GREMLIN Database
XANP - Xanthine permease XanP
UniProt: P0AGM9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11194
Length: 463 (403)
Sequences: 4348 (2218)
Seq/√Len: 110.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
208_L231_A5.4701.00
204_V235_L5.3131.00
181_I202_A4.2451.00
168_I447_G4.1231.00
209_I228_A4.0421.00
253_L367_A3.9101.00
234_A238_F3.7551.00
77_F363_G3.7321.00
142_T275_M3.2371.00
212_L227_I3.2201.00
418_V450_T3.2021.00
201_L236_A3.1771.00
80_G360_I2.8541.00
244_E247_E2.8301.00
260_L325_V2.8141.00
201_L241_M2.7911.00
204_V231_A2.7441.00
251_Q367_A2.6891.00
415_S451_A2.6711.00
137_M324_A2.6411.00
407_R459_P2.6071.00
206_L386_V2.5441.00
289_I312_G2.4871.00
82_A319_N2.4821.00
245_S250_T2.4491.00
43_L358_M2.4041.00
230_A234_A2.3991.00
39_A354_V2.3981.00
96_G306_M2.3721.00
201_L239_M2.3161.00
133_F324_A2.2061.00
35_T354_V2.2051.00
200_L204_V2.1991.00
78_A326_F2.1991.00
204_V208_L2.1501.00
249_M252_E2.1461.00
234_A237_W2.1181.00
84_I356_A2.1091.00
36_L358_M2.0981.00
84_I353_F2.0971.00
156_I456_L2.0821.00
137_M321_F2.0771.00
208_L212_L2.0711.00
208_L235_L2.0401.00
346_V351_V2.0081.00
57_I111_L1.9781.00
196_P200_L1.9781.00
87_I353_F1.9511.00
197_K241_M1.9251.00
124_D127_T1.9031.00
233_Y374_H1.9001.00
27_E298_Q1.8771.00
235_L239_M1.8451.00
453_V457_I1.8421.00
77_F360_I1.8361.00
137_M141_C1.8351.00
212_L216_R1.8241.00
209_I383_A1.8111.00
233_Y242_L1.7911.00
251_Q370_G1.7871.00
200_L203_G1.7681.00
357_L361_V1.7671.00
171_L392_A1.7601.00
246_N374_H1.7421.00
158_T455_N1.7121.00
238_F241_M1.6831.00
206_L414_L1.6671.00
180_S377_E1.6641.00
211_L215_Q1.6541.00
267_E270_L1.6491.00
43_L355_V1.6291.00
415_S450_T1.5831.00
219_Y223_A1.5711.00
245_S249_M1.5641.00
141_C145_V1.5531.00
29_R350_Y1.5501.00
79_S100_I1.5361.00
259_P325_V1.5321.00
308_R311_G1.5311.00
203_G207_A1.5261.00
246_N249_M1.5261.00
246_N250_T1.5201.00
89_A96_G1.5071.00
144_M321_F1.5051.00
112_I115_G1.5001.00
411_I454_L1.4881.00
232_G379_V1.4821.00
259_P327_N1.4631.00
235_L238_F1.4561.00
197_K239_M1.4461.00
216_R220_L1.4301.00
298_Q308_R1.4281.00
261_Y327_N1.4211.00
220_L227_I1.4141.00
247_E251_Q1.3911.00
266_I271_L1.3881.00
137_M140_S1.3871.00
418_V446_A1.3811.00
160_L412_I1.3751.00
140_S321_F1.3611.00
42_H337_N1.3581.00
184_G194_G1.3571.00
84_I87_I1.3561.00
449_I453_V1.3411.00
128_M131_A1.3401.00
341_I347_A1.3180.99
81_V360_I1.3170.99
108_V112_I1.3170.99
437_K441_S1.3150.99
114_G270_L1.3110.99
144_M317_G1.3110.99
111_L132_L1.3110.99
115_G132_L1.3100.99
140_S314_L1.3070.99
294_D401_R1.3060.99
25_R28_D1.3040.99
33_P37_F1.3040.99
83_S100_I1.3020.99
130_A266_I1.3010.99
88_K353_F1.2870.99
46_M50_V1.2850.99
237_W244_E1.2850.99
207_A211_L1.2830.99
216_R221_R1.2790.99
84_I360_I1.2770.99
301_S308_R1.2760.99
147_S310_K1.2670.99
402_E408_A1.2660.99
414_L450_T1.2650.99
182_G193_F1.2610.99
247_E371_F1.2600.99
367_A370_G1.2530.99
231_A235_L1.2460.99
404_L412_I1.2440.99
131_A135_T1.2430.99
64_P258_T1.2400.99
223_A227_I1.2390.99
101_Q333_C1.2380.99
192_T195_A1.2350.99
292_T341_I1.2330.99
24_Y28_D1.2310.99
87_I352_G1.2250.99
132_L135_T1.1920.99
25_R298_Q1.1840.99
99_S333_C1.1840.99
293_S300_V1.1790.99
168_I419_G1.1730.99
144_M318_L1.1620.99
99_S292_T1.1600.99
77_F326_F1.1590.99
296_S299_P1.1550.99
434_E437_K1.1540.99
104_S281_T1.1530.99
260_L263_G1.1440.99
260_L265_G1.1440.99
178_L421_G1.1320.98
285_T289_I1.1310.98
365_F369_S1.1290.98
200_L239_M1.1170.98
106_N281_T1.1110.98
237_W242_L1.1100.98
255_M366_P1.1100.98
130_A263_G1.1050.98
134_G271_L1.1030.98
288_D335_G1.0970.98
361_V365_F1.0960.98
114_G274_L1.0930.98
227_I231_A1.0930.98
436_L439_L1.0920.98
138_L271_L1.0900.98
127_T267_E1.0900.98
268_W271_L1.0880.98
204_V239_M1.0870.98
139_A278_F1.0830.98
160_L164_V1.0740.98
110_P277_V1.0730.98
30_P348_S1.0690.98
240_G243_P1.0680.98
183_G193_F1.0660.98
144_M148_R1.0590.98
81_V322_V1.0570.98
436_L440_L1.0510.97
289_I316_N1.0440.97
24_Y30_P1.0390.97
288_D338_N1.0340.97
145_V149_V1.0310.97
65_A72_I1.0280.97
416_L420_L1.0260.97
30_P35_T1.0150.97
262_Y265_G1.0140.97
179_T193_F1.0140.97
32_L36_L1.0120.97
131_A136_L1.0110.97
140_S147_S1.0090.97
89_A318_L1.0070.97
323_S331_N1.0020.97
134_G266_I1.0000.97
102_G334_F0.9950.96
30_P351_V0.9800.96
45_A340_V0.9740.96
236_A240_G0.9730.96
53_P105_F0.9630.96
100_I355_V0.9630.96
129_M133_F0.9620.96
167_M416_L0.9590.96
94_G311_G0.9570.96
296_S347_A0.9570.96
197_K201_L0.9560.96
244_E374_H0.9560.96
84_I357_L0.9530.96
410_L414_L0.9490.95
197_K200_L0.9490.95
206_L210_I0.9460.95
217_N221_R0.9440.95
136_L324_A0.9440.95
285_T312_G0.9420.95
81_V85_I0.9420.95
151_H310_K0.9350.95
36_L40_C0.9300.95
174_I417_A0.9270.95
211_L457_I0.9260.95
193_F425_Q0.9250.95
40_C358_M0.9210.95
130_A134_G0.9190.95
134_G138_L0.9170.94
113_M117_A0.9170.94
183_G194_G0.9110.94
252_E255_M0.9090.94
42_H46_M0.9060.94
234_A361_V0.9040.94
322_V326_F0.9030.94
167_M396_V0.9030.94
113_M116_T0.8970.94
198_N378_P0.8910.94
207_A210_I0.8830.93
29_R35_T0.8780.93
269_S273_P0.8750.93
100_I352_G0.8740.93
243_P246_N0.8730.93
368_V371_F0.8700.93
350_Y353_F0.8680.93
85_I89_A0.8650.93
201_L235_L0.8650.93
208_L228_A0.8650.93
405_N408_A0.8650.93
127_T270_L0.8640.93
55_L72_I0.8610.92
157_I448_G0.8580.92
86_Q97_L0.8580.92
240_G245_S0.8540.92
236_A241_M0.8540.92
293_S301_S0.8480.92
144_M314_L0.8480.92
31_P34_Q0.8470.92
258_T261_Y0.8460.92
114_G127_T0.8450.92
26_L29_R0.8440.92
253_L257_P0.8420.92
177_G205_V0.8380.91
386_V410_L0.8370.91
195_A198_N0.8310.91
24_Y31_P0.8290.91
253_L365_F0.8280.91
46_M337_N0.8270.91
140_S317_G0.8240.91
177_G202_A0.8230.91
80_G356_A0.8210.91
166_V288_D0.8200.90
285_T316_N0.8190.90
43_L362_L0.8180.90
233_Y375_I0.8150.90
172_S444_I0.8110.90
392_A416_L0.8090.90
407_R411_I0.8070.90
164_V415_S0.8060.90
193_F196_P0.8060.90
78_A328_T0.8050.90
143_E314_L0.8020.89
393_A409_I0.8020.89
296_S300_V0.8010.89
78_A323_S0.7990.89
212_L220_L0.7970.89
135_T139_A0.7970.89
184_G193_F0.7920.89
131_A267_E0.7890.89
135_T143_E0.7880.89
180_S388_F0.7860.89
108_V279_M0.7860.89
286_I309_L0.7860.89
36_L354_V0.7860.89
344_T358_M0.7850.88
307_K311_G0.7840.88
353_F356_A0.7820.88
414_L454_L0.7800.88
128_M132_L0.7780.88
256_V364_L0.7780.88
49_A336_Q0.7760.88
426_P440_L0.7750.88
106_N387_M0.7750.88
156_I452_I0.7710.88
201_L378_P0.7700.87
148_R314_L0.7700.87
279_M283_L0.7680.87
42_H45_A0.7680.87
411_I415_S0.7620.87
318_L322_V0.7610.87
136_L140_S0.7600.87
226_V230_A0.7560.87
353_F357_L0.7550.86
87_I349_R0.7540.86
142_T282_S0.7540.86
138_L266_I0.7540.86
203_G239_M0.7520.86
49_A388_F0.7520.86
53_P103_T0.7500.86
285_T332_S0.7470.86
73_S369_S0.7460.86
74_M77_F0.7450.86
78_A322_V0.7450.86
55_L380_L0.7440.86
362_L368_V0.7440.86
182_G194_G0.7410.85
338_N341_I0.7390.85
99_S289_I0.7370.85
422_V446_A0.7350.85
268_W272_L0.7340.85
180_S380_L0.7340.85
109_A112_I0.7320.85
239_M368_V0.7320.85
103_T107_F0.7290.84
179_T182_G0.7280.84
152_L156_I0.7270.84
98_L352_G0.7250.84
413_A417_A0.7230.84
213_N343_L0.7210.84
75_S329_F0.7200.84
212_L228_A0.7190.84
136_L143_E0.7170.83
38_A42_H0.7170.83
99_S340_V0.7160.83
50_V79_S0.7130.83
256_V363_G0.7130.83
389_G393_A0.7130.83
104_S332_S0.7120.83
208_L227_I0.7090.83
418_V422_V0.7060.83
419_G447_G0.7050.82
139_A143_E0.7050.82
104_S107_F0.7040.82
85_I315_A0.7040.82
127_T131_A0.7030.82
357_L401_R0.7030.82
213_N410_L0.7010.82
134_G137_M0.7000.82
134_G147_S0.6990.82
393_A412_I0.6980.82
264_L325_V0.6980.82
412_I416_L0.6950.82
321_F325_V0.6940.81
214_R393_A0.6930.81
77_F364_L0.6920.81
228_A231_A0.6900.81
143_E278_F0.6880.81
209_I386_V0.6870.81
56_L112_I0.6870.81
52_T180_S0.6860.81
160_L408_A0.6850.81
279_M291_A0.6840.81
292_T338_N0.6840.81
75_S79_S0.6830.80
399_V402_E0.6800.80
138_L142_T0.6800.80
46_M100_I0.6790.80
39_A355_V0.6790.80
404_L408_A0.6750.80
182_G199_L0.6730.79
247_E374_H0.6720.79
50_V75_S0.6700.79
181_I385_L0.6690.79
101_Q285_T0.6690.79
57_I229_M0.6680.79
299_P307_K0.6670.79
256_V259_P0.6670.79
176_V180_S0.6660.79
281_T284_E0.6640.79
240_G244_E0.6640.79
229_M383_A0.6630.78
125_V129_M0.6610.78
212_L231_A0.6610.78
225_L340_V0.6610.78
167_M399_V0.6590.78
211_L216_R0.6590.78
46_M397_R0.6590.78
370_G373_Q0.6570.78
443_G447_G0.6570.78
75_S103_T0.6530.77
192_T241_M0.6530.77
200_L235_L0.6520.77
52_T55_L0.6510.77
143_E281_T0.6490.77
48_V54_A0.6480.77
36_L249_M0.6470.77
106_N169_I0.6460.77
342_Q397_R0.6450.77
284_E316_N0.6450.77
169_I334_F0.6440.76
358_M362_L0.6430.76
292_T333_C0.6410.76
130_A265_G0.6400.76
411_I459_P0.6380.76
131_A134_G0.6380.76
166_V169_I0.6380.76
136_L139_A0.6380.76
281_T332_S0.6360.76
284_E332_S0.6340.75
229_M283_L0.6340.75
152_L306_M0.6340.75
297_E347_A0.6330.75
275_M278_F0.6330.75
214_R391_I0.6330.75
404_L409_I0.6330.75
32_L358_M0.6320.75
97_L312_G0.6310.75
320_S331_N0.6240.74
370_G374_H0.6240.74
392_A396_V0.6230.74
195_A200_L0.6220.74
26_L30_P0.6200.74
134_G139_A0.6200.74
222_V459_P0.6190.74
74_M78_A0.6140.73
363_G369_S0.6130.73
198_N201_L0.6130.73
81_V326_F0.6130.73
179_T185_Y0.6130.73
133_F139_A0.6120.73
247_E367_A0.6110.73
236_A239_M0.6090.72
158_T339_G0.6080.72
143_E147_S0.6070.72
115_G128_M0.6060.72
159_P409_I0.6050.72
133_F321_F0.6050.72
162_S366_P0.6010.71
207_A434_E0.6000.71
146_I313_V0.6000.71
124_D128_M0.5990.71
78_A319_N0.5990.71
417_A420_L0.5990.71
298_Q301_S0.5980.71
111_L274_L0.5980.71
82_A315_A0.5980.71
42_H340_V0.5970.71
246_N326_F0.5970.71
316_N413_A0.5960.71
237_W457_I0.5930.70
419_G443_G0.5930.70
237_W240_G0.5910.70
201_L379_V0.5910.70
77_F345_G0.5910.70
174_I420_L0.5900.70
220_L224_S0.5900.70
221_R404_L0.5890.70
209_I396_V0.5890.70
83_S356_A0.5880.70
141_C254_I0.5870.70
257_P386_V0.5870.70
112_I116_T0.5870.70
98_L296_S0.5860.69
199_L203_G0.5850.69
230_A371_F0.5850.69
133_F136_L0.5840.69
274_L378_P0.5840.69
336_Q388_F0.5830.69
212_L224_S0.5820.69
152_L157_I0.5820.69
251_Q366_P0.5810.69
312_G316_N0.5810.69
229_M380_L0.5810.69
447_G451_A0.5800.69
238_F256_V0.5790.69
278_F320_S0.5760.68
50_V53_P0.5760.68
287_G419_G0.5740.68
335_G394_S0.5730.68
288_D394_S0.5720.68
286_I290_T0.5720.68
139_A146_I0.5720.68
111_L115_G0.5710.68
174_I413_A0.5710.68
95_S308_R0.5700.67
163_G395_G0.5700.67
132_L136_L0.5690.67
321_F324_A0.5690.67
216_R219_Y0.5680.67
50_V359_L0.5660.67
167_M209_I0.5650.67
180_S384_T0.5650.67
29_R32_L0.5650.67
52_T56_L0.5650.67
231_A234_A0.5650.67
346_V380_L0.5640.67
157_I218_P0.5640.67
320_S323_S0.5640.67
295_V342_Q0.5630.66
183_G199_L0.5620.66
39_A166_V0.5620.66
207_A230_A0.5600.66
127_T130_A0.5600.66
79_S99_S0.5600.66
291_A394_S0.5590.66
62_G65_A0.5560.65
165_V206_L0.5550.65
101_Q320_S0.5550.65
164_V404_L0.5550.65
243_P247_E0.5540.65
203_G217_N0.5540.65
254_I365_F0.5540.65
151_H155_R0.5500.65
107_F320_S0.5490.64
233_Y244_E0.5490.64
167_M392_A0.5460.64
43_L273_P0.5440.64
397_R401_R0.5430.64
38_A157_I0.5430.64
114_G128_M0.5420.64
403_P408_A0.5410.63
131_A270_L0.5410.63
231_A238_F0.5410.63
170_G177_G0.5410.63
28_D348_S0.5410.63
247_E370_G0.5380.63
106_N332_S0.5380.63
132_L212_L0.5380.63
435_W438_N0.5360.63
62_G116_T0.5350.63
292_T372_V0.5350.63
109_A113_M0.5350.63
74_M327_N0.5350.63
318_L353_F0.5350.63
227_I230_A0.5340.62
80_G84_I0.5340.62
184_G192_T0.5340.62
218_P228_A0.5330.62
285_T333_C0.5330.62
198_N241_M0.5320.62
172_S442_S0.5320.62
281_T288_D0.5310.62
225_L297_E0.5300.62
38_A335_G0.5270.61
84_I88_K0.5270.61
150_L286_I0.5260.61
258_T263_G0.5260.61
125_V131_A0.5250.61
63_L329_F0.5240.61
103_T177_G0.5240.61
77_F261_Y0.5240.61
402_E409_I0.5240.61
432_A437_K0.5230.61
105_F169_I0.5230.61
240_G379_V0.5210.60
290_T345_G0.5200.60
389_G409_I0.5190.60
452_I460_P0.5190.60
399_V404_L0.5190.60
133_F142_T0.5180.60
233_Y237_W0.5170.60
164_V451_A0.5170.60
218_P221_R0.5170.60
103_T288_D0.5160.60
209_I212_L0.5160.60
74_M133_F0.5160.60
281_T289_I0.5150.60
103_T169_I0.5150.60
234_A249_M0.5150.60
137_M264_L0.5140.59
397_R405_N0.5130.59
140_S143_E0.5120.59
199_L423_S0.5100.59
361_V439_L0.5100.59
335_G445_A0.5100.59
141_C144_M0.5090.59
129_M132_L0.5090.59
293_S297_E0.5090.59
300_V308_R0.5080.59
172_S443_G0.5070.58
155_R456_L0.5070.58
130_A133_F0.5070.58
213_N221_R0.5060.58
318_L321_F0.5060.58
399_V412_I0.5060.58
146_I247_E0.5060.58
106_N277_V0.5050.58
414_L420_L0.5050.58
40_C182_G0.5050.58
178_L182_G0.5050.58
349_R353_F0.5050.58
337_N340_V0.5040.58
77_F441_S0.5030.58
279_M452_I0.5020.58
184_G198_N0.5020.58
79_S277_V0.5010.58
101_Q288_D0.5010.58
88_K357_L0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qe7A 2 0.8596 100 0.44 Contact Map
3o7qA 1 0.4363 96 0.945 Contact Map
1pw4A 1 0.8726 91.9 0.954 Contact Map
2cfqA 1 0.4708 88.1 0.958 Contact Map
4ikvA 1 0.8963 87.7 0.958 Contact Map
4j05A 3 0.8078 86.2 0.959 Contact Map
4u4vA 1 0.8467 82 0.961 Contact Map
2gfpA 2 0.4233 81.4 0.961 Contact Map
3wdoA 1 0.5724 72.5 0.964 Contact Map
2jlnA 1 0.7862 67.8 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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