GREMLIN Database
RIMK - Ribosomal protein S6--L-glutamate ligase
UniProt: P0C0U4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10852
Length: 300 (269)
Sequences: 28137 (16732)
Seq/√Len: 1020.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
116_V178_E4.0481.00
231_E235_K3.3661.00
156_T159_A3.2051.00
131_D157_R2.9731.00
127_S161_E2.9231.00
136_A157_R2.7121.00
51_K55_L2.6041.00
122_S125_D2.5111.00
78_R95_A2.4551.00
107_L236_A2.3531.00
107_L258_V2.3421.00
118_G132_M2.3041.00
234_I238_R2.2481.00
101_L119_I2.1601.00
181_K253_N2.0791.00
157_R161_E2.0561.00
104_M177_Q2.0251.00
153_L179_Y2.0091.00
78_R82_M1.9951.00
284_R289_H1.9891.00
105_Q109_R1.9481.00
101_L105_Q1.9231.00
155_E159_A1.8971.00
127_S157_R1.8581.00
102_R105_Q1.8441.00
54_K83_L1.8381.00
161_E165_D1.8071.00
108_A116_V1.8061.00
129_L133_V1.7781.00
252_A255_G1.7391.00
103_S107_L1.7311.00
79_Q83_L1.7181.00
105_Q108_A1.6931.00
52_G56_P1.6711.00
232_I256_P1.6661.00
129_L132_M1.6601.00
96_R102_R1.6591.00
109_R239_T1.6531.00
99_D143_V1.6431.00
280_G284_R1.6281.00
95_A102_R1.6181.00
22_A29_V1.6101.00
61_V85_S1.5991.00
237_A245_A1.5851.00
73_G98_R1.5851.00
277_D280_G1.5781.00
113_D232_I1.5711.00
96_R106_L1.5611.00
228_Q232_I1.5441.00
110_Q239_T1.5421.00
235_K238_R1.5421.00
251_R256_P1.5281.00
46_S49_H1.5191.00
162_S166_A1.4981.00
123_P165_D1.4981.00
139_V153_L1.4831.00
232_I235_K1.4821.00
123_P161_E1.4771.00
127_S131_D1.4701.00
130_I136_A1.4691.00
90_E93_A1.4651.00
235_K239_T1.4641.00
155_E181_K1.4591.00
118_G129_L1.4451.00
152_V166_A1.4441.00
228_Q231_E1.4081.00
123_P127_S1.3961.00
192_V197_V1.3941.00
178_E257_L1.3921.00
112_I258_V1.3911.00
128_D132_M1.3851.00
164_I168_R1.3821.00
186_C202_E1.3821.00
92_V96_R1.3771.00
79_Q82_M1.3511.00
121_H173_H1.3491.00
252_A257_L1.3451.00
106_L239_T1.3431.00
283_I287_E1.3411.00
24_Q280_G1.3371.00
143_V173_H1.3371.00
138_L176_V1.3321.00
47_S50_Y1.3301.00
101_L143_V1.3291.00
108_A114_L1.3291.00
236_A240_M1.3101.00
46_S50_Y1.3081.00
106_L109_R1.3021.00
139_V179_Y1.2931.00
236_A239_T1.2831.00
51_K54_K1.2711.00
25_R284_R1.2701.00
81_E91_S1.2691.00
139_V151_V1.2671.00
168_R172_A1.2651.00
247_V261_V1.2601.00
27_H283_I1.2461.00
25_R280_G1.2421.00
136_A156_T1.2411.00
106_L110_Q1.2341.00
104_M114_L1.2311.00
116_V132_M1.2211.00
250_L259_M1.2091.00
208_G212_S1.2081.00
78_R91_S1.1981.00
281_K284_R1.1841.00
81_E87_P1.1811.00
21_A280_G1.1751.00
188_I251_R1.1691.00
180_I259_M1.1661.00
119_I173_H1.1641.00
121_H125_D1.1631.00
230_R234_I1.1621.00
185_G193_V1.1601.00
81_E90_E1.1591.00
18_L62_I1.1571.00
180_I257_L1.1451.00
105_Q117_T1.1441.00
97_A240_M1.1381.00
53_R58_F1.1321.00
116_V133_V1.1291.00
166_A169_G1.1251.00
80_F87_P1.1161.00
182_E253_N1.1111.00
133_V138_L1.1091.00
61_V80_F1.1041.00
128_D131_D1.1021.00
16_K20_E1.0991.00
92_V95_A1.0911.00
125_D128_D1.0881.00
276_I281_K1.0811.00
138_L154_A1.0791.00
113_D257_L1.0791.00
120_A129_L1.0771.00
167_F174_I1.0751.00
154_A163_V1.0731.00
17_R20_E1.0581.00
165_D169_G1.0531.00
152_V163_V1.0521.00
123_P164_I1.0451.00
124_D127_S1.0451.00
101_L173_H1.0431.00
136_A160_A1.0421.00
237_A240_M1.0251.00
24_Q279_A1.0251.00
130_I138_L1.0151.00
80_F85_S1.0151.00
16_K45_A1.0131.00
21_A24_Q1.0121.00
78_R92_V1.0121.00
229_E256_P1.0121.00
186_C251_R1.0081.00
223_A273_T1.0071.00
97_A261_V1.0041.00
196_E238_R1.0041.00
115_P180_I0.9981.00
178_E252_A0.9961.00
19_R29_V0.9951.00
99_D144_E0.9911.00
227_P231_E0.9891.00
27_H287_E0.9881.00
53_R56_P0.9781.00
166_A170_L0.9781.00
204_R220_A0.9711.00
162_S165_D0.9671.00
271_E274_T0.9651.00
195_D238_R0.9641.00
191_L244_V0.9611.00
152_V167_F0.9601.00
143_V175_L0.9601.00
126_T160_A0.9601.00
130_I157_R0.9511.00
181_K252_A0.9501.00
190_C233_A0.9501.00
232_I236_A0.9401.00
188_I229_E0.9381.00
108_A117_T0.9361.00
117_T177_Q0.9341.00
94_I263_A0.9281.00
244_V264_S0.9281.00
231_E234_I0.9181.00
86_Y287_E0.9141.00
52_G55_L0.9021.00
228_Q255_G0.8961.00
168_R174_I0.8941.00
20_E24_Q0.8941.00
219_A222_V0.8931.00
182_E185_G0.8921.00
233_A249_I0.8891.00
159_A162_S0.8881.00
229_E232_I0.8791.00
228_Q235_K0.8741.00
22_A27_H0.8701.00
124_D128_D0.8701.00
33_D38_Y0.8701.00
199_A230_R0.8671.00
123_P168_R0.8651.00
73_G76_A0.8611.00
23_I45_A0.8591.00
30_E58_F0.8541.00
77_L87_P0.8401.00
185_G191_L0.8331.00
254_R257_L0.8291.00
251_R255_G0.8251.00
75_A78_R0.8191.00
202_E205_A0.8181.00
140_V176_V0.8161.00
158_Q161_E0.8151.00
123_P126_T0.8141.00
83_L86_Y0.8131.00
211_R215_H0.8111.00
31_I42_N0.8081.00
67_T74_T0.8081.00
191_L281_K0.8071.00
54_K58_F0.8061.00
140_V154_A0.8041.00
130_I160_A0.8001.00
99_D173_H0.8001.00
53_R85_S0.7971.00
283_I286_I0.7961.00
76_A80_F0.7951.00
135_G178_E0.7931.00
115_P257_L0.7841.00
225_I251_R0.7821.00
62_I282_M0.7811.00
126_T164_I0.7801.00
215_H218_G0.7801.00
23_I26_G0.7801.00
120_A126_T0.7791.00
101_L175_L0.7781.00
203_R206_K0.7771.00
232_I249_I0.7761.00
284_R287_E0.7761.00
251_R254_R0.7751.00
229_E249_I0.7691.00
19_R45_A0.7691.00
189_R192_V0.7661.00
21_A25_R0.7651.00
19_R23_I0.7581.00
140_V163_V0.7581.00
140_V174_I0.7541.00
28_L48_I0.7501.00
72_Y76_A0.7471.00
218_G221_S0.7461.00
158_Q162_S0.7341.00
180_I252_A0.7341.00
187_D193_V0.7331.00
131_D161_E0.7331.00
213_N216_R0.7311.00
135_G138_L0.7291.00
125_D129_L0.7271.00
249_I256_P0.7251.00
271_E275_G0.7221.00
107_L261_V0.7221.00
23_I29_V0.7221.00
230_R233_A0.7201.00
17_R278_I0.7191.00
99_D102_R0.7181.00
247_V258_V0.7171.00
204_R222_V0.7151.00
193_V196_E0.7151.00
265_P278_I0.7151.00
93_A241_A0.7131.00
188_I200_A0.7121.00
92_V102_R0.7081.00
227_P230_R0.7061.00
130_I133_V0.7051.00
233_A247_V0.6991.00
60_A88_L0.6951.00
35_L38_Y0.6921.00
102_R106_L0.6911.00
45_A49_H0.6901.00
278_I282_M0.6901.00
78_R81_E0.6871.00
197_V234_I0.6871.00
167_F171_N0.6861.00
97_A263_A0.6841.00
133_V178_E0.6841.00
163_V167_F0.6821.00
72_Y77_L0.6801.00
185_G189_R0.6781.00
22_A283_I0.6731.00
77_L81_E0.6711.00
72_Y75_A0.6671.00
220_A223_A0.6641.00
112_I232_I0.6631.00
54_K57_H0.6591.00
61_V64_R0.6561.00
60_A289_H0.6481.00
188_I191_L0.6471.00
189_R193_V0.6461.00
164_I174_I0.6451.00
90_E241_A0.6441.00
19_R31_I0.6431.00
106_L236_A0.6431.00
224_S255_G0.6411.00
41_I45_A0.6411.00
21_A277_D0.6391.00
242_L245_A0.6381.00
64_R67_T0.6381.00
74_T95_A0.6371.00
144_E171_N0.6371.00
179_Y250_L0.6341.00
73_G77_L0.6341.00
244_V265_P0.6321.00
127_S130_I0.6281.00
199_A223_A0.6221.00
38_Y41_I0.6191.00
108_A118_G0.6171.00
199_A203_R0.6171.00
106_L240_M0.6171.00
101_L117_T0.6161.00
216_R219_A0.6161.00
105_Q119_I0.6151.00
60_A63_P0.6131.00
80_F83_L0.6121.00
91_S95_A0.6111.00
36_S42_N0.6111.00
192_V234_I0.6091.00
39_M44_A0.6081.00
237_A242_L0.6081.00
132_M135_G0.6061.00
93_A242_L0.6041.00
167_F170_L0.6021.00
110_Q236_A0.6001.00
87_P91_S0.5981.00
137_P179_Y0.5981.00
33_D43_P0.5951.00
267_L270_I0.5941.00
155_E179_Y0.5851.00
279_A283_I0.5851.00
194_G288_R0.5841.00
144_E173_H0.5841.00
28_L47_S0.5831.00
140_V164_I0.5831.00
225_I228_Q0.5821.00
130_I135_G0.5791.00
109_R240_M0.5781.00
196_E234_I0.5761.00
112_I235_K0.5751.00
204_R207_E0.5741.00
89_N242_L0.5731.00
76_A79_Q0.5721.00
202_E222_V0.5691.00
154_A159_A0.5681.00
210_F213_N0.5671.00
182_E187_D0.5651.00
233_A237_A0.5651.00
236_A258_V0.5651.00
186_C189_R0.5641.00
114_L117_T0.5641.00
152_V162_S0.5601.00
93_A97_A0.5581.00
154_A160_A0.5551.00
104_M117_T0.5541.00
181_K250_L0.5521.00
53_R61_V0.5521.00
202_E226_T0.5521.00
193_V281_K0.5501.00
115_P178_E0.5501.00
228_Q256_P0.5491.00
115_P259_M0.5491.00
190_C249_I0.5481.00
218_G273_T0.5481.00
198_V201_I0.5471.00
113_D255_G0.5461.00
77_L80_F0.5441.00
191_L285_W0.5431.00
160_A164_I0.5431.00
193_V198_V0.5401.00
214_L217_G0.5391.00
237_A247_V0.5391.00
159_A163_V0.5381.00
284_R288_R0.5371.00
152_V170_L0.5371.00
113_D228_Q0.5341.00
188_I230_R0.5321.00
25_R283_I0.5321.00
127_S165_D0.5321.00
215_H219_A0.5311.00
193_V285_W0.5301.00
16_K19_R0.5281.00
107_L110_Q0.5261.00
110_Q240_M0.5251.00
92_V241_A0.5241.00
75_A95_A0.5231.00
187_D192_V0.5231.00
190_C237_A0.5191.00
137_P153_L0.5171.00
233_A236_A0.5171.00
136_A155_E0.5171.00
276_I284_R0.5161.00
212_S215_H0.5141.00
63_P88_L0.5141.00
163_V166_A0.5121.00
104_M175_L0.5101.00
75_A79_Q0.5091.00
129_L176_V0.5081.00
17_R269_G0.5071.00
168_R171_N0.5071.00
207_E212_S0.5061.00
192_V247_V0.5031.00
107_L114_L0.5021.00
89_N93_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4iwxA 3 0.9667 100 0.284 Contact Map
3vpbA 3 0.9233 100 0.313 Contact Map
3vpdA 3 0.9233 100 0.319 Contact Map
1a9xA 3 0.9767 100 0.322 Contact Map
3se7A 4 0.9433 100 0.34 Contact Map
3u9tA 3 0.9533 100 0.342 Contact Map
4qshA 4 0.8 100 0.343 Contact Map
3n6rA 1 0.7767 100 0.344 Contact Map
2qf7A 4 0.8567 100 0.347 Contact Map
3hblA 4 0.98 100 0.348 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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