GREMLIN Database
PAAJ - 3-oxoadipyl-CoA/3-oxo-5,6-dehydrosuberyl-CoA thiolase
UniProt: P0C7L2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13744
Length: 401 (379)
Sequences: 13901 (7567)
Seq/√Len: 388.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
187_R191_R3.4641.00
3_E268_E3.4331.00
180_D335_R3.4151.00
270_M274_Q3.3211.00
36_E39_V2.9241.00
109_G112_L2.8781.00
186_L232_L2.7991.00
97_L367_A2.7791.00
197_S228_P2.7041.00
370_A382_A2.7011.00
187_R190_Q2.6981.00
194_K198_S2.6911.00
268_E272_A2.6521.00
181_Q247_V2.6291.00
270_M273_A2.4621.00
5_F271_A2.4401.00
9_G368_L2.4151.00
306_V310_A2.3681.00
306_V397_I2.3581.00
172_E243_R2.3371.00
34_L113_I2.2921.00
10_I40_R2.2631.00
104_I265_I2.2521.00
37_L264_I2.2111.00
202_A221_Q2.1271.00
280_A371_S2.1041.00
30_A54_L2.0891.00
196_Q226_L2.0771.00
374_L379_G2.0761.00
284_A310_A2.0731.00
319_V348_P2.0421.00
225_H255_G1.9861.00
111_L266_A1.9841.00
100_A112_L1.9781.00
104_I267_S1.9721.00
281_R399_E1.9571.00
279_R375_H1.9411.00
177_S180_D1.9221.00
32_I208_V1.9181.00
179_E183_S1.8921.00
312_L381_Y1.8811.00
45_D48_C1.8741.00
261_A364_A1.8341.00
235_L251_G1.8291.00
7_C266_A1.8251.00
284_A306_V1.8241.00
193_A226_L1.8241.00
187_R343_A1.8151.00
318_D379_G1.7921.00
48_C274_Q1.7821.00
3_E281_R1.7661.00
334_L343_A1.7611.00
209_V219_E1.7491.00
303_T385_T1.7251.00
266_A271_A1.7061.00
193_A197_S1.6961.00
212_N218_T1.6891.00
202_A222_H1.6841.00
196_Q205_I1.6791.00
20_A220_I1.6731.00
196_Q222_H1.6521.00
349_N373_E1.6381.00
54_L115_G1.6351.00
334_L346_V1.6301.00
263_L364_A1.6181.00
173_L294_L1.6151.00
34_L71_A1.6081.00
373_E377_R1.6051.00
266_A270_M1.6051.00
314_I320_I1.6031.00
110_D267_S1.5981.00
312_L317_M1.5941.00
234_Q237_G1.5931.00
186_L190_Q1.5831.00
304_R308_E1.5771.00
200_I349_N1.5741.00
84_T99_F1.5681.00
30_A71_A1.5681.00
32_I206_V1.5651.00
342_D345_H1.5631.00
203_E375_H1.5571.00
317_M397_I1.5541.00
317_M320_I1.5431.00
164_P242_F1.5421.00
267_S270_M1.5311.00
100_A265_I1.5261.00
119_S122_R1.5201.00
110_D270_M1.5191.00
103_A109_G1.5081.00
36_E206_V1.5001.00
319_V373_E1.4801.00
28_D74_L1.4661.00
312_L397_I1.4611.00
183_S187_R1.4571.00
35_R39_V1.4551.00
170_V176_I1.4291.00
373_E376_R1.4271.00
301_P304_R1.4201.00
37_L42_P1.4161.00
283_V399_E1.4121.00
190_Q194_K1.4121.00
200_I373_E1.4071.00
33_P262_A1.4031.00
102_R108_D1.4011.00
21_L220_I1.3971.00
380_R399_E1.3961.00
98_G396_M1.3931.00
320_I383_L1.3931.00
180_D183_S1.3751.00
36_E40_R1.3721.00
367_A398_L1.3711.00
79_Q291_E1.3601.00
183_S232_L1.3561.00
67_V117_V1.3541.00
286_A305_R1.3441.00
286_A306_V1.3341.00
8_D37_L1.3321.00
5_F281_R1.3161.00
383_L397_I1.3031.00
193_A229_E1.2861.00
304_R336_E1.2811.00
302_A395_A1.2801.00
111_L270_M1.2741.00
54_L262_A1.2721.00
212_N215_G1.2681.00
14_I361_M1.2641.00
91_G394_I1.2641.00
190_Q229_E1.2631.00
200_I376_R1.2591.00
33_P260_A1.2561.00
305_R308_E1.2511.00
317_M381_Y1.2421.00
97_L263_L1.2401.00
269_Q273_A1.2291.00
303_T383_L1.2211.00
98_G285_M1.2191.00
91_G388_I1.2171.00
31_A74_L1.2141.00
14_I355_L1.2131.00
4_A265_I1.2051.00
49_I111_L1.1941.00
348_P373_E1.1931.00
50_D109_G1.1921.00
56_C59_Q1.1921.00
288_A301_P1.1881.00
368_L372_H1.1851.00
10_I206_V1.1831.00
113_I264_I1.1811.00
176_I181_Q1.1591.00
176_I331_L1.1581.00
371_S375_H1.1551.00
290_V297_L1.1491.00
203_E376_R1.1401.00
307_L314_I1.1391.00
24_V32_I1.1311.00
34_L77_L1.1241.00
94_L367_A1.1211.00
204_E369_A1.1161.00
310_A397_I1.1141.00
174_L297_L1.1081.00
9_G372_H1.1081.00
318_D345_H1.1001.00
297_L300_V1.1001.00
370_A384_C1.0921.00
5_F266_A1.0921.00
184_F330_A1.0811.00
5_F268_E1.0681.00
100_A114_A1.0661.00
8_D42_P1.0651.00
108_D309_R1.0611.00
319_V377_R1.0611.00
18_G132_S1.0601.00
313_S316_D1.0591.00
95_D99_F1.0561.00
32_I36_E1.0471.00
13_P220_I1.0471.00
53_I112_L1.0451.00
48_C270_M1.0411.00
105_K108_D1.0411.00
283_V381_Y1.0381.00
38_L77_L1.0381.00
318_D374_L1.0361.00
210_L218_T1.0331.00
203_E372_H1.0291.00
193_A228_P1.0261.00
164_P241_P1.0231.00
6_I398_L1.0211.00
381_Y399_E1.0211.00
314_I317_M1.0211.00
50_D110_D1.0191.00
294_L297_L1.0121.00
282_I396_M1.0121.00
348_P377_R1.0121.00
187_R344_P1.0111.00
230_T235_L1.0071.00
284_A397_I1.0061.00
317_M383_L1.0051.00
48_C273_A1.0011.00
52_V72_T0.9991.00
215_G218_T0.9941.00
186_L229_E0.9931.00
300_V304_R0.9871.00
165_E243_R0.9861.00
365_R369_A0.9831.00
261_A361_M0.9781.00
33_P36_E0.9781.00
232_L236_R0.9761.00
7_C276_L0.9761.00
173_L293_R0.9741.00
366_L384_C0.9731.00
102_R106_A0.9731.00
8_D40_R0.9681.00
288_A305_R0.9681.00
339_L346_V0.9671.00
97_L265_I0.9631.00
12_T33_P0.9621.00
268_E281_R0.9591.00
284_A309_R0.9561.00
14_I257_N0.9541.00
279_R371_S0.9531.00
349_N376_R0.9411.00
174_L336_E0.9391.00
10_I36_E0.9371.00
25_R28_D0.9361.00
238_L251_G0.9351.00
129_K134_F0.9351.00
381_Y397_I0.9301.00
53_I96_A0.9251.00
192_T226_L0.9251.00
9_G371_S0.9231.00
168_E246_G0.9161.00
16_R225_H0.9151.00
171_A328_A0.9141.00
297_L332_G0.9111.00
77_L81_V0.9081.00
184_F331_L0.9081.00
196_Q202_A0.9071.00
170_V297_L0.9071.00
37_L113_I0.9061.00
55_G92_S0.9031.00
73_L79_Q0.8981.00
178_R249_T0.8951.00
12_T32_I0.8931.00
266_A276_L0.8901.00
388_I394_I0.8811.00
367_A396_M0.8801.00
352_A362_S0.8791.00
168_E172_E0.8771.00
4_A267_S0.8761.00
297_L336_E0.8751.00
31_A35_R0.8731.00
53_I100_A0.8671.00
170_V332_G0.8671.00
48_C111_L0.8641.00
322_L385_T0.8641.00
38_L44_L0.8631.00
13_P32_I0.8621.00
320_I339_L0.8611.00
190_Q193_A0.8561.00
290_V298_G0.8561.00
300_V336_E0.8551.00
15_G224_E0.8521.00
334_L339_L0.8491.00
114_A263_L0.8491.00
53_I84_T0.8481.00
150_V155_A0.8481.00
169_N173_L0.8471.00
168_E243_R0.8451.00
182_D252_N0.8441.00
198_S376_R0.8381.00
261_A368_L0.8381.00
327_A353_I0.8361.00
210_L215_G0.8361.00
196_Q228_P0.8331.00
268_E271_A0.8331.00
305_R309_R0.8311.00
191_R343_A0.8271.00
319_V370_A0.8271.00
277_T375_H0.8231.00
3_E105_K0.8211.00
371_S398_L0.8211.00
54_L68_A0.8201.00
330_A334_L0.8181.00
101_A282_I0.8181.00
379_G382_A0.8141.00
349_N377_R0.8131.00
303_T395_A0.8101.00
96_A364_A0.8091.00
4_A105_K0.8091.00
186_L235_L0.8011.00
290_V301_P0.7991.00
9_G263_L0.7961.00
150_V162_S0.7931.00
210_L220_I0.7921.00
282_I285_M0.7921.00
108_D285_M0.7921.00
304_R337_L0.7911.00
33_P37_L0.7901.00
130_A134_F0.7881.00
26_A117_V0.7851.00
155_A160_T0.7841.00
191_R194_K0.7831.00
50_D305_R0.7831.00
14_I365_R0.7821.00
194_K197_S0.7811.00
98_G394_I0.7811.00
12_T208_V0.7741.00
88_R95_D0.7731.00
194_K200_I0.7731.00
56_C62_E0.7711.00
12_T29_L0.7711.00
49_I113_I0.7671.00
4_A101_A0.7661.00
197_S222_H0.7651.00
62_E122_R0.7641.00
52_V81_V0.7621.00
230_T234_Q0.7611.00
38_L49_I0.7601.00
315_H345_H0.7581.00
113_I262_A0.7571.00
27_D62_E0.7561.00
269_Q272_A0.7551.00
186_L234_Q0.7521.00
303_T337_L0.7521.00
99_F102_R0.7511.00
94_L396_M0.7511.00
312_L316_D0.7461.00
101_A105_K0.7461.00
192_T196_Q0.7461.00
189_Q225_H0.7451.00
231_T234_Q0.7441.00
37_L262_A0.7401.00
303_T322_L0.7391.00
51_D287_T0.7361.00
388_I392_Q0.7341.00
24_V28_D0.7331.00
166_T295_M0.7331.00
338_G342_D0.7321.00
25_R122_R0.7291.00
94_L384_C0.7271.00
110_D309_R0.7241.00
211_K215_G0.7201.00
35_R76_G0.7191.00
211_K218_T0.7171.00
279_R372_H0.7171.00
86_I99_F0.7131.00
51_D103_A0.7131.00
195_A221_Q0.7111.00
35_R46_A0.7111.00
103_A108_D0.7101.00
88_R287_T0.7101.00
77_L113_I0.7091.00
315_H338_G0.7091.00
180_D331_L0.7081.00
378_N382_A0.7081.00
127_M134_F0.7071.00
102_R105_K0.7061.00
24_V122_R0.7051.00
314_I339_L0.7041.00
263_L368_L0.7041.00
174_L294_L0.7041.00
56_C67_V0.7021.00
287_T394_I0.7021.00
54_L71_A0.7011.00
306_V383_L0.6981.00
28_D31_A0.6971.00
50_D112_L0.6951.00
162_S165_E0.6930.99
121_S258_D0.6930.99
283_V310_A0.6930.99
169_N172_E0.6880.99
385_T388_I0.6870.99
332_G336_E0.6860.99
238_L249_T0.6850.99
248_I253_A0.6840.99
32_I35_R0.6830.99
38_L43_R0.6820.99
53_I99_F0.6800.99
189_Q226_L0.6780.99
20_A218_T0.6780.99
110_D273_A0.6770.99
322_L333_V0.6770.99
30_A115_G0.6750.99
186_L230_T0.6750.99
100_A109_G0.6740.99
320_I385_T0.6720.99
374_L382_A0.6720.99
47_E80_S0.6720.99
6_I265_I0.6700.99
20_A224_E0.6690.99
18_G121_S0.6690.99
179_E232_L0.6680.99
99_F103_A0.6680.99
120_M359_L0.6670.99
291_E294_L0.6670.99
61_G126_V0.6660.99
318_D381_Y0.6650.99
189_Q193_A0.6640.99
167_A328_A0.6640.99
46_A78_P0.6630.99
125_F130_A0.6630.99
362_S366_L0.6610.99
82_S287_T0.6600.99
10_I37_L0.6580.99
388_I393_G0.6580.99
339_L342_D0.6570.99
186_L231_T0.6560.99
4_A104_I0.6540.99
378_N381_Y0.6530.99
307_L312_L0.6510.99
66_N392_Q0.6500.99
31_A75_A0.6500.99
72_T83_G0.6490.99
179_E236_R0.6480.99
192_T354_A0.6470.99
10_I33_P0.6460.99
49_I77_L0.6460.99
165_E169_N0.6450.99
103_A112_L0.6440.99
192_T355_L0.6430.99
72_T77_L0.6420.99
38_L46_A0.6420.99
51_D88_R0.6410.99
8_D279_R0.6410.99
5_F267_S0.6400.99
130_A133_A0.6390.99
35_R75_A0.6390.99
24_V119_S0.6380.99
84_T95_D0.6380.99
265_I282_I0.6370.99
97_L114_A0.6310.99
57_A359_L0.6290.99
230_T251_G0.6280.99
200_I377_R0.6250.99
318_D380_R0.6250.99
59_Q85_T0.6250.99
303_T314_I0.6240.99
367_A384_C0.6240.99
95_D98_G0.6240.99
209_V212_N0.6240.99
283_V312_L0.6230.99
71_A117_V0.6230.99
34_L38_L0.6220.99
30_A117_V0.6200.99
111_L274_Q0.6200.99
176_I335_R0.6190.99
167_A248_I0.6180.99
161_D165_E0.6180.99
34_L52_V0.6170.99
308_E313_S0.6150.99
5_F274_Q0.6150.99
7_C271_A0.6150.99
199_G202_A0.6110.99
331_L335_R0.6110.99
38_L42_P0.6090.99
330_A346_V0.6070.99
361_M364_A0.6060.99
139_E142_D0.6040.99
282_I398_L0.6040.99
239_K250_A0.6010.99
161_D293_R0.6000.99
44_L264_I0.5990.99
29_L208_V0.5970.98
127_M130_A0.5960.98
6_I371_S0.5940.98
183_S343_A0.5940.98
174_L332_G0.5920.98
374_L398_L0.5920.98
375_H378_N0.5910.98
57_A89_L0.5900.98
34_L262_A0.5900.98
7_C270_M0.5900.98
105_K285_M0.5890.98
204_E372_H0.5890.98
94_L394_I0.5890.98
134_F143_T0.5880.98
382_A398_L0.5870.98
266_A274_Q0.5870.98
23_S122_R0.5870.98
22_S132_S0.5860.98
5_F270_M0.5860.98
71_A75_A0.5800.98
161_D169_N0.5790.98
252_N327_A0.5790.98
307_L310_A0.5780.98
95_D287_T0.5770.98
304_R338_G0.5750.98
95_D103_A0.5750.98
167_A171_A0.5750.98
385_T390_V0.5740.98
286_A309_R0.5730.98
306_V317_M0.5720.98
329_Q333_V0.5720.98
185_A235_L0.5720.98
189_Q353_I0.5710.98
15_G21_L0.5710.98
3_E399_E0.5690.98
351_G354_A0.5670.98
207_P221_Q0.5650.98
241_P250_A0.5640.98
176_I180_D0.5630.98
34_L75_A0.5600.98
242_F246_G0.5600.98
215_G219_E0.5600.98
52_V113_I0.5590.98
69_R73_L0.5580.98
303_T333_V0.5570.98
189_Q229_E0.5550.98
190_Q232_L0.5530.98
115_G262_A0.5530.98
222_H226_L0.5520.98
53_I86_I0.5520.98
184_F351_G0.5510.97
243_R246_G0.5510.97
225_H257_N0.5500.97
322_L330_A0.5490.97
42_P264_I0.5490.97
172_E245_N0.5480.97
58_N123_A0.5480.97
27_D74_L0.5480.97
233_E237_G0.5460.97
201_L355_L0.5460.97
24_V211_K0.5460.97
362_S384_C0.5460.97
355_L365_R0.5450.97
334_L342_D0.5450.97
292_P295_M0.5440.97
283_V397_I0.5420.97
50_D81_V0.5420.97
13_P205_I0.5420.97
170_V174_L0.5360.97
13_P221_Q0.5330.97
364_A368_L0.5300.97
96_A114_A0.5290.97
325_A357_H0.5280.97
355_L369_A0.5270.97
168_E248_I0.5270.97
316_D381_Y0.5240.97
320_I345_H0.5230.97
92_S360_G0.5230.97
229_E234_Q0.5190.96
170_V328_A0.5190.96
209_V218_T0.5180.96
32_I209_V0.5180.96
278_P281_R0.5180.96
140_M143_T0.5170.96
97_L364_A0.5170.96
15_G220_I0.5160.96
98_G287_T0.5160.96
21_L24_V0.5150.96
154_M158_F0.5150.96
191_R346_V0.5140.96
52_V77_L0.5140.96
8_D264_I0.5130.96
10_I372_H0.5120.96
171_A247_V0.5120.96
140_M150_V0.5110.96
335_R338_G0.5110.96
183_S236_R0.5100.96
129_K132_S0.5090.96
174_L335_R0.5070.96
13_P222_H0.5050.96
343_A346_V0.5030.96
240_A246_G0.5030.96
267_S271_A0.5020.96
139_E143_T0.5010.96
280_A398_L0.5000.96
279_R283_V0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ulqA 4 0.99 100 0.241 Contact Map
4n46A 4 0.9776 100 0.257 Contact Map
3ss6A 4 0.9751 100 0.257 Contact Map
2vu1A 4 0.9751 100 0.258 Contact Map
2wu9A 2 0.9551 100 0.26 Contact Map
1wdkC 2 0.9551 100 0.263 Contact Map
4e1lA 4 0.9626 100 0.265 Contact Map
3goaA 2 0.9401 100 0.267 Contact Map
2ib8A 4 0.9676 100 0.27 Contact Map
4c2jA 4 0.9701 100 0.271 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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