GREMLIN Database
IBPA - Small heat shock protein IbpA
UniProt: P0C054 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11534
Length: 137 (131)
Sequences: 1112 (559)
Seq/√Len: 48.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_E133_R4.3041.00
48_R120_D4.2601.00
72_V119_I3.7311.00
106_H124_V3.1441.00
48_R118_Y3.0281.00
50_A116_L2.8721.00
43_D46_H2.6111.00
53_V112_L2.5091.00
54_A93_R2.4501.00
73_K96_E2.3441.00
53_V61_L2.2961.00
64_T71_V2.2011.00
34_Y93_R2.1701.00
58_E61_L2.0941.00
108_R122_E2.0841.00
104_N129_K2.0481.00
63_I72_V1.8870.99
60_E76_H1.8780.99
57_A60_E1.7910.99
10_Y76_H1.7720.99
48_R123_R1.7510.99
41_L94_N1.7170.98
42_V46_H1.6880.98
41_L84_T1.6610.98
8_P11_R1.6500.98
51_I72_V1.6440.98
50_A118_Y1.5530.97
108_R111_N1.5040.96
57_A114_N1.4420.95
23_L26_N1.3900.94
60_E77_A1.3800.94
10_Y20_F1.3500.93
40_E83_R1.3120.92
22_H26_N1.2950.92
58_E111_N1.2360.90
24_E69_L1.2190.89
107_V121_L1.2170.89
41_L92_E1.2140.89
112_L116_L1.2000.89
24_E37_Y1.1880.88
61_L112_L1.1870.88
14_I41_L1.1860.88
9_L26_N1.1800.88
112_L118_Y1.1800.88
62_E75_A1.1690.87
128_A131_P1.1590.87
73_K133_R1.1260.85
51_I132_R1.0980.84
59_S62_E1.0620.82
40_E56_F1.0240.79
88_Q92_E1.0090.78
34_Y97_R1.0000.77
63_I107_V0.9980.77
10_Y21_N0.9950.77
47_Y131_P0.9880.77
9_L47_Y0.9790.76
18_R47_Y0.9710.75
40_E50_A0.9710.75
34_Y40_E0.9700.75
105_I124_V0.9660.75
41_L65_A0.9480.74
81_K111_N0.9430.73
6_L20_F0.9340.72
71_V87_Y0.9290.72
54_A91_A0.9260.72
83_R87_Y0.9250.72
36_P54_A0.9240.72
96_E100_Q0.9160.71
127_E130_K0.9090.70
45_N72_V0.9020.70
10_Y37_Y0.9000.70
33_G73_K0.8930.69
66_Q87_Y0.8930.69
22_H135_E0.8920.69
20_F23_L0.8880.69
41_L98_K0.8860.68
20_F24_E0.8840.68
77_A81_K0.8780.68
11_R14_I0.8770.68
16_F90_I0.8700.67
63_I81_K0.8670.67
24_E32_G0.8670.67
13_A20_F0.8660.67
11_R17_D0.8630.66
10_Y22_H0.8540.66
50_A90_I0.8520.65
73_K106_H0.8480.65
86_L102_A0.8410.64
47_Y96_E0.8380.64
60_E75_A0.8290.63
46_H82_E0.8230.63
61_L64_T0.8190.62
13_A18_R0.8180.62
109_G120_D0.8180.62
7_S133_R0.8180.62
62_E73_K0.8090.61
97_R103_E0.8030.61
46_H109_G0.7990.60
34_Y54_A0.7980.60
125_I130_K0.7950.60
58_E135_E0.7890.59
65_A82_E0.7790.58
10_Y105_I0.7740.58
9_L104_N0.7730.58
37_Y87_Y0.7690.57
15_G52_A0.7640.57
74_G127_E0.7640.57
62_E118_Y0.7500.55
99_F110_A0.7480.55
38_N88_Q0.7480.55
75_A88_Q0.7460.55
64_T100_Q0.7300.53
36_P93_R0.7260.53
124_V128_A0.7260.53
81_K135_E0.7250.53
131_P134_I0.7250.53
33_G45_N0.7180.52
113_V118_Y0.7140.52
12_S19_L0.7130.52
32_G84_T0.7120.52
46_H127_E0.7090.51
68_N103_E0.7060.51
126_P130_K0.7010.51
108_R124_V0.6930.50
32_G38_N0.6920.50
68_N100_Q0.6910.50
44_E47_Y0.6900.49
15_G93_R0.6880.49
41_L63_I0.6810.49
66_Q112_L0.6770.48
46_H88_Q0.6700.47
124_V131_P0.6640.47
21_N71_V0.6630.47
34_Y65_A0.6600.46
106_H122_E0.6590.46
10_Y92_E0.6560.46
25_N113_V0.6510.45
72_V82_E0.6490.45
73_K79_E0.6480.45
67_D129_K0.6460.45
67_D90_I0.6460.45
17_D36_P0.6380.44
49_I101_L0.6370.44
13_A41_L0.6370.44
119_I133_R0.6350.44
110_A134_I0.6330.44
88_Q102_A0.6320.44
84_T88_Q0.6300.43
18_R105_I0.6260.43
111_N120_D0.6180.42
43_D116_L0.6130.42
62_E135_E0.6080.41
78_D113_V0.6080.41
65_A97_R0.6060.41
52_A93_R0.6050.41
6_L68_N0.6030.41
60_E82_E0.5790.38
56_F102_A0.5780.38
49_I105_I0.5750.38
28_S38_N0.5720.38
56_F93_R0.5710.38
111_N119_I0.5680.37
129_K133_R0.5670.37
82_E128_A0.5620.37
37_Y65_A0.5620.37
53_V91_A0.5610.37
73_K112_L0.5610.37
79_E82_E0.5610.37
38_N118_Y0.5600.37
71_V100_Q0.5510.36
19_L39_V0.5480.35
61_L97_R0.5450.35
27_Q43_D0.5430.35
14_I47_Y0.5410.35
75_A79_E0.5410.35
56_F74_G0.5390.35
21_N133_R0.5370.34
13_A102_A0.5360.34
14_I49_I0.5350.34
20_F64_T0.5310.34
88_Q132_R0.5280.34
14_I39_V0.5270.34
12_S130_K0.5260.33
13_A100_Q0.5240.33
44_E81_K0.5230.33
36_P63_I0.5230.33
86_L116_L0.5220.33
17_D123_R0.5220.33
72_V80_Q0.5210.33
47_Y50_A0.5150.32
72_V107_V0.5110.32
6_L28_S0.5110.32
40_E85_Y0.5110.32
31_N76_H0.5050.32
12_S18_R0.5040.32
61_L136_I0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2klrA 2 0.5766 99.8 0.644 Contact Map
2bolA 2 0.9343 99.8 0.645 Contact Map
3w1zA 7 0.9635 99.8 0.646 Contact Map
1gmeA 6 0.9781 99.8 0.661 Contact Map
4eldA 4 0.7737 99.7 0.67 Contact Map
4ydzA 4 0.8321 99.7 0.672 Contact Map
3aabA 2 0.8102 99.7 0.676 Contact Map
4jutA 4 0.635 99.6 0.698 Contact Map
3l1eA 2 0.7153 99.6 0.699 Contact Map
4ye0A 2 0.7007 99.6 0.701 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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