GREMLIN Database
YAIE - UPF0345 protein YaiE
UniProt: P0C037 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12159
Length: 94 (90)
Sequences: 625 (409)
Seq/√Len: 43.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_T80_H3.5341.00
36_T78_E3.3981.00
53_N82_Q3.3841.00
42_P75_G3.1531.00
38_S93_Y3.0581.00
55_L80_H2.9491.00
66_E69_S2.8321.00
59_A63_Q2.3931.00
34_E82_Q1.9310.99
55_L62_W1.8600.99
6_E13_K1.7990.98
52_L81_L1.7630.98
6_E10_G1.6600.97
55_L60_T1.6550.97
4_S13_K1.6340.97
47_V87_T1.6180.97
42_P74_P1.5380.95
12_V33_G1.4940.95
74_P77_S1.4920.95
53_N64_V1.4870.94
42_P72_N1.4510.94
54_V65_Y1.4290.93
31_V86_P1.3920.92
30_M83_V1.3850.92
51_A66_E1.3850.92
32_E86_P1.3750.92
51_A85_E1.3680.92
38_S78_E1.3680.92
13_K29_V1.3610.91
19_S25_A1.3590.91
54_V57_P1.3440.91
12_V35_Y1.2980.89
46_T70_V1.2300.86
16_G26_S1.2130.86
7_Y93_Y1.2110.86
19_S92_R1.2050.85
4_S15_I1.1750.84
51_A64_V1.1310.81
51_A84_A1.1180.81
24_R41_E1.1110.80
19_S23_G1.0650.77
40_A93_Y1.0500.76
40_A76_H1.0400.76
61_D64_V1.0050.73
44_E72_N1.0030.73
12_V30_M0.9910.72
19_S22_T0.9820.71
46_T92_R0.9810.71
47_V67_A0.9650.70
57_P65_Y0.9560.69
44_E70_V0.9520.69
31_V81_L0.9190.66
55_L63_Q0.9170.66
27_V88_S0.9070.65
73_V77_S0.8820.63
55_L76_H0.8580.61
7_Y56_L0.8200.57
35_Y81_L0.7920.55
63_Q69_S0.7780.53
33_G83_V0.7770.53
52_L71_F0.7660.52
24_R74_P0.7650.52
51_A83_V0.7580.51
9_S82_Q0.7520.51
25_A46_T0.7500.51
23_G92_R0.7430.50
57_P78_E0.7430.50
34_E64_V0.7380.50
17_F27_V0.7360.49
32_E46_T0.7260.48
65_Y69_S0.7250.48
56_L59_A0.7190.48
48_I88_S0.7100.47
8_F45_M0.7010.46
7_Y62_W0.6940.45
30_M81_L0.6900.45
25_A86_P0.6700.43
52_L87_T0.6560.42
45_M71_F0.6530.42
19_S24_R0.6520.41
27_V46_T0.6510.41
51_A70_V0.6500.41
26_S42_P0.6450.41
56_L75_G0.6430.41
53_N84_A0.6420.40
27_V86_P0.6400.40
63_Q82_Q0.6370.40
47_V65_Y0.6360.40
32_E70_V0.6330.40
25_A92_R0.6320.40
52_L82_Q0.6310.39
40_A77_S0.6280.39
3_Q22_T0.6270.39
59_A72_N0.6240.39
41_E72_N0.6100.38
16_G27_V0.5990.37
29_V86_P0.5980.37
15_I25_A0.5960.36
23_G46_T0.5900.36
21_S25_A0.5880.36
41_E75_G0.5870.36
81_L84_A0.5850.35
7_Y11_K0.5820.35
42_P77_S0.5810.35
68_G77_S0.5730.34
4_S19_S0.5710.34
31_V35_Y0.5700.34
7_Y12_V0.5690.34
7_Y45_M0.5690.34
22_T25_A0.5650.34
17_F24_R0.5640.34
48_I86_P0.5600.33
59_A80_H0.5590.33
9_S38_S0.5580.33
48_I68_G0.5550.33
6_E27_V0.5530.33
30_M65_Y0.5440.32
4_S92_R0.5380.31
12_V87_T0.5340.31
32_E52_L0.5340.31
62_W82_Q0.5290.31
30_M87_T0.5260.30
60_T63_Q0.5250.30
6_E63_Q0.5250.30
60_T64_V0.5240.30
47_V52_L0.5220.30
9_S69_S0.5170.30
30_M35_Y0.5140.29
15_I88_S0.5140.29
25_A49_S0.5080.29
44_E92_R0.5080.29
13_K31_V0.5030.29
51_A67_A0.5010.28
34_E57_P0.5010.28
32_E84_A0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2oyzA 2 0.9894 100 0.052 Contact Map
3hqxA 2 1 100 0.067 Contact Map
3eo6A 2 0.9894 100 0.113 Contact Map
1yhfA 2 0.9681 95 0.858 Contact Map
3es4A 2 0.9894 94.9 0.859 Contact Map
3rnsA 1 0.9681 94.6 0.861 Contact Map
2f4pA 2 0.9787 94 0.865 Contact Map
2opkA 2 0.9894 94 0.865 Contact Map
3myxA 1 0.9255 93.7 0.866 Contact Map
3bcwA 2 0.9574 93.5 0.867 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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