GREMLIN Database
ISCX - Protein IscX
UniProt: P0C0L9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12311
Length: 66 (63)
Sequences: 405 (195)
Seq/√Len: 24.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_I57_I3.5071.00
34_Q38_D3.0631.00
10_E14_A2.8010.99
4_K44_D2.4430.98
33_H49_S2.2330.97
10_E13_E2.2190.97
33_H37_C2.0910.96
13_E16_Y1.9610.94
16_Y65_A1.8470.92
8_S60_V1.8200.91
32_M36_I1.6070.85
28_R31_D1.6050.85
59_L62_L1.5390.82
3_L41_D1.5290.82
9_R60_V1.4410.78
27_V31_D1.4190.77
31_D35_W1.4050.76
22_L35_W1.3460.73
19_Y22_L1.2820.69
49_S53_I1.2720.69
13_E17_D1.2020.64
37_C49_S1.1870.63
59_L63_D1.1790.63
30_T50_N1.1780.62
24_P27_V1.1100.58
4_K43_D1.0850.56
25_K59_L1.0760.55
11_I36_I1.0750.55
46_P49_S1.0680.55
28_R50_N1.0400.53
9_R52_K1.0400.53
33_H50_N1.0090.51
6_T53_I1.0070.50
26_T52_K0.9860.49
18_A40_E0.9390.46
16_Y24_P0.9010.43
27_V59_L0.9010.43
24_P65_A0.8740.41
11_I50_N0.8720.41
9_R13_E0.8670.41
18_A22_L0.8600.40
8_S59_L0.8500.39
24_P62_L0.8410.39
11_I57_I0.8380.39
30_T34_Q0.8270.38
58_L63_D0.8250.38
19_Y35_W0.8190.37
7_D53_I0.8090.37
16_Y63_D0.8050.36
12_G60_V0.7970.36
58_L62_L0.7560.33
32_M58_L0.7400.32
9_R17_D0.7360.32
47_Q53_I0.7140.30
10_E47_Q0.7100.30
3_L44_D0.7090.30
34_Q49_S0.7050.30
30_T33_H0.6770.28
22_L26_T0.6740.28
3_L26_T0.6700.28
9_R62_L0.6660.28
18_A38_D0.6650.28
19_Y58_L0.6630.27
47_Q65_A0.6610.27
48_A52_K0.6450.26
36_I44_D0.6420.26
27_V35_W0.6310.26
13_E36_I0.6260.25
41_D44_D0.6200.25
25_K40_E0.6130.25
36_I60_V0.6030.24
33_H46_P0.6000.24
6_T38_D0.5840.23
43_D52_K0.5800.23
37_C50_N0.5780.23
16_Y22_L0.5680.22
23_D37_C0.5680.22
28_R63_D0.5670.22
10_E17_D0.5610.22
8_S47_Q0.5590.22
14_A41_D0.5580.22
20_P45_D0.5550.22
35_W62_L0.5500.21
3_L14_A0.5470.21
14_A46_P0.5440.21
31_D40_E0.5360.21
25_K65_A0.5340.21
3_L17_D0.5300.21
21_D48_A0.5260.20
27_V56_A0.5170.20
6_T45_D0.5060.19
14_A47_Q0.5010.19
37_C48_A0.5010.19
56_A64_E0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1uj8A 1 0.9848 100 0.074 Contact Map
2kzvA 1 0.9091 30.4 0.904 Contact Map
2kpmA 1 0.9697 19.2 0.913 Contact Map
3u3lC 1 0.9545 14.1 0.918 Contact Map
1xl3C 1 0.9242 11.2 0.921 Contact Map
1wj6A 1 0.6818 9.6 0.924 Contact Map
3ap1A 2 0.8485 9.3 0.924 Contact Map
2z6vA 1 0.8485 5.7 0.931 Contact Map
4goxA 1 0.8485 5.4 0.932 Contact Map
3gffA 2 0.303 5.3 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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