GREMLIN Database
OSMC - Peroxiredoxin OsmC
UniProt: P0C0L2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10680
Length: 143 (135)
Sequences: 1006 (599)
Seq/√Len: 51.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_D17_R4.8221.00
61_S80_T3.5921.00
111_A115_D3.5351.00
95_I127_V3.1511.00
15_I66_L3.0981.00
113_T116_G2.9091.00
110_D113_T2.7971.00
83_D101_K2.5451.00
76_T105_A2.3821.00
10_H79_D2.2401.00
119_Q123_A2.2341.00
103_E140_Q2.1931.00
52_I131_L2.1401.00
97_K134_E2.0431.00
78_I102_S2.0221.00
118_I137_L1.9511.00
61_S78_I1.9200.99
102_S137_L1.8450.99
67_M117_I1.8290.99
63_A67_M1.8290.99
52_I127_V1.8150.99
94_A129_Q1.7980.99
10_H77_S1.7820.99
67_M120_K1.7650.99
78_I104_V1.7190.99
120_K124_G1.6450.98
101_K138_D1.5800.98
22_V58_A1.5430.97
4_H83_D1.5420.97
73_F109_I1.5380.97
84_V98_I1.4960.97
115_D119_Q1.4820.97
104_V141_L1.4490.96
69_G75_P1.4400.96
114_F141_L1.4190.96
116_G120_K1.4190.96
14_D69_G1.3810.95
122_K137_L1.3720.95
99_A136_T1.3710.95
28_V32_Q1.3560.94
82_A98_I1.2770.92
73_F113_T1.2760.92
77_S105_A1.1970.90
66_L70_E1.1950.90
9_A57_A1.1880.89
67_M124_G1.1850.89
103_E138_D1.1630.88
95_I130_V1.1360.87
6_K81_T1.1350.87
130_V133_A1.1260.87
113_T117_I1.1220.87
63_A124_G1.1150.86
76_T107_P1.0850.85
7_G22_V1.0840.85
9_A34_Y1.0710.84
43_E47_N1.0590.83
28_V44_K1.0390.82
24_T29_L1.0260.81
106_V141_L1.0170.81
109_I117_I1.0160.80
55_A127_V1.0070.80
99_A138_D1.0040.80
114_F139_Y1.0000.79
33_P43_E0.9970.79
40_F47_N0.9910.79
66_L69_G0.9880.79
67_M70_E0.9770.78
79_D103_E0.9660.77
5_K42_G0.9500.76
84_V122_K0.9260.74
119_Q122_K0.9230.74
27_G30_N0.9140.73
64_L106_V0.9050.72
69_G74_T0.8930.71
86_L93_F0.8880.71
104_V114_F0.8790.70
5_K35_G0.8740.70
26_S43_E0.8730.69
36_F86_L0.8690.69
12_E77_S0.8630.69
61_S65_S0.8610.68
5_K26_S0.8530.68
33_P44_K0.8500.67
56_H128_S0.8430.67
81_T101_K0.8320.66
37_N41_E0.8320.66
115_D139_Y0.8260.65
11_W14_D0.8190.64
15_I69_G0.8150.64
109_I113_T0.8050.63
117_I120_K0.8040.63
85_S99_A0.7990.63
87_D96_T0.7940.62
87_D92_G0.7940.62
85_S96_T0.7870.61
21_T31_Q0.7830.61
111_A119_Q0.7820.61
127_V130_V0.7780.60
5_K53_G0.7740.60
38_T43_E0.7710.60
52_I130_V0.7710.60
12_E76_T0.7670.59
93_F129_Q0.7590.59
70_E120_K0.7480.57
26_S38_T0.7430.57
8_Q81_T0.7370.56
87_D93_F0.7360.56
80_T100_L0.7350.56
71_A113_T0.7340.56
63_A93_F0.7340.56
22_V32_Q0.7300.56
6_K25_E0.7260.55
83_D99_A0.7190.54
36_F40_F0.7180.54
34_Y58_A0.6970.52
35_G38_T0.6930.52
36_F93_F0.6920.52
63_A70_E0.6910.52
16_K41_E0.6880.51
41_E45_G0.6850.51
28_V33_P0.6820.51
40_F45_G0.6820.51
91_A94_A0.6800.50
11_W76_T0.6800.50
84_V133_A0.6690.49
77_S107_P0.6650.49
104_V115_D0.6640.49
63_A120_K0.6640.49
12_E79_D0.6580.48
130_V134_E0.6570.48
22_V34_Y0.6530.48
64_L102_S0.6480.47
101_K140_Q0.6470.47
102_S117_I0.6460.47
4_H97_K0.6450.47
32_Q58_A0.6430.47
21_T79_D0.6360.46
60_F121_A0.6320.45
84_V132_K0.6320.45
32_Q43_E0.6300.45
12_E19_K0.6280.45
69_G78_I0.6280.45
52_I57_A0.6270.45
63_A66_L0.6250.45
16_K37_N0.6170.44
34_Y40_F0.6160.44
106_V114_F0.6160.44
29_L32_Q0.6130.44
65_S69_G0.6120.43
98_I104_V0.6100.43
112_S115_D0.6080.43
52_I98_I0.6050.43
78_I137_L0.6050.43
81_T103_E0.6030.42
42_G138_D0.6030.42
5_K25_E0.6030.42
116_G123_A0.6010.42
5_K47_N0.6000.42
24_T32_Q0.6000.42
75_P107_P0.5960.42
6_K83_D0.5880.41
11_W15_I0.5820.40
8_Q79_D0.5810.40
106_V109_I0.5800.40
46_T58_A0.5800.40
9_A40_F0.5800.40
118_I122_K0.5770.40
16_K66_L0.5720.39
101_K139_Y0.5690.39
60_F102_S0.5680.39
53_G82_A0.5680.39
31_Q140_Q0.5640.39
99_A137_L0.5630.38
27_G44_K0.5600.38
11_W75_P0.5580.38
112_S116_G0.5570.38
19_K38_T0.5570.38
73_F117_I0.5490.37
16_K34_Y0.5470.37
34_Y47_N0.5440.37
98_I133_A0.5440.37
8_Q23_S0.5400.36
24_T40_F0.5400.36
35_G44_K0.5390.36
76_T108_G0.5370.36
68_L107_P0.5290.35
33_P92_G0.5270.35
104_V121_A0.5260.35
14_D64_L0.5230.35
57_A80_T0.5210.34
71_A117_I0.5200.34
98_I122_K0.5150.34
24_T30_N0.5150.34
107_P141_L0.5140.34
19_K37_N0.5130.34
104_V118_I0.5120.34
127_V131_L0.5090.33
41_E44_K0.5090.33
86_L129_Q0.5070.33
29_L34_Y0.5020.33
64_L115_D0.5020.33
5_K32_Q0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nyeA 5 1 100 0.492 Contact Map
1qwiA 2 0.993 100 0.516 Contact Map
1ukkA 2 0.965 100 0.536 Contact Map
4mh4A 2 0.9371 99.9 0.582 Contact Map
4nozA 2 0.9441 99.9 0.589 Contact Map
1uspA 2 0.9441 99.9 0.59 Contact Map
1n2fA 2 0.951 99.9 0.593 Contact Map
1zb9A 2 0.951 99.9 0.595 Contact Map
2onfA 2 0.958 99.9 0.609 Contact Map
3eerA 2 0.9441 99.9 0.613 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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