GREMLIN Database
INSH6 - Transposase InsH for insertion sequence element IS5H
UniProt: P0CE53 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG40008
Length: 338 (304)
Sequences: 1949 (1449)
Seq/√Len: 83.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_G114_R3.9301.00
92_A96_I3.8861.00
247_V253_I3.7991.00
195_V287_V3.7001.00
244_L253_I3.6501.00
205_L316_A3.5861.00
244_L247_V3.4751.00
75_I93_L3.4051.00
202_T319_F3.3111.00
192_H208_T3.2371.00
248_D253_I3.0601.00
204_S224_G2.9731.00
79_Q89_M2.7921.00
167_N170_Q2.7601.00
58_P62_N2.6641.00
240_Q243_E2.6641.00
70_E74_R2.6601.00
205_L319_F2.4681.00
93_L103_A2.4281.00
191_A315_L2.2841.00
95_E98_S2.2831.00
136_T139_R2.2011.00
52_V132_Q2.1171.00
86_D121_R2.0861.00
74_R103_A2.0071.00
141_L327_A2.0021.00
201_L326_R1.9791.00
157_T295_K1.9721.00
154_V194_G1.9331.00
17_L20_A1.9181.00
307_G310_K1.8831.00
192_H235_Y1.8331.00
305_Y310_K1.8311.00
115_T118_M1.7921.00
193_I291_F1.7851.00
90_E114_R1.7791.00
41_E104_R1.7661.00
31_T38_S1.7451.00
294_I318_L1.7331.00
75_I117_I1.7271.00
152_T194_G1.7011.00
206_V312_D1.6921.00
265_Q268_R1.6891.00
156_A190_K1.6801.00
139_R143_E1.6561.00
71_T105_L1.6351.00
80_H314_Q1.6261.00
303_A311_N1.6241.00
72_M120_F1.5931.00
152_T203_H1.5781.00
39_R43_I1.5751.00
134_F319_F1.5681.00
263_L267_P1.5631.00
244_L249_V1.5531.00
156_A214_D1.5491.00
266_H269_K1.5471.00
57_Y123_L1.5421.00
78_M99_M1.5381.00
141_L201_L1.5311.00
208_T217_Q1.5291.00
115_T119_N1.5250.99
273_A276_I1.5050.99
212_E217_Q1.5050.99
207_T312_D1.5040.99
195_V290_P1.4980.99
131_R135_K1.4890.99
176_M189_M1.4830.99
160_E302_K1.4610.99
281_A284_R1.4590.99
125_E313_N1.4560.99
296_R301_V1.4530.99
90_E113_D1.4520.99
50_V70_E1.4500.99
239_P253_I1.4470.99
202_T323_N1.4340.99
179_T190_K1.3890.99
50_V68_P1.3890.99
196_D199_S1.3830.99
240_Q253_I1.3830.99
264_K269_K1.3740.99
218_L222_L1.3600.99
49_M53_I1.3580.99
277_E284_R1.3560.99
151_G228_F1.3430.99
265_Q269_K1.3370.99
267_P271_K1.3200.99
48_N136_T1.3200.99
45_P74_R1.3180.99
231_A234_G1.3130.98
239_P247_V1.3120.98
88_A92_A1.2980.98
193_I290_P1.2870.98
45_P48_N1.2700.98
287_V290_P1.2600.98
201_L327_A1.2520.98
153_L197_A1.2500.98
263_L266_H1.2490.98
194_G204_S1.2490.98
256_R259_K1.2480.98
130_A316_A1.2370.98
177_H209_A1.2300.98
217_Q220_N1.2290.98
217_Q221_L1.2270.98
203_H225_E1.2170.97
274_I277_E1.2150.97
303_A314_Q1.2120.97
41_E74_R1.2100.97
300_F318_L1.2080.97
251_W254_A1.2080.97
150_Q227_Q1.2040.97
35_I95_E1.1940.97
32_R35_I1.1910.97
75_I112_P1.1880.97
179_T210_A1.1730.97
204_S221_L1.1680.97
298_F322_A1.1630.97
154_V218_L1.1600.97
133_L320_T1.1600.97
90_E111_L1.1560.97
160_E186_H1.1540.97
192_H221_L1.1450.96
292_R297_Q1.1440.96
256_R262_T1.1300.96
75_I89_M1.1190.96
52_V136_T1.1170.96
22_S25_S1.1120.96
92_A99_M1.1100.96
67_Y71_T1.1090.96
89_M117_I1.0970.95
244_L252_L1.0970.95
153_L286_K1.0910.95
322_A326_R1.0900.95
84_L116_T1.0890.95
105_L109_S1.0740.95
82_Y99_M1.0710.95
257_P260_V1.0700.95
90_E94_Y1.0700.95
285_A289_H1.0620.94
282_S285_A1.0540.94
206_V217_Q1.0530.94
193_I202_T1.0470.94
36_F40_M1.0460.94
305_Y314_Q1.0420.94
253_I256_R1.0410.94
126_Q309_L1.0370.94
154_V231_A1.0360.94
90_E117_I1.0360.94
207_T315_L1.0350.94
157_T191_A1.0330.94
47_Q50_V1.0290.94
262_T265_Q1.0250.93
243_E247_V1.0160.93
194_G225_E1.0130.93
158_I179_T1.0130.93
263_L269_K1.0130.93
264_K267_P1.0060.93
156_A192_H1.0000.93
192_H214_D0.9980.92
200_G322_A0.9910.92
293_I298_F0.9870.92
294_I300_F0.9830.92
38_S101_L0.9650.91
105_L111_L0.9640.91
293_I322_A0.9620.91
223_H226_E0.9610.91
248_D252_L0.9600.91
294_I322_A0.9480.90
220_N223_H0.9440.90
151_G230_S0.9410.90
244_L248_D0.9340.90
102_F187_F0.9300.90
293_I325_F0.9270.89
247_V252_L0.9260.89
213_H216_N0.9210.89
315_L319_F0.9190.89
178_Q185_W0.9160.89
180_K185_W0.9150.89
89_M202_T0.9120.89
237_G240_Q0.9110.89
218_L240_Q0.9110.89
67_Y109_S0.9100.88
182_G185_W0.9050.88
78_M82_Y0.9040.88
228_F252_L0.9020.88
242_E246_E0.8990.88
219_G243_E0.8990.88
250_D253_I0.8940.88
179_T188_G0.8930.88
234_G237_G0.8880.87
182_G186_H0.8780.87
90_E118_M0.8690.86
194_G221_L0.8640.86
137_I320_T0.8570.85
314_Q318_L0.8550.85
114_R118_M0.8540.85
245_A248_D0.8520.85
218_L231_A0.8500.85
52_V55_P0.8490.85
312_D316_A0.8480.85
241_R254_A0.8470.85
290_P322_A0.8430.84
72_M116_T0.8350.84
261_R267_P0.8350.84
191_A319_F0.8320.84
292_R296_R0.8310.83
265_Q271_K0.8300.83
37_L102_F0.8300.83
305_Y311_N0.8280.83
189_M311_N0.8280.83
262_T267_P0.8260.83
162_P306_K0.8250.83
175_E308_L0.8230.83
19_F24_F0.8220.83
202_T322_A0.8200.83
77_C81_W0.8200.83
326_R330_M0.8160.82
75_I103_A0.8150.82
264_K268_R0.8120.82
25_S42_Q0.8120.82
158_I214_D0.8110.82
323_N326_R0.8110.82
276_I280_K0.8080.82
137_I141_L0.8070.82
176_M187_F0.8010.81
249_V253_I0.7990.81
190_K214_D0.7990.81
157_T291_F0.7970.81
244_L254_A0.7970.81
178_Q187_F0.7930.81
238_A244_L0.7930.81
247_V254_A0.7890.80
200_G290_P0.7870.80
215_L237_G0.7840.80
277_E280_K0.7840.80
62_N65_R0.7800.79
254_A257_P0.7780.79
189_M308_L0.7730.79
57_Y66_P0.7710.79
241_R256_R0.7710.79
51_E54_E0.7680.78
182_G234_G0.7670.78
230_S283_I0.7640.78
321_L325_F0.7600.78
181_K186_H0.7580.77
108_D112_P0.7570.77
137_I324_L0.7540.77
35_I72_M0.7520.77
131_R224_G0.7520.77
276_I279_M0.7490.77
303_A315_L0.7470.76
96_I99_M0.7460.76
279_M284_R0.7450.76
244_L255_E0.7430.76
192_H217_Q0.7410.76
165_T187_F0.7410.76
244_L250_D0.7400.76
48_N143_E0.7400.76
327_A330_M0.7350.75
286_K289_H0.7340.75
241_R247_V0.7340.75
241_R253_I0.7330.75
283_I286_K0.7320.75
81_W321_L0.7300.75
59_K62_N0.7260.74
138_N141_L0.7250.74
37_L46_W0.7240.74
193_I287_V0.7220.74
208_T212_E0.7220.74
205_L315_L0.7190.74
134_F316_A0.7190.74
182_G200_G0.7170.73
18_T24_F0.7140.73
44_L74_R0.7100.73
295_K300_F0.7100.73
183_N310_K0.7090.73
131_R312_D0.7070.72
143_E258_G0.7040.72
35_I161_A0.7020.72
239_P244_L0.6990.72
35_I98_S0.6990.72
200_G293_I0.6990.72
37_L82_Y0.6980.71
74_R102_F0.6980.71
156_A179_T0.6970.71
141_L173_D0.6970.71
47_Q102_F0.6960.71
131_R204_S0.6960.71
326_R329_Q0.6940.71
241_R244_L0.6930.71
69_L163_S0.6930.71
39_R42_Q0.6930.71
206_V220_N0.6920.71
308_L312_D0.6900.71
173_D177_H0.6890.70
179_T186_H0.6890.70
259_K262_T0.6860.70
17_L25_S0.6850.70
246_E249_V0.6830.70
97_A107_L0.6820.70
200_G326_R0.6800.69
192_H212_E0.6800.69
181_K235_Y0.6800.69
97_A100_R0.6750.69
134_F325_F0.6740.69
69_L87_G0.6720.69
213_H237_G0.6710.68
137_I140_W0.6700.68
173_D189_M0.6690.68
20_A23_E0.6680.68
67_Y75_I0.6670.68
304_R314_Q0.6670.68
164_S172_R0.6660.68
100_R111_L0.6660.68
72_M117_I0.6650.68
231_A236_Q0.6640.68
93_L111_L0.6620.67
291_F295_K0.6600.67
313_N317_M0.6590.67
273_A277_E0.6560.67
258_G263_L0.6520.66
122_H310_K0.6480.66
324_L328_D0.6470.66
294_I319_F0.6470.66
250_D255_E0.6470.66
82_Y95_E0.6450.65
206_V221_L0.6430.65
321_L328_D0.6420.65
86_D120_F0.6410.65
246_E253_I0.6390.65
293_I297_Q0.6390.65
130_A313_N0.6340.64
156_A291_F0.6340.64
150_Q198_K0.6320.64
147_M199_S0.6300.64
251_W256_R0.6290.63
171_Q178_Q0.6280.63
249_V254_A0.6260.63
118_M122_H0.6230.63
293_I326_R0.6220.63
251_W258_G0.6210.62
194_G229_V0.6190.62
163_S187_F0.6190.62
86_D118_M0.6180.62
243_E246_E0.6160.62
166_K178_Q0.6120.61
50_V54_E0.6070.61
221_L224_G0.6050.60
299_G314_Q0.6050.60
170_Q278_Y0.6010.60
51_E227_Q0.6000.60
159_I191_A0.6000.60
248_D257_P0.5990.60
134_F205_L0.5960.59
224_G242_E0.5950.59
96_I133_L0.5940.59
94_Y170_Q0.5920.59
102_F115_T0.5920.59
274_I284_R0.5920.59
40_M45_P0.5920.59
25_S38_S0.5910.59
67_Y119_N0.5900.59
166_K182_G0.5870.58
200_G289_H0.5850.58
218_L229_V0.5840.58
316_A319_F0.5830.58
255_E265_Q0.5820.58
126_Q282_S0.5820.58
87_G118_M0.5820.58
200_G286_K0.5800.57
126_Q167_N0.5790.57
46_W102_F0.5790.57
158_I210_A0.5740.57
238_A242_E0.5730.56
54_E59_K0.5730.56
91_D95_E0.5720.56
163_S172_R0.5720.56
321_L326_R0.5690.56
149_T196_D0.5680.56
31_T37_L0.5680.56
153_L195_V0.5680.56
35_I101_L0.5660.55
262_T271_K0.5650.55
48_N52_V0.5640.55
176_M321_L0.5630.55
166_K284_R0.5630.55
67_Y120_F0.5630.55
166_K200_G0.5610.55
205_L320_T0.5590.55
39_R328_D0.5580.54
84_L138_N0.5550.54
46_W49_M0.5540.54
215_L234_G0.5530.54
311_N320_T0.5520.54
51_E132_Q0.5510.53
41_E102_F0.5470.53
81_W325_F0.5470.53
247_V250_D0.5460.53
94_Y100_R0.5440.53
127_H313_N0.5440.53
17_L42_Q0.5430.52
183_N188_G0.5430.52
54_E58_P0.5420.52
268_R271_K0.5420.52
250_D261_R0.5420.52
192_H210_A0.5420.52
59_K65_R0.5410.52
204_S225_E0.5390.52
175_E189_M0.5370.52
187_F295_K0.5370.52
126_Q136_T0.5370.52
113_D119_N0.5370.52
51_E245_A0.5360.52
116_T119_N0.5350.51
311_N315_L0.5350.51
68_P320_T0.5350.51
66_P72_M0.5340.51
80_H318_L0.5340.51
322_A327_A0.5330.51
262_T266_H0.5330.51
76_H317_M0.5330.51
45_P70_E0.5330.51
58_P61_G0.5310.51
113_D118_M0.5310.51
119_N133_L0.5300.51
240_Q244_L0.5290.51
298_F303_A0.5250.50
54_E144_A0.5250.50
66_P69_L0.5240.50
277_E281_A0.5230.50
206_V224_G0.5230.50
239_P248_D0.5220.50
208_T221_L0.5210.50
150_Q228_F0.5200.49
57_Y133_L0.5190.49
85_S121_R0.5180.49
37_L78_M0.5160.49
318_L321_L0.5150.49
249_V256_R0.5140.49
173_D176_M0.5140.49
170_Q220_N0.5140.49
153_L289_H0.5130.48
166_K187_F0.5120.48
163_S306_K0.5120.48
35_I38_S0.5110.48
141_L176_M0.5110.48
102_F291_F0.5100.48
280_K283_I0.5090.48
286_K292_R0.5090.48
69_L121_R0.5080.48
53_I124_L0.5070.48
275_N282_S0.5060.48
246_E261_R0.5040.47
241_R251_W0.5040.47
164_S214_D0.5040.47
45_P50_V0.5030.47
51_E143_E0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.7692 98.4 0.88 Contact Map
4u7bA 2 0.8077 76.4 0.948 Contact Map
1c6vA 4 0.3757 52.4 0.955 Contact Map
3l3uA 2 0.3935 42.5 0.958 Contact Map
4mq3A 1 0.3609 40.9 0.958 Contact Map
4dyqA 5 0.3698 38.7 0.959 Contact Map
1bcoA 1 0.4645 33.2 0.96 Contact Map
1ex4A 5 0.3994 32.3 0.96 Contact Map
3kksA 2 0.3964 30.7 0.961 Contact Map
4fw1A 2 0.426 30.1 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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