911	0.89
67_Y	109_S	0.910	0.88
182_G	185_W	0.905	0.88
78_M	82_Y	0.904	0.88
228_F	252_L	0.902	0.88
242_E	246_E	0.899	0.88
219_G	243_E	0.899	0.88
250_D	253_I	0.894	0.88
179_T	188_G	0.893	0.88
234_G	237_G	0.888	0.87
182_G	186_H	0.878	0.87
90_E	118_M	0.869	0.86
194_G	221_L	0.864	0.86
137_I	320_T	0.857	0.85
314_Q	318_L	0.855	0.85
114_R	118_M	0.854	0.85
245_A	248_D	0.852	0.85
218_L	231_A	0.850	0.85
52_V	55_P	0.849	0.85
312_D	316_A	0.848	0.85
241_R	254_A	0.847	0.85
290_P	322_A	0.843	0.84
72_M	116_T	0.835	0.84
261_R	267_P	0.835	0.84
191_A	319_F	0.832	0.84
292_R	296_R	0.831	0.83
265_Q	271_K	0.830	0.83
37_L	102_F	0.830	0.83
305_Y	311_N	0.828	0.83
189_M	311_N	0.828	0.83
262_T	267_P	0.826	0.83
162_P	306_K	0.825	0.83
175_E	308_L	0.823	0.83
19_F	24_F	0.822	0.83
202_T	322_A	0.820	0.83
77_C	81_W	0.820	0.83
326_R	330_M	0.816	0.82
75_I	103_A	0.815	0.82
264_K	268_R	0.812	0.82
25_S	42_Q	0.812	0.82
158_I	214_D	0.811	0.82
323_N	326_R	0.811	0.82
276_I	280_K	0.808	0.82
137_I	141_L	0.807	0.82
176_M	187_F	0.801	0.81
249_V	253_I	0.799	0.81
190_K	214_D	0.799	0.81
157_T	291_F	0.797	0.81
244_L	254_A	0.797	0.81
178_Q	187_F	0.793	0.81
238_A	244_L	0.793	0.81
247_V	254_A	0.789	0.80
200_G	290_P	0.787	0.80
215_L	237_G	0.784	0.80
277_E	280_K	0.784	0.80
62_N	65_R	0.780	0.79
254_A	257_P	0.778	0.79
189_M	308_L	0.773	0.79
57_Y	66_P	0.771	0.79
241_R	256_R	0.771	0.79
51_E	54_E	0.768	0.78
182_G	234_G	0.767	0.78
230_S	283_I	0.764	0.78
321_L	325_F	0.760	0.78
181_K	186_H	0.758	0.77
108_D	112_P	0.757	0.77
137_I	324_L	0.754	0.77
35_I	72_M	0.752	0.77
131_R	224_G	0.752	0.77
276_I	279_M	0.749	0.77
303_A	315_L	0.747	0.76
96_I	99_M	0.746	0.76
279_M	284_R	0.745	0.76
244_L	255_E	0.743	0.76
192_H	217_Q	0.741	0.76
165_T	187_F	0.741	0.76
244_L	250_D	0.740	0.76
48_N	143_E	0.740	0.76
327_A	330_M	0.735	0.75
286_K	289_H	0.734	0.75
241_R	247_V	0.734	0.75
241_R	253_I	0.733	0.75
283_I	286_K	0.732	0.75
81_W	321_L	0.730	0.75
59_K	62_N	0.726	0.74
138_N	141_L	0.725	0.74
37_L	46_W	0.724	0.74
193_I	287_V	0.722	0.74
208_T	212_E	0.722	0.74
205_L	315_L	0.719	0.74
134_F	316_A	0.719	0.74
182_G	200_G	0.717	0.73
18_T	24_F	0.714	0.73
44_L	74_R	0.710	0.73
295_K	300_F	0.710	0.73
183_N	310_K	0.709	0.73
131_R	312_D	0.707	0.72
143_E	258_G	0.704	0.72
35_I	161_A	0.702	0.72
239_P	244_L	0.699	0.72
35_I	98_S	0.699	0.72
200_G	293_I	0.699	0.72
37_L	82_Y	0.698	0.71
74_R	102_F	0.698	0.71
156_A	179_T	0.697	0.71
141_L	173_D	0.697	0.71
47_Q	102_F	0.696	0.71
131_R	204_S	0.696	0.71
326_R	329_Q	0.694	0.71
241_R	244_L	0.693	0.71
69_L	163_S	0.693	0.71
39_R	42_Q	0.693	0.71
206_V	220_N	0.692	0.71
308_L	312_D	0.690	0.71
173_D	177_H	0.689	0.70
179_T	186_H	0.689	0.70
259_K	262_T	0.686	0.70
17_L	25_S	0.685	0.70
246_E	249_V	0.683	0.70
97_A	107_L	0.682	0.70
200_G	326_R	0.680	0.69
192_H	212_E	0.680	0.69
181_K	235_Y	0.680	0.69
97_A	100_R	0.675	0.69
134_F	325_F	0.674	0.69
69_L	87_G	0.672	0.69
213_H	237_G	0.671	0.68
137_I	140_W	0.670	0.68
173_D	189_M	0.669	0.68
20_A	23_E	0.668	0.68
67_Y	75_I	0.667	0.68
304_R	314_Q	0.667	0.68
164_S	172_R	0.666	0.68
100_R	111_L	0.666	0.68
72_M	117_I	0.665	0.68
231_A	236_Q	0.664	0.68
93_L	111_L	0.662	0.67
291_F	295_K	0.660	0.67
313_N	317_M	0.659	0.67
273_A	277_E	0.656	0.67
258_G	263_L	0.652	0.66
122_H	310_K	0.648	0.66
324_L	328_D	0.647	0.66
294_I	319_F	0.647	0.66
250_D	255_E	0.647	0.66
82_Y	95_E	0.645	0.65
206_V	221_L	0.643	0.65
321_L	328_D	0.642	0.65
86_D	120_F	0.641	0.65
246_E	253_I	0.639	0.65
293_I	297_Q	0.639	0.65
130_A	313_N	0.634	0.64
156_A	291_F	0.634	0.64
150_Q	198_K	0.632	0.64
147_M	199_S	0.630	0.64
251_W	256_R	0.629	0.63
171_Q	178_Q	0.628	0.63
249_V	254_A	0.626	0.63
118_M	122_H	0.623	0.63
293_I	326_R	0.622	0.63
251_W	258_G	0.621	0.62
194_G	229_V	0.619	0.62
163_S	187_F	0.619	0.62
86_D	118_M	0.618	0.62
243_E	246_E	0.616	0.62
166_K	178_Q	0.612	0.61
50_V	54_E	0.607	0.61
221_L	224_G	0.605	0.60
299_G	314_Q	0.605	0.60
170_Q	278_Y	0.601	0.60
51_E	227_Q	0.600	0.60
159_I	191_A	0.600	0.60
248_D	257_P	0.599	0.60
134_F	205_L	0.596	0.59
224_G	242_E	0.595	0.59
96_I	133_L	0.594	0.59
94_Y	170_Q	0.592	0.59
102_F	115_T	0.592	0.59
274_I	284_R	0.592	0.59
40_M	45_P	0.592	0.59
25_S	38_S	0.591	0.59
67_Y	119_N	0.590	0.59
166_K	182_G	0.587	0.58
200_G	289_H	0.585	0.58
218_L	229_V	0.584	0.58
316_A	319_F	0.583	0.58
255_E	265_Q	0.582	0.58
126_Q	282_S	0.582	0.58
87_G	118_M	0.582	0.58
200_G	286_K	0.580	0.57
126_Q	167_N	0.579	0.57
46_W	102_F	0.579	0.57
158_I	210_A	0.574	0.57
238_A	242_E	0.573	0.56
54_E	59_K	0.573	0.56
91_D	95_E	0.572	0.56
163_S	172_R	0.572	0.56
321_L	326_R	0.569	0.56
149_T	196_D	0.568	0.56
31_T	37_L	0.568	0.56
153_L	195_V	0.568	0.56
35_I	101_L	0.566	0.55
262_T	271_K	0.565	0.55
48_N	52_V	0.564	0.55
176_M	321_L	0.563	0.55
166_K	284_R	0.563	0.55
67_Y	120_F	0.563	0.55
166_K	200_G	0.561	0.55
205_L	320_T	0.559	0.55
39_R	328_D	0.558	0.54
84_L	138_N	0.555	0.54
46_W	49_M	0.554	0.54
215_L	234_G	0.553	0.54
311_N	320_T	0.552	0.54
51_E	132_Q	0.551	0.53
41_E	102_F	0.547	0.53
81_W	325_F	0.547	0.53
247_V	250_D	0.546	0.53
94_Y	100_R	0.544	0.53
127_H	313_N	0.544	0.53
17_L	42_Q	0.543	0.52
183_N	188_G	0.543	0.52
54_E	58_P	0.542	0.52
268_R	271_K	0.542	0.52
250_D	261_R	0.542	0.52
192_H	210_A	0.542	0.52
59_K	65_R	0.541	0.52
204_S	225_E	0.539	0.52
175_E	189_M	0.537	0.52
187_F	295_K	0.537	0.52
126_Q	136_T	0.537	0.52
113_D	119_N	0.537	0.52
51_E	245_A	0.536	0.52
116_T	119_N	0.535	0.51
311_N	315_L	0.535	0.51
68_P	320_T	0.535	0.51
66_P	72_M	0.534	0.51
80_H	318_L	0.534	0.51
322_A	327_A	0.533	0.51
262_T	266_H	0.533	0.51
76_H	317_M	0.533	0.51
45_P	70_E	0.533	0.51
58_P	61_G	0.531	0.51
113_D	118_M	0.531	0.51
119_N	133_L	0.530	0.51
240_Q	244_L	0.529	0.51
298_F	303_A	0.525	0.50
54_E	144_A	0.525	0.50
66_P	69_L	0.524	0.50
277_E	281_A	0.523	0.50
206_V	224_G	0.523	0.50
239_P	248_D	0.522	0.50
208_T	221_L	0.521	0.50
150_Q	228_F	0.520	0.49
57_Y	133_L	0.519	0.49
85_S	121_R	0.518	0.49
37_L	78_M	0.516	0.49
318_L	321_L	0.515	0.49
249_V	256_R	0.514	0.49
173_D	176_M	0.514	0.49
170_Q	220_N	0.514	0.49
153_L	289_H	0.513	0.48
166_K	187_F	0.512	0.48
163_S	306_K	0.512	0.48
35_I	38_S	0.511	0.48
141_L	176_M	0.511	0.48
102_F	291_F	0.510	0.48
280_K	283_I	0.509	0.48
286_K	292_R	0.509	0.48
69_L	121_R	0.508	0.48
53_I	124_L	0.507	0.48
275_N	282_S	0.506	0.48
246_E	261_R	0.504	0.47
241_R	251_W	0.504	0.47
164_S	214_D	0.504	0.47
45_P	50_V	0.503	0.47
51_E	143_E	0.500	0.47

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1musA	2	0.7692	98.4	0.88	Contact Map
4u7bA	2	0.8077	76.4	0.948	Contact Map
1c6vA	4	0.3757	52.4	0.955	Contact Map
3l3uA	2	0.3935	42.5	0.958	Contact Map
4mq3A	1	0.3609	40.9	0.958	Contact Map
4dyqA	5	0.3698	38.7	0.959	Contact Map
1bcoA	1	0.4645	33.2	0.96	Contact Map
1ex4A	5	0.3994	32.3	0.96	Contact Map
3kksA	2	0.3964	30.7	0.961	Contact Map
4fw1A	2	0.426	30.1	0.961	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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