GREMLIN Database
GATZ - D-tagatose-1,6-bisphosphate aldolase subunit GatZ
UniProt: P0C8J8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12418
Length: 420 (415)
Sequences: 368 (255)
Seq/√Len: 12.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
235_Y273_D6.8831.00
107_V147_V6.0441.00
73_D79_R4.7881.00
237_P272_R4.4721.00
366_M403_I4.4401.00
97_E105_K4.0451.00
114_V121_I3.9020.99
28_E74_K3.7580.99
150_F154_S3.7490.99
234_H391_Q3.6620.99
332_T341_I3.5620.99
167_V218_A3.5220.99
7_R12_E3.4900.99
110_V151_A3.4870.99
389_R405_D3.3440.98
318_V358_I3.2800.98
410_V413_A3.2730.98
28_E75_V3.2650.98
47_S93_C3.1360.97
299_E368_N3.0700.97
299_E309_S3.0700.97
153_E166_Y3.0040.96
403_I407_I2.9340.96
51_N93_C2.8950.95
316_E341_I2.8830.95
31_L41_V2.8650.95
53_F105_K2.8460.95
315_I358_I2.6900.93
47_S92_N2.6820.93
309_S368_N2.6620.93
32_A404_M2.4190.88
33_F408_Y2.4170.88
27_I81_R2.3700.87
256_A275_F2.3500.87
110_V152_A2.3250.86
301_E343_Y2.2810.85
193_A219_I2.2610.85
65_R84_L2.2100.83
97_E101_A2.1900.83
25_L366_M2.1860.83
178_E226_E2.1600.82
139_E195_N2.0990.80
27_I71_I2.0650.79
128_S174_V2.0510.78
264_R416_Y1.9790.76
370_E399_P1.9500.74
405_D412_R1.9350.74
170_T200_H1.9320.74
334_F337_S1.8880.72
398_I401_Q1.8740.71
345_L376_L1.8450.70
47_S95_Q1.8330.70
30_A41_V1.7910.68
7_R10_A1.7750.67
19_V411_L1.7600.66
379_I397_A1.7220.65
340_D345_L1.7100.64
93_C109_L1.7080.64
33_F37_S1.7030.64
60_T187_I1.6750.62
268_W272_R1.6480.61
267_Y283_A1.6470.61
309_S314_V1.6430.61
291_A403_I1.6380.61
41_V82_I1.6320.60
370_E398_I1.6310.60
128_S132_D1.6000.59
51_N296_A1.5970.58
170_T353_W1.5830.58
114_V156_A1.5830.58
143_E206_A1.5810.58
200_H353_W1.5750.57
244_A382_Y1.5730.57
191_E209_L1.5540.56
16_I83_I1.5470.56
108_E112_E1.5130.54
396_S401_Q1.5130.54
141_V174_V1.5090.54
174_V329_Y1.5000.54
296_A314_V1.4990.54
293_F316_E1.4970.53
21_S64_F1.4820.53
311_C362_V1.4680.52
65_R71_I1.4600.52
108_E111_K1.4570.51
293_F342_R1.4480.51
386_Q405_D1.4470.51
283_A405_D1.4390.50
296_A309_S1.4330.50
291_A407_I1.4230.50
31_L75_V1.4170.49
43_I68_V1.4130.49
115_R158_D1.3980.48
59_M67_F1.3910.48
15_G271_V1.3720.47
98_N101_A1.3670.47
390_I397_A1.3620.47
41_V51_N1.3510.46
247_I274_H1.3490.46
8_H274_H1.3450.46
216_V250_T1.3200.44
216_V252_M1.3190.44
119_S163_Q1.3180.44
287_A410_V1.3080.44
288_L292_I1.3070.44
198_R202_K1.3070.44
300_Q308_R1.3030.44
386_Q406_K1.3030.44
292_I362_V1.3020.43
28_E400_H1.3020.43
147_V192_D1.2990.43
247_I345_L1.2930.43
100_D131_G1.2810.42
51_N105_K1.2800.42
21_S26_V1.2700.42
203_A206_A1.2630.42
99_A131_G1.2590.41
45_A118_F1.2510.41
128_S141_V1.2460.41
5_I9_K1.2410.40
264_R413_A1.2390.40
292_I311_C1.2360.40
293_F315_I1.2320.40
67_F187_I1.2030.39
28_E71_I1.1920.38
178_E182_I1.1810.37
74_K104_E1.1720.37
299_E358_I1.1690.37
129_C256_A1.1660.37
145_A275_F1.1590.36
194_A249_N1.1570.36
297_Q399_P1.1520.36
164_L274_H1.1510.36
183_Q399_P1.1480.36
52_Q109_L1.1430.36
385_K409_D1.1420.36
178_E316_E1.1390.35
390_I402_L1.1380.35
73_D370_E1.1340.35
92_N329_Y1.1320.35
201_Q213_L1.1260.35
389_R409_D1.1230.35
36_N189_H1.1230.35
41_V335_N1.1190.35
92_N170_T1.1150.34
125_A274_H1.1130.34
69_F82_I1.1080.34
8_H95_Q1.1030.34
218_A322_E1.0990.34
213_L250_T1.0870.33
51_N109_L1.0790.33
205_I210_T1.0780.33
387_F390_I1.0770.33
62_A100_D1.0720.32
174_V228_D1.0650.32
145_A256_A1.0620.32
94_W227_F1.0600.32
111_K155_V1.0590.32
112_E115_R1.0430.31
322_E355_H1.0420.31
237_P269_E1.0400.31
34_D417_G1.0280.30
93_C106_S1.0230.30
77_F82_I1.0170.30
9_K27_I1.0170.30
129_C170_T1.0150.30
69_F79_R1.0050.29
45_A51_N1.0010.29
95_Q128_S1.0010.29
250_T356_S0.9990.29
386_Q395_L0.9940.29
118_F222_Q0.9940.29
320_L390_I0.9900.29
138_P341_I0.9890.29
379_I399_P0.9860.29
17_C415_R0.9860.29
290_E380_S0.9860.29
408_Y412_R0.9840.29
150_F207_R0.9830.29
38_T81_R0.9820.29
299_E310_G0.9820.29
101_A183_Q0.9820.29
17_C137_A0.9790.28
23_H92_N0.9770.28
34_D41_V0.9750.28
100_D399_P0.9730.28
129_C193_A0.9710.28
52_Q105_K0.9630.28
47_S109_L0.9590.28
113_Y118_F0.9590.28
201_Q364_T0.9560.27
95_Q109_L0.9530.27
345_L387_F0.9510.27
119_S162_E0.9500.27
198_R210_T0.9490.27
379_I390_I0.9480.27
19_V256_A0.9410.27
95_Q229_H0.9400.27
222_Q346_S0.9400.27
267_Y336_D0.9380.27
92_N353_W0.9340.27
338_L341_I0.9320.26
184_S239_E0.9290.26
129_C200_H0.9290.26
27_I67_F0.9280.26
379_I398_I0.9280.26
288_L413_A0.9220.26
275_F353_W0.9220.26
45_A65_R0.9200.26
296_A299_E0.9180.26
66_E411_L0.9160.26
397_A402_L0.9120.26
99_A104_E0.9080.26
65_R69_F0.9070.25
97_E254_Y0.9050.25
47_S141_V0.9010.25
27_I322_E0.9000.25
356_S360_N0.8990.25
17_C39_R0.8980.25
395_L415_R0.8930.25
180_S331_R0.8910.25
27_I294_A0.8900.25
228_D418_C0.8870.25
218_A399_P0.8850.25
329_Y403_I0.8760.24
240_A273_D0.8760.24
95_Q106_S0.8750.24
129_C275_F0.8750.24
6_A74_K0.8730.24
201_Q205_I0.8720.24
32_A408_Y0.8700.24
69_F73_D0.8660.24
407_I411_L0.8640.24
28_E354_P0.8630.24
33_F411_L0.8620.24
315_I329_Y0.8610.24
80_E210_T0.8550.23
299_E386_Q0.8470.23
71_I75_V0.8450.23
108_E370_E0.8420.23
186_H403_I0.8410.23
16_I208_G0.8390.23
183_Q367_V0.8370.23
92_N182_I0.8360.23
274_H418_C0.8350.23
77_F81_R0.8330.23
180_S190_V0.8310.23
132_D228_D0.8300.23
297_Q382_Y0.8300.23
298_I378_M0.8290.23
236_Q239_E0.8280.23
408_Y411_L0.8270.22
200_H256_A0.8270.22
8_H248_E0.8260.22
53_F109_L0.8250.22
267_Y387_F0.8230.22
312_L411_L0.8220.22
167_V328_K0.8210.22
163_Q195_N0.8210.22
333_G336_D0.8200.22
311_C365_M0.8170.22
200_H229_H0.8160.22
128_S135_P0.8160.22
109_L386_Q0.8100.22
380_S393_G0.8090.22
343_Y382_Y0.8090.22
182_I416_Y0.8080.22
315_I318_V0.8070.22
380_S387_F0.8050.22
118_F410_V0.8040.22
216_V408_Y0.8020.22
93_C125_A0.8000.22
109_L151_A0.7980.21
25_L403_I0.7980.21
25_L204_F0.7940.21
127_M240_A0.7910.21
167_V400_H0.7910.21
109_L132_D0.7900.21
31_L35_R0.7900.21
237_P273_D0.7900.21
167_V377_G0.7880.21
332_T338_L0.7870.21
35_R71_I0.7850.21
51_N138_P0.7840.21
27_I68_V0.7820.21
218_A369_L0.7820.21
141_V296_A0.7800.21
267_Y417_G0.7800.21
138_P160_Q0.7790.21
77_F379_I0.7790.21
197_L246_W0.7780.21
65_R395_L0.7730.21
238_Q241_Q0.7720.21
53_F283_A0.7720.21
92_N129_C0.7710.21
379_I402_L0.7710.21
200_H270_L0.7700.21
181_A396_S0.7690.20
24_P99_A0.7680.20
165_S213_L0.7650.20
404_M415_R0.7640.20
47_S219_I0.7640.20
128_S329_Y0.7630.20
266_A410_V0.7630.20
16_I344_S0.7610.20
79_R82_I0.7600.20
223_P346_S0.7580.20
229_H340_D0.7560.20
394_E398_I0.7560.20
33_F267_Y0.7560.20
392_S413_A0.7520.20
47_S193_A0.7510.20
100_D154_S0.7500.20
334_F341_I0.7500.20
27_I41_V0.7490.20
78_A191_E0.7470.20
17_C37_S0.7470.20
53_F97_E0.7460.20
180_S266_A0.7450.20
150_F238_Q0.7440.20
246_W274_H0.7410.20
23_H349_I0.7410.20
235_Y399_P0.7400.20
33_F415_R0.7400.20
316_E320_L0.7400.20
51_N349_I0.7390.19
114_V195_N0.7390.19
23_H145_A0.7380.19
100_D313_A0.7360.19
47_S283_A0.7360.19
167_V364_T0.7340.19
47_S267_Y0.7330.19
164_L267_Y0.7320.19
77_F187_I0.7320.19
139_E218_A0.7310.19
212_A219_I0.7300.19
129_C270_L0.7300.19
151_A155_V0.7300.19
198_R201_Q0.7290.19
62_A82_I0.7290.19
97_E137_A0.7280.19
47_S386_Q0.7260.19
271_V346_S0.7250.19
36_N408_Y0.7250.19
150_F211_E0.7240.19
17_C411_L0.7240.19
27_I402_L0.7230.19
263_T391_Q0.7220.19
246_W269_E0.7220.19
110_V155_V0.7220.19
92_N200_H0.7200.19
6_A27_I0.7200.19
39_R288_L0.7170.19
128_S228_D0.7140.19
237_P267_Y0.7140.19
27_I407_I0.7120.19
145_A200_H0.7110.19
284_L293_F0.7110.19
100_D104_E0.7090.19
281_G350_R0.7080.19
397_A410_V0.7070.18
45_A185_V0.7060.18
149_C212_A0.7050.18
190_V193_A0.7050.18
181_A409_D0.7040.18
21_S226_E0.7040.18
17_C417_G0.7030.18
27_I397_A0.7020.18
337_S389_R0.7010.18
51_N151_A0.7010.18
35_R38_T0.7010.18
73_D269_E0.6980.18
404_M416_Y0.6980.18
217_I245_Q0.6960.18
53_F386_Q0.6940.18
213_L231_N0.6940.18
246_W254_Y0.6930.18
20_C46_T0.6930.18
190_V240_A0.6910.18
194_A209_L0.6910.18
32_A75_V0.6900.18
302_L372_V0.6880.18
71_I105_K0.6880.18
182_I233_I0.6870.18
409_D412_R0.6860.18
141_V229_H0.6860.18
145_A170_T0.6860.18
67_F379_I0.6840.18
403_I415_R0.6840.18
315_I349_I0.6820.18
182_I186_H0.6820.18
345_L411_L0.6790.18
47_S379_I0.6790.18
252_M333_G0.6790.18
392_S407_I0.6770.18
47_S51_N0.6770.18
12_E416_Y0.6770.18
105_K212_A0.6750.18
296_A377_G0.6750.18
125_A151_A0.6740.17
247_I325_Y0.6740.17
334_F366_M0.6730.17
99_A256_A0.6720.17
174_V180_S0.6720.17
96_Q210_T0.6710.17
310_G313_A0.6700.17
22_A226_E0.6670.17
127_M381_Q0.6640.17
242_P272_R0.6630.17
230_S345_L0.6630.17
35_R78_A0.6620.17
317_E357_R0.6570.17
192_D311_C0.6570.17
70_T74_K0.6570.17
314_V317_E0.6550.17
240_A244_A0.6510.17
17_C413_A0.6510.17
302_L374_I0.6500.17
383_L402_L0.6490.17
19_V45_A0.6480.17
332_T340_D0.6470.17
79_R398_I0.6460.17
4_L13_H0.6460.17
401_Q412_R0.6460.17
27_I40_K0.6450.17
296_A300_Q0.6420.17
139_E245_Q0.6420.17
77_F277_I0.6410.17
183_Q398_I0.6410.17
328_K402_L0.6400.16
327_K360_N0.6400.16
275_F349_I0.6400.16
345_L377_G0.6390.16
129_C353_W0.6390.16
149_C155_V0.6390.16
332_T337_S0.6380.16
315_I332_T0.6380.16
73_D76_G0.6360.16
79_R357_R0.6350.16
332_T336_D0.6340.16
32_A119_S0.6330.16
277_I344_S0.6310.16
137_A408_Y0.6280.16
318_V355_H0.6270.16
27_I394_E0.6270.16
70_T407_I0.6250.16
38_T372_V0.6240.16
245_Q248_E0.6230.16
187_I390_I0.6220.16
360_N367_V0.6220.16
203_A343_Y0.6210.16
138_P178_E0.6210.16
127_M346_S0.6200.16
240_A346_S0.6170.16
74_K197_L0.6160.16
229_H344_S0.6140.16
329_Y392_S0.6130.16
168_I343_Y0.6120.16
164_L235_Y0.6100.16
194_A401_Q0.6090.16
390_I395_L0.6080.16
62_A139_E0.6080.16
34_D213_L0.6070.16
196_T223_P0.6060.16
129_C145_A0.6060.16
73_D379_I0.6060.16
20_C26_V0.6030.15
198_R373_D0.6030.15
5_I389_R0.6020.15
371_G403_I0.6020.15
335_N338_L0.5990.15
104_E199_T0.5990.15
70_T401_Q0.5980.15
33_F379_I0.5980.15
292_I383_L0.5970.15
383_L406_K0.5960.15
8_H92_N0.5960.15
170_T229_H0.5950.15
41_V391_Q0.5940.15
53_F406_K0.5930.15
258_S262_Q0.5930.15
125_A230_S0.5920.15
389_R412_R0.5920.15
168_I369_L0.5910.15
99_A353_W0.5890.15
73_D404_M0.5880.15
296_A311_C0.5880.15
349_I353_W0.5870.15
397_A403_I0.5860.15
128_S248_E0.5850.15
394_E413_A0.5850.15
47_S125_A0.5840.15
106_S411_L0.5830.15
153_E176_G0.5820.15
30_A105_K0.5820.15
218_A321_D0.5820.15
76_G185_V0.5820.15
337_S415_R0.5810.15
201_Q245_Q0.5810.15
65_R77_F0.5790.15
194_A395_L0.5780.15
46_T350_R0.5780.15
46_T281_G0.5780.15
21_S284_L0.5770.15
151_A212_A0.5760.15
37_S288_L0.5760.15
128_S229_H0.5750.15
349_I386_Q0.5750.15
214_T324_Q0.5750.15
132_D345_L0.5750.15
156_A164_L0.5740.15
143_E203_A0.5740.15
93_C274_H0.5700.15
8_H13_H0.5690.15
119_S302_L0.5690.15
135_P187_I0.5680.15
156_A302_L0.5680.15
4_L324_Q0.5680.15
115_R297_Q0.5680.15
380_S386_Q0.5680.15
93_C284_L0.5670.15
265_T407_I0.5670.15
19_V99_A0.5660.15
392_S397_A0.5660.15
151_A168_I0.5650.14
202_K206_A0.5630.14
10_A327_K0.5630.14
285_T350_R0.5620.14
281_G285_T0.5620.14
247_I341_I0.5610.14
149_C231_N0.5600.14
35_R329_Y0.5600.14
293_F358_I0.5590.14
127_M271_V0.5580.14
156_A269_E0.5580.14
253_V361_S0.5580.14
134_I197_L0.5580.14
40_K185_V0.5570.14
215_R353_W0.5570.14
9_K354_P0.5570.14
258_S289_R0.5570.14
298_I374_I0.5560.14
373_D382_Y0.5560.14
174_V240_A0.5550.14
213_L342_R0.5550.14
191_E214_T0.5530.14
44_E86_G0.5530.14
228_D274_H0.5530.14
222_Q254_Y0.5520.14
134_I218_A0.5520.14
5_I8_H0.5510.14
37_S382_Y0.5510.14
319_M347_D0.5510.14
175_P223_P0.5490.14
385_K405_D0.5490.14
302_L320_L0.5480.14
206_A242_P0.5460.14
114_V270_L0.5460.14
354_P407_I0.5460.14
57_T196_T0.5460.14
156_A160_Q0.5440.14
404_M408_Y0.5420.14
308_R356_S0.5400.14
65_R400_H0.5400.14
196_T221_V0.5400.14
274_H316_E0.5400.14
307_N364_T0.5390.14
229_H386_Q0.5380.14
379_I409_D0.5380.14
22_A64_F0.5370.14
74_K416_Y0.5370.14
11_G31_L0.5370.14
77_F140_T0.5370.14
143_E181_A0.5360.14
95_Q228_D0.5350.14
400_H404_M0.5350.14
396_S416_Y0.5340.14
101_A327_K0.5340.14
143_E394_E0.5320.14
317_E407_I0.5300.14
123_L200_H0.5290.14
151_A160_Q0.5290.14
206_A360_N0.5280.14
44_E258_S0.5270.14
154_S367_V0.5270.14
92_N256_A0.5250.13
146_A208_G0.5230.13
221_V226_E0.5210.13
264_R385_K0.5210.13
164_L273_D0.5200.13
195_N199_T0.5190.13
234_H355_H0.5180.13
154_S241_Q0.5180.13
111_K115_R0.5180.13
27_I387_F0.5170.13
112_E146_A0.5170.13
202_K242_P0.5170.13
77_F80_E0.5170.13
76_G96_Q0.5160.13
265_T308_R0.5150.13
4_L11_G0.5150.13
258_S347_D0.5130.13
234_H292_I0.5130.13
262_Q347_D0.5120.13
128_S296_A0.5110.13
154_S211_E0.5110.13
372_V389_R0.5110.13
170_T256_A0.5110.13
99_A275_F0.5110.13
376_L384_P0.5100.13
203_A325_Y0.5090.13
157_T160_Q0.5080.13
22_A57_T0.5070.13
38_T398_I0.5070.13
287_A411_L0.5060.13
138_P165_S0.5060.13
209_L313_A0.5030.13
110_V125_A0.5030.13
385_K406_K0.5020.13
228_D299_E0.5020.13
363_E366_M0.5000.13
39_R415_R0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fiqA 4 0.9786 100 0.375 Contact Map
3txvA 2 0.919 100 0.394 Contact Map
4to8A 2 0.6524 99.9 0.868 Contact Map
3elfA 4 0.7214 99.9 0.872 Contact Map
1gvfA 3 0.6452 99.9 0.874 Contact Map
3pm6A 2 0.6571 99.1 0.931 Contact Map
1rvgA 3 0.6643 99 0.933 Contact Map
1dosA 2 0.6929 98.9 0.935 Contact Map
3qm3A 4 0.7119 98.9 0.936 Contact Map
3n9rA 3 0.6429 98.9 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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