GREMLIN Database
RL18 - 50S ribosomal protein L18
UniProt: P0C018 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10879
Length: 117 (112)
Sequences: 2782 (1389)
Seq/√Len: 131.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
88_K116_Q3.6151.00
73_A76_K3.2371.00
89_D116_Q3.2111.00
68_K105_A2.9741.00
11_A95_S2.8491.00
83_L88_K2.6521.00
67_N70_A2.5591.00
80_E84_E2.4811.00
76_K80_E2.3901.00
39_V82_A2.2771.00
55_E81_R2.2071.00
26_L37_A2.1891.00
72_A112_E2.1361.00
77_A81_R1.9441.00
79_A113_A1.9251.00
41_A44_G1.8711.00
35_I106_L1.8221.00
69_D72_A1.7081.00
51_A77_A1.6641.00
110_A115_L1.5921.00
64_Y67_N1.5561.00
72_A109_A1.5401.00
27_V95_S1.5151.00
53_T70_A1.4551.00
77_A80_E1.4431.00
109_A113_A1.4241.00
20_E24_T1.3861.00
7_R97_F1.3721.00
6_A10_R1.3701.00
72_A76_K1.3691.00
76_K112_E1.3581.00
104_Q108_D1.2831.00
8_I11_A1.2631.00
27_V40_I1.2491.00
19_Q43_N1.2451.00
73_A77_A1.2311.00
4_K8_I1.2261.00
82_A115_L1.2111.00
24_T42_P1.1970.99
46_E85_K1.1950.99
80_E83_L1.1910.99
67_N102_R1.1770.99
66_G102_R1.1710.99
39_V78_V1.1470.99
32_P66_G1.1170.99
39_V90_V1.1000.99
76_K109_A1.0990.99
81_R85_K1.0740.99
30_R102_R1.0740.99
8_I12_T1.0720.99
69_D73_A1.0420.99
56_K59_A1.0300.98
51_A81_R1.0250.98
79_A109_A1.0150.98
66_G69_D1.0100.98
14_A18_L1.0080.98
83_L113_A1.0000.98
26_L78_V0.9980.98
34_H53_T0.9900.98
106_L109_A0.9810.98
37_A78_V0.9810.98
12_T16_R0.9740.98
68_K72_A0.9460.97
39_V87_I0.9220.97
10_R34_H0.9220.97
26_L110_A0.9180.97
78_V110_A0.9150.97
66_G70_A0.9080.96
7_R96_G0.8850.96
34_H54_V0.8850.96
23_A89_D0.8640.95
4_K97_F0.8590.95
75_G110_A0.8570.95
7_R11_A0.8510.95
29_H97_F0.8510.95
51_A55_E0.8480.95
90_V117_F0.8470.95
75_G106_L0.8380.94
35_I74_V0.8300.94
58_I73_A0.8250.94
49_V81_R0.8200.94
26_L90_V0.8020.93
16_R19_Q0.7950.93
83_L116_Q0.7910.93
42_P47_V0.7840.92
55_E77_A0.7750.92
27_V97_F0.7740.92
10_R13_R0.7550.91
65_T70_A0.7440.90
79_A110_A0.7340.89
72_A105_A0.7310.89
74_V106_L0.7270.89
29_H36_Y0.7240.89
11_A96_G0.7220.89
48_L87_I0.7180.88
11_A21_L0.7100.88
57_A80_E0.7090.88
20_E42_P0.7050.88
75_G109_A0.7040.87
16_R20_E0.7000.87
11_A27_V0.6880.86
51_A74_V0.6850.86
9_R12_T0.6800.86
76_K113_A0.6790.86
42_P45_S0.6740.85
64_Y70_A0.6730.85
7_R20_E0.6730.85
78_V106_L0.6720.85
4_K7_R0.6610.84
78_V115_L0.6590.84
14_A21_L0.6480.83
41_A46_E0.6430.82
65_T102_R0.6410.82
24_T91_S0.6410.82
17_K21_L0.6390.82
10_R98_Q0.6380.82
3_K36_Y0.6380.82
100_H104_Q0.6330.81
78_V82_A0.6250.80
53_T65_T0.6250.80
15_R95_S0.6230.80
71_A75_G0.6190.80
11_A14_A0.6150.79
68_K104_Q0.6020.78
40_I45_S0.6020.78
82_A110_A0.5990.78
68_K71_A0.5980.78
49_V85_K0.5960.77
29_H32_P0.5910.77
86_G112_E0.5880.76
56_K77_A0.5860.76
72_A108_D0.5840.76
79_A115_L0.5820.76
4_K10_R0.5800.75
25_R42_P0.5760.75
36_Y52_S0.5760.75
30_R65_T0.5750.75
12_T27_V0.5730.74
57_A81_R0.5690.74
105_A108_D0.5680.74
22_G89_D0.5660.74
24_T41_A0.5660.74
7_R16_R0.5640.73
3_K11_A0.5570.72
10_R58_I0.5560.72
80_E113_A0.5500.71
52_S55_E0.5470.71
32_P64_Y0.5460.71
63_K73_A0.5440.71
37_A106_L0.5410.70
9_R13_R0.5390.70
27_V47_V0.5360.70
70_A102_R0.5360.70
12_T17_K0.5360.70
46_E50_A0.5300.69
41_A45_S0.5290.69
99_Y111_R0.5280.68
17_K20_E0.5250.68
55_E58_I0.5220.68
57_A77_A0.5220.68
24_T48_L0.5190.67
49_V87_I0.5190.67
53_T67_N0.5150.67
50_A74_V0.5080.65
9_R107_A0.5080.65
11_A104_Q0.5060.65
58_I77_A0.5030.65
68_K102_R0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bboQ 1 1 100 0.151 Contact Map
4tp9O 1 0.0171 100 0.175 Contact Map
4rb6S 1 0.9402 100 0.181 Contact Map
1ovyA 1 0.8205 100 0.201 Contact Map
2zjrL 1 0.8547 100 0.202 Contact Map
1vq8N 1 0.9829 100 0.283 Contact Map
4w20D 1 1 100 0.284 Contact Map
3j7yP 1 0.9487 100 0.287 Contact Map
3j39D 1 1 100 0.289 Contact Map
1vx7R 1 1 100 0.29 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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