XANP - ECOLI - GREMLIN Contacts

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XANP - Xanthine permease XanP

UniProt:	P0AGM9	Sequences: MSVSTLESENAQPVAQTQNSELIYRLEDRPPLPQTLFAACQHLLAMFVAVITPALLICQALGLPAQDTQHIISMSLFASGVASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKTGGADVPTMMAALFGTLMLASCTEMVISRVLHLARRIITPLVSGVVVMIIGLSLIQVGLTSIGGGYAAMSDNTFGAPKNLLLAGVVLALIILLNRQRNPYLRVASLVIAMAAGYALAWFMGMLPESNEPMTQELIMVPTPLYYGLGIEWSLLLPLMLVFMITSLETIGDITATSDVSEQPVSGPLYMKRLKGGVLANGLNSFVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLIVLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVRIVSREPLNRRAILIIALSLAVGLGVSQQPLILQFAPEWLKNLLSSGIAAGGITAIVLNLIFPPEKQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG11194
Length:	463 (403)
Sequences:	4348 (2218)
Seq/√Len:	110.5

ECOLI - XANP UACT XANQ YBBY RUTG URAA
BACSU - PUCK PBUX PUCJ YWDJ PYRP

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
208_L	231_A	5.470	1.00
204_V	235_L	5.313	1.00
181_I	202_A	4.245	1.00
168_I	447_G	4.123	1.00
209_I	228_A	4.042	1.00
253_L	367_A	3.910	1.00
234_A	238_F	3.755	1.00
77_F	363_G	3.732	1.00
142_T	275_M	3.237	1.00
212_L	227_I	3.220	1.00
418_V	450_T	3.202	1.00
201_L	236_A	3.177	1.00
80_G	360_I	2.854	1.00
244_E	247_E	2.830	1.00
260_L	325_V	2.814	1.00
201_L	241_M	2.791	1.00
204_V	231_A	2.744	1.00
251_Q	367_A	2.689	1.00
415_S	451_A	2.671	1.00
137_M	324_A	2.641	1.00
407_R	459_P	2.607	1.00
206_L	386_V	2.544	1.00
289_I	312_G	2.487	1.00
82_A	319_N	2.482	1.00
245_S	250_T	2.449	1.00
43_L	358_M	2.404	1.00
230_A	234_A	2.399	1.00
39_A	354_V	2.398	1.00
96_G	306_M	2.372	1.00
201_L	239_M	2.316	1.00
133_F	324_A	2.206	1.00
35_T	354_V	2.205	1.00
200_L	204_V	2.199	1.00
78_A	326_F	2.199	1.00
204_V	208_L	2.150	1.00
249_M	252_E	2.146	1.00
234_A	237_W	2.118	1.00
84_I	356_A	2.109	1.00
36_L	358_M	2.098	1.00
84_I	353_F	2.097	1.00
156_I	456_L	2.082	1.00
137_M	321_F	2.077	1.00
208_L	212_L	2.071	1.00
208_L	235_L	2.040	1.00
346_V	351_V	2.008	1.00
57_I	111_L	1.978	1.00
196_P	200_L	1.978	1.00
87_I	353_F	1.951	1.00
197_K	241_M	1.925	1.00
124_D	127_T	1.903	1.00
233_Y	374_H	1.900	1.00
27_E	298_Q	1.877	1.00
235_L	239_M	1.845	1.00
453_V	457_I	1.842	1.00
77_F	360_I	1.836	1.00
137_M	141_C	1.835	1.00
212_L	216_R	1.824	1.00
209_I	383_A	1.811	1.00
233_Y	242_L	1.791	1.00
251_Q	370_G	1.787	1.00
200_L	203_G	1.768	1.00
357_L	361_V	1.767	1.00
171_L	392_A	1.760	1.00
246_N	374_H	1.742	1.00
158_T	455_N	1.712	1.00
238_F	241_M	1.683	1.00
206_L	414_L	1.667	1.00
180_S	377_E	1.664	1.00
211_L	215_Q	1.654	1.00
267_E	270_L	1.649	1.00
43_L	355_V	1.629	1.00
415_S	450_T	1.583	1.00
219_Y	223_A	1.571	1.00
245_S	249_M	1.564	1.00
141_C	145_V	1.553	1.00
29_R	350_Y	1.550	1.00
79_S	100_I	1.536	1.00
259_P	325_V	1.532	1.00
308_R	311_G	1.531	1.00
203_G	207_A	1.526	1.00
246_N	249_M	1.526	1.00
246_N	250_T	1.520	1.00
89_A	96_G	1.507	1.00
144_M	321_F	1.505	1.00
112_I	115_G	1.500	1.00
411_I	454_L	1.488	1.00
232_G	379_V	1.482	1.00
259_P	327_N	1.463	1.00
235_L	238_F	1.456	1.00
197_K	239_M	1.446	1.00
216_R	220_L	1.430	1.00
298_Q	308_R	1.428	1.00
261_Y	327_N	1.421	1.00
220_L	227_I	1.414	1.00
247_E	251_Q	1.391	1.00
266_I	271_L	1.388	1.00
137_M	140_S	1.387	1.00
418_V	446_A	1.381	1.00
160_L	412_I	1.375	1.00
140_S	321_F	1.361	1.00
42_H	337_N	1.358	1.00
184_G	194_G	1.357	1.00
84_I	87_I	1.356	1.00
449_I	453_V	1.341	1.00
128_M	131_A	1.340	1.00
341_I	347_A	1.318	0.99
81_V	360_I	1.317	0.99
108_V	112_I	1.317	0.99
437_K	441_S	1.315	0.99
114_G	270_L	1.311	0.99
144_M	317_G	1.311	0.99
111_L	132_L	1.311	0.99
115_G	132_L	1.310	0.99
140_S	314_L	1.307	0.99
294_D	401_R	1.306	0.99
25_R	28_D	1.304	0.99
33_P	37_F	1.304	0.99
83_S	100_I	1.302	0.99
130_A	266_I	1.301	0.99
88_K	353_F	1.287	0.99
46_M	50_V	1.285	0.99
237_W	244_E	1.285	0.99
207_A	211_L	1.283	0.99
216_R	221_R	1.279	0.99
84_I	360_I	1.277	0.99
301_S	308_R	1.276	0.99
147_S	310_K	1.267	0.99
402_E	408_A	1.266	0.99
414_L	450_T	1.265	0.99
182_G	193_F	1.261	0.99
247_E	371_F	1.260	0.99
367_A	370_G	1.253	0.99
231_A	235_L	1.246	0.99
404_L	412_I	1.244	0.99
131_A	135_T	1.243	0.99
64_P	258_T	1.240	0.99
223_A	227_I	1.239	0.99
101_Q	333_C	1.238	0.99
192_T	195_A	1.235	0.99
292_T	341_I	1.233	0.99
24_Y	28_D	1.231	0.99
87_I	352_G	1.225	0.99
132_L	135_T	1.192	0.99
25_R	298_Q	1.184	0.99
99_S	333_C	1.184	0.99
293_S	300_V	1.179	0.99
168_I	419_G	1.173	0.99
144_M	318_L	1.162	0.99
99_S	292_T	1.160	0.99
77_F	326_F	1.159	0.99
296_S	299_P	1.155	0.99
434_E	437_K	1.154	0.99
104_S	281_T	1.153	0.99
260_L	263_G	1.144	0.99
260_L	265_G	1.144	0.99
178_L	421_G	1.132	0.98
285_T	289_I	1.131	0.98
365_F	369_S	1.129	0.98
200_L	239_M	1.117	0.98
106_N	281_T	1.111	0.98
237_W	242_L	1.110	0.98
255_M	366_P	1.110	0.98
130_A	263_G	1.105	0.98
134_G	271_L	1.103	0.98
288_D	335_G	1.097	0.98
361_V	365_F	1.096	0.98
114_G	274_L	1.093	0.98
227_I	231_A	1.093	0.98
436_L	439_L	1.092	0.98
138_L	271_L	1.090	0.98
127_T	267_E	1.090	0.98
268_W	271_L	1.088	0.98
204_V	239_M	1.087	0.98
139_A	278_F	1.083	0.98
160_L	164_V	1.074	0.98
110_P	277_V	1.073	0.98
30_P	348_S	1.069	0.98
240_G	243_P	1.068	0.98
183_G	193_F	1.066	0.98
144_M	148_R	1.059	0.98
81_V	322_V	1.057	0.98
436_L	440_L	1.051	0.97
289_I	316_N	1.044	0.97
24_Y	30_P	1.039	0.97
288_D	338_N	1.034	0.97
145_V	149_V	1.031	0.97
65_A	72_I	1.028	0.97
416_L	420_L	1.026	0.97
30_P	35_T	1.015	0.97
262_Y	265_G	1.014	0.97
179_T	193_F	1.014	0.97
32_L	36_L	1.012	0.97
131_A	136_L	1.011	0.97
140_S	147_S	1.009	0.97
89_A	318_L	1.007	0.97
323_S	331_N	1.002	0.97
134_G	266_I	1.000	0.97
102_G	334_F	0.995	0.96
30_P	351_V	0.980	0.96
45_A	340_V	0.974	0.96
236_A	240_G	0.973	0.96
53_P	105_F	0.963	0.96
100_I	355_V	0.963	0.96
129_M	133_F	0.962	0.96
167_M	416_L	0.959	0.96
94_G	311_G	0.957	0.96
296_S	347_A	0.957	0.96
197_K	201_L	0.956	0.96
244_E	374_H	0.956	0.96
84_I	357_L	0.953	0.96
410_L	414_L	0.949	0.95
197_K	200_L	0.949	0.95
206_L	210_I	0.946	0.95
217_N	221_R	0.944	0.95
136_L	324_A	0.944	0.95
285_T	312_G	0.942	0.95
81_V	85_I	0.942	0.95
151_H	310_K	0.935	0.95
36_L	40_C	0.930	0.95
174_I	417_A	0.927	0.95
211_L	457_I	0.926	0.95
193_F	425_Q	0.925	0.95
40_C	358_M	0.921	0.95
130_A	134_G	0.919	0.95
134_G	138_L	0.917	0.94
113_M	117_A	0.917	0.94
183_G	194_G	0.911	0.94
252_E	255_M	0.909	0.94
42_H	46_M	0.906	0.94
234_A	361_V	0.904	0.94
322_V	326_F	0.903	0.94
167_M	396_V	0.903	0.94
113_M	116_T	0.897	0.94
198_N	378_P	0.891	0.94
207_A	210_I	0.883	0.93
29_R	35_T	0.878	0.93
269_S	273_P	0.875	0.93
100_I	352_G	0.874	0.93
243_P	246_N	0.873	0.93
368_V	371_F	0.870	0.93
350_Y	353_F	0.868	0.93
85_I	89_A	0.865	0.93
201_L	235_L	0.865	0.93
208_L	228_A	0.865	0.93
405_N	408_A	0.865	0.93
127_T	270_L	0.864	0.93
55_L	72_I	0.861	0.92
157_I	448_G	0.858	0.92
86_Q	97_L	0.858	0.92
240_G	245_S	0.854	0.92
236_A	241_M	0.854	0.92
293_S	301_S	0.848	0.92
144_M	314_L	0.848	0.92
31_P	34_Q	0.847	0.92
258_T	261_Y	0.846	0.92
114_G	127_T	0.845	0.92
26_L	29_R	0.844	0.92
253_L	257_P	0.842	0.92
177_G	205_V	0.838	0.91
386_V	410_L	0.837	0.91
195_A	198_N	0.831	0.91
24_Y	31_P	0.829	0.91
253_L	365_F	0.828	0.91
46_M	337_N	0.827	0.91
140_S	317_G	0.824	0.91
177_G	202_A	0.823	0.91
80_G	356_A	0.821	0.91
166_V	288_D	0.820	0.90
285_T	316_N	0.819	0.90
43_L	362_L	0.818	0.90
233_Y	375_I	0.815	0.90
172_S	444_I	0.811	0.90
392_A	416_L	0.809	0.90
407_R	411_I	0.807	0.90
164_V	415_S	0.806	0.90
193_F	196_P	0.806	0.90
78_A	328_T	0.805	0.90
143_E	314_L	0.802	0.89
393_A	409_I	0.802	0.89
296_S	300_V	0.801	0.89
78_A	323_S	0.799	0.89
212_L	220_L	0.797	0.89
135_T	139_A	0.797	0.89
184_G	193_F	0.792	0.89
131_A	267_E	0.789	0.89
135_T	143_E	0.788	0.89
180_S	388_F	0.786	0.89
108_V	279_M	0.786	0.89
286_I	309_L	0.786	0.89
36_L	354_V	0.786	0.89
344_T	358_M	0.785	0.88
307_K	311_G	0.784	0.88
353_F	356_A	0.782	0.88
414_L	454_L	0.780	0.88
128_M	132_L	0.778	0.88
256_V	364_L	0.778	0.88
49_A	336_Q	0.776	0.88
426_P	440_L	0.775	0.88
106_N	387_M	0.775	0.88
156_I	452_I	0.771	0.88
201_L	378_P	0.770	0.87
148_R	314_L	0.770	0.87
279_M	283_L	0.768	0.87
42_H	45_A	0.768	0.87
411_I	415_S	0.762	0.87
318_L	322_V	0.761	0.87
136_L	140_S	0.760	0.87
226_V	230_A	0.756	0.87
353_F	357_L	0.755	0.86
87_I	349_R	0.754	0.86
142_T	282_S	0.754	0.86
138_L	266_I	0.754	0.86
203_G	239_M	0.752	0.86
49_A	388_F	0.752	0.86
53_P	103_T	0.750	0.86
285_T	332_S	0.747	0.86
73_S	369_S	0.746	0.86
74_M	77_F	0.745	0.86
78_A	322_V	0.745	0.86
55_L	380_L	0.744	0.86
362_L	368_V	0.744	0.86
182_G	194_G	0.741	0.85
338_N	341_I	0.739	0.85
99_S	289_I	0.737	0.85
422_V	446_A	0.735	0.85
268_W	272_L	0.734	0.85
180_S	380_L	0.734	0.85
109_A	112_I	0.732	0.85
239_M	368_V	0.732	0.85
103_T	107_F	0.729	0.84
179_T	182_G	0.728	0.84
152_L	156_I	0.727	0.84
98_L	352_G	0.725	0.84
413_A	417_A	0.723	0.84
213_N	343_L	0.721	0.84
75_S	329_F	0.720	0.84
212_L	228_A	0.719	0.84
136_L	143_E	0.717	0.83
38_A	42_H	0.717	0.83
99_S	340_V	0.716	0.83
50_V	79_S	0.713	0.83
256_V	363_G	0.713	0.83
389_G	393_A	0.713	0.83
104_S	332_S	0.712	0.83
208_L	227_I	0.709	0.83
418_V	422_V	0.706	0.83
419_G	447_G	0.705	0.82
139_A	143_E	0.705	0.82
104_S	107_F	0.704	0.82
85_I	315_A	0.704	0.82
127_T	131_A	0.703	0.82
357_L	401_R	0.703	0.82
213_N	410_L	0.701	0.82
134_G	137_M	0.700	0.82
134_G	147_S	0.699	0.82
393_A	412_I	0.698	0.82
264_L	325_V	0.698	0.82
412_I	416_L	0.695	0.82
321_F	325_V	0.694	0.81
214_R	393_A	0.693	0.81
77_F	364_L	0.692	0.81
228_A	231_A	0.690	0.81
143_E	278_F	0.688	0.81
209_I	386_V	0.687	0.81
56_L	112_I	0.687	0.81
52_T	180_S	0.686	0.81
160_L	408_A	0.685	0.81
279_M	291_A	0.684	0.81
292_T	338_N	0.684	0.81
75_S	79_S	0.683	0.80
399_V	402_E	0.680	0.80
138_L	142_T	0.680	0.80
46_M	100_I	0.679	0.80
39_A	355_V	0.679	0.80
404_L	408_A	0.675	0.80
182_G	199_L	0.673	0.79
247_E	374_H	0.672	0.79
50_V	75_S	0.670	0.79
181_I	385_L	0.669	0.79
101_Q	285_T	0.669	0.79
57_I	229_M	0.668	0.79
299_P	307_K	0.667	0.79
256_V	259_P	0.667	0.79
176_V	180_S	0.666	0.79
281_T	284_E	0.664	0.79
240_G	244_E	0.664	0.79
229_M	383_A	0.663	0.78
125_V	129_M	0.661	0.78
212_L	231_A	0.661	0.78
225_L	340_V	0.661	0.78
167_M	399_V	0.659	0.78
211_L	216_R	0.659	0.78
46_M	397_R	0.659	0.78
370_G	373_Q	0.657	0.78
443_G	447_G	0.657	0.78
75_S	103_T	0.653	0.77
192_T	241_M	0.653	0.77
200_L	235_L	0.652	0.77
52_T	55_L	0.651	0.77
143_E	281_T	0.649	0.77
48_V	54_A	0.648	0.77
36_L	249_M	0.647	0.77
106_N	169_I	0.646	0.77
342_Q	397_R	0.645	0.77
284_E	316_N	0.645	0.77
169_I	334_F	0.644	0.76
358_M	362_L	0.643	0.76
292_T	333_C	0.641	0.76
130_A	265_G	0.640	0.76
411_I	459_P	0.638	0.76
131_A	134_G	0.638	0.76
166_V	169_I	0.638	0.76
136_L	139_A	0.638	0.76
281_T	332_S	0.636	0.76
284_E	332_S	0.634	0.75
229_M	283_L	0.634	0.75
152_L	306_M	0.634	0.75
297_E	347_A	0.633	0.75
275_M	278_F	0.633	0.75
214_R	391_I	0.633	0.75
404_L	409_I	0.633	0.75
32_L	358_M	0.632	0.75
97_L	312_G	0.631	0.75
320_S	331_N	0.624	0.74
370_G	374_H	0.624	0.74
392_A	396_V	0.623	0.74
195_A	200_L	0.622	0.74
26_L	30_P	0.620	0.74
134_G	139_A	0.620	0.74
222_V	459_P	0.619	0.74
74_M	78_A	0.614	0.73
363_G	369_S	0.613	0.73
198_N	201_L	0.613	0.73
81_V	326_F	0.613	0.73
179_T	185_Y	0.613	0.73
133_F	139_A	0.612	0.73
247_E	367_A	0.611	0.73
236_A	239_M	0.609	0.72
158_T	339_G	0.608	0.72
143_E	147_S	0.607	0.72
115_G	128_M	0.606	0.72
159_P	409_I	0.605	0.72
133_F	321_F	0.605	0.72
162_S	366_P	0.601	0.71
207_A	434_E	0.600	0.71
146_I	313_V	0.600	0.71
124_D	128_M	0.599	0.71
78_A	319_N	0.599	0.71
417_A	420_L	0.599	0.71
298_Q	301_S	0.598	0.71
111_L	274_L	0.598	0.71
82_A	315_A	0.598	0.71
42_H	340_V	0.597	0.71
246_N	326_F	0.597	0.71
316_N	413_A	0.596	0.71
237_W	457_I	0.593	0.70
419_G	443_G	0.593	0.70
237_W	240_G	0.591	0.70
201_L	379_V	0.591	0.70
77_F	345_G	0.591	0.70
174_I	420_L	0.590	0.70
220_L	224_S	0.590	0.70
221_R	404_L	0.589	0.70
209_I	396_V	0.589	0.70
83_S	356_A	0.588	0.70
141_C	254_I	0.587	0.70
257_P	386_V	0.587	0.70
112_I	116_T	0.587	0.70
98_L	296_S	0.586	0.69
199_L	203_G	0.585	0.69
230_A	371_F	0.585	0.69
133_F	136_L	0.584	0.69
274_L	378_P	0.584	0.69
336_Q	388_F	0.583	0.69
212_L	224_S	0.582	0.69
152_L	157_I	0.582	0.69
251_Q	366_P	0.581	0.69
312_G	316_N	0.581	0.69
229_M	380_L	0.581	0.69
447_G	451_A	0.580	0.69
238_F	256_V	0.579	0.69
278_F	320_S	0.576	0.68
50_V	53_P	0.576	0.68
287_G	419_G	0.574	0.68
335_G	394_S	0.573	0.68
288_D	394_S	0.572	0.68
286_I	290_T	0.572	0.68
139_A	146_I	0.572	0.68
111_L	115_G	0.571	0.68
174_I	413_A	0.571	0.68
95_S	308_R	0.570	0.67
163_G	395_G	0.570	0.67
132_L	136_L	0.569	0.67
321_F	324_A	0.569	0.67
216_R	219_Y	0.568	0.67
50_V	359_L	0.566	0.67
167_M	209_I	0.565	0.67
180_S	384_T	0.565	0.67
29_R	32_L	0.565	0.67
52_T	56_L	0.565	0.67
231_A	234_A	0.565	0.67
346_V	380_L	0.564	0.67
157_I	218_P	0.564	0.67
320_S	323_S	0.564	0.67
295_V	342_Q	0.563	0.66
183_G	199_L	0.562	0.66
39_A	166_V	0.562	0.66
207_A	230_A	0.560	0.66
127_T	130_A	0.560	0.66
79_S	99_S	0.560	0.66
291_A	394_S	0.559	0.66
62_G	65_A	0.556	0.65
165_V	206_L	0.555	0.65
101_Q	320_S	0.555	0.65
164_V	404_L	0.555	0.65
243_P	247_E	0.554	0.65
203_G	217_N	0.554	0.65
254_I	365_F	0.554	0.65
151_H	155_R	0.550	0.65
107_F	320_S	0.549	0.64
233_Y	244_E	0.549	0.64
167_M	392_A	0.546	0.64
43_L	273_P	0.544	0.64
397_R	401_R	0.543	0.64
38_A	157_I	0.543	0.64
114_G	128_M	0.542	0.64
403_P	408_A	0.541	0.63
131_A	270_L	0.541	0.63
231_A	238_F	0.541	0.63
170_G	177_G	0.541	0.63
28_D	348_S	0.541	0.63
247_E	370_G	0.538	0.63
106_N	332_S	0.538	0.63
132_L	212_L	0.538	0.63
435_W	438_N	0.536	0.63
62_G	116_T	0.535	0.63
292_T	372_V	0.535	0.63
109_A	113_M	0.535	0.63
74_M	327_N	0.535	0.63
318_L	353_F	0.535	0.63
227_I	230_A	0.534	0.62
80_G	84_I	0.534	0.62
184_G	192_T	0.534	0.62
218_P	228_A	0.533	0.62
285_T	333_C	0.533	0.62
198_N	241_M	0.532	0.62
172_S	442_S	0.532	0.62
281_T	288_D	0.531	0.62
225_L	297_E	0.530	0.62
38_A	335_G	0.527	0.61
84_I	88_K	0.527	0.61
150_L	286_I	0.526	0.61
258_T	263_G	0.526	0.61
125_V	131_A	0.525	0.61
63_L	329_F	0.524	0.61
103_T	177_G	0.524	0.61
77_F	261_Y	0.524	0.61
402_E	409_I	0.524	0.61
432_A	437_K	0.523	0.61
105_F	169_I	0.523	0.61
240_G	379_V	0.521	0.60
290_T	345_G	0.520	0.60
389_G	409_I	0.519	0.60
452_I	460_P	0.519	0.60
399_V	404_L	0.519	0.60
133_F	142_T	0.518	0.60
233_Y	237_W	0.517	0.60
164_V	451_A	0.517	0.60
218_P	221_R	0.517	0.60
103_T	288_D	0.516	0.60
209_I	212_L	0.516	0.60
74_M	133_F	0.516	0.60
281_T	289_I	0.515	0.60
103_T	169_I	0.515	0.60
234_A	249_M	0.515	0.60
137_M	264_L	0.514	0.59
397_R	405_N	0.513	0.59
140_S	143_E	0.512	0.59
199_L	423_S	0.510	0.59
361_V	439_L	0.510	0.59
335_G	445_A	0.510	0.59
141_C	144_M	0.509	0.59
129_M	132_L	0.509	0.59
293_S	297_E	0.509	0.59
300_V	308_R	0.508	0.59
172_S	443_G	0.507	0.58
155_R	456_L	0.507	0.58
130_A	133_F	0.507	0.58
213_N	221_R	0.506	0.58
318_L	321_F	0.506	0.58
399_V	412_I	0.506	0.58
146_I	247_E	0.506	0.58
106_N	277_V	0.505	0.58
414_L	420_L	0.505	0.58
40_C	182_G	0.505	0.58
178_L	182_G	0.505	0.58
349_R	353_F	0.505	0.58
337_N	340_V	0.504	0.58
77_F	441_S	0.503	0.58
279_M	452_I	0.502	0.58
184_G	198_N	0.502	0.58
79_S	277_V	0.501	0.58
101_Q	288_D	0.501	0.58
88_K	357_L	0.500	0.57

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3qe7A	2	0.8596	100	0.44	Contact Map
3o7qA	1	0.4363	96	0.945	Contact Map
1pw4A	1	0.8726	91.9	0.954	Contact Map
2cfqA	1	0.4708	88.1	0.958	Contact Map
4ikvA	1	0.8963	87.7	0.958	Contact Map
4j05A	3	0.8078	86.2	0.959	Contact Map
4u4vA	1	0.8467	82	0.961	Contact Map
2gfpA	2	0.4233	81.4	0.961	Contact Map
3wdoA	1	0.5724	72.5	0.964	Contact Map
2jlnA	1	0.7862	67.8	0.965	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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