GREMLIN Database
EMTA - Endo-type membrane-bound lytic murein transglycosylase A
UniProt: P0C960 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13897
Length: 203 (158)
Sequences: 3590 (2356)
Seq/√Len: 187.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
76_N84_K3.2421.00
122_N126_T2.9151.00
43_S61_I2.6921.00
125_E142_L2.6311.00
57_I118_A2.6281.00
83_L116_M2.4121.00
46_A49_A2.3951.00
56_L143_V2.3391.00
152_A155_R2.2871.00
40_M44_Q2.2191.00
78_I108_K2.1941.00
128_P154_L2.1871.00
63_I186_A2.0981.00
72_V108_K2.0871.00
144_V180_V2.0191.00
98_W116_M2.0191.00
44_Q54_P1.9721.00
46_A115_S1.9381.00
152_A173_A1.8591.00
164_A168_I1.8141.00
60_I121_L1.8101.00
75_S84_K1.7871.00
42_I111_E1.7411.00
165_I168_I1.7401.00
148_N152_A1.7331.00
164_A167_K1.7211.00
127_G154_L1.7051.00
50_W119_A1.6731.00
72_V78_I1.5771.00
43_S58_T1.5641.00
106_E112_R1.5451.00
25_P28_N1.5311.00
128_P145_S1.5271.00
26_P29_A1.4851.00
123_I127_G1.4811.00
148_N176_F1.4801.00
87_T120_Y1.4661.00
46_A118_A1.4491.00
83_L88_S1.4461.00
61_I80_L1.4391.00
167_K170_D1.4381.00
50_W115_S1.4371.00
63_I182_R1.4351.00
187_P191_R1.4181.00
128_P150_A1.4171.00
90_R123_I1.4101.00
46_A111_E1.4071.00
50_W122_N1.3801.00
143_V183_N1.3801.00
125_E137_V1.3661.00
68_N71_A1.3501.00
163_K166_S1.2951.00
144_V176_F1.2821.00
43_S67_G1.2611.00
47_G118_A1.2571.00
166_S169_N1.2481.00
39_W69_P1.2051.00
25_P29_A1.1961.00
90_R150_A1.1861.00
179_H183_N1.1711.00
109_N112_R1.1471.00
127_G150_A1.1451.00
24_N28_N1.1431.00
60_I183_N1.1391.00
140_Y184_H1.1371.00
124_L145_S1.1241.00
163_K167_K1.1011.00
141_A157_F1.0861.00
61_I114_I1.0831.00
45_K111_E1.0831.00
164_A169_N1.0821.00
169_N172_D1.0591.00
55_Q187_P1.0571.00
88_S107_L1.0541.00
49_A115_S1.0521.00
125_E139_Q1.0501.00
188_Q191_R1.0461.00
167_K172_D1.0331.00
154_L158_S1.0291.00
40_M58_T1.0211.00
163_K169_N1.0191.00
115_S119_A1.0181.00
57_I81_M1.0020.99
83_L113_N1.0010.99
50_W118_A0.9870.99
81_M113_N0.9870.99
88_S100_G0.9670.99
24_N31_V0.9630.99
83_L117_G0.9550.99
124_L150_A0.9550.99
42_I46_A0.9520.99
26_P30_K0.9450.99
185_P189_A0.9430.99
81_M117_G0.9300.99
168_I172_D0.9280.99
27_W30_K0.9180.99
176_F179_H0.9030.99
145_S150_A0.8990.99
164_A172_D0.8990.99
52_V118_A0.8970.99
28_N31_V0.8930.99
46_A50_W0.8680.99
96_M119_A0.8650.98
148_N153_L0.8620.98
162_K167_K0.8610.98
148_N173_A0.8590.98
80_L110_P0.8580.98
162_K165_I0.8490.98
73_S77_A0.8480.98
73_S175_E0.8460.98
69_P80_L0.8440.98
34_Q37_M0.8440.98
181_A185_P0.8440.98
166_S170_D0.8360.98
123_I150_A0.8330.98
156_T171_L0.8310.98
83_L96_M0.8280.98
78_I107_L0.8230.98
112_R116_M0.8190.98
37_M194_Y0.8100.98
42_I110_P0.8060.98
120_Y150_A0.8030.98
57_I61_I0.7980.97
45_K49_A0.7980.97
141_A153_L0.7970.97
151_G155_R0.7970.97
154_L157_F0.7820.97
47_G57_I0.7810.97
57_I67_G0.7810.97
147_A175_E0.7780.97
25_P31_V0.7740.97
150_A154_L0.7720.97
61_I117_G0.7700.97
46_A114_I0.7630.97
24_N29_A0.7600.97
111_E115_S0.7540.96
86_S90_R0.7500.96
61_I81_M0.7450.96
47_G54_P0.7400.96
96_M123_I0.7400.96
139_Q187_P0.7380.96
81_M114_I0.7350.96
103_T106_E0.7300.96
162_K170_D0.7240.95
90_R127_G0.7230.95
60_I81_M0.7200.95
129_L138_L0.7200.95
153_L173_A0.7180.95
152_A156_T0.7170.95
164_A170_D0.7140.95
52_V121_L0.7100.95
43_S47_G0.7070.95
151_G154_L0.7060.95
24_N30_K0.7000.95
188_Q192_Y0.6980.94
41_P45_K0.6950.94
43_S114_I0.6910.94
106_E109_N0.6870.94
96_M116_M0.6850.94
59_A187_P0.6840.94
24_N27_W0.6820.94
59_A183_N0.6790.94
162_K168_I0.6780.94
144_V153_L0.6750.93
163_K172_D0.6690.93
42_I114_I0.6690.93
42_I115_S0.6680.93
119_A123_I0.6650.93
171_L180_V0.6640.93
39_W110_P0.6630.93
71_A75_S0.6590.93
54_P58_T0.6530.92
157_F160_D0.6530.92
107_L116_M0.6520.92
26_P31_V0.6420.92
52_V56_L0.6410.92
69_P110_P0.6400.91
77_A85_A0.6380.91
83_L107_L0.6360.91
179_H190_P0.6290.91
84_K87_T0.6290.91
107_L113_N0.6290.91
165_I169_N0.6260.91
77_A82_Q0.6240.90
52_V122_N0.6190.90
168_I171_L0.6130.90
53_D187_P0.6110.90
37_M40_M0.6100.89
189_A192_Y0.6080.89
120_Y124_L0.6080.89
167_K171_L0.6080.89
72_V76_N0.6050.89
77_A175_E0.6010.89
78_I85_A0.5980.89
138_L141_A0.5960.88
90_R119_A0.5950.88
47_G52_V0.5950.88
47_G53_D0.5910.88
148_N177_L0.5910.88
129_L157_F0.5910.88
184_H187_P0.5880.88
62_A66_G0.5860.88
77_A84_K0.5850.87
178_E182_R0.5810.87
27_W31_V0.5780.87
112_R115_S0.5740.86
48_A54_P0.5710.86
138_L142_L0.5690.86
60_I143_V0.5650.86
151_G156_T0.5630.85
61_I67_G0.5620.85
162_K166_S0.5570.85
25_P30_K0.5550.85
36_A40_M0.5450.83
51_G122_N0.5430.83
52_V125_E0.5420.83
51_G151_G0.5370.83
148_N156_T0.5360.82
56_L75_S0.5350.82
70_N108_K0.5340.82
140_Y143_V0.5330.82
183_N190_P0.5330.82
175_E183_N0.5290.82
162_K169_N0.5280.82
78_I84_K0.5200.81
163_K170_D0.5190.80
174_D178_E0.5180.80
176_F183_N0.5170.80
176_F180_V0.5150.80
47_G114_I0.5110.79
118_A122_N0.5110.79
121_L179_H0.5080.79
71_A108_K0.5040.79
44_Q57_I0.5030.78
43_S57_I0.5030.78
168_I174_D0.5010.78
63_I66_G0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qsaA 1 0.9606 100 0.285 Contact Map
4cfpA 1 0.9507 100 0.301 Contact Map
4hjzA 1 0.8374 100 0.303 Contact Map
4p0gA 1 0.9113 100 0.351 Contact Map
3gxrA 1 0.8374 100 0.435 Contact Map
1gbsA 1 0.8325 100 0.441 Contact Map
3w6bA 1 0.7438 100 0.448 Contact Map
4g9sA 1 0.8325 100 0.453 Contact Map
3bkhA 1 0.8719 100 0.487 Contact Map
4fdyA 1 0.6946 99.9 0.542 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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