GREMLIN Database
EFTU2 - Elongation factor Tu 2
UniProt: P0CE48 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11037
Length: 394 (340)
Sequences: 17507 (8175)
Seq/√Len: 443.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
269_G275_V5.3911.00
238_K268_E4.3161.00
134_F173_G4.2841.00
236_I268_E4.1991.00
171_V195_F3.5811.00
144_E148_E2.8751.00
212_L234_R2.8381.00
254_S257_T2.8371.00
241_E295_K2.7031.00
151_E155_R2.5601.00
211_F232_V2.5181.00
238_K241_E2.5121.00
109_T140_M2.5021.00
242_E251_T2.4711.00
144_E149_L2.4441.00
258_G265_L2.4061.00
173_G192_L2.3201.00
239_V267_D2.2741.00
194_G198_S2.2631.00
54_P58_A2.1831.00
244_E251_T2.1361.00
236_I270_R2.0801.00
101_G200_I2.0791.00
211_F237_I2.0501.00
149_L153_E2.0491.00
71_D76_H2.0451.00
16_G99_M1.9931.00
230_G277_V1.9911.00
206_A209_K1.9691.00
15_V77_Y1.9601.00
270_R273_E1.9421.00
151_E172_R1.9061.00
351_V357_I1.8921.00
239_V265_L1.8901.00
209_K234_R1.8671.00
219_F229_T1.8581.00
108_A135_L1.8281.00
29_T79_H1.8281.00
35_V190_L1.8261.00
228_V287_I1.7821.00
232_V269_G1.7791.00
211_F243_V1.7711.00
103_I134_F1.7691.00
227_V276_G1.7551.00
55_E63_I1.7531.00
213_L230_G1.7391.00
255_T280_R1.7271.00
195_F199_Y1.7261.00
232_V275_V1.7111.00
147_L151_E1.7011.00
50_I68_V1.6951.00
107_A110_D1.6901.00
244_E296_P1.6821.00
151_E170_I1.6761.00
159_S162_D1.6651.00
120_I154_V1.6641.00
17_T29_T1.6391.00
106_V116_T1.6361.00
69_E76_H1.6341.00
215_I228_V1.6161.00
246_V294_A1.6061.00
42_G45_R1.5851.00
254_S258_G1.5691.00
152_M156_E1.5531.00
75_R197_D1.5251.00
226_T333_F1.5181.00
73_P194_G1.5121.00
237_I256_C1.5071.00
134_F175_A1.5021.00
148_E152_M1.4871.00
188_K191_E1.4721.00
190_L194_G1.4691.00
158_L161_Y1.4631.00
317_G320_H1.4461.00
28_L105_V1.4241.00
71_D74_T1.4091.00
244_E249_K1.4061.00
110_D113_M1.3951.00
28_L175_A1.3921.00
320_H323_F1.3861.00
261_M264_K1.3801.00
310_Y316_E1.3751.00
143_D147_L1.3601.00
136_N175_A1.3321.00
254_S259_V1.3221.00
11_P75_R1.3211.00
150_V153_E1.3191.00
41_G44_A1.3131.00
31_A34_T1.3091.00
32_I70_Y1.3071.00
207_I270_R1.3041.00
43_A48_D1.2991.00
39_T49_Q1.2991.00
163_F167_D1.2981.00
153_E156_E1.2921.00
332_Y338_V1.2841.00
158_L162_D1.2811.00
147_L158_L1.2741.00
266_L269_G1.2711.00
319_R322_P1.2561.00
231_R274_N1.2551.00
102_A123_G1.2541.00
32_I189_I1.2521.00
29_T50_I1.2451.00
72_T194_G1.2421.00
31_A178_A1.2411.00
213_L232_V1.2271.00
344_L347_G1.2181.00
155_R159_S1.2181.00
41_G48_D1.2161.00
237_I277_V1.2161.00
323_F326_G1.2151.00
28_L192_L1.2141.00
117_R157_L1.2071.00
93_I122_L1.2041.00
322_P325_K1.2031.00
104_L133_V1.2021.00
36_L193_A1.1951.00
153_E158_L1.1921.00
151_E159_S1.1881.00
70_Y79_H1.1871.00
174_S177_K1.1871.00
242_E255_T1.1821.00
50_I62_T1.1781.00
310_Y315_D1.1781.00
169_P199_Y1.1751.00
53_A64_N1.1751.00
331_F335_T1.1741.00
191_E194_G1.1611.00
18_I123_G1.1571.00
102_A128_V1.1551.00
73_P197_D1.1541.00
18_I104_L1.1511.00
341_T352_M1.1491.00
328_R331_F1.1441.00
70_Y77_Y1.1441.00
36_L70_Y1.1401.00
135_L172_R1.1391.00
133_V170_I1.1371.00
14_N78_A1.1371.00
119_H122_L1.1331.00
306_E358_K1.1281.00
138_C179_L1.1241.00
80_V99_M1.1161.00
277_V293_L1.1141.00
295_K298_T1.1061.00
248_I291_Q1.1051.00
310_Y313_S1.1051.00
327_Y366_P1.1021.00
250_E286_E1.1001.00
335_T338_V1.0961.00
151_E158_L1.0871.00
304_K362_T1.0871.00
153_E157_L1.0831.00
37_A40_Y1.0811.00
322_P326_G1.0791.00
288_E291_Q1.0751.00
77_Y197_D1.0731.00
138_C172_R1.0671.00
242_E296_P1.0551.00
309_V339_T1.0541.00
230_G275_V1.0531.00
43_A47_F1.0521.00
313_S316_E1.0511.00
51_D56_E1.0511.00
302_H305_F1.0511.00
144_E150_V1.0511.00
11_P74_T1.0491.00
313_S352_M1.0461.00
31_A35_V1.0451.00
147_L150_V1.0371.00
243_V293_L1.0301.00
311_I315_D1.0291.00
244_E299_I1.0241.00
169_P195_F1.0231.00
112_P116_T1.0171.00
44_A48_D1.0141.00
155_R158_L1.0091.00
45_R48_D1.0061.00
35_V178_A1.0021.00
139_D174_S1.0011.00
42_G47_F1.0011.00
41_G45_R1.0011.00
351_V362_T0.9981.00
18_I102_A0.9951.00
251_T296_P0.9951.00
238_K267_D0.9931.00
269_G273_E0.9911.00
46_A49_Q0.9841.00
321_T325_K0.9831.00
323_F327_Y0.9711.00
44_A47_F0.9701.00
52_N66_S0.9691.00
237_I269_G0.9691.00
304_K360_V0.9691.00
52_N64_N0.9671.00
338_V362_T0.9671.00
311_I316_E0.9651.00
319_R327_Y0.9601.00
151_E162_D0.9601.00
345_P348_V0.9601.00
148_E151_E0.9601.00
328_R335_T0.9601.00
144_E147_L0.9591.00
154_V158_L0.9571.00
245_I287_I0.9571.00
54_P57_K0.9541.00
308_E358_K0.9531.00
104_L116_T0.9461.00
150_V158_L0.9441.00
245_I293_L0.9401.00
40_Y43_A0.9401.00
133_V168_T0.9381.00
307_S310_Y0.9371.00
338_V351_V0.9361.00
45_R49_Q0.9291.00
132_I195_F0.9271.00
42_G46_A0.9251.00
310_Y314_K0.9211.00
41_G46_A0.9211.00
215_I287_I0.9211.00
43_A46_A0.9171.00
309_V359_M0.9101.00
55_E59_R0.9101.00
352_M355_D0.9021.00
306_E360_V0.8981.00
243_V256_C0.8961.00
31_A189_I0.8941.00
28_L134_F0.8921.00
331_F338_V0.8911.00
239_V259_V0.8801.00
17_T103_I0.8791.00
247_G291_Q0.8791.00
207_I271_A0.8781.00
15_V196_L0.8751.00
294_A300_K0.8701.00
311_I314_K0.8681.00
39_T45_R0.8671.00
123_G131_I0.8661.00
210_P295_K0.8601.00
248_I288_E0.8581.00
245_I254_S0.8571.00
108_A138_C0.8561.00
147_L160_Q0.8551.00
343_E346_E0.8511.00
328_R337_D0.8491.00
207_I210_P0.8411.00
329_P332_Y0.8411.00
324_F327_Y0.8411.00
255_T258_G0.8401.00
27_T175_A0.8401.00
50_I66_S0.8401.00
65_T80_V0.8371.00
44_A49_Q0.8281.00
147_L159_S0.8271.00
143_D149_L0.8261.00
16_G82_C0.8201.00
208_D236_I0.8101.00
346_E350_M0.8101.00
155_R160_Q0.8091.00
35_V189_I0.8051.00
147_L155_R0.8051.00
154_V162_D0.8051.00
56_E60_G0.8031.00
335_T340_G0.8011.00
109_T142_D0.7941.00
237_I243_V0.7931.00
255_T259_V0.7931.00
143_D153_E0.7921.00
22_D85_H0.7901.00
149_L152_M0.7891.00
322_P327_Y0.7871.00
207_I236_I0.7861.00
266_L273_E0.7811.00
103_I192_L0.7781.00
254_S280_R0.7761.00
41_G49_Q0.7721.00
319_R323_F0.7721.00
32_I193_A0.7711.00
236_I271_A0.7631.00
155_R162_D0.7631.00
147_L172_R0.7631.00
328_R333_F0.7621.00
308_E314_K0.7621.00
120_I131_I0.7611.00
331_F340_G0.7591.00
20_H23_H0.7561.00
135_L147_L0.7561.00
12_H78_A0.7541.00
150_V154_V0.7531.00
156_E159_S0.7511.00
106_V133_V0.7511.00
132_I171_V0.7511.00
104_L119_H0.7501.00
239_V258_G0.7451.00
258_G266_L0.7431.00
260_E265_L0.7401.00
328_R340_G0.7361.00
40_Y44_A0.7331.00
152_M155_R0.7311.00
28_L189_I0.7301.00
39_T43_A0.7251.00
133_V154_V0.7241.00
101_G132_I0.7241.00
112_P150_V0.7241.00
148_E172_R0.7221.00
296_P299_I0.7221.00
134_F192_L0.7211.00
195_F198_S0.7201.00
294_A299_I0.7191.00
150_V162_D0.7161.00
213_L216_E0.7161.00
309_V312_L0.7151.00
144_E151_E0.7131.00
37_A45_R0.7121.00
51_D57_K0.7121.00
157_L162_D0.7111.00
101_G201_P0.7111.00
329_P342_I0.7101.00
332_Y336_T0.7081.00
320_H325_K0.7071.00
205_R234_R0.7061.00
331_F336_T0.7011.00
163_F166_D0.7011.00
325_K329_P0.6991.00
319_R325_K0.6971.00
16_G96_A0.6971.00
34_T42_G0.6921.00
329_P340_G0.6911.00
212_L300_K0.6881.00
308_E311_I0.6871.00
37_A41_G0.6871.00
149_L158_L0.6871.00
259_V269_G0.6831.00
19_G23_H0.6821.00
329_P365_H0.6811.00
332_Y335_T0.6801.00
309_V314_K0.6801.00
221_I224_R0.6801.00
325_K330_Q0.6791.00
282_I287_I0.6781.00
332_Y340_G0.6761.00
329_P333_F0.6751.00
256_C259_V0.6741.00
150_V155_R0.6741.00
150_V157_L0.6731.00
120_I124_R0.6691.00
306_E309_V0.6691.00
244_E297_G0.6691.00
138_C147_L0.6681.00
150_V159_S0.6681.00
16_G102_A0.6671.00
105_V136_N0.6671.00
324_F333_F0.6661.00
308_E313_S0.6631.00
21_V61_I0.6601.00
144_E158_L0.6591.00
245_I248_I0.6571.00
344_L348_V0.6571.00
326_G329_P0.6561.00
263_R276_G0.6551.00
278_L281_G0.6541.00
305_F363_L0.6521.00
40_Y45_R0.6511.00
244_E294_A0.6511.00
134_F188_K0.6501.00
21_V85_H0.6490.99
205_R209_K0.6450.99
259_V277_V0.6450.99
194_G197_D0.6440.99
22_D61_I0.6440.99
266_L275_V0.6400.99
156_E160_Q0.6400.99
37_A44_A0.6400.99
221_I227_V0.6390.99
151_E161_Y0.6390.99
213_L277_V0.6390.99
107_A140_M0.6380.99
328_R334_R0.6370.99
39_T42_G0.6350.99
337_D360_V0.6340.99
147_L157_L0.6330.99
312_L315_D0.6330.99
18_I96_A0.6290.99
340_G343_E0.6290.99
243_V254_S0.6290.99
41_G47_F0.6280.99
13_V203_P0.6270.99
103_I196_L0.6240.99
234_R300_K0.6230.99
211_F256_C0.6230.99
254_S282_I0.6220.99
92_M119_H0.6220.99
205_R271_A0.6210.99
295_K299_I0.6200.99
33_T68_V0.6180.99
309_V315_D0.6170.99
64_N91_N0.6170.99
246_V300_K0.6170.99
61_I85_H0.6160.99
143_D150_V0.6160.99
157_L160_Q0.6130.99
42_G48_D0.6130.99
307_S311_I0.6120.99
341_T355_D0.6100.99
155_R161_Y0.6100.99
328_R336_T0.6080.99
65_T95_G0.6070.99
332_Y339_T0.6070.99
330_Q333_F0.6050.99
328_R342_I0.6050.99
147_L162_D0.6030.99
74_T198_S0.6030.99
318_G323_F0.5990.99
319_R326_G0.5990.99
210_P298_T0.5960.99
162_D166_D0.5940.99
72_T193_A0.5930.99
336_T340_G0.5930.99
90_K337_D0.5890.99
33_T49_Q0.5890.99
72_T197_D0.5880.99
73_P198_S0.5860.99
327_Y333_F0.5850.99
323_F330_Q0.5850.99
213_L237_I0.5830.99
93_I119_H0.5830.99
257_T280_R0.5830.99
100_D231_R0.5820.99
144_E159_S0.5820.99
153_E162_D0.5810.99
196_L200_I0.5800.99
47_F57_K0.5800.99
48_D57_K0.5790.99
305_F308_E0.5790.99
22_D60_G0.5770.99
188_K192_L0.5740.99
239_V257_T0.5740.99
337_D341_T0.5740.99
320_H324_F0.5730.99
346_E349_E0.5730.99
192_L196_L0.5700.99
331_F334_R0.5680.99
133_V158_L0.5670.99
239_V268_E0.5630.99
211_F236_I0.5610.99
39_T44_A0.5610.99
55_E58_A0.5580.98
321_T324_F0.5580.98
69_E78_A0.5570.98
215_I230_G0.5560.98
338_V343_E0.5550.98
32_I36_L0.5550.98
261_M266_L0.5550.98
246_V299_I0.5530.98
256_C277_V0.5510.98
312_L316_E0.5490.98
148_E155_R0.5490.98
97_A233_E0.5490.98
212_L302_H0.5470.98
204_E209_K0.5450.98
21_V62_T0.5430.98
82_C92_M0.5430.98
328_R343_E0.5430.98
331_F337_D0.5420.98
318_G322_P0.5410.98
116_T133_V0.5400.98
309_V316_E0.5400.98
107_A113_M0.5390.98
155_R170_I0.5360.98
328_R338_V0.5350.98
327_Y331_F0.5320.98
222_S225_G0.5310.98
154_V157_L0.5290.98
330_Q335_T0.5290.98
288_E307_S0.5280.98
147_L153_E0.5270.98
40_Y49_Q0.5260.98
232_V237_I0.5260.98
335_T343_E0.5260.98
77_Y196_L0.5250.98
49_Q57_K0.5220.98
345_P349_E0.5220.98
151_E157_L0.5200.98
76_H273_E0.5190.98
156_E162_D0.5180.98
46_A57_K0.5180.98
153_E161_Y0.5160.98
313_S350_M0.5160.98
324_F331_F0.5140.97
212_L294_A0.5140.97
59_R63_I0.5130.97
124_R127_G0.5130.97
307_S313_S0.5120.97
179_L188_K0.5110.97
326_G330_Q0.5110.97
319_R324_F0.5100.97
317_G323_F0.5080.97
219_F276_G0.5080.97
154_V159_S0.5070.97
327_Y335_T0.5060.97
339_T360_V0.5050.97
12_H76_H0.5040.97
131_I163_F0.5040.97
285_E332_Y0.5030.97
86_A114_P0.5030.97
335_T341_T0.5030.97
20_H113_M0.5030.97
107_A137_K0.5020.97
153_E159_S0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1d2eA 3 0.9594 100 0.267 Contact Map
2c78A 1 0.9594 100 0.267 Contact Map
3avxA 1 0.9213 100 0.281 Contact Map
1f60A 1 0.9772 100 0.283 Contact Map
1jnyA 1 0.9391 100 0.284 Contact Map
3wy9A 1 0.9619 100 0.285 Contact Map
4crnP 1 0.967 100 0.286 Contact Map
3mcaA 1 0.8604 100 0.286 Contact Map
4d61i 1 0.9619 100 0.292 Contact Map
1r5bA 1 0.901 100 0.305 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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