GREMLIN Database
DEGP - Periplasmic serine endoprotease DegP
UniProt: P0C0V0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10463
Length: 474 (377)
Sequences: 1933 (1352)
Seq/√Len: 69.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
242_N246_E7.3021.00
367_L376_V6.0501.00
338_S366_G5.5251.00
231_I265_G4.3051.00
130_N156_K3.7281.00
316_V330_I3.5991.00
184_L248_I3.3541.00
180_D183_A3.3001.00
139_I153_M3.2721.00
340_N357_M3.0011.00
177_K246_E2.8781.00
366_G373_Q2.8411.00
364_T375_N2.8081.00
443_N446_E2.7941.00
152_K168_Q2.7871.00
208_V225_I2.7871.00
164_L281_V2.7831.00
117_V239_A2.7801.00
117_V247_L2.7731.00
330_I367_L2.6711.00
362_K377_N2.6371.00
182_D271_N2.4281.00
127_V273_V2.4191.00
118_I143_L2.3801.00
149_F167_I2.3651.00
93_P96_Q2.3621.00
322_N326_A2.3561.00
127_V277_T2.3321.00
367_L374_V2.2951.00
180_D271_N2.2641.00
337_T368_L2.2521.00
100_G103_G2.2401.00
362_K379_E2.1911.00
184_L208_V2.1461.00
239_A247_L2.1171.00
86_G90_Q2.1131.00
176_I241_V2.0771.00
364_T377_N1.9851.00
298_L308_V1.9661.00
125_Y154_V1.9331.00
126_V167_I1.9241.00
327_K381_Q1.9201.00
119_I277_T1.8981.00
94_F98_G1.8771.00
99_Q103_G1.8501.00
152_K166_Q1.8441.00
294_M318_Q1.8391.00
86_G89_F1.8291.00
125_Y164_L1.8211.00
291_L378_L1.8121.00
98_G101_G1.7441.00
338_S343_P1.7081.00
86_G91_S1.7041.00
121_A172_N1.6971.00
195_N253_A1.6911.00
151_A165_I1.6871.00
82_F85_E1.6781.00
89_F94_F1.6711.00
81_P85_E1.6580.99
138_V150_D1.6500.99
88_P91_S1.6440.99
83_C86_G1.6220.99
316_V336_I1.6200.99
83_C90_Q1.6190.99
91_S94_F1.6120.99
334_D369_R1.5960.99
82_F86_G1.5960.99
331_K370_D1.5890.99
90_Q93_P1.5670.99
93_P98_G1.5640.99
321_P326_A1.5590.99
366_G375_N1.5500.99
118_I173_L1.5390.99
190_T248_I1.5340.99
338_S341_G1.5300.99
85_E93_P1.5200.99
140_K148_K1.5140.99
84_Q90_Q1.5040.99
190_T208_V1.4990.99
87_S94_F1.4780.99
227_T240_L1.4760.99
89_F98_G1.4730.99
216_L219_E1.4710.99
91_S98_G1.4440.99
299_N302_L1.4420.99
195_N200_G1.4360.98
176_I247_L1.4250.98
291_L380_L1.4230.98
436_A441_V1.3890.98
91_S96_Q1.3840.98
178_M270_S1.3840.98
95_C98_G1.3750.98
87_S91_S1.3620.98
100_G105_G1.3580.98
339_L357_M1.3420.98
80_S83_C1.3370.98
397_I402_M1.3310.97
446_E450_V1.3190.97
114_G132_V1.3160.97
85_E94_F1.3060.97
94_F103_G1.3060.97
330_I376_V1.3040.97
84_Q88_P1.3020.97
339_L354_V1.3020.97
89_F96_Q1.3010.97
85_E90_Q1.2920.97
125_Y166_Q1.2770.97
94_F99_Q1.2760.97
131_H161_D1.2650.97
85_E89_F1.2640.97
181_S271_N1.2600.96
278_S282_E1.2540.96
85_E91_S1.2520.96
88_P94_F1.2510.96
261_N265_G1.2490.96
295_G347_F1.2480.96
413_V427_L1.2450.96
117_V241_V1.2440.96
89_F93_P1.2440.96
83_C87_S1.2420.96
278_S281_V1.2390.96
83_C93_P1.2260.96
357_M361_S1.2200.96
80_S85_E1.2140.96
125_Y281_V1.2090.96
143_L147_R1.2030.95
162_I250_I1.1970.95
134_D158_P1.1730.95
96_Q99_Q1.1660.95
81_P86_G1.1590.94
93_P99_Q1.1570.94
94_F97_G1.1530.94
131_H236_S1.1500.94
442_K446_E1.1470.94
81_P89_F1.1460.94
441_V446_E1.1410.94
352_A356_T1.1390.94
337_T366_G1.1380.94
357_M380_L1.1340.94
86_G93_P1.1300.94
81_P84_Q1.1290.94
86_G96_Q1.1280.94
87_S90_Q1.1260.93
358_P361_S1.1070.93
178_M274_K1.1000.93
133_V156_K1.0950.92
274_K278_S1.0950.92
86_G94_F1.0950.92
160_S276_L1.0940.92
283_Y287_K1.0940.92
101_G105_G1.0880.92
81_P88_P1.0830.92
337_T373_Q1.0810.92
136_A139_I1.0770.92
140_K150_D1.0760.92
94_F102_N1.0740.92
86_G95_C1.0730.92
293_I314_A1.0680.92
96_Q101_G1.0650.91
189_Y205_S1.0600.91
422_A426_G1.0560.91
155_G280_M1.0540.91
90_Q96_Q1.0510.91
142_Q148_K1.0500.91
112_A296_T1.0450.91
439_Q449_K1.0440.91
234_G237_G1.0410.90
79_D83_C1.0400.90
83_C91_S1.0380.90
330_I365_L1.0350.90
94_F100_G1.0340.90
233_R257_P1.0320.90
209_S226_Q1.0250.90
85_E88_P1.0240.90
257_P262_I1.0210.90
340_N364_T1.0180.89
277_T281_V1.0140.89
201_E241_V1.0110.89
250_I273_V1.0110.89
83_C89_F1.0090.89
85_E97_G1.0040.89
81_P90_Q1.0040.89
161_D236_S1.0010.89
208_V248_I0.9990.89
93_P101_G0.9990.89
419_G423_A0.9900.88
82_F91_S0.9820.88
297_E347_F0.9820.88
89_F95_C0.9810.88
98_G103_G0.9790.88
290_E324_S0.9780.87
226_Q232_N0.9750.87
141_V165_I0.9660.87
436_A447_L0.9650.87
85_E95_C0.9630.87
285_Q382_Q0.9610.87
87_S93_P0.9510.86
369_R374_V0.9500.86
363_L380_L0.9500.86
185_R188_D0.9480.86
218_A222_E0.9480.86
146_G257_P0.9420.85
80_S84_Q0.9420.85
444_I447_L0.9420.85
192_A251_N0.9410.85
82_F87_S0.9320.85
229_A265_G0.9320.85
117_V176_I0.9300.85
153_M220_N0.9220.84
275_N279_Q0.9220.84
86_G97_G0.9210.84
446_E449_K0.9200.84
169_N173_L0.9170.84
235_N238_G0.9170.84
319_V329_G0.9150.84
298_L311_Q0.9130.84
436_A460_L0.9110.83
289_G380_L0.9030.83
130_N207_I0.9010.83
90_Q99_Q0.9000.83
84_Q87_S0.8990.83
143_L149_F0.8960.82
178_M273_V0.8960.82
347_F350_L0.8950.82
445_A448_R0.8920.82
81_P93_P0.8920.82
216_L220_N0.8910.82
256_A259_G0.8890.82
96_Q100_G0.8830.82
99_Q102_N0.8820.81
129_N132_V0.8800.81
130_N134_D0.8770.81
95_C102_N0.8750.81
401_E404_N0.8720.81
169_N172_N0.8680.80
240_L267_A0.8660.80
306_M335_V0.8660.80
85_E96_Q0.8650.80
117_V250_I0.8630.80
340_N361_S0.8630.80
224_F254_I0.8620.80
439_Q450_V0.8600.80
145_D149_F0.8600.80
90_Q94_F0.8500.79
339_L363_L0.8470.79
91_S95_C0.8460.79
302_L305_A0.8440.79
160_S288_R0.8410.78
119_I164_L0.8390.78
102_N105_G0.8390.78
282_E285_Q0.8390.78
124_G166_Q0.8370.78
83_C88_P0.8360.78
204_T210_A0.8270.77
197_F254_I0.8260.77
82_F89_F0.8240.77
79_D86_G0.8220.77
374_V377_N0.8190.76
120_D359_V0.8190.76
129_N236_S0.8100.76
221_Y355_G0.8090.76
363_L378_L0.8050.75
101_G106_Q0.8040.75
214_S219_E0.8030.75
88_P93_P0.8010.75
126_V165_I0.7990.75
328_A378_L0.7980.75
103_G106_Q0.7970.74
157_D288_R0.7940.74
411_V441_V0.7940.74
448_R451_L0.7930.74
87_S95_C0.7920.74
99_Q106_Q0.7900.74
90_Q100_G0.7890.74
82_F88_P0.7860.73
218_A272_M0.7820.73
320_L323_S0.7810.73
160_S272_M0.7780.73
254_I259_G0.7780.73
287_K382_Q0.7750.72
195_N252_T0.7750.72
296_T315_F0.7750.72
437_N459_A0.7750.72
79_D85_E0.7740.72
393_I396_G0.7730.72
302_L306_M0.7720.72
84_Q89_F0.7680.72
95_C101_G0.7670.72
153_M156_K0.7670.72
454_K458_L0.7660.71
222_E253_A0.7650.71
445_A449_K0.7650.71
232_N235_N0.7630.71
129_N251_N0.7610.71
447_L451_L0.7600.71
97_G100_G0.7560.70
338_S373_Q0.7560.70
87_S99_Q0.7530.70
193_I272_M0.7510.70
412_V432_V0.7500.70
279_Q282_E0.7450.69
192_A240_L0.7420.69
118_I167_I0.7420.69
90_Q97_G0.7400.69
273_V276_L0.7390.69
130_N158_P0.7340.68
99_Q104_G0.7340.68
295_G344_I0.7330.68
296_T302_L0.7300.68
128_T161_D0.7300.68
455_P458_L0.7270.67
308_V315_F0.7270.67
128_T206_G0.7250.67
402_M405_K0.7220.67
209_S232_N0.7210.67
439_Q453_S0.7200.67
131_H235_N0.7200.67
344_I386_N0.7200.67
449_K452_D0.7190.67
268_I276_L0.7180.67
324_S381_Q0.7180.67
98_G102_N0.7160.66
318_Q332_A0.7150.66
222_E252_T0.7150.66
199_L202_T0.7120.66
79_D84_Q0.7120.66
226_Q266_F0.7120.66
95_C100_G0.7070.65
289_G355_G0.7070.65
195_N266_F0.7050.65
83_C96_Q0.7020.65
87_S96_Q0.7000.65
128_T131_H0.6980.64
100_G107_Q0.6980.64
162_I265_G0.6970.64
118_I174_T0.6970.64
225_I240_L0.6950.64
93_P100_G0.6920.64
217_N222_E0.6910.64
252_T268_I0.6900.63
191_V243_L0.6900.63
87_S185_R0.6890.63
155_G284_G0.6870.63
129_N161_D0.6860.63
419_G422_A0.6860.63
331_K369_R0.6850.63
179_A270_S0.6850.63
147_R171_K0.6840.63
129_N234_G0.6830.63
99_Q105_G0.6820.63
232_N236_S0.6810.62
345_S349_A0.6790.62
95_C103_G0.6780.62
139_I165_I0.6770.62
441_V447_L0.6770.62
454_K459_A0.6750.62
188_D242_N0.6730.62
142_Q146_G0.6720.61
85_E98_G0.6710.61
153_M165_I0.6700.61
228_D232_N0.6690.61
87_S103_G0.6690.61
127_V270_S0.6690.61
312_R343_P0.6690.61
179_A356_T0.6650.61
91_S99_Q0.6640.60
161_D226_Q0.6640.60
219_E306_M0.6640.60
133_V165_I0.6610.60
101_G104_G0.6600.60
131_H234_G0.6590.60
131_H226_Q0.6580.60
91_S104_G0.6580.60
160_S355_G0.6560.60
237_G269_P0.6550.59
93_P97_G0.6550.59
217_N221_Y0.6540.59
448_R452_D0.6530.59
87_S100_G0.6530.59
114_G238_G0.6530.59
354_V378_L0.6520.59
435_G438_Q0.6510.59
372_K375_N0.6500.59
226_Q234_G0.6500.59
202_T252_T0.6490.59
217_N347_F0.6440.58
87_S98_G0.6410.58
90_Q98_G0.6410.58
455_P459_A0.6410.58
327_K379_E0.6380.57
213_R266_F0.6370.57
392_S396_G0.6330.57
312_R345_S0.6310.57
422_A431_D0.6290.56
251_N254_I0.6290.56
223_N229_A0.6280.56
290_E384_S0.6280.56
217_N220_N0.6270.56
120_D175_A0.6270.56
148_K268_I0.6250.56
86_G102_N0.6230.56
308_V368_L0.6230.56
292_G329_G0.6200.55
129_N235_N0.6200.55
409_Q442_K0.6170.55
327_K443_N0.6170.55
388_V391_S0.6170.55
80_S87_S0.6150.55
120_D166_Q0.6140.55
294_M317_S0.6140.55
226_Q236_S0.6110.54
109_K112_A0.6090.54
433_I447_L0.6050.53
293_I328_A0.6040.53
181_S240_L0.6040.53
161_D206_G0.6020.53
131_H269_P0.6020.53
450_V453_S0.6000.53
447_L450_V0.6000.53
415_N429_K0.6000.53
368_L373_Q0.5990.53
344_I365_L0.5980.53
89_F101_G0.5980.53
273_V277_T0.5970.53
211_L225_I0.5970.53
315_F333_G0.5960.52
90_Q104_G0.5950.52
188_D201_E0.5950.52
144_S201_E0.5940.52
148_K257_P0.5940.52
148_K300_S0.5940.52
96_Q103_G0.5920.52
331_K362_K0.5900.52
219_E222_E0.5900.52
168_Q377_N0.5890.52
184_L225_I0.5860.51
401_E405_K0.5850.51
222_E239_A0.5830.51
218_A224_F0.5820.51
411_V444_I0.5810.51
222_E241_V0.5810.51
161_D234_G0.5810.51
82_F98_G0.5800.50
188_D205_S0.5800.50
94_F101_G0.5790.50
411_V417_K0.5790.50
257_P260_G0.5790.50
170_P173_L0.5790.50
93_P102_N0.5780.50
80_S90_Q0.5780.50
435_G440_A0.5780.50
200_G265_G0.5770.50
413_V449_K0.5770.50
90_Q101_G0.5760.50
81_P94_F0.5760.50
454_K457_V0.5740.50
229_A252_T0.5740.50
131_H206_G0.5740.50
326_A329_G0.5730.50
152_K454_K0.5730.50
211_L261_N0.5710.49
441_V451_L0.5700.49
154_V286_V0.5700.49
456_S459_A0.5690.49
157_D160_S0.5680.49
312_R373_Q0.5660.49
164_L191_V0.5660.49
161_D235_N0.5660.49
82_F248_I0.5650.49
307_K312_R0.5650.49
389_D393_I0.5640.49
86_G98_G0.5630.48
279_Q283_Y0.5620.48
201_E214_S0.5620.48
342_K353_Q0.5620.48
165_I306_M0.5610.48
200_G257_P0.5590.48
328_A371_G0.5590.48
199_L264_I0.5580.48
309_D312_R0.5570.48
231_I235_N0.5570.48
198_G268_I0.5540.47
229_A253_A0.5530.47
197_F259_G0.5530.47
121_A175_A0.5520.47
80_S86_G0.5520.47
307_K388_V0.5510.47
139_I340_N0.5510.47
259_G262_I0.5510.47
164_L212_G0.5510.47
258_D264_I0.5500.47
189_Y211_L0.5500.47
85_E100_G0.5500.47
126_V139_I0.5490.47
195_N229_A0.5490.47
347_F352_A0.5470.46
153_M346_S0.5470.46
157_D213_R0.5470.46
161_D237_G0.5460.46
279_Q286_V0.5460.46
244_N372_K0.5450.46
124_G173_L0.5450.46
132_V236_S0.5420.46
254_I264_I0.5400.46
192_A235_N0.5390.46
229_A234_G0.5390.46
126_V306_M0.5370.45
198_G209_S0.5370.45
444_I448_R0.5360.45
296_T317_S0.5360.45
95_C99_Q0.5360.45
129_N226_Q0.5350.45
131_H237_G0.5350.45
208_V449_K0.5340.45
89_F99_Q0.5340.45
88_P99_Q0.5340.45
88_P105_G0.5340.45
288_R355_G0.5330.45
154_V166_Q0.5310.45
222_E247_L0.5300.44
382_Q385_Q0.5300.44
189_Y199_L0.5280.44
146_G179_A0.5260.44
407_K442_K0.5260.44
222_E272_M0.5250.44
116_G126_V0.5250.44
113_L199_L0.5240.44
439_Q446_E0.5230.44
191_V212_G0.5230.44
320_L365_L0.5230.44
87_S105_G0.5220.43
129_N229_A0.5210.43
397_I405_K0.5210.43
189_Y289_G0.5200.43
254_I262_I0.5200.43
295_G314_A0.5200.43
449_K453_S0.5190.43
182_D360_G0.5180.43
230_A277_T0.5170.43
390_S396_G0.5170.43
202_T213_R0.5150.43
226_Q237_G0.5150.43
117_V222_E0.5140.43
301_E450_V0.5130.42
210_A291_L0.5120.42
411_V443_N0.5120.42
371_G376_V0.5110.42
365_L376_V0.5080.42
421_P425_I0.5080.42
117_V162_I0.5080.42
390_S394_F0.5060.42
188_D211_L0.5060.42
453_S456_S0.5050.41
178_M277_T0.5050.41
127_V306_M0.5050.41
152_K331_K0.5040.41
253_A272_M0.5030.41
146_G223_N0.5030.41
85_E101_G0.5030.41
88_P95_C0.5020.41
97_G101_G0.5020.41
318_Q322_N0.5010.41
81_P98_G0.5010.41
341_G364_T0.5010.41
150_D168_Q0.5010.41
152_K171_K0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ky9A 5 0.8397 100 0.346 Contact Map
3pv2A 6 0.7975 100 0.367 Contact Map
4a8cA 5 0.827 100 0.388 Contact Map
4flnA 5 0.8101 100 0.454 Contact Map
3stjA 6 0.6308 100 0.484 Contact Map
1lcyA 3 0.6118 100 0.534 Contact Map
4ic6A 4 0.6582 100 0.54 Contact Map
4ri0A 3 0.6435 100 0.541 Contact Map
3qo6A 5 0.6561 100 0.549 Contact Map
1te0A 6 0.6624 100 0.55 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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