GREMLIN Database
RELE - mRNA interferase RelE
UniProt: P0C077 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11131
Length: 95 (93)
Sequences: 349 (231)
Seq/√Len: 24.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_R49_D4.0101.00
47_M50_C3.6721.00
12_L16_R3.4051.00
5_L34_L3.0001.00
29_K32_E2.9921.00
34_L73_V2.9411.00
33_V39_I2.9291.00
6_D70_K2.8050.99
27_K31_V2.7300.99
33_V42_N2.6900.99
76_I86_V2.3680.98
5_L73_V2.0400.95
63_V90_A1.9560.94
10_R74_F1.7970.90
77_S90_A1.7720.90
50_C65_Q1.7470.89
15_W27_K1.6670.86
13_K21_T1.6580.86
39_I42_N1.5730.83
47_M90_A1.4400.77
49_D65_Q1.4380.77
23_R78_V1.3750.74
6_D72_V1.3360.71
17_K36_S1.3220.71
16_R28_K1.3160.70
7_F11_A1.2970.69
88_S91_V1.2730.68
20_S23_R1.2700.67
67_I72_V1.2360.65
7_F15_W1.2230.64
32_E49_D1.2150.64
73_V85_E1.1180.57
15_W28_K1.1130.57
10_R71_V1.0510.53
11_A75_V1.0400.52
47_M65_Q1.0340.51
8_D74_F1.0070.50
16_R26_L0.9880.48
76_I91_V0.9730.47
23_R41_A0.9620.46
50_C90_A0.9420.45
10_R76_I0.9310.44
9_E89_E0.9270.44
43_K65_Q0.9270.44
14_E93_R0.9070.42
13_K26_L0.8990.42
88_S92_K0.8940.42
57_S83_R0.8870.41
38_R63_V0.8860.41
25_Q29_K0.8850.41
43_K48_P0.8700.40
21_T25_Q0.8680.40
3_Y38_R0.8630.39
13_K25_Q0.8340.37
9_E45_R0.8300.37
69_E72_V0.8300.37
37_P81_R0.8090.36
22_V85_E0.8040.36
20_S36_S0.7980.35
58_S88_S0.7910.35
2_A71_V0.7880.34
11_A15_W0.7860.34
63_V86_V0.7810.34
57_S85_E0.7770.34
22_V69_E0.7760.34
16_R23_R0.7710.33
33_V74_F0.7670.33
36_S41_A0.7630.33
13_K55_L0.7620.33
9_E76_I0.7570.33
25_Q78_V0.7570.33
50_C76_I0.7490.32
31_V71_V0.7380.31
67_I74_F0.7360.31
82_E85_E0.7290.31
10_R65_Q0.7230.30
25_Q58_S0.7160.30
4_F16_R0.7080.30
35_E69_E0.7070.29
31_V70_K0.7070.29
81_R87_Y0.6870.28
26_L73_V0.6840.28
3_Y40_E0.6820.28
24_E31_V0.6810.28
59_G64_Y0.6780.28
9_E50_C0.6780.28
70_K74_F0.6760.28
5_L60_Y0.6700.27
25_Q55_L0.6600.27
26_L58_S0.6590.27
80_K93_R0.6440.26
40_E50_C0.6410.26
38_R51_Y0.6400.26
23_R32_E0.6360.25
87_Y93_R0.6210.25
4_F22_V0.6150.24
20_S24_E0.6110.24
8_D33_V0.6100.24
63_V77_S0.6060.24
5_L33_V0.6060.24
56_R82_E0.6030.24
50_C77_S0.6020.24
21_T32_E0.5900.23
75_V82_E0.5870.23
38_R67_I0.5860.23
9_E53_I0.5820.23
19_G22_V0.5810.23
34_L75_V0.5790.23
2_A21_T0.5770.22
44_L50_C0.5770.22
69_E78_V0.5720.22
58_S65_Q0.5600.22
4_F86_V0.5600.22
7_F75_V0.5590.22
45_R69_E0.5580.22
61_R75_V0.5560.21
90_A93_R0.5540.21
58_S92_K0.5520.21
68_D92_K0.5490.21
85_E92_K0.5460.21
51_Y89_E0.5430.21
3_Y60_Y0.5400.21
24_E28_K0.5370.21
44_L58_S0.5360.20
10_R78_V0.5320.20
36_S70_K0.5300.20
10_R67_I0.5270.20
47_M57_S0.5270.20
29_K79_G0.5260.20
23_R38_R0.5230.20
23_R27_K0.5220.20
67_I70_K0.5180.20
43_K47_M0.5170.20
6_D40_E0.5160.20
31_V86_V0.5130.19
77_S83_R0.5080.19
26_L79_G0.5050.19
2_A82_E0.5030.19
53_I64_Y0.5020.19
84_S91_V0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fxiA 2 0.9895 99.5 0.655 Contact Map
3g5oB 1 0.8316 99.4 0.683 Contact Map
2kheA 1 0.8842 99.3 0.693 Contact Map
1wmiA 2 0.8632 99.2 0.715 Contact Map
4lttA 1 0.8842 99.2 0.715 Contact Map
4nrnA 2 0.8737 99.2 0.719 Contact Map
4ml2A 1 0.8526 99.1 0.725 Contact Map
3oeiC 2 0.8211 99.1 0.729 Contact Map
3bpqB 1 0.8421 98.8 0.756 Contact Map
2a6sA 1 0.8105 98.5 0.78 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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