GREMLIN Database
EFTU1 - Elongation factor Tu 1
UniProt: P0CE47 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11036
Length: 394 (342)
Sequences: 18755 (8623)
Seq/√Len: 466.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
269_G275_V5.5501.00
238_K268_E4.5441.00
134_F173_G4.5151.00
236_I268_E4.3951.00
171_V195_F3.7241.00
212_L234_R3.0171.00
144_E149_L2.8841.00
241_E295_K2.8741.00
144_E148_E2.8181.00
109_T140_M2.6541.00
238_K241_E2.5991.00
258_G265_L2.5611.00
242_E251_T2.4791.00
151_E172_R2.4581.00
211_F232_V2.4121.00
239_V267_D2.3871.00
117_R157_L2.3491.00
71_D76_H2.3341.00
173_G192_L2.3231.00
194_G198_S2.2991.00
254_S257_T2.2971.00
151_E155_R2.2441.00
244_E251_T2.1751.00
270_R273_E2.1201.00
239_V265_L2.1101.00
236_I270_R2.0811.00
206_A209_K2.0591.00
257_T261_M2.0481.00
69_E76_H2.0471.00
16_G99_M2.0411.00
54_P58_A2.0391.00
211_F237_I2.0291.00
101_G200_I2.0001.00
351_V357_I1.9981.00
209_K234_R1.9751.00
15_V77_Y1.9281.00
149_L153_E1.9141.00
35_V190_L1.9021.00
151_E170_I1.8891.00
228_V287_I1.8561.00
230_G277_V1.8381.00
261_M264_K1.8141.00
219_F229_T1.8071.00
108_A135_L1.8051.00
227_V276_G1.7881.00
195_F199_Y1.7771.00
244_E296_P1.7681.00
31_A178_A1.7661.00
29_T79_H1.7611.00
42_G45_R1.7471.00
211_F243_V1.7411.00
103_I134_F1.7061.00
55_E63_I1.6731.00
188_K191_E1.6721.00
213_L230_G1.6641.00
215_I228_V1.6391.00
152_M156_E1.6161.00
232_V275_V1.6091.00
232_V269_G1.6021.00
50_I68_V1.6011.00
17_T29_T1.6001.00
41_G44_A1.5891.00
120_I154_V1.5741.00
75_R197_D1.5741.00
107_A110_D1.5521.00
106_V116_T1.5461.00
71_D74_T1.5441.00
246_V294_A1.5431.00
31_A34_T1.5371.00
329_P333_F1.5371.00
258_G261_M1.5231.00
258_G262_F1.5091.00
148_E152_M1.4841.00
322_P325_K1.4741.00
73_P194_G1.4721.00
237_I256_C1.4681.00
28_L105_V1.4531.00
169_P195_F1.4521.00
136_N175_A1.4451.00
32_I189_I1.4261.00
150_V153_E1.4091.00
138_C179_L1.4071.00
346_E350_M1.3771.00
254_S261_M1.3761.00
190_L194_G1.3751.00
254_S260_E1.3631.00
102_A123_G1.3591.00
153_E156_E1.3581.00
32_I70_Y1.3341.00
110_D113_M1.3311.00
164_P168_T1.3301.00
134_F175_A1.3301.00
169_P199_Y1.3271.00
257_T260_E1.3191.00
330_Q333_F1.3091.00
257_T262_F1.3031.00
226_T335_T1.3011.00
254_S258_G1.3011.00
259_V262_F1.2951.00
72_T194_G1.2911.00
11_P75_R1.2901.00
266_L269_G1.2781.00
319_R322_P1.2721.00
28_L175_A1.2581.00
135_L172_R1.2571.00
138_C172_R1.2531.00
104_L133_V1.2511.00
36_L193_A1.2501.00
147_L151_E1.2501.00
45_R48_D1.2371.00
244_E249_K1.2351.00
344_L347_G1.2271.00
328_R332_Y1.2191.00
31_A189_I1.2101.00
309_V341_T1.2091.00
207_I270_R1.2071.00
29_T50_I1.1941.00
70_Y79_H1.1931.00
174_S177_K1.1781.00
80_V99_M1.1741.00
277_V293_L1.1741.00
133_V170_I1.1731.00
18_I123_G1.1681.00
237_I277_V1.1671.00
36_L70_Y1.1601.00
93_I122_L1.1441.00
28_L192_L1.1401.00
231_R274_N1.1261.00
53_A64_N1.1251.00
50_I62_T1.1201.00
14_N78_A1.1181.00
44_A48_D1.1181.00
77_Y197_D1.1161.00
43_A48_D1.1151.00
355_D358_K1.1141.00
41_G48_D1.1131.00
345_P348_V1.1121.00
352_M355_D1.1041.00
70_Y77_Y1.0971.00
243_V293_L1.0951.00
248_I291_Q1.0941.00
353_P357_I1.0861.00
151_E163_F1.0831.00
133_V154_V1.0821.00
102_A128_V1.0811.00
213_L232_V1.0761.00
45_R49_Q1.0751.00
43_A47_F1.0701.00
331_F334_R1.0691.00
337_D341_T1.0671.00
119_H122_L1.0631.00
46_A49_Q1.0621.00
302_H305_F1.0601.00
242_E255_T1.0601.00
288_E291_Q1.0591.00
158_L162_D1.0541.00
353_P358_K1.0531.00
40_Y49_Q1.0461.00
191_E194_G1.0441.00
306_E358_K1.0421.00
103_I196_L1.0421.00
325_K328_R1.0391.00
345_P349_E1.0381.00
269_G273_E1.0311.00
295_K298_T1.0221.00
40_Y43_A1.0221.00
344_L348_V1.0211.00
343_E352_M1.0171.00
336_T339_T1.0161.00
311_I314_K1.0091.00
250_E286_E1.0071.00
123_G131_I1.0001.00
357_I361_V0.9991.00
31_A35_V0.9971.00
304_K362_T0.9941.00
40_Y44_A0.9941.00
112_P116_T0.9891.00
35_V178_A0.9871.00
73_P197_D0.9861.00
144_E150_V0.9831.00
18_I104_L0.9771.00
158_L161_Y0.9721.00
244_E299_I0.9651.00
242_E296_P0.9651.00
328_R331_F0.9631.00
334_R340_G0.9611.00
54_P57_K0.9571.00
304_K360_V0.9531.00
354_G357_I0.9531.00
11_P74_T0.9521.00
210_P295_K0.9521.00
39_T42_G0.9511.00
51_D56_E0.9501.00
239_V259_V0.9481.00
347_G350_M0.9471.00
18_I102_A0.9451.00
230_G275_V0.9451.00
324_F327_Y0.9441.00
243_V256_C0.9381.00
147_L172_R0.9371.00
44_A47_F0.9331.00
254_S262_F0.9291.00
155_R159_S0.9271.00
346_E353_P0.9261.00
261_M266_L0.9241.00
52_N64_N0.9211.00
39_T45_R0.9201.00
43_A46_A0.9181.00
32_I193_A0.9081.00
251_T296_P0.9081.00
148_E151_E0.9061.00
260_E265_L0.9041.00
41_G46_A0.9031.00
132_I195_F0.9001.00
40_Y45_R0.9001.00
139_D174_S0.8961.00
351_V362_T0.8951.00
237_I269_G0.8951.00
152_M155_R0.8951.00
317_G320_H0.8941.00
339_T342_I0.8871.00
147_L150_V0.8871.00
159_S162_D0.8851.00
323_F326_G0.8851.00
28_L134_F0.8841.00
161_Y168_T0.8761.00
37_A44_A0.8721.00
254_S259_V0.8711.00
328_R333_F0.8701.00
357_I360_V0.8651.00
41_G45_R0.8621.00
326_G329_P0.8581.00
207_I271_A0.8531.00
245_I293_L0.8521.00
42_G47_F0.8511.00
329_P335_T0.8511.00
37_A40_Y0.8501.00
27_T175_A0.8461.00
39_T43_A0.8451.00
172_R179_L0.8401.00
37_A41_G0.8391.00
108_A138_C0.8371.00
337_D340_G0.8351.00
245_I287_I0.8341.00
329_P332_Y0.8321.00
328_R334_R0.8291.00
52_N66_S0.8281.00
104_L116_T0.8281.00
354_G360_V0.8271.00
155_R160_Q0.8271.00
346_E349_E0.8261.00
215_I287_I0.8241.00
135_L147_L0.8241.00
333_F338_V0.8201.00
148_E172_R0.8171.00
143_D147_L0.8161.00
329_P366_P0.8121.00
294_A300_K0.8071.00
238_K267_D0.8041.00
55_E59_R0.8041.00
331_F335_T0.8041.00
332_Y335_T0.8031.00
65_T80_V0.8031.00
17_T103_I0.8031.00
313_S352_M0.8001.00
340_G351_V0.7951.00
306_E360_V0.7931.00
213_L216_E0.7921.00
319_R325_K0.7901.00
247_G291_Q0.7891.00
117_R121_L0.7831.00
160_Q164_P0.7761.00
195_F198_S0.7731.00
324_F333_F0.7681.00
368_A372_G0.7671.00
207_I236_I0.7651.00
333_F336_T0.7651.00
349_E355_D0.7641.00
50_I66_S0.7641.00
22_D85_H0.7611.00
207_I210_P0.7611.00
42_G46_A0.7591.00
255_T259_V0.7571.00
345_P353_P0.7571.00
245_I254_S0.7561.00
258_G278_L0.7561.00
37_A45_R0.7551.00
16_G102_A0.7551.00
39_T49_Q0.7531.00
353_P356_N0.7521.00
161_Y164_P0.7511.00
109_T142_D0.7491.00
245_I248_I0.7471.00
302_H306_E0.7451.00
16_G82_C0.7411.00
28_L189_I0.7371.00
243_V254_S0.7341.00
309_V314_K0.7321.00
221_I224_R0.7321.00
308_E313_S0.7311.00
120_I131_I0.7291.00
338_V341_T0.7291.00
134_F192_L0.7281.00
35_V189_I0.7281.00
296_P299_I0.7261.00
308_E358_K0.7261.00
363_L367_I0.7251.00
333_F337_D0.7211.00
103_I192_L0.7211.00
76_H273_E0.7171.00
51_D57_K0.7131.00
266_L273_E0.7111.00
256_C259_V0.7091.00
325_K330_Q0.7091.00
309_V312_L0.7071.00
12_H78_A0.7061.00
34_T178_A0.7061.00
282_I287_I0.7061.00
15_V196_L0.7041.00
153_E157_L0.7041.00
237_I243_V0.7041.00
179_L188_K0.7041.00
151_E159_S0.7031.00
44_A49_Q0.7031.00
367_I371_D0.7031.00
330_Q334_R0.7011.00
366_P370_D0.7011.00
155_R158_L0.6991.00
367_I370_D0.6981.00
308_E311_I0.6941.00
355_D360_V0.6911.00
143_D149_L0.6911.00
323_F327_Y0.6901.00
358_K362_T0.6901.00
239_V258_G0.6891.00
205_R209_K0.6851.00
318_G322_P0.6851.00
20_H23_H0.6851.00
334_R342_I0.6831.00
258_G266_L0.6831.00
350_M353_P0.6821.00
236_I271_A0.6811.00
248_I288_E0.6811.00
310_Y313_S0.6801.00
208_D236_I0.6791.00
325_K329_P0.6791.00
255_T261_M0.6741.00
205_R234_R0.6741.00
149_L152_M0.6741.00
151_E162_D0.6731.00
337_D342_I0.6711.00
16_G96_A0.6681.00
106_V154_V0.6661.00
234_R300_K0.6661.00
154_V162_D0.6631.00
39_T44_A0.6631.00
355_D362_T0.6631.00
354_G358_K0.6571.00
355_D359_M0.6551.00
56_E60_G0.6531.00
69_E78_A0.6531.00
294_A299_I0.6531.00
368_A371_D0.6511.00
42_G48_D0.6511.00
349_E353_P0.6501.00
337_D360_V0.6491.00
340_G362_T0.6491.00
106_V133_V0.6471.00
150_V158_L0.6461.00
19_G23_H0.6451.00
344_L349_E0.6451.00
154_V158_L0.6451.00
329_P365_H0.6431.00
350_M357_I0.6411.00
263_R276_G0.6411.00
105_V136_N0.6391.00
357_I364_I0.6391.00
101_G201_P0.6361.00
155_R162_D0.6351.00
309_V359_M0.6341.00
256_C260_E0.6341.00
221_I227_V0.6331.00
104_L119_H0.6320.99
349_E358_K0.6290.99
367_I372_G0.6280.99
350_M354_G0.6280.99
37_A42_G0.6250.99
101_G132_I0.6250.99
354_G361_V0.6250.99
72_T193_A0.6250.99
254_S282_I0.6250.99
112_P150_V0.6220.99
34_T42_G0.6210.99
124_R158_L0.6180.99
320_H325_K0.6130.99
305_F309_V0.6110.99
321_T324_F0.6110.99
321_T325_K0.6100.99
303_T306_E0.6100.99
344_L350_M0.6100.99
353_P359_M0.6070.99
310_Y314_K0.6070.99
156_E159_S0.6070.99
37_A48_D0.6060.99
157_L160_Q0.6030.99
339_T360_V0.6030.99
39_T48_D0.6020.99
295_K299_I0.6010.99
348_V355_D0.6000.99
213_L237_I0.5990.99
132_I171_V0.5990.99
150_V162_D0.5980.99
213_L277_V0.5980.99
259_V269_G0.5940.99
321_T329_P0.5930.99
310_Y316_E0.5920.99
259_V277_V0.5910.99
230_G293_L0.5910.99
219_F276_G0.5910.99
341_T355_D0.5900.99
320_H323_F0.5880.99
22_D61_I0.5860.99
244_E297_G0.5790.99
32_I36_L0.5790.99
144_E147_L0.5790.99
10_K75_R0.5770.99
21_V85_H0.5760.99
132_I196_L0.5740.99
64_N91_N0.5730.99
307_S310_Y0.5730.99
318_G321_T0.5720.99
205_R271_A0.5720.99
134_F188_K0.5720.99
353_P361_V0.5710.99
362_T365_H0.5710.99
255_T262_F0.5680.99
65_T95_G0.5670.99
305_F363_L0.5660.99
37_A49_Q0.5650.99
312_L315_D0.5630.99
351_V356_N0.5620.99
347_G355_D0.5610.99
107_A140_M0.5610.99
310_Y315_D0.5570.99
362_T366_P0.5570.99
358_K366_P0.5560.99
322_P326_G0.5560.99
155_R163_F0.5560.99
232_V237_I0.5540.99
212_L300_K0.5530.99
344_L355_D0.5520.99
222_S225_G0.5520.99
33_T49_Q0.5520.99
72_T197_D0.5510.99
120_I124_R0.5490.99
255_T258_G0.5480.99
21_V61_I0.5480.99
356_N360_V0.5460.99
322_P327_Y0.5460.99
244_E294_A0.5460.99
147_L155_R0.5450.99
319_R324_F0.5440.98
349_E357_I0.5430.98
345_P350_M0.5430.98
227_V278_L0.5430.98
215_I230_G0.5430.98
288_E307_S0.5410.98
338_V343_E0.5410.98
351_V354_G0.5390.98
349_E352_M0.5380.98
358_K364_I0.5380.98
163_F168_T0.5370.98
211_F236_I0.5360.98
357_I366_P0.5350.98
329_P334_R0.5340.98
97_A233_E0.5340.98
86_A114_P0.5320.98
246_V300_K0.5310.98
330_Q337_D0.5300.98
335_T338_V0.5300.98
98_Q214_P0.5290.98
347_G353_P0.5290.98
155_R161_Y0.5290.98
18_I96_A0.5280.98
213_L217_D0.5280.98
327_Y330_Q0.5250.98
313_S316_E0.5240.98
211_F256_C0.5240.98
336_T341_T0.5210.98
358_K365_H0.5200.98
248_I285_E0.5190.98
224_R278_L0.5180.98
92_M119_H0.5180.98
74_T198_S0.5170.98
365_H369_M0.5170.98
357_I362_T0.5170.98
194_G197_D0.5170.98
144_E152_M0.5140.98
33_T68_V0.5130.98
49_Q57_K0.5120.98
212_L302_H0.5120.98
48_D57_K0.5090.98
255_T260_E0.5090.98
192_L196_L0.5070.98
40_Y47_F0.5050.98
161_Y170_I0.5050.98
353_P364_I0.5040.98
138_C147_L0.5040.98
73_P198_S0.5040.98
211_F295_K0.5030.98
143_D150_V0.5020.97
319_R335_T0.5010.97
220_S226_T0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2c78A 1 0.9594 100 0.261 Contact Map
1d2eA 3 0.9772 100 0.263 Contact Map
3avxA 1 0.9391 100 0.275 Contact Map
3mcaA 1 0.8604 100 0.291 Contact Map
1jnyA 1 0.9391 100 0.292 Contact Map
3wy9A 1 0.9619 100 0.294 Contact Map
4crnP 1 0.967 100 0.294 Contact Map
1f60A 1 0.9772 100 0.298 Contact Map
4d61i 1 0.9619 100 0.299 Contact Map
1r5bA 1 0.8959 100 0.312 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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