GREMLIN Database
GATY - D-tagatose-1,6-bisphosphate aldolase subunit GatY
UniProt: P0C8J6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12419
Length: 284 (276)
Sequences: 3919 (1975)
Seq/√Len: 118.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
162_E166_A3.9421.00
40_N272_S3.3131.00
40_N268_R3.2881.00
12_N16_G3.0101.00
110_F162_E2.9571.00
161_R165_E2.7031.00
43_A280_C2.6141.00
41_L276_A2.6061.00
110_F114_I2.5411.00
94_V129_V2.4231.00
39_A74_H2.3911.00
195_E199_Q2.3791.00
119_E122_D2.3681.00
190_D193_R2.3681.00
245_N249_E2.3641.00
36_E268_R2.3621.00
91_A123_F2.3421.00
109_P112_Q2.3191.00
176_I194_L2.2831.00
103_I116_R2.2671.00
34_V45_V2.2421.00
215_T277_D2.2231.00
115_S119_E2.1821.00
49_G98_V2.1801.00
41_L272_S2.0881.00
12_N18_Y2.0651.00
242_A266_A2.0461.00
6_T78_A2.0331.00
41_L281_E2.0011.00
9_M78_A1.9731.00
191_F220_Q1.9571.00
125_H170_D1.9541.00
265_S269_D1.8991.00
95_R123_F1.8761.00
268_R272_S1.8581.00
118_K122_D1.8561.00
195_E224_L1.8431.00
214_S217_D1.8141.00
161_R200_W1.7951.00
14_Q227_C1.7751.00
11_N15_R1.7671.00
7_K11_N1.7591.00
6_T171_S1.7451.00
35_V73_Y1.7211.00
105_A108_L1.7171.00
276_A281_E1.7041.00
91_A95_R1.6921.00
112_Q115_S1.6781.00
121_V131_V1.6631.00
220_Q223_K1.6261.00
22_A48_A1.6021.00
159_Q162_E1.5681.00
111_A166_A1.5471.00
242_A245_N1.5421.00
108_L112_Q1.5361.00
275_I281_E1.5271.00
45_V77_L1.5201.00
220_Q224_L1.5091.00
191_F224_L1.5081.00
80_H100_S1.5051.00
39_A73_Y1.5031.00
95_R127_F1.4981.00
195_E220_Q1.4951.00
158_A200_W1.4931.00
205_L226_I1.4851.00
25_I47_I1.4831.00
31_M69_M1.4651.00
269_D272_S1.4511.00
241_Q245_N1.4411.00
14_Q198_R1.4381.00
123_F127_F1.4351.00
32_Q264_K1.4261.00
35_V77_L1.4021.00
21_P271_V1.3801.00
156_N159_Q1.3791.00
110_F159_Q1.3561.00
196_N199_Q1.3451.00
266_A269_D1.3241.00
87_F91_A1.3061.00
67_S71_K1.2961.00
64_A68_A1.2961.00
244_K247_L1.2871.00
246_Y250_H1.2851.00
87_F119_E1.2821.00
215_T273_K1.2811.00
178_T213_L1.2781.00
223_K279_G1.2500.99
64_A67_S1.2480.99
110_F166_A1.2310.99
270_V273_K1.2270.99
31_M66_V1.2060.99
25_I31_M1.1950.99
17_G223_K1.1950.99
25_I34_V1.1930.99
37_T271_V1.1910.99
60_E72_Q1.1900.99
193_R197_I1.1880.99
67_S79_I1.1870.99
122_D126_R1.1850.99
36_E264_K1.1790.99
114_I166_A1.1630.99
38_A45_V1.1620.99
117_V133_A1.1610.99
42_H74_H1.1590.99
222_I278_C1.1560.99
118_K166_A1.1550.99
63_L79_I1.1510.99
262_S265_S1.1510.99
120_V131_V1.1510.99
215_T219_Q1.1470.99
37_T41_L1.1460.99
51_P89_D1.1440.99
108_L116_R1.1430.99
111_A115_S1.1370.99
147_V152_A1.1370.99
87_F123_F1.1310.99
243_L263_A1.1200.99
232_A236_K1.1140.99
5_S130_S1.1110.99
101_V124_C1.1020.99
37_T268_R1.0980.99
60_E92_Q1.0980.99
193_R196_N1.0960.99
111_A162_E1.0870.98
201_V205_L1.0850.98
101_V120_V1.0840.98
101_V131_V1.0770.98
94_V127_F1.0750.98
196_N200_W1.0660.98
116_R119_E1.0640.98
164_A203_L1.0610.98
265_S268_R1.0550.98
94_V123_F1.0510.98
91_A127_F1.0440.98
246_Y253_A1.0320.98
51_P86_K1.0300.98
198_R227_C1.0250.98
105_A116_R1.0220.98
12_N15_R1.0170.98
231_V278_C1.0150.98
269_D273_K1.0110.97
21_P275_I1.0100.97
192_S196_N1.0090.97
8_Q12_N1.0050.97
273_K277_D0.9980.97
174_V197_I0.9970.97
94_V124_C0.9940.97
33_V267_M0.9940.97
21_P278_C0.9910.97
88_D92_Q0.9900.97
133_A169_I0.9880.97
253_A258_D0.9840.97
68_A71_K0.9750.97
37_T272_S0.9730.97
272_S276_A0.9730.97
157_P200_W0.9620.97
49_G62_L0.9600.97
238_A270_V0.9560.96
73_Y77_L0.9550.96
192_S195_E0.9550.96
160_A201_V0.9520.96
66_V79_I0.9480.96
99_R130_S0.9450.96
10_L171_S0.9430.96
26_H53_T0.9380.96
43_A279_G0.9270.96
38_A275_I0.9220.96
57_A62_L0.9200.96
26_H30_T0.9170.96
190_D196_N0.9170.96
191_F217_D0.9170.96
31_M47_I0.9160.95
60_E71_K0.9100.95
34_V271_V0.9060.95
243_L259_Y0.9050.95
154_Y193_R0.9040.95
229_I278_C0.9000.95
17_G227_C0.8940.95
133_A163_F0.8920.95
219_Q223_K0.8900.95
9_M20_V0.8810.94
18_Y43_A0.8800.94
112_Q116_R0.8740.94
250_H253_A0.8740.94
157_P196_N0.8740.94
207_L221_T0.8730.94
218_I278_C0.8660.94
271_V275_I0.8540.93
86_K89_D0.8540.93
219_Q279_G0.8510.93
275_I280_C0.8510.93
160_A197_I0.8480.93
176_I207_L0.8470.93
5_S8_Q0.8470.93
10_L20_V0.8390.93
50_T232_A0.8380.93
137_Q152_A0.8380.93
182_M237_N0.8340.93
61_N69_M0.8320.93
155_T160_A0.8270.92
44_P76_P0.8240.92
5_S128_D0.8230.92
63_L67_S0.8220.92
218_I222_I0.8220.92
123_F126_R0.8220.92
125_H128_D0.8190.92
162_E165_E0.8170.92
38_A75_H0.8150.92
117_V121_V0.8140.92
27_N30_T0.8130.92
101_V129_V0.8120.92
48_A232_A0.8080.91
39_A75_H0.8050.91
124_C129_V0.8040.91
135_L164_A0.7990.91
141_Q146_Q0.7980.91
48_A80_H0.7950.91
155_T174_V0.7950.91
178_T189_L0.7930.91
50_T53_T0.7910.91
120_V123_F0.7870.90
214_S218_I0.7850.90
37_T275_I0.7850.90
28_L65_L0.7840.90
53_T232_A0.7800.90
23_F271_V0.7800.90
23_F45_V0.7750.90
262_S266_A0.7750.90
218_I229_I0.7700.89
103_I120_V0.7690.89
234_E274_V0.7660.89
164_A201_V0.7660.89
49_G54_F0.7640.89
6_T130_S0.7610.89
194_L226_I0.7580.89
121_V125_H0.7490.88
85_T107_H0.7490.88
86_K90_I0.7490.88
239_F260_L0.7450.88
242_A263_A0.7440.88
24_N50_T0.7430.88
158_A161_R0.7430.88
245_N248_T0.7420.88
70_A73_Y0.7370.87
8_Q11_N0.7370.87
219_Q277_D0.7330.87
23_F34_V0.7320.87
43_A282_G0.7310.87
197_I201_V0.7290.87
255_D258_D0.7270.86
93_K98_V0.7200.86
103_I108_L0.7200.86
194_L224_L0.7190.86
109_P115_S0.7150.86
63_L98_V0.7080.85
235_L267_M0.7070.85
26_H232_A0.7070.85
155_T197_I0.7040.85
137_Q147_V0.6970.84
244_K248_T0.6970.84
267_M271_V0.6960.84
6_T9_M0.6930.84
50_T257_R0.6930.84
222_I225_G0.6910.84
78_A130_S0.6890.83
143_D147_V0.6880.83
157_P193_R0.6870.83
11_N14_Q0.6870.83
135_L160_A0.6870.83
52_G257_R0.6840.83
135_L163_F0.6840.83
26_H50_T0.6820.83
63_L96_S0.6810.83
216_K219_Q0.6810.83
141_Q144_D0.6800.83
110_F135_L0.6780.82
242_A246_Y0.6770.82
247_L259_Y0.6720.82
23_F275_I0.6710.82
216_K220_Q0.6680.81
84_H90_I0.6680.81
9_M12_N0.6680.81
140_G143_D0.6680.81
105_A133_A0.6670.81
46_I78_A0.6650.81
10_L130_S0.6650.81
171_S206_V0.6630.81
39_A42_H0.6610.81
29_E239_F0.6610.81
31_M65_L0.6540.80
151_D156_N0.6530.80
154_Y190_D0.6530.80
32_Q36_E0.6520.80
59_T92_Q0.6510.80
246_Y249_E0.6480.79
275_I282_G0.6470.79
87_F120_V0.6470.79
70_A77_L0.6450.79
139_G210_A0.6420.79
240_S247_L0.6380.78
26_H256_P0.6380.78
121_V168_G0.6370.78
68_A72_Q0.6350.78
51_P85_T0.6340.78
183_Y225_G0.6330.78
239_F263_A0.6320.78
6_T46_I0.6310.78
174_V194_L0.6260.77
62_L66_V0.6250.77
15_R196_N0.6250.77
133_A167_T0.6220.77
43_A275_I0.6210.77
218_I277_D0.6190.76
35_V47_I0.6180.76
237_N241_Q0.6170.76
94_V101_V0.6170.76
5_S99_R0.6160.76
218_I231_V0.6110.75
92_Q96_S0.6110.75
197_I205_L0.6070.75
140_G144_D0.6050.75
189_L221_T0.6050.75
164_A169_I0.6030.74
159_Q166_A0.6030.74
53_T255_D0.6010.74
270_V274_V0.5980.74
140_G145_V0.5970.74
54_F89_D0.5950.73
114_I162_E0.5910.73
14_Q202_N0.5910.73
6_T10_L0.5910.73
18_Y279_G0.5900.73
113_N136_G0.5860.72
87_F90_I0.5860.72
210_A231_V0.5850.72
63_L70_A0.5840.72
183_Y187_P0.5810.72
246_Y262_S0.5780.71
78_A99_R0.5770.71
42_H282_G0.5750.71
94_V125_H0.5740.71
243_L260_L0.5740.71
111_A114_I0.5730.71
133_A156_N0.5730.71
13_A18_Y0.5720.71
211_S234_E0.5690.70
231_V234_E0.5690.70
256_P259_Y0.5670.70
116_R120_V0.5660.70
242_A262_S0.5650.70
179_A187_P0.5650.70
35_V75_H0.5640.69
176_I224_L0.5640.69
90_I120_V0.5630.69
28_L57_A0.5630.69
258_D262_S0.5620.69
17_G198_R0.5620.69
59_T96_S0.5620.69
26_H49_G0.5600.69
25_I62_L0.5580.69
30_T53_T0.5570.69
67_S73_Y0.5570.69
137_Q193_R0.5570.69
117_V167_T0.5560.68
89_D92_Q0.5540.68
33_V37_T0.5530.68
56_H257_R0.5530.68
45_V275_I0.5520.68
33_V264_K0.5510.68
213_L217_D0.5500.68
130_S171_S0.5490.67
65_L68_A0.5490.67
231_V274_V0.5480.67
118_K121_V0.5480.67
24_N56_H0.5480.67
236_K255_D0.5470.67
198_R202_N0.5470.67
135_L156_N0.5450.67
261_Q265_S0.5450.67
189_L217_D0.5440.67
217_D220_Q0.5430.67
265_S276_A0.5370.66
41_L275_I0.5360.66
156_N193_R0.5310.65
79_I99_R0.5310.65
226_I229_I0.5310.65
67_S70_A0.5300.65
62_L65_L0.5280.64
59_T93_K0.5260.64
110_F172_L0.5240.64
155_T163_F0.5230.64
141_Q145_V0.5220.64
219_Q222_I0.5220.64
158_A162_E0.5220.64
58_G61_N0.5190.63
169_I203_L0.5180.63
85_T89_D0.5140.62
27_N256_P0.5130.62
182_M234_E0.5090.62
53_T257_R0.5090.62
176_I221_T0.5090.62
14_Q203_L0.5080.62
6_T99_R0.5070.61
50_T256_P0.5050.61
88_D91_A0.5050.61
156_N196_N0.5040.61
21_P48_A0.5030.61
39_A72_Q0.5030.61
51_P55_T0.5020.61
232_A256_P0.5020.61
174_V226_I0.5020.61
30_T267_M0.5010.60
90_I124_C0.5010.60
279_G282_G0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gvfA 3 0.9683 100 0.031 Contact Map
3n9rA 3 0.9613 100 0.043 Contact Map
1rvgA 3 0.993 100 0.045 Contact Map
2iswA 2 0.9437 100 0.047 Contact Map
4to8A 2 0.9683 100 0.049 Contact Map
3elfA 4 0.9507 100 0.085 Contact Map
3pm6A 2 0.9718 100 0.101 Contact Map
1dosA 2 0.9472 100 0.109 Contact Map
3qm3A 4 0.9824 100 0.114 Contact Map
3txvA 2 0.8592 100 0.241 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0092 seconds.