GREMLIN Database
MLTC - Membrane-bound lytic murein transglycosylase C
UniProt: P0C066 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12986
Length: 359 (299)
Sequences: 1225 (908)
Seq/√Len: 52.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
229_D237_V5.4221.00
236_V269_T4.5491.00
209_L296_I4.1351.00
275_A279_N3.4621.00
117_D121_D3.4101.00
113_P116_V3.2731.00
196_V214_M3.1651.00
210_I271_T3.1311.00
79_N82_D2.9761.00
135_G138_V2.9431.00
129_K135_G2.9111.00
129_K138_V2.8791.00
228_S237_V2.7831.00
130_E135_G2.7611.00
128_S131_P2.7231.00
216_T352_A2.7011.00
337_H346_L2.6041.00
305_S339_S2.5931.00
297_T346_L2.5551.00
134_Y138_V2.5451.00
130_E138_V2.5221.00
231_L261_F2.4901.00
318_A331_Q2.4631.00
216_T348_K2.4351.00
71_Q83_G2.3961.00
131_P135_G2.2701.00
197_R207_E2.2191.00
133_L138_V2.2051.00
130_E134_Y2.1861.00
280_V307_L2.1501.00
195_M264_A2.1161.00
248_S276_M2.0781.00
338_P342_S2.0491.00
127_I130_E2.0161.00
131_P136_Q1.9481.00
128_S135_G1.9411.00
225_V261_F1.9371.00
305_S308_R1.9090.99
112_D117_D1.8950.99
301_G309_V1.8850.99
128_S132_F1.8810.99
130_E133_L1.8800.99
129_K133_L1.8670.99
245_V269_T1.8640.99
309_V337_H1.8590.99
129_K134_Y1.8170.99
128_S138_V1.7640.99
233_L266_N1.7450.99
127_I131_P1.7110.99
147_W150_R1.6800.99
160_K164_K1.6780.99
294_A310_F1.6720.99
301_G337_H1.6710.99
131_P134_Y1.6440.98
162_R165_S1.6160.98
132_F135_G1.6120.98
236_V241_A1.5980.98
244_D276_M1.5850.98
228_S231_L1.5550.98
281_Y307_L1.5450.98
113_P121_D1.5290.97
196_V200_S1.5260.97
259_F265_S1.4740.97
236_V260_L1.4630.97
88_E104_I1.4540.96
129_K139_D1.4500.96
131_P139_D1.4310.96
133_L137_V1.4180.96
114_S118_L1.4180.96
132_F138_V1.4070.96
296_I349_V1.4000.96
127_I134_Y1.3970.96
273_Y303_A1.3950.95
131_P138_V1.3880.95
161_N164_K1.3820.95
113_P117_D1.3750.95
162_R166_R1.3740.95
155_A164_K1.3510.95
133_L139_D1.3490.95
298_A306_V1.3480.95
127_I135_G1.3400.94
256_S259_F1.3380.94
132_F137_V1.3310.94
344_R348_K1.3280.94
104_I108_L1.3070.94
129_K136_Q1.3020.93
133_L136_Q1.3010.93
225_V231_L1.2990.93
115_S118_L1.2690.93
109_M117_D1.2560.92
108_L116_V1.2530.92
224_A231_L1.2500.92
154_F158_L1.2450.92
130_E137_V1.2310.91
230_A235_Q1.2260.91
229_D295_V1.2180.91
240_T273_Y1.2170.91
292_R353_Q1.2140.91
295_V303_A1.2060.91
131_P137_V1.2050.90
192_Y196_V1.1990.90
134_Y137_V1.1960.90
192_Y222_P1.1910.90
216_T344_R1.1780.89
214_M267_I1.1580.89
72_Y100_R1.1570.89
316_Q331_Q1.1420.88
123_D130_E1.1320.88
132_F136_Q1.1210.87
135_G139_D1.1140.87
136_Q139_D1.1130.87
84_T104_I1.1130.87
301_G342_S1.1120.87
198_Q264_A1.1030.86
215_Q309_V1.0990.86
234_M270_G1.0850.85
210_I220_F1.0770.85
317_A333_L1.0640.84
111_D115_S1.0610.84
216_T356_Y1.0600.84
92_G95_P1.0590.84
317_A331_Q1.0580.84
108_L111_D1.0560.84
129_K132_F1.0370.82
146_R149_G1.0300.82
234_M267_I1.0260.82
199_A202_K1.0240.82
161_N166_R1.0220.82
134_Y139_D1.0210.81
210_I234_M1.0160.81
47_N50_N1.0150.81
104_I107_L1.0120.81
236_V270_G1.0110.81
313_D317_A1.0080.81
299_Y345_Y1.0060.80
154_F157_Y1.0010.80
262_D265_S0.9930.80
333_L355_S0.9920.80
215_Q355_S0.9910.79
228_S301_G0.9900.79
196_V211_L0.9820.79
229_D303_A0.9770.78
141_T144_P0.9760.78
71_Q90_I0.9750.78
234_M238_Q0.9680.78
189_A215_Q0.9670.78
208_S353_Q0.9670.78
175_S180_M0.9620.77
116_V119_Y0.9610.77
117_D120_S0.9610.77
229_D301_G0.9590.77
130_E139_D0.9590.77
245_V276_M0.9530.77
278_N295_V0.9500.77
50_N53_G0.9480.76
212_A349_V0.9470.76
333_L348_K0.9460.76
74_T212_A0.9420.76
249_Q269_T0.9390.76
112_D115_S0.9360.75
161_N165_S0.9340.75
214_M233_L0.9330.75
132_F139_D0.9300.75
215_Q335_T0.9230.74
152_S161_N0.9220.74
127_I138_V0.9200.74
276_M280_V0.9190.74
202_K268_D0.9140.74
225_V228_S0.8970.72
168_N171_R0.8950.72
236_V273_Y0.8920.72
130_E136_Q0.8890.72
84_T111_D0.8850.71
200_S207_E0.8830.71
217_E300_N0.8770.71
199_A203_Y0.8760.70
38_D42_G0.8660.70
229_D240_T0.8610.69
249_Q268_D0.8500.68
216_T219_S0.8490.68
217_E230_A0.8450.68
56_E60_A0.8450.68
193_L197_R0.8420.67
87_I90_I0.8380.67
229_D239_H0.8340.67
212_A353_Q0.8310.66
38_D41_M0.8310.66
173_I177_T0.8310.66
41_M45_A0.8300.66
306_V310_F0.8300.66
337_H342_S0.8300.66
56_E61_G0.8270.66
251_K269_T0.8270.66
201_R243_K0.8250.66
306_V338_P0.8230.66
200_S271_T0.8220.66
141_T145_I0.8200.65
265_S268_D0.8160.65
296_I305_S0.8150.65
194_G198_Q0.8140.65
128_S136_Q0.8130.65
304_G307_L0.8090.64
123_D127_I0.8080.64
85_I236_V0.8080.64
301_G339_S0.8070.64
42_G49_E0.8060.64
175_S186_D0.8060.64
281_Y298_A0.7980.63
193_L211_L0.7960.63
109_M112_D0.7950.63
266_N338_P0.7940.63
145_I149_G0.7880.62
352_A356_Y0.7870.62
118_L121_D0.7850.62
83_G107_L0.7820.62
272_A276_M0.7810.62
64_D94_E0.7790.61
39_I42_G0.7790.61
109_M121_D0.7770.61
215_Q356_Y0.7760.61
190_H211_L0.7760.61
275_A351_T0.7740.61
87_I91_A0.7710.61
152_S156_D0.7680.60
143_Q146_R0.7670.60
260_L266_N0.7650.60
277_L298_A0.7650.60
157_Y161_N0.7640.60
251_K298_A0.7620.60
188_R215_Q0.7610.60
160_K163_L0.7610.60
41_M44_F0.7560.59
106_T110_G0.7540.59
229_D297_T0.7530.59
80_F107_L0.7500.58
112_D121_D0.7490.58
251_K268_D0.7480.58
128_S137_V0.7480.58
91_A94_E0.7450.58
236_V266_N0.7430.58
227_R304_G0.7430.58
314_K317_A0.7420.58
313_D333_L0.7380.57
109_M137_V0.7340.57
281_Y303_A0.7280.56
116_V121_D0.7260.56
172_I175_S0.7250.56
209_L241_A0.7240.56
299_Y302_G0.7230.56
214_M312_N0.7230.56
102_A106_T0.7220.56
217_E232_G0.7210.55
302_G345_Y0.7170.55
297_T342_S0.7140.55
218_S232_G0.7140.55
68_Y72_Y0.7130.55
37_F45_A0.7120.55
74_T187_K0.7120.55
209_L353_Q0.7120.55
118_L194_G0.7110.54
240_T301_G0.7080.54
244_D248_S0.7080.54
72_Y75_R0.7080.54
110_G304_G0.7080.54
48_I51_I0.7010.53
71_Q75_R0.6990.53
194_G271_T0.6980.53
191_K211_L0.6970.53
213_I274_L0.6900.52
61_G65_Y0.6900.52
133_L140_N0.6890.52
339_S342_S0.6890.52
200_S203_Y0.6860.52
245_V272_A0.6860.52
188_R191_K0.6860.52
185_L190_H0.6820.51
203_Y210_I0.6790.51
111_D114_S0.6790.51
166_R262_D0.6790.51
309_V339_S0.6770.51
331_Q334_T0.6760.51
215_Q301_G0.6740.51
157_Y163_L0.6710.50
237_V304_G0.6700.50
92_G113_P0.6700.50
237_V339_S0.6680.50
56_E64_D0.6640.49
245_V254_T0.6590.49
227_R231_L0.6570.49
222_P255_P0.6560.49
333_L337_H0.6550.49
332_T336_R0.6540.48
44_F48_I0.6520.48
232_G302_G0.6490.48
316_Q333_L0.6480.48
205_V271_T0.6470.48
153_N156_D0.6470.48
290_S301_G0.6470.48
270_G306_V0.6460.48
119_Y122_V0.6440.47
151_A165_S0.6440.47
96_A201_R0.6440.47
133_L333_L0.6430.47
296_I350_N0.6420.47
100_R103_I0.6420.47
233_L267_I0.6420.47
49_E52_W0.6420.47
310_F313_D0.6400.47
196_V317_A0.6400.47
213_I267_I0.6390.47
113_P118_L0.6380.47
232_G345_Y0.6370.47
198_Q201_R0.6350.46
90_I94_E0.6330.46
65_Y68_Y0.6330.46
232_G235_Q0.6320.46
248_S280_V0.6300.46
304_G308_R0.6290.46
335_T347_Y0.6280.46
103_I107_L0.6270.46
228_S240_T0.6250.45
266_N269_T0.6250.45
80_F106_T0.6240.45
216_T349_V0.6240.45
230_A300_N0.6230.45
128_S134_Y0.6220.45
235_Q299_Y0.6220.45
292_R350_N0.6200.45
343_R349_V0.6200.45
228_S236_V0.6190.45
244_D304_G0.6180.45
191_K352_A0.6180.45
232_G299_Y0.6150.44
245_V273_Y0.6140.44
158_L348_K0.6120.44
42_G47_N0.6100.44
149_G165_S0.6100.44
102_A105_K0.6060.43
227_R243_K0.6060.43
155_A160_K0.6030.43
88_E96_A0.6030.43
278_N290_S0.6020.43
240_T346_L0.6020.43
156_D159_L0.6010.43
224_A240_T0.6010.43
225_V239_H0.6000.43
144_P147_W0.6000.43
277_L280_V0.5990.43
209_L274_L0.5970.42
278_N296_I0.5950.42
203_Y272_A0.5930.42
72_Y102_A0.5930.42
128_S133_L0.5900.42
195_M199_A0.5880.42
40_L49_E0.5880.42
348_K356_Y0.5880.42
305_S338_P0.5880.42
236_V277_L0.5860.41
43_Q47_N0.5860.41
233_L263_P0.5860.41
128_S139_D0.5850.41
69_T87_I0.5840.41
270_G274_L0.5830.41
49_E57_V0.5800.41
132_F355_S0.5790.41
213_I349_V0.5780.41
113_P119_Y0.5780.41
195_M214_M0.5770.40
291_R337_H0.5740.40
39_I50_N0.5740.40
210_I278_N0.5710.40
300_N345_Y0.5710.40
236_V245_V0.5700.40
203_Y275_A0.5670.39
80_F83_G0.5670.39
277_L295_V0.5660.39
194_G239_H0.5650.39
259_F262_D0.5620.39
199_A267_I0.5620.39
67_K99_L0.5610.39
152_S162_R0.5610.39
231_L260_L0.5600.39
88_E111_D0.5590.39
224_A261_F0.5580.39
187_K238_Q0.5560.38
39_I43_Q0.5560.38
59_I205_V0.5550.38
314_K351_T0.5540.38
63_K205_V0.5530.38
116_V124_D0.5530.38
129_K298_A0.5520.38
205_V209_L0.5520.38
87_I205_V0.5520.38
87_I107_L0.5510.38
172_I179_N0.5510.38
214_M270_G0.5510.38
157_Y160_K0.5500.38
124_D131_P0.5480.38
37_F40_L0.5470.37
334_T337_H0.5460.37
281_Y334_T0.5450.37
217_E302_G0.5440.37
71_Q87_I0.5390.37
210_I270_G0.5380.37
218_S302_G0.5380.37
281_Y306_V0.5360.36
112_D116_V0.5360.36
156_D163_L0.5350.36
219_S333_L0.5350.36
226_S300_N0.5330.36
212_A352_A0.5300.36
297_T309_V0.5300.36
217_E345_Y0.5300.36
91_A102_A0.5300.36
124_D132_F0.5300.36
158_L162_R0.5280.36
238_Q270_G0.5260.35
135_G140_N0.5260.35
127_I133_L0.5260.35
217_E235_Q0.5260.35
49_E53_G0.5250.35
215_Q291_R0.5240.35
218_S345_Y0.5230.35
45_A49_E0.5220.35
95_P260_L0.5220.35
213_I237_V0.5200.35
232_G300_N0.5200.35
52_W56_E0.5190.35
196_V210_I0.5180.35
351_T355_S0.5170.35
218_S235_Q0.5170.35
86_T89_T0.5160.34
276_M279_N0.5130.34
212_A315_I0.5120.34
217_E299_Y0.5100.34
196_V292_R0.5070.34
294_A301_G0.5070.34
89_T92_G0.5060.34
52_W62_P0.5040.33
69_T73_Q0.5030.33
218_S299_Y0.5030.33
110_G113_P0.5020.33
51_I92_G0.5020.33
115_S119_Y0.5010.33
80_F273_Y0.5010.33
267_I271_T0.5000.33
208_S292_R0.5000.33
40_L44_F0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cfpA 1 0.9081 100 0.339 Contact Map
1qsaA 1 0.9443 100 0.403 Contact Map
4hjzA 1 0.5097 100 0.503 Contact Map
4p0gA 1 0.8357 100 0.583 Contact Map
1gbsA 1 0.493 100 0.603 Contact Map
3gxrA 1 0.4875 100 0.612 Contact Map
4g9sA 1 0.4986 100 0.619 Contact Map
3w6bA 1 0.4039 100 0.63 Contact Map
3bkhA 1 0.7019 100 0.643 Contact Map
4fdyA 1 0.3565 100 0.673 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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