MLTC - ECOLI - GREMLIN Contacts

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MLTC - Membrane-bound lytic murein transglycosylase C

UniProt:	P0C066	Sequences: MKKYLALALIAPLLISCSTTKKGDTYNEAWVKDTNGFDILMGQFAHNIENIWGFKEVVIAGPKDYVKYTDQYQTRSHINFDDGTITIETIAGTEPAAHLRRAIIKTLLMGDDPSSVDLYSDVDDITISKEPFLYGQVVDNTGQPIRWEGRASNFADYLLKNRLKSRSNGLRIIYSVTINMVPNHLDKRAHKYLGMVRQASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQHTAGKDVFRSQGKSGTPSRSFLFDPASNIDTGTAYLAMLNNVYLGGIDNPTSRRYAVITAYNGGAGSVLRVFSNDKIQAANIINTMTPGDVYQTLTTRHPSAESRRYLYKVNTAQKSYRRR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG12986
Length:	359 (299)
Sequences:	1225 (908)
Seq/√Len:	52.5

ECOLI - MLTC SLT EMTA
BACSU - YJBJ

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
229_D	237_V	5.422	1.00
236_V	269_T	4.549	1.00
209_L	296_I	4.135	1.00
275_A	279_N	3.462	1.00
117_D	121_D	3.410	1.00
113_P	116_V	3.273	1.00
196_V	214_M	3.165	1.00
210_I	271_T	3.131	1.00
79_N	82_D	2.976	1.00
135_G	138_V	2.943	1.00
129_K	135_G	2.911	1.00
129_K	138_V	2.879	1.00
228_S	237_V	2.783	1.00
130_E	135_G	2.761	1.00
128_S	131_P	2.723	1.00
216_T	352_A	2.701	1.00
337_H	346_L	2.604	1.00
305_S	339_S	2.593	1.00
297_T	346_L	2.555	1.00
134_Y	138_V	2.545	1.00
130_E	138_V	2.522	1.00
231_L	261_F	2.490	1.00
318_A	331_Q	2.463	1.00
216_T	348_K	2.435	1.00
71_Q	83_G	2.396	1.00
131_P	135_G	2.270	1.00
197_R	207_E	2.219	1.00
133_L	138_V	2.205	1.00
130_E	134_Y	2.186	1.00
280_V	307_L	2.150	1.00
195_M	264_A	2.116	1.00
248_S	276_M	2.078	1.00
338_P	342_S	2.049	1.00
127_I	130_E	2.016	1.00
131_P	136_Q	1.948	1.00
128_S	135_G	1.941	1.00
225_V	261_F	1.937	1.00
305_S	308_R	1.909	0.99
112_D	117_D	1.895	0.99
301_G	309_V	1.885	0.99
128_S	132_F	1.881	0.99
130_E	133_L	1.880	0.99
129_K	133_L	1.867	0.99
245_V	269_T	1.864	0.99
309_V	337_H	1.859	0.99
129_K	134_Y	1.817	0.99
128_S	138_V	1.764	0.99
233_L	266_N	1.745	0.99
127_I	131_P	1.711	0.99
147_W	150_R	1.680	0.99
160_K	164_K	1.678	0.99
294_A	310_F	1.672	0.99
301_G	337_H	1.671	0.99
131_P	134_Y	1.644	0.98
162_R	165_S	1.616	0.98
132_F	135_G	1.612	0.98
236_V	241_A	1.598	0.98
244_D	276_M	1.585	0.98
228_S	231_L	1.555	0.98
281_Y	307_L	1.545	0.98
113_P	121_D	1.529	0.97
196_V	200_S	1.526	0.97
259_F	265_S	1.474	0.97
236_V	260_L	1.463	0.97
88_E	104_I	1.454	0.96
129_K	139_D	1.450	0.96
131_P	139_D	1.431	0.96
133_L	137_V	1.418	0.96
114_S	118_L	1.418	0.96
132_F	138_V	1.407	0.96
296_I	349_V	1.400	0.96
127_I	134_Y	1.397	0.96
273_Y	303_A	1.395	0.95
131_P	138_V	1.388	0.95
161_N	164_K	1.382	0.95
113_P	117_D	1.375	0.95
162_R	166_R	1.374	0.95
155_A	164_K	1.351	0.95
133_L	139_D	1.349	0.95
298_A	306_V	1.348	0.95
127_I	135_G	1.340	0.94
256_S	259_F	1.338	0.94
132_F	137_V	1.331	0.94
344_R	348_K	1.328	0.94
104_I	108_L	1.307	0.94
129_K	136_Q	1.302	0.93
133_L	136_Q	1.301	0.93
225_V	231_L	1.299	0.93
115_S	118_L	1.269	0.93
109_M	117_D	1.256	0.92
108_L	116_V	1.253	0.92
224_A	231_L	1.250	0.92
154_F	158_L	1.245	0.92
130_E	137_V	1.231	0.91
230_A	235_Q	1.226	0.91
229_D	295_V	1.218	0.91
240_T	273_Y	1.217	0.91
292_R	353_Q	1.214	0.91
295_V	303_A	1.206	0.91
131_P	137_V	1.205	0.90
192_Y	196_V	1.199	0.90
134_Y	137_V	1.196	0.90
192_Y	222_P	1.191	0.90
216_T	344_R	1.178	0.89
214_M	267_I	1.158	0.89
72_Y	100_R	1.157	0.89
316_Q	331_Q	1.142	0.88
123_D	130_E	1.132	0.88
132_F	136_Q	1.121	0.87
135_G	139_D	1.114	0.87
136_Q	139_D	1.113	0.87
84_T	104_I	1.113	0.87
301_G	342_S	1.112	0.87
198_Q	264_A	1.103	0.86
215_Q	309_V	1.099	0.86
234_M	270_G	1.085	0.85
210_I	220_F	1.077	0.85
317_A	333_L	1.064	0.84
111_D	115_S	1.061	0.84
216_T	356_Y	1.060	0.84
92_G	95_P	1.059	0.84
317_A	331_Q	1.058	0.84
108_L	111_D	1.056	0.84
129_K	132_F	1.037	0.82
146_R	149_G	1.030	0.82
234_M	267_I	1.026	0.82
199_A	202_K	1.024	0.82
161_N	166_R	1.022	0.82
134_Y	139_D	1.021	0.81
210_I	234_M	1.016	0.81
47_N	50_N	1.015	0.81
104_I	107_L	1.012	0.81
236_V	270_G	1.011	0.81
313_D	317_A	1.008	0.81
299_Y	345_Y	1.006	0.80
154_F	157_Y	1.001	0.80
262_D	265_S	0.993	0.80
333_L	355_S	0.992	0.80
215_Q	355_S	0.991	0.79
228_S	301_G	0.990	0.79
196_V	211_L	0.982	0.79
229_D	303_A	0.977	0.78
141_T	144_P	0.976	0.78
71_Q	90_I	0.975	0.78
234_M	238_Q	0.968	0.78
189_A	215_Q	0.967	0.78
208_S	353_Q	0.967	0.78
175_S	180_M	0.962	0.77
116_V	119_Y	0.961	0.77
117_D	120_S	0.961	0.77
229_D	301_G	0.959	0.77
130_E	139_D	0.959	0.77
245_V	276_M	0.953	0.77
278_N	295_V	0.950	0.77
50_N	53_G	0.948	0.76
212_A	349_V	0.947	0.76
333_L	348_K	0.946	0.76
74_T	212_A	0.942	0.76
249_Q	269_T	0.939	0.76
112_D	115_S	0.936	0.75
161_N	165_S	0.934	0.75
214_M	233_L	0.933	0.75
132_F	139_D	0.930	0.75
215_Q	335_T	0.923	0.74
152_S	161_N	0.922	0.74
127_I	138_V	0.920	0.74
276_M	280_V	0.919	0.74
202_K	268_D	0.914	0.74
225_V	228_S	0.897	0.72
168_N	171_R	0.895	0.72
236_V	273_Y	0.892	0.72
130_E	136_Q	0.889	0.72
84_T	111_D	0.885	0.71
200_S	207_E	0.883	0.71
217_E	300_N	0.877	0.71
199_A	203_Y	0.876	0.70
38_D	42_G	0.866	0.70
229_D	240_T	0.861	0.69
249_Q	268_D	0.850	0.68
216_T	219_S	0.849	0.68
217_E	230_A	0.845	0.68
56_E	60_A	0.845	0.68
193_L	197_R	0.842	0.67
87_I	90_I	0.838	0.67
229_D	239_H	0.834	0.67
212_A	353_Q	0.831	0.66
38_D	41_M	0.831	0.66
173_I	177_T	0.831	0.66
41_M	45_A	0.830	0.66
306_V	310_F	0.830	0.66
337_H	342_S	0.830	0.66
56_E	61_G	0.827	0.66
251_K	269_T	0.827	0.66
201_R	243_K	0.825	0.66
306_V	338_P	0.823	0.66
200_S	271_T	0.822	0.66
141_T	145_I	0.820	0.65
265_S	268_D	0.816	0.65
296_I	305_S	0.815	0.65
194_G	198_Q	0.814	0.65
128_S	136_Q	0.813	0.65
304_G	307_L	0.809	0.64
123_D	127_I	0.808	0.64
85_I	236_V	0.808	0.64
301_G	339_S	0.807	0.64
42_G	49_E	0.806	0.64
175_S	186_D	0.806	0.64
281_Y	298_A	0.798	0.63
193_L	211_L	0.796	0.63
109_M	112_D	0.795	0.63
266_N	338_P	0.794	0.63
145_I	149_G	0.788	0.62
352_A	356_Y	0.787	0.62
118_L	121_D	0.785	0.62
83_G	107_L	0.782	0.62
272_A	276_M	0.781	0.62
64_D	94_E	0.779	0.61
39_I	42_G	0.779	0.61
109_M	121_D	0.777	0.61
215_Q	356_Y	0.776	0.61
190_H	211_L	0.776	0.61
275_A	351_T	0.774	0.61
87_I	91_A	0.771	0.61
152_S	156_D	0.768	0.60
143_Q	146_R	0.767	0.60
260_L	266_N	0.765	0.60
277_L	298_A	0.765	0.60
157_Y	161_N	0.764	0.60
251_K	298_A	0.762	0.60
188_R	215_Q	0.761	0.60
160_K	163_L	0.761	0.60
41_M	44_F	0.756	0.59
106_T	110_G	0.754	0.59
229_D	297_T	0.753	0.59
80_F	107_L	0.750	0.58
112_D	121_D	0.749	0.58
251_K	268_D	0.748	0.58
128_S	137_V	0.748	0.58
91_A	94_E	0.745	0.58
236_V	266_N	0.743	0.58
227_R	304_G	0.743	0.58
314_K	317_A	0.742	0.58
313_D	333_L	0.738	0.57
109_M	137_V	0.734	0.57
281_Y	303_A	0.728	0.56
116_V	121_D	0.726	0.56
172_I	175_S	0.725	0.56
209_L	241_A	0.724	0.56
299_Y	302_G	0.723	0.56
214_M	312_N	0.723	0.56
102_A	106_T	0.722	0.56
217_E	232_G	0.721	0.55
302_G	345_Y	0.717	0.55
297_T	342_S	0.714	0.55
218_S	232_G	0.714	0.55
68_Y	72_Y	0.713	0.55
37_F	45_A	0.712	0.55
74_T	187_K	0.712	0.55
209_L	353_Q	0.712	0.55
118_L	194_G	0.711	0.54
240_T	301_G	0.708	0.54
244_D	248_S	0.708	0.54
72_Y	75_R	0.708	0.54
110_G	304_G	0.708	0.54
48_I	51_I	0.701	0.53
71_Q	75_R	0.699	0.53
194_G	271_T	0.698	0.53
191_K	211_L	0.697	0.53
213_I	274_L	0.690	0.52
61_G	65_Y	0.690	0.52
133_L	140_N	0.689	0.52
339_S	342_S	0.689	0.52
200_S	203_Y	0.686	0.52
245_V	272_A	0.686	0.52
188_R	191_K	0.686	0.52
185_L	190_H	0.682	0.51
203_Y	210_I	0.679	0.51
111_D	114_S	0.679	0.51
166_R	262_D	0.679	0.51
309_V	339_S	0.677	0.51
331_Q	334_T	0.676	0.51
215_Q	301_G	0.674	0.51
157_Y	163_L	0.671	0.50
237_V	304_G	0.670	0.50
92_G	113_P	0.670	0.50
237_V	339_S	0.668	0.50
56_E	64_D	0.664	0.49
245_V	254_T	0.659	0.49
227_R	231_L	0.657	0.49
222_P	255_P	0.656	0.49
333_L	337_H	0.655	0.49
332_T	336_R	0.654	0.48
44_F	48_I	0.652	0.48
232_G	302_G	0.649	0.48
316_Q	333_L	0.648	0.48
205_V	271_T	0.647	0.48
153_N	156_D	0.647	0.48
290_S	301_G	0.647	0.48
270_G	306_V	0.646	0.48
119_Y	122_V	0.644	0.47
151_A	165_S	0.644	0.47
96_A	201_R	0.644	0.47
133_L	333_L	0.643	0.47
296_I	350_N	0.642	0.47
100_R	103_I	0.642	0.47
233_L	267_I	0.642	0.47
49_E	52_W	0.642	0.47
310_F	313_D	0.640	0.47
196_V	317_A	0.640	0.47
213_I	267_I	0.639	0.47
113_P	118_L	0.638	0.47
232_G	345_Y	0.637	0.47
198_Q	201_R	0.635	0.46
90_I	94_E	0.633	0.46
65_Y	68_Y	0.633	0.46
232_G	235_Q	0.632	0.46
248_S	280_V	0.630	0.46
304_G	308_R	0.629	0.46
335_T	347_Y	0.628	0.46
103_I	107_L	0.627	0.46
228_S	240_T	0.625	0.45
266_N	269_T	0.625	0.45
80_F	106_T	0.624	0.45
216_T	349_V	0.624	0.45
230_A	300_N	0.623	0.45
128_S	134_Y	0.622	0.45
235_Q	299_Y	0.622	0.45
292_R	350_N	0.620	0.45
343_R	349_V	0.620	0.45
228_S	236_V	0.619	0.45
244_D	304_G	0.618	0.45
191_K	352_A	0.618	0.45
232_G	299_Y	0.615	0.44
245_V	273_Y	0.614	0.44
158_L	348_K	0.612	0.44
42_G	47_N	0.610	0.44
149_G	165_S	0.610	0.44
102_A	105_K	0.606	0.43
227_R	243_K	0.606	0.43
155_A	160_K	0.603	0.43
88_E	96_A	0.603	0.43
278_N	290_S	0.602	0.43
240_T	346_L	0.602	0.43
156_D	159_L	0.601	0.43
224_A	240_T	0.601	0.43
225_V	239_H	0.600	0.43
144_P	147_W	0.600	0.43
277_L	280_V	0.599	0.43
209_L	274_L	0.597	0.42
278_N	296_I	0.595	0.42
203_Y	272_A	0.593	0.42
72_Y	102_A	0.593	0.42
128_S	133_L	0.590	0.42
195_M	199_A	0.588	0.42
40_L	49_E	0.588	0.42
348_K	356_Y	0.588	0.42
305_S	338_P	0.588	0.42
236_V	277_L	0.586	0.41
43_Q	47_N	0.586	0.41
233_L	263_P	0.586	0.41
128_S	139_D	0.585	0.41
69_T	87_I	0.584	0.41
270_G	274_L	0.583	0.41
49_E	57_V	0.580	0.41
132_F	355_S	0.579	0.41
213_I	349_V	0.578	0.41
113_P	119_Y	0.578	0.41
195_M	214_M	0.577	0.40
291_R	337_H	0.574	0.40
39_I	50_N	0.574	0.40
210_I	278_N	0.571	0.40
300_N	345_Y	0.571	0.40
236_V	245_V	0.570	0.40
203_Y	275_A	0.567	0.39
80_F	83_G	0.567	0.39
277_L	295_V	0.566	0.39
194_G	239_H	0.565	0.39
259_F	262_D	0.562	0.39
199_A	267_I	0.562	0.39
67_K	99_L	0.561	0.39
152_S	162_R	0.561	0.39
231_L	260_L	0.560	0.39
88_E	111_D	0.559	0.39
224_A	261_F	0.558	0.39
187_K	238_Q	0.556	0.38
39_I	43_Q	0.556	0.38
59_I	205_V	0.555	0.38
314_K	351_T	0.554	0.38
63_K	205_V	0.553	0.38
116_V	124_D	0.553	0.38
129_K	298_A	0.552	0.38
205_V	209_L	0.552	0.38
87_I	205_V	0.552	0.38
87_I	107_L	0.551	0.38
172_I	179_N	0.551	0.38
214_M	270_G	0.551	0.38
157_Y	160_K	0.550	0.38
124_D	131_P	0.548	0.38
37_F	40_L	0.547	0.37
334_T	337_H	0.546	0.37
281_Y	334_T	0.545	0.37
217_E	302_G	0.544	0.37
71_Q	87_I	0.539	0.37
210_I	270_G	0.538	0.37
218_S	302_G	0.538	0.37
281_Y	306_V	0.536	0.36
112_D	116_V	0.536	0.36
156_D	163_L	0.535	0.36
219_S	333_L	0.535	0.36
226_S	300_N	0.533	0.36
212_A	352_A	0.530	0.36
297_T	309_V	0.530	0.36
217_E	345_Y	0.530	0.36
91_A	102_A	0.530	0.36
124_D	132_F	0.530	0.36
158_L	162_R	0.528	0.36
238_Q	270_G	0.526	0.35
135_G	140_N	0.526	0.35
127_I	133_L	0.526	0.35
217_E	235_Q	0.526	0.35
49_E	53_G	0.525	0.35
215_Q	291_R	0.524	0.35
218_S	345_Y	0.523	0.35
45_A	49_E	0.522	0.35
95_P	260_L	0.522	0.35
213_I	237_V	0.520	0.35
232_G	300_N	0.520	0.35
52_W	56_E	0.519	0.35
196_V	210_I	0.518	0.35
351_T	355_S	0.517	0.35
218_S	235_Q	0.517	0.35
86_T	89_T	0.516	0.34
276_M	279_N	0.513	0.34
212_A	315_I	0.512	0.34
217_E	299_Y	0.510	0.34
196_V	292_R	0.507	0.34
294_A	301_G	0.507	0.34
89_T	92_G	0.506	0.34
52_W	62_P	0.504	0.33
69_T	73_Q	0.503	0.33
218_S	299_Y	0.503	0.33
110_G	113_P	0.502	0.33
51_I	92_G	0.502	0.33
115_S	119_Y	0.501	0.33
80_F	273_Y	0.501	0.33
267_I	271_T	0.500	0.33
208_S	292_R	0.500	0.33
40_L	44_F	0.500	0.33

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4cfpA	1	0.9081	100	0.339	Contact Map
1qsaA	1	0.9443	100	0.403	Contact Map
4hjzA	1	0.5097	100	0.503	Contact Map
4p0gA	1	0.8357	100	0.583	Contact Map
1gbsA	1	0.493	100	0.603	Contact Map
3gxrA	1	0.4875	100	0.612	Contact Map
4g9sA	1	0.4986	100	0.619	Contact Map
3w6bA	1	0.4039	100	0.63	Contact Map
3bkhA	1	0.7019	100	0.643	Contact Map
4fdyA	1	0.3565	100	0.673	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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