GREMLIN Database
RDOA - Protein RdoA
UniProt: P0C0K3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11831
Length: 328 (274)
Sequences: 7242 (5536)
Seq/√Len: 334.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_Q51_R3.6351.00
86_A107_P3.5991.00
126_G251_A3.1621.00
45_Q51_R3.1551.00
123_E251_A3.0811.00
88_V107_P3.0401.00
43_Q108_S2.9791.00
109_V214_M2.9091.00
124_A127_R2.7831.00
127_R251_A2.7171.00
131_R255_F2.6731.00
127_R254_E2.6631.00
53_V108_S2.5601.00
184_A188_H2.5331.00
32_T43_Q2.3681.00
129_L202_C2.3451.00
130_G255_F2.3231.00
54_V105_V2.3101.00
30_G45_Q2.2921.00
78_V86_A2.2621.00
51_R108_S2.2571.00
198_L224_G2.2511.00
196_L226_A2.2201.00
127_R255_F2.1851.00
74_A87_P2.1681.00
233_L248_I2.1151.00
123_E250_E2.0861.00
134_Q256_S2.0181.00
208_L216_V1.9741.00
51_R110_G1.9631.00
177_A180_E1.9481.00
170_L173_A1.8921.00
46_D52_F1.8681.00
154_I158_K1.8661.00
128_Y215_F1.8551.00
123_E254_E1.8511.00
125_V207_I1.8501.00
133_H252_Y1.8291.00
75_L89_A1.7841.00
76_Q139_Q1.7751.00
126_G248_I1.7701.00
80_D138_K1.7671.00
183_A187_A1.7501.00
44_F105_V1.7431.00
202_C215_F1.7301.00
246_E250_E1.7241.00
113_Q208_L1.7151.00
167_P170_L1.6981.00
17_M21_F1.6731.00
71_H87_P1.6661.00
124_A212_G1.6501.00
127_R131_R1.6281.00
81_E131_R1.6071.00
251_A254_E1.6041.00
253_E263_I1.6021.00
130_G256_S1.5931.00
52_F88_V1.5761.00
32_T45_Q1.5601.00
134_Q255_F1.5511.00
119_I247_T1.5331.00
46_D50_R1.5201.00
68_L72_Q1.5191.00
259_D262_E1.5031.00
73_F221_A1.4781.00
123_E126_G1.4771.00
56_F101_F1.4721.00
20_L105_V1.4261.00
244_Q247_T1.4121.00
250_E254_E1.4111.00
164_T168_S1.4091.00
136_G139_Q1.4061.00
34_L53_V1.3901.00
231_W270_R1.3741.00
230_L249_I1.3601.00
179_D183_A1.3561.00
31_L44_F1.3491.00
74_A218_L1.3351.00
110_G210_R1.3261.00
123_E127_R1.3261.00
19_A89_A1.3211.00
283_R287_D1.3131.00
171_K175_L1.3071.00
50_R107_P1.3041.00
109_V213_P1.3011.00
247_T251_A1.2991.00
147_I151_E1.2961.00
38_E219_D1.2931.00
132_M215_F1.2881.00
13_P17_M1.2781.00
230_L248_I1.2471.00
148_G151_E1.2461.00
64_A102_Y1.2411.00
128_Y131_R1.2201.00
156_P160_F1.1971.00
12_H15_T1.1901.00
170_L174_F1.1871.00
124_A128_Y1.1791.00
71_H94_T1.1781.00
14_D17_M1.1741.00
78_V87_P1.1701.00
138_K144_R1.1681.00
74_A85_A1.1491.00
125_V233_L1.1441.00
120_D123_E1.1391.00
76_Q138_K1.1311.00
15_T18_D1.1161.00
39_N55_K1.1121.00
56_F103_F1.1121.00
54_V103_F1.1071.00
234_L245_L1.1031.00
281_L284_R1.1021.00
55_K70_E1.0991.00
75_L79_N1.0941.00
154_I186_T1.0901.00
277_Y280_W1.0861.00
210_R213_P1.0791.00
41_V53_V1.0681.00
123_E247_T1.0671.00
251_A255_F1.0671.00
135_T140_L1.0611.00
89_A94_T1.0591.00
194_T262_E1.0561.00
194_T226_A1.0431.00
175_L179_D1.0431.00
75_L87_P1.0401.00
129_L133_H1.0371.00
109_V208_L1.0361.00
67_I70_E1.0311.00
182_I186_T1.0291.00
82_V132_M1.0261.00
281_L285_W1.0221.00
277_Y281_L1.0181.00
181_L184_A1.0161.00
164_T167_P1.0141.00
29_S47_E1.0101.00
90_F93_Q1.0041.00
201_D206_N1.0001.00
133_H229_D0.9961.00
43_Q53_V0.9931.00
122_M243_M0.9811.00
72_Q75_L0.9791.00
46_D49_R0.9771.00
250_E253_E0.9771.00
247_T250_E0.9741.00
208_L213_P0.9721.00
71_H104_A0.9721.00
137_R256_S0.9711.00
166_I171_K0.9701.00
18_D22_E0.9701.00
194_T258_F0.9701.00
178_T182_I0.9611.00
249_I253_E0.9541.00
253_E257_E0.9471.00
180_E183_A0.9441.00
194_T256_S0.9441.00
128_Y212_G0.9421.00
166_I170_L0.9271.00
76_Q135_T0.9221.00
245_L267_E0.9221.00
125_V202_C0.9171.00
279_A282_M0.9161.00
176_K180_E0.9131.00
13_P31_L0.9021.00
40_R56_F0.9011.00
85_A214_M0.8981.00
29_S44_F0.8971.00
126_G130_G0.8961.00
276_Y280_W0.8951.00
121_Q209_W0.8891.00
184_A268_P0.8881.00
280_W284_R0.8871.00
118_N121_Q0.8851.00
249_I263_I0.8841.00
145_P148_G0.8801.00
276_Y279_A0.8801.00
68_L90_F0.8791.00
82_V128_Y0.8781.00
195_V223_N0.8731.00
64_A68_L0.8731.00
146_T151_E0.8721.00
181_L185_V0.8691.00
157_R161_E0.8561.00
72_Q139_Q0.8561.00
73_F136_G0.8541.00
25_I28_D0.8501.00
115_E205_G0.8481.00
166_I174_F0.8481.00
201_D217_D0.8471.00
166_I169_G0.8471.00
71_H75_L0.8461.00
282_M286_A0.8451.00
278_L281_L0.8451.00
39_N219_D0.8441.00
243_M247_T0.8421.00
241_Q244_Q0.8391.00
33_P40_R0.8381.00
63_T66_Q0.8361.00
278_L282_M0.8351.00
206_N217_D0.8341.00
192_D261_A0.8341.00
150_N155_E0.8331.00
52_F105_V0.8301.00
137_R197_R0.8231.00
152_Y156_P0.8191.00
110_G211_D0.8191.00
200_G222_R0.8181.00
47_E50_R0.8171.00
18_D21_F0.8161.00
87_P107_P0.8151.00
122_M126_G0.8141.00
128_Y202_C0.8031.00
226_A256_S0.8001.00
186_T189_W0.7951.00
153_L156_P0.7911.00
281_L289_A0.7901.00
209_W213_P0.7891.00
36_S40_R0.7881.00
171_K174_F0.7811.00
146_T149_L0.7801.00
122_M244_Q0.7781.00
150_N154_I0.7761.00
75_L86_A0.7751.00
203_H235_N0.7751.00
130_G134_Q0.7721.00
196_L256_S0.7711.00
169_G174_F0.7701.00
172_A176_K0.7691.00
21_F26_R0.7571.00
184_A187_A0.7561.00
87_P90_F0.7551.00
169_G172_A0.7541.00
154_I157_R0.7490.99
269_L273_R0.7460.99
80_D135_T0.7440.99
41_V203_H0.7440.99
25_I105_V0.7420.99
157_R179_D0.7410.99
172_A175_L0.7360.99
199_H202_C0.7310.99
232_M235_N0.7300.99
129_L200_G0.7230.99
121_Q124_A0.7230.99
39_N70_E0.7220.99
176_K179_D0.7190.99
165_L169_G0.7190.99
28_D46_D0.7190.99
76_Q79_N0.7170.99
126_G233_L0.7160.99
259_D263_I0.7090.99
161_E164_T0.7090.99
40_R101_F0.7020.99
73_F197_R0.7020.99
129_L229_D0.7000.99
137_R140_L0.6990.99
14_D18_D0.6980.99
111_G211_D0.6980.99
37_Y41_V0.6940.99
131_R134_Q0.6900.99
135_T139_Q0.6870.99
147_I152_Y0.6850.99
65_D68_L0.6850.99
70_E74_A0.6840.99
149_L153_L0.6820.99
151_E155_E0.6800.99
240_E243_M0.6790.99
183_A186_T0.6790.99
206_N219_D0.6750.99
222_R228_Q0.6700.99
200_G228_Q0.6680.99
261_A264_G0.6670.99
126_G255_F0.6670.99
144_R148_G0.6650.99
146_T150_N0.6620.99
75_L94_T0.6620.99
161_E182_I0.6610.99
132_M218_L0.6610.99
173_A176_K0.6610.99
155_E159_L0.6560.99
146_T221_A0.6540.99
203_H220_D0.6530.99
114_F207_I0.6510.99
153_L182_I0.6490.99
167_P172_A0.6470.99
143_H146_T0.6460.99
182_I272_M0.6450.98
17_M28_D0.6440.98
120_D124_A0.6430.98
15_T99_Q0.6420.98
180_E184_A0.6390.98
258_F263_I0.6380.98
38_E41_V0.6370.98
260_T264_G0.6370.98
34_L43_Q0.6340.98
70_E224_G0.6340.98
71_H90_F0.6320.98
75_L78_V0.6320.98
92_G95_L0.6250.98
57_Y70_E0.6240.98
279_A283_R0.6210.98
112_R210_R0.6200.98
119_I123_E0.6180.98
82_V135_T0.6150.98
55_K219_D0.6150.98
21_F27_V0.6150.98
70_E219_D0.6150.98
63_T70_E0.6140.98
279_A284_R0.6140.98
136_G140_L0.6140.98
20_L23_H0.6130.98
145_P150_N0.6120.98
133_H198_L0.6120.98
157_R160_F0.6100.98
26_R46_D0.6090.98
72_Q142_I0.6090.98
245_L249_I0.6080.98
287_D290_F0.6080.98
145_P149_L0.6060.98
24_G47_E0.6030.98
165_L168_S0.6010.98
112_R208_L0.6010.98
168_S172_A0.5980.98
258_F262_E0.5960.97
57_Y104_A0.5920.97
57_Y67_I0.5900.97
68_L93_Q0.5900.97
130_G251_A0.5890.97
148_G156_P0.5880.97
148_G152_Y0.5870.97
144_R147_I0.5860.97
37_Y215_F0.5850.97
38_E58_R0.5850.97
207_I212_G0.5830.97
145_P151_E0.5820.97
90_F102_Y0.5810.97
83_P128_Y0.5810.97
209_W212_G0.5790.97
41_V280_W0.5750.97
167_P171_K0.5740.97
58_R101_F0.5740.97
267_E271_A0.5730.97
20_L44_F0.5720.97
231_W269_L0.5710.97
185_V188_H0.5700.97
23_H90_F0.5690.97
92_G99_Q0.5690.97
12_H18_D0.5690.97
285_W289_A0.5680.97
207_I216_V0.5660.97
248_I252_Y0.5660.97
212_G215_F0.5640.97
85_A106_F0.5640.97
139_Q142_I0.5630.96
274_L277_Y0.5610.96
265_L269_L0.5610.96
76_Q80_D0.5610.96
197_R223_N0.5600.96
16_I19_A0.5590.96
152_Y157_R0.5560.96
227_V258_F0.5540.96
168_S171_K0.5520.96
133_H136_G0.5510.96
72_Q145_P0.5500.96
85_A107_P0.5490.96
234_L267_E0.5440.96
134_Q137_R0.5440.96
186_T190_R0.5440.96
146_T155_E0.5420.96
55_K203_H0.5420.96
226_A262_E0.5400.96
277_Y284_R0.5400.96
85_A109_V0.5380.95
193_F225_P0.5380.95
231_W267_E0.5370.95
74_A106_F0.5350.95
234_L263_I0.5350.95
44_F54_V0.5340.95
19_A103_F0.5340.95
252_Y256_S0.5340.95
41_V220_D0.5330.95
25_I46_D0.5330.95
156_P159_L0.5290.95
265_L268_P0.5270.95
69_E142_I0.5250.95
58_R220_D0.5240.95
39_N57_Y0.5230.95
29_S45_Q0.5210.95
15_T19_A0.5180.94
38_E220_D0.5180.94
195_V225_P0.5180.94
161_E175_L0.5170.94
27_V47_E0.5170.94
169_G173_A0.5140.94
220_D273_R0.5130.94
137_R194_T0.5120.94
23_H26_R0.5110.94
200_G224_G0.5100.94
26_R47_E0.5100.94
220_D232_M0.5100.94
146_T152_Y0.5090.94
23_H28_D0.5080.94
125_V248_I0.5080.94
41_V67_I0.5070.94
55_K231_W0.5060.94
83_P212_G0.5060.94
235_N270_R0.5040.94
82_V131_R0.5040.94
276_Y281_L0.5030.94
188_H268_P0.5020.93
150_N153_L0.5010.93
165_L174_F0.5010.93
39_N53_V0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zylA 1 0.9909 100 0.314 Contact Map
2ppqA 2 0.9085 100 0.425 Contact Map
4pdyA 1 0.9177 100 0.438 Contact Map
2q83A 1 0.8963 100 0.448 Contact Map
4ocvA 1 0.936 100 0.463 Contact Map
3dxpA 2 0.8963 100 0.518 Contact Map
3i1aA 1 0.9146 100 0.522 Contact Map
3csvA 2 0.8811 100 0.543 Contact Map
3atsA 1 0.9024 100 0.548 Contact Map
1nw1A 2 0.9207 100 0.556 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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