GREMLIN Database
KBAZ - D-tagatose-1,6-bisphosphate aldolase subunit KbaZ
UniProt: P0C8K0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12763
Length: 426 (419)
Sequences: 366 (254)
Seq/√Len: 12.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
239_Y278_D6.9861.00
110_D150_R6.1051.00
76_D82_Q4.9391.00
241_P277_I4.6181.00
371_V408_I4.5441.00
117_V124_I4.0140.99
100_L108_N3.9710.99
31_E77_S3.7880.99
10_Q15_K3.6630.99
171_V222_A3.6480.99
337_G346_R3.6210.99
153_K157_E3.5890.99
238_D396_R3.5850.99
323_V363_I3.4930.99
113_I154_V3.4630.98
415_I418_Q3.3600.98
31_E78_L3.3390.98
394_K410_N3.3380.98
304_E373_N3.1260.97
50_S96_R3.1250.97
304_E314_S3.1020.97
156_E170_Y3.0370.96
408_I412_I3.0190.96
56_F108_N2.9130.95
321_E346_R2.9100.95
54_D96_R2.9060.95
34_I44_L2.8730.95
320_L363_I2.7360.93
314_S373_N2.6940.93
50_S95_N2.6290.92
35_R409_I2.4910.90
100_L104_Q2.4860.89
36_Y413_Q2.4600.89
261_A280_F2.4400.89
30_L84_A2.4250.88
113_I155_A2.3290.86
68_R87_L2.2490.84
197_A223_L2.2440.84
306_E348_Y2.2220.83
28_L371_V2.2170.83
142_D199_A2.0980.79
131_S178_V2.0790.79
30_L74_L2.0710.78
269_P421_T2.0440.77
182_A230_E2.0210.77
375_A404_P2.0130.76
403_T406_E1.9670.75
174_T204_H1.9560.74
410_N417_A1.9180.73
339_G342_R1.9140.73
350_Y381_L1.8790.71
22_V416_L1.8590.70
33_A44_L1.8330.69
314_S319_V1.7730.66
10_Q13_A1.7570.66
273_R277_I1.7410.65
96_R112_L1.7360.65
36_Y40_N1.7140.64
345_A350_Y1.6880.62
44_L85_L1.6840.62
146_E210_K1.6820.62
63_T191_V1.6780.62
375_A403_T1.6650.61
50_S98_Q1.6570.61
296_A408_I1.6530.61
384_I402_P1.6400.60
131_S135_D1.6270.59
204_H358_W1.6070.59
174_T358_W1.6060.58
178_V334_H1.5830.57
117_V159_C1.5820.57
272_L288_A1.5790.57
54_D301_A1.5690.57
301_A319_V1.5490.56
401_Q406_E1.5160.54
19_I86_I1.5110.54
18_G276_V1.5020.53
220_I255_E1.5020.53
195_D213_L1.4970.53
111_D114_K1.4890.53
4_L221_I1.4800.52
24_S67_F1.4470.50
31_E405_R1.4400.50
111_D115_S1.4380.50
255_E361_S1.4380.50
11_H279_H1.4350.50
391_Q410_N1.4310.50
62_M70_F1.4230.49
301_A314_S1.4160.49
298_F321_E1.4090.48
68_R74_L1.4070.48
298_F347_G1.4010.48
296_A412_I1.3890.47
288_A410_N1.3890.47
101_P104_Q1.3790.47
325_L395_V1.3750.47
248_S387_Y1.3680.46
34_I78_L1.3570.46
395_V402_P1.3550.46
48_A121_F1.3520.46
220_I257_L1.3380.45
222_A327_R1.3320.45
316_L367_F1.3250.44
251_V279_H1.3250.44
46_I71_V1.3240.44
297_L367_F1.3180.44
293_L297_L1.3140.44
54_D108_N1.3070.43
150_R196_A1.3030.43
292_A415_I1.3010.43
103_A134_D1.2960.43
391_Q411_H1.2920.43
77_S107_A1.2800.42
144_V178_V1.2790.42
131_S144_V1.2750.42
202_E206_H1.2710.42
207_A210_K1.2670.41
44_L54_D1.2650.41
102_A134_D1.2550.41
305_E313_C1.2530.41
122_K166_A1.2520.41
251_V350_Y1.2510.41
269_P418_Q1.2490.40
24_S29_V1.2470.40
132_C261_A1.2310.40
55_Q112_L1.2190.39
395_V407_L1.2040.38
95_N174_T1.1980.38
95_N334_H1.1970.38
8_V12_K1.1940.38
209_E214_N1.1810.37
12_K30_L1.1710.37
148_A280_F1.1690.37
70_F191_V1.1680.37
298_F320_L1.1610.36
304_E363_I1.1590.36
198_R253_N1.1580.36
184_E194_P1.1490.36
302_A404_P1.1450.35
31_E74_L1.1450.35
392_Y395_V1.1390.35
168_L279_H1.1360.35
96_R109_A1.1270.35
72_C85_L1.1220.34
76_D375_A1.1210.34
122_K167_D1.1050.34
115_S118_A1.0990.33
413_Q417_A1.0850.33
54_D112_L1.0820.33
148_A261_A1.0820.33
128_C279_H1.0770.32
98_Q109_A1.0730.32
394_K414_D1.0640.32
37_A422_A1.0630.32
182_A186_L1.0620.32
205_R217_W1.0580.31
241_P274_Q1.0530.31
80_F85_L1.0490.31
44_L340_N1.0350.30
114_K158_T1.0310.30
6_E38_S1.0310.30
182_A321_E1.0210.30
304_E315_G1.0200.30
132_C174_T1.0200.30
153_K211_Q1.0190.30
201_L254_Y1.0170.30
55_Q108_N1.0130.30
22_V261_A1.0100.29
141_D346_R1.0040.29
178_V232_D0.9990.29
391_Q400_L0.9960.29
20_Y140_T0.9900.29
103_A404_P0.9900.29
98_Q112_L0.9850.28
95_N358_W0.9850.28
50_S144_V0.9810.28
72_C82_Q0.9770.28
350_Y392_Y0.9740.28
132_C197_A0.9730.28
295_E385_S0.9710.28
222_A404_P0.9710.28
116_Y121_F0.9700.28
20_Y420_H0.9690.28
30_L70_F0.9650.28
297_L316_L0.9650.28
50_S112_L0.9600.27
343_R346_R0.9600.27
390_L414_D0.9520.27
121_F226_Q0.9520.27
41_Q84_A0.9470.27
11_H252_E0.9460.27
98_Q131_S0.9420.27
205_R369_H0.9400.27
11_H98_Q0.9380.26
226_Q351_S0.9360.26
293_L418_Q0.9340.26
132_C204_H0.9330.26
232_D423_C0.9280.26
19_I212_G0.9260.26
81_P195_D0.9250.26
30_L299_S0.9240.26
48_A54_D0.9210.26
6_E79_N0.9200.26
37_A44_L0.9170.26
26_H95_N0.9150.26
244_A278_D0.9100.25
31_E359_P0.9090.25
205_R209_E0.9090.25
171_V333_S0.9060.25
334_H408_I0.9060.25
48_A68_R0.9040.25
400_L420_H0.9030.25
280_F358_W0.9020.25
132_C280_F0.9020.25
39_A193_T0.9010.25
402_P407_L0.8960.25
6_E9_R0.8940.25
301_A304_E0.8930.25
35_R413_Q0.8890.25
97_W231_F0.8880.25
36_Y416_L0.8870.24
384_I403_T0.8860.24
271_S415_I0.8850.24
56_F112_L0.8830.24
76_D255_E0.8820.24
68_R72_C0.8820.24
184_E336_H0.8810.24
153_K215_A0.8790.24
50_S223_L0.8700.24
338_D341_A0.8700.24
95_N186_L0.8690.24
385_S392_Y0.8680.24
20_Y42_T0.8630.24
320_L334_H0.8620.24
112_L154_V0.8570.23
384_I404_P0.8570.23
98_Q233_H0.8540.23
56_F100_L0.8520.23
10_Q14_G0.8480.23
304_E391_Q0.8450.23
96_R128_C0.8440.23
50_S197_A0.8400.23
54_D141_D0.8390.23
103_A107_A0.8370.23
95_N132_C0.8340.23
69_G416_L0.8340.23
302_A387_Y0.8330.23
102_A261_A0.8300.22
204_H261_A0.8300.22
268_T396_R0.8290.22
135_D232_D0.8280.22
412_I416_L0.8280.22
384_I407_L0.8250.22
168_L272_L0.8250.22
80_F84_A0.8250.22
104_Q187_S0.8240.22
251_V330_Y0.8210.22
83_D214_N0.8200.22
187_S404_P0.8190.22
413_Q416_L0.8190.22
19_I349_S0.8150.22
54_D354_V0.8150.22
112_L391_Q0.8140.22
250_M274_Q0.8110.22
56_F288_A0.8090.22
39_A413_Q0.8090.22
279_H423_C0.8080.22
70_F384_I0.8080.22
73_Q412_I0.8060.22
102_A107_A0.8050.22
202_E214_N0.8050.22
317_R416_L0.8040.21
160_L164_G0.7980.21
171_V369_H0.7980.21
272_L341_A0.7970.21
112_L135_D0.7970.21
72_C76_D0.7970.21
50_S54_D0.7960.21
186_L421_T0.7960.21
28_L208_F0.7960.21
385_S398_G0.7950.21
132_C275_L0.7950.21
272_L392_Y0.7930.21
50_S288_A0.7920.21
50_S272_L0.7920.21
222_A374_L0.7890.21
30_L44_L0.7850.21
276_V351_S0.7840.21
233_H345_A0.7830.21
65_A103_A0.7820.21
272_L422_A0.7810.21
204_H275_L0.7810.21
50_S384_I0.7810.21
103_A318_Q0.7800.21
4_L42_T0.7790.21
26_H354_V0.7790.21
100_L140_T0.7770.21
36_Y272_L0.7760.21
95_N204_H0.7730.20
171_V382_P0.7730.20
216_I223_L0.7720.20
320_L323_V0.7710.20
204_H233_H0.7710.20
250_M259_F0.7690.20
227_P351_S0.7690.20
26_H148_A0.7670.20
121_F415_I0.7650.20
361_S365_D0.7650.20
190_A408_I0.7650.20
250_M279_H0.7640.20
34_I38_S0.7640.20
131_S334_H0.7620.20
30_L71_V0.7620.20
409_I420_H0.7600.20
201_L250_M0.7600.20
15_K421_T0.7590.20
111_D375_A0.7590.20
240_Q243_K0.7580.20
74_L78_L0.7580.20
56_F391_Q0.7530.20
171_V405_R0.7500.20
20_Y422_A0.7500.20
402_P415_I0.7500.20
399_E403_T0.7470.20
36_Y420_H0.7460.20
297_L388_L0.7460.20
220_I413_Q0.7430.19
30_L407_L0.7400.19
316_L370_L0.7400.19
319_V322_D0.7380.19
202_E205_R0.7370.19
100_L259_F0.7350.19
130_M244_A0.7330.19
28_L408_I0.7320.19
24_S230_E0.7320.19
241_P278_D0.7310.19
257_L338_D0.7310.19
30_L412_I0.7310.19
80_F191_V0.7310.19
74_L108_N0.7290.19
50_S391_Q0.7250.19
198_R213_L0.7250.19
144_V301_A0.7230.19
80_F282_I0.7220.19
131_S232_D0.7220.19
4_L71_V0.7200.19
194_P197_A0.7190.19
337_G341_A0.7190.19
377_S394_K0.7180.19
301_A382_P0.7180.19
254_Y323_V0.7170.19
185_T401_Q0.7170.19
20_Y416_L0.7160.19
388_L407_L0.7160.19
406_E417_A0.7150.19
117_V199_A0.7150.19
20_Y40_N0.7150.19
409_I421_T0.7140.19
131_S138_P0.7130.19
80_F384_I0.7110.18
113_I158_T0.7110.18
337_G343_R0.7100.18
169_E217_W0.7090.18
322_D362_Q0.7080.18
167_D199_A0.7080.18
76_D274_Q0.7070.18
154_V158_T0.7070.18
384_I395_V0.7060.18
239_Y404_P0.7060.18
397_S418_Q0.7060.18
194_P244_A0.7060.18
289_L298_F0.7060.18
42_T293_L0.7050.18
320_L354_V0.7040.18
368_A371_V0.7040.18
38_S74_L0.7040.18
148_A204_H0.7020.18
153_K242_A0.7000.18
258_I366_A0.6990.18
286_G355_R0.6970.18
408_I420_H0.6960.18
207_A348_Y0.6950.18
348_Y387_Y0.6950.18
25_A230_E0.6930.18
185_T414_D0.6920.18
184_E255_E0.6920.18
339_G346_R0.6920.18
315_G318_Q0.6890.18
68_R400_L0.6880.18
82_Q403_T0.6880.18
82_Q85_L0.6860.18
334_H397_S0.6840.18
30_L399_E0.6840.18
152_A216_I0.6830.18
217_W235_N0.6830.18
313_C361_S0.6810.18
397_S412_I0.6770.17
4_L24_S0.6770.17
76_D79_N0.6770.17
187_S372_R0.6760.17
20_Y418_Q0.6750.17
107_A203_A0.6740.17
339_G371_V0.6730.17
144_V233_H0.6730.17
128_C154_V0.6730.17
27_P102_A0.6710.17
195_D218_P0.6710.17
202_E378_P0.6680.17
40_N387_Y0.6670.17
376_D408_I0.6670.17
196_A316_L0.6660.17
30_L402_P0.6640.17
80_F143_I0.6630.17
148_A174_T0.6590.17
30_L43_P0.6590.17
337_G345_A0.6580.17
327_R360_D0.6560.17
172_I374_L0.6520.17
168_L278_D0.6510.17
184_E187_S0.6500.17
54_D154_V0.6490.17
307_L377_S0.6490.17
270_Q313_C0.6470.17
109_A416_L0.6460.17
234_T350_Y0.6460.17
130_M351_S0.6460.17
303_I379_I0.6440.16
303_I383_L0.6440.16
48_A189_L0.6440.16
103_A157_E0.6440.16
301_A305_E0.6420.16
132_C358_W0.6410.16
307_L379_I0.6410.16
174_T233_H0.6410.16
168_L239_Y0.6390.16
35_R122_K0.6390.16
191_V395_V0.6380.16
130_M386_Q0.6380.16
209_E327_R0.6380.16
210_K365_D0.6350.16
231_F236_V0.6350.16
152_A158_T0.6340.16
241_P272_L0.6340.16
206_H210_K0.6330.16
192_T266_Y0.6320.16
350_Y416_L0.6300.16
23_C49_T0.6290.16
282_I349_S0.6280.16
49_T286_G0.6260.16
333_S407_L0.6260.16
49_T355_R0.6260.16
38_S41_Q0.6250.16
206_H246_A0.6250.16
157_E215_A0.6240.16
200_T227_P0.6230.16
184_E189_L0.6220.16
26_H327_R0.6210.16
205_R249_Q0.6200.16
280_F354_V0.6190.16
132_C148_A0.6170.16
38_S334_H0.6160.16
140_T413_Q0.6120.16
201_L330_Y0.6100.16
323_V360_D0.6100.16
56_F411_H0.6100.16
35_R78_L0.6060.15
60_T200_T0.6060.15
322_D412_I0.6060.15
405_R409_I0.6050.15
96_R279_H0.6030.15
332_Q365_D0.6020.15
251_V346_R0.6020.15
157_E372_R0.6000.15
41_Q377_S0.5990.15
23_C29_V0.5970.15
159_C168_L0.5970.15
76_D384_I0.5960.15
354_V391_Q0.5960.15
44_L396_R0.5960.15
279_H321_E0.5950.15
263_S267_Q0.5940.15
188_E243_K0.5940.15
43_P189_L0.5940.15
50_S128_C0.5930.15
232_D279_H0.5920.15
401_Q421_T0.5920.15
319_V323_V0.5910.15
244_A351_S0.5900.15
397_S402_P0.5890.15
246_A277_I0.5890.15
115_S159_C0.5890.15
128_C164_G0.5870.15
7_M14_G0.5860.15
350_Y382_P0.5830.15
233_H349_S0.5820.15
146_E399_E0.5810.15
36_Y384_I0.5800.15
188_E218_P0.5800.15
201_L405_R0.5800.15
131_S252_E0.5790.15
76_D409_I0.5790.15
378_P387_Y0.5790.15
210_K246_A0.5770.15
37_A217_W0.5760.15
65_A142_D0.5740.15
95_N261_A0.5730.15
207_A330_Y0.5720.15
183_H233_H0.5710.15
14_G34_I0.5710.15
198_R406_E0.5710.15
40_N293_L0.5700.15
102_A358_W0.5690.14
44_L139_L0.5690.14
47_E263_S0.5680.14
154_V172_I0.5680.14
244_A248_S0.5670.14
178_V233_H0.5660.14
8_V256_T0.5660.14
79_N189_L0.5650.14
318_Q413_Q0.5650.14
414_D417_A0.5630.14
73_Q406_E0.5630.14
315_G321_E0.5630.14
146_E207_A0.5630.14
298_F363_I0.5620.14
9_R322_D0.5620.14
24_S289_L0.5610.14
82_Q362_Q0.5610.14
30_L303_I0.5600.14
118_A302_A0.5590.14
354_V358_W0.5590.14
114_K118_A0.5580.14
340_N343_R0.5570.14
270_Q412_I0.5560.14
399_E418_Q0.5560.14
122_K165_E0.5550.14
142_D222_A0.5550.14
7_M146_E0.5540.14
263_S294_R0.5530.14
218_P329_E0.5530.14
159_C307_L0.5530.14
342_R420_H0.5530.14
226_Q259_F0.5520.14
38_S81_P0.5510.14
6_E410_N0.5500.14
86_I241_P0.5500.14
135_D350_Y0.5500.14
394_K417_A0.5500.14
219_R358_W0.5500.14
157_E245_S0.5490.14
174_T261_A0.5490.14
337_G342_R0.5490.14
73_Q270_Q0.5470.14
258_I413_Q0.5460.14
172_I348_Y0.5460.14
194_P387_Y0.5450.14
326_D338_D0.5450.14
128_C234_T0.5450.14
7_M348_Y0.5450.14
286_G290_T0.5440.14
290_T355_R0.5440.14
77_S201_L0.5400.14
5_T410_N0.5390.14
200_T225_V0.5390.14
20_Y394_K0.5380.14
320_L337_G0.5380.14
179_P227_P0.5360.14
154_V216_I0.5350.14
80_F83_D0.5350.14
30_L392_Y0.5340.14
126_L204_H0.5320.14
130_M276_V0.5310.14
96_R289_L0.5300.14
185_T188_E0.5300.14
381_L389_P0.5300.14
159_C274_Q0.5300.14
89_G263_S0.5260.13
22_V48_A0.5260.13
46_I397_S0.5240.13
95_N116_Y0.5240.13
233_H391_Q0.5240.13
68_R405_R0.5240.13
108_N216_I0.5230.13
186_L190_A0.5220.13
402_P408_I0.5200.13
186_L237_I0.5200.13
98_Q288_A0.5200.13
263_S352_D0.5200.13
141_D169_E0.5200.13
238_D297_L0.5190.13
388_L411_H0.5190.13
117_V275_L0.5190.13
216_I371_V0.5180.13
39_A378_P0.5170.13
33_A108_N0.5170.13
321_E339_G0.5170.13
25_A67_F0.5170.13
267_Q352_D0.5160.13
22_V102_A0.5150.13
216_I273_R0.5150.13
269_P390_L0.5150.13
13_A332_Q0.5140.13
275_L358_W0.5130.13
184_E344_L0.5130.13
168_L382_P0.5130.13
395_V406_E0.5130.13
395_V400_L0.5120.13
413_Q422_A0.5110.13
392_Y396_R0.5100.13
109_A324_M0.5100.13
187_S403_T0.5100.13
137_I201_L0.5090.13
22_V33_A0.5090.13
73_Q77_S0.5090.13
385_S391_Q0.5090.13
4_L19_I0.5090.13
77_S421_T0.5090.13
259_F291_F0.5090.13
298_F346_R0.5060.13
146_E404_P0.5050.13
206_H215_A0.5040.13
99_N399_E0.5040.13
8_V363_I0.5040.13
26_H261_A0.5040.13
132_C159_C0.5030.13
34_I344_L0.5010.13
99_N214_N0.5000.13
131_S233_H0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fiqA 4 0.9648 100 0.382 Contact Map
3txvA 2 0.9085 100 0.396 Contact Map
4to8A 2 0.6268 99.9 0.873 Contact Map
3elfA 4 0.7183 99.9 0.876 Contact Map
1gvfA 3 0.6432 99.9 0.882 Contact Map
3pm6A 2 0.6549 98.9 0.936 Contact Map
1rvgA 3 0.6455 98.8 0.939 Contact Map
2iswA 2 0.6667 98.7 0.94 Contact Map
3qm3A 4 0.7113 98.6 0.942 Contact Map
1dosA 2 0.6901 98.6 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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