GREMLIN Database
URAA - Uracil permease
UniProt: P0AGM7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12129
Length: 429 (392)
Sequences: 4296 (2229)
Seq/√Len: 112.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
164_T195_L5.1181.00
168_V191_V5.1151.00
95_I278_G4.7761.00
144_A162_S4.2751.00
131_V395_A4.0271.00
169_T188_G3.6811.00
48_L317_S3.5941.00
100_L232_L3.4601.00
194_A198_A3.4551.00
212_W321_K3.4031.00
205_T209_N3.3451.00
172_G187_I3.2041.00
375_I398_V3.0791.00
92_G223_F3.0561.00
88_E222_R3.0501.00
161_I196_S2.8991.00
204_T207_I2.8581.00
51_G314_I2.7131.00
89_V222_R2.7081.00
164_T191_V2.6901.00
96_M228_I2.6611.00
219_Y279_F2.6411.00
372_I399_G2.6401.00
161_I201_I2.6221.00
210_A321_K2.5681.00
364_Q407_K2.4041.00
246_L266_S2.3451.00
166_L340_L2.3341.00
53_G273_S2.3201.00
21_S308_G2.3031.00
25_L312_F2.2981.00
161_I199_M2.2901.00
193_Y202_V2.2211.00
18_I312_F2.2071.00
95_I275_V2.2061.00
190_L194_A2.2001.00
164_T168_V2.1791.00
99_V103_L2.1431.00
64_K260_D2.1361.00
160_I164_T2.0891.00
49_F280_F2.0581.00
55_L307_G2.0551.00
55_L310_A2.0381.00
17_T308_G2.0131.00
168_V172_G2.0131.00
157_K201_I1.9601.00
168_V195_L1.9531.00
119_L404_L1.9491.00
102_C268_F1.9431.00
194_A197_F1.9321.00
207_I325_A1.9291.00
300_V305_V1.9161.00
401_G405_I1.9061.00
99_V275_V1.9041.00
39_F79_V1.8861.00
58_L307_G1.8861.00
169_T337_V1.8701.00
206_P328_M1.8661.00
208_I211_H1.8641.00
95_I221_P1.8601.00
105_S268_F1.8341.00
79_V90_A1.7761.00
102_C275_V1.7691.00
193_Y328_M1.7611.00
256_D259_R1.7561.00
48_L314_I1.7381.00
156_S160_I1.7231.00
9_S255_K1.7101.00
134_L346_G1.7091.00
104_V239_I1.7061.00
171_L175_L1.7061.00
210_A324_A1.7011.00
195_L199_M1.6951.00
198_A201_I1.6681.00
205_T208_I1.6571.00
121_P403_S1.6571.00
86_G89_V1.6271.00
172_G176_F1.6201.00
207_I210_A1.6051.00
94_F278_G1.5921.00
143_M331_L1.5791.00
311_I315_L1.5381.00
224_E227_A1.5361.00
25_L309_A1.5291.00
259_R262_G1.5181.00
372_I398_V1.5151.00
368_L402_L1.5041.00
11_R304_W1.5041.00
262_G265_R1.4871.00
160_I163_I1.4811.00
50_N68_Y1.4701.00
179_F183_I1.4631.00
163_I167_A1.4571.00
180_L187_I1.4511.00
98_G275_V1.4511.00
397_I401_G1.4491.00
157_K199_M1.4451.00
192_G333_V1.4431.00
166_L371_V1.4241.00
375_I394_L1.4211.00
80_L83_L1.4161.00
195_L198_A1.4141.00
123_A369_T1.3931.00
85_L224_E1.3851.00
206_P209_N1.3821.00
55_L58_L1.3641.00
384_I387_A1.3541.00
176_F180_L1.3521.00
255_K262_G1.3401.00
89_V224_E1.3381.00
145_G153_T1.3131.00
98_G274_T1.3111.00
197_F204_T1.3081.00
251_N357_K1.3071.00
98_G271_G1.3040.99
76_I80_L1.3000.99
24_H291_N1.2930.99
295_M301_Y1.2820.99
55_L314_I1.2810.99
176_F181_A1.2670.99
218_L281_G1.2660.99
15_L19_P1.2610.99
321_K324_A1.2570.99
102_C272_L1.2570.99
191_V195_L1.2540.99
167_A171_L1.2510.99
59_F307_G1.2460.99
28_M32_T1.2450.99
371_V398_V1.2430.99
82_L227_A1.2420.99
48_L280_F1.2330.99
102_C271_G1.2320.99
58_L306_I1.2200.99
152_Q155_D1.2090.99
249_T295_M1.2090.99
183_I187_I1.2080.99
384_I388_E1.1930.99
245_H289_G1.1890.99
360_Y369_T1.1840.99
52_I314_I1.1750.99
131_V376_G1.1720.99
358_V365_N1.1650.99
149_A152_Q1.1640.99
54_T68_Y1.1520.99
62_K265_R1.1490.99
83_L90_A1.1440.99
223_F228_I1.1390.99
42_N217_T1.1320.99
67_A249_T1.1280.99
218_L279_F1.1230.98
101_F238_V1.1220.98
214_A320_G1.1170.98
92_G96_M1.1160.98
250_A257_L1.1120.98
61_C272_L1.1110.98
187_I191_V1.1100.98
123_A127_A1.1090.98
70_G288_Y1.1040.98
72_S238_V1.0990.98
141_A378_S1.0890.98
319_V323_A1.0890.98
95_I279_F1.0800.98
92_G221_P1.0690.98
37_V43_P1.0610.98
74_A238_V1.0580.98
385_G389_L1.0480.98
373_L377_V1.0410.97
246_L270_N1.0400.97
82_L231_I1.0340.97
69_L287_T1.0310.97
164_T199_M1.0300.97
130_A373_L1.0240.97
149_A153_T1.0220.97
12_P302_S1.0210.97
245_H292_I1.0200.97
241_E286_T1.0180.97
12_P17_T1.0150.97
242_H246_L1.0080.97
157_K160_I1.0050.97
277_S285_N1.0000.97
88_E220_T0.9920.97
160_I199_M0.9900.97
27_A294_V0.9890.97
81_L84_P0.9890.97
157_K161_I0.9890.97
103_L107_I0.9860.97
193_Y204_T0.9830.96
142_G153_T0.9800.96
52_I276_I0.9760.96
14_L18_I0.9750.96
52_I56_L0.9700.96
78_P234_A0.9690.96
196_S200_G0.9630.96
197_F202_V0.9600.96
97_C235_A0.9540.96
140_A162_S0.9540.96
315_L319_V0.9470.96
8_V11_R0.9470.96
215_L218_L0.9460.96
177_R181_A0.9460.96
161_I195_L0.9420.95
68_Y309_A0.9390.95
150_E155_D0.9390.95
22_L312_F0.9380.95
137_A374_I0.9350.95
225_W228_I0.9330.95
367_I371_V0.9260.95
155_D158_T0.9240.95
48_L218_L0.9230.95
67_A287_T0.9230.95
171_L405_I0.9220.95
276_I280_F0.9210.95
196_S201_I0.9140.95
12_P305_V0.9090.95
55_L311_I0.9070.94
158_T332_P0.9020.94
168_V188_G0.9010.94
203_D206_P0.8970.94
242_H266_S0.8940.94
304_W307_G0.8940.94
18_I22_L0.8940.94
11_R17_T0.8920.94
35_V73_F0.8910.94
99_V102_C0.8890.94
114_G264_H0.8860.94
135_E392_M0.8830.94
253_V301_Y0.8760.93
13_P16_Q0.8740.93
93_G97_C0.8740.93
166_L170_V0.8680.93
60_I272_L0.8650.93
57_Y65_I0.8620.93
24_H28_M0.8600.93
347_A366_L0.8590.93
18_I308_G0.8560.93
24_H27_A0.8540.92
105_S264_H0.8530.92
130_A350_I0.8510.92
361_N365_N0.8460.92
153_T382_V0.8450.92
51_G310_A0.8420.92
186_L190_L0.8370.92
307_G310_A0.8320.91
173_S367_I0.8300.91
160_I195_L0.8210.91
85_L227_A0.8150.91
150_E153_T0.8110.90
215_L318_C0.8110.90
49_F276_I0.8100.90
207_I321_K0.8100.90
89_V227_A0.8070.90
292_I295_M0.8060.90
67_A294_V0.8040.90
322_L325_A0.8030.90
129_V245_H0.8000.90
364_Q368_L0.7980.90
37_V334_M0.7980.90
242_H270_N0.7960.90
143_M342_Y0.7950.90
120_F396_T0.7950.90
31_A290_E0.7920.89
172_G188_G0.7920.89
204_T328_M0.7920.89
140_A165_T0.7900.89
253_V256_D0.7900.89
236_L240_A0.7880.89
193_Y329_I0.7870.89
212_W319_V0.7850.89
67_A246_L0.7820.89
106_F268_F0.7790.89
196_S199_M0.7760.88
346_G373_L0.7740.88
101_F271_G0.7740.88
368_L372_I0.7730.88
226_F230_T0.7690.88
93_G227_A0.7630.88
176_F179_F0.7610.87
211_H214_A0.7600.87
243_V263_L0.7600.87
272_L276_I0.7600.87
68_Y306_I0.7600.87
25_L316_L0.7600.87
46_V283_T0.7570.87
32_T35_V0.7520.87
49_F277_S0.7510.87
242_H286_T0.7500.87
340_L367_I0.7480.86
173_S297_I0.7480.86
58_L303_T0.7470.86
95_I99_V0.7460.86
91_L95_I0.7450.86
20_L24_H0.7420.86
163_I199_M0.7400.86
171_L176_F0.7400.86
18_I208_I0.7400.86
307_G311_I0.7380.86
145_G159_I0.7350.86
88_E91_L0.7340.85
72_S286_T0.7340.85
172_G191_V0.7330.85
225_W229_L0.7320.85
207_I328_M0.7320.85
31_A342_Y0.7290.85
145_G154_P0.7250.85
77_S80_L0.7240.85
127_A372_I0.7240.85
74_A341_L0.7240.85
202_V328_M0.7230.85
71_S75_F0.7230.85
371_V402_L0.7210.84
35_V71_S0.7190.84
28_M291_N0.7190.84
49_F282_S0.7180.84
187_I190_L0.7170.84
72_S75_F0.7170.84
89_V93_G0.7160.84
34_L143_M0.7120.84
274_T285_N0.7110.84
108_V267_M0.7110.84
347_A369_T0.7110.84
44_A323_A0.7110.84
379_G394_L0.7090.83
238_V286_T0.7090.83
21_S309_A0.7080.83
115_W119_L0.7060.83
129_V132_I0.7050.83
143_M334_M0.7040.83
142_G145_G0.7030.83
28_M68_Y0.7020.83
215_L317_S0.7010.83
316_L322_L0.6980.82
105_S271_G0.6960.82
119_L400_I0.6960.82
324_A328_M0.6960.82
236_L248_V0.6950.82
150_E154_P0.6950.82
249_T287_T0.6940.82
66_P306_I0.6930.82
56_L269_A0.6930.82
370_S374_I0.6920.82
76_I236_L0.6900.82
368_L407_K0.6890.82
32_T50_N0.6870.81
137_A377_V0.6870.81
48_L318_C0.6860.81
376_G395_A0.6850.81
261_P265_R0.6850.81
256_D261_P0.6840.81
45_T49_F0.6830.81
153_T156_S0.6820.81
212_W216_P0.6800.81
56_L60_I0.6800.81
161_I332_P0.6780.81
221_P278_G0.6760.80
52_I280_F0.6740.80
312_F316_L0.6740.80
275_V279_F0.6730.80
188_G191_V0.6700.80
182_I407_K0.6680.80
185_I294_V0.6670.80
376_G391_G0.6660.79
189_V337_V0.6640.79
353_L358_V0.6630.79
46_V50_N0.6610.79
69_L242_H0.6570.78
400_I404_L0.6570.78
22_L145_G0.6560.78
232_L235_A0.6560.78
298_T312_F0.6560.78
194_A315_L0.6520.78
8_V12_P0.6520.78
254_K301_Y0.6490.78
50_N67_A0.6490.78
252_I296_A0.6480.78
101_F239_I0.6470.77
324_A327_Q0.6470.77
375_I379_G0.6470.77
45_T218_L0.6460.77
159_I163_I0.6460.77
253_V257_L0.6440.77
30_G36_P0.6440.77
172_G184_P0.6440.77
144_A339_L0.6420.77
45_T48_L0.6420.77
207_I324_A0.6410.77
165_T192_G0.6410.77
95_I223_F0.6410.77
32_T46_V0.6380.76
215_L236_L0.6380.76
343_G366_L0.6380.76
123_A365_N0.6350.76
241_E270_N0.6340.76
46_V71_S0.6280.75
236_L400_I0.6280.75
296_A351_R0.6280.75
130_A353_L0.6280.75
238_V241_E0.6280.75
197_F405_I0.6280.75
231_I332_P0.6270.75
343_G347_A0.6270.75
82_L93_G0.6270.75
24_H294_V0.6230.75
101_F235_A0.6220.75
174_V347_A0.6220.75
191_V194_A0.6210.75
190_L325_A0.6210.75
125_M320_G0.6180.74
123_A368_L0.6180.74
155_D160_I0.6140.74
51_G55_L0.6130.74
42_N57_Y0.6120.73
28_M351_R0.6110.73
289_G348_S0.6090.73
114_G118_V0.6080.73
249_T292_I0.6070.73
74_A132_I0.6040.72
172_G180_L0.6030.72
79_V94_F0.6030.72
135_E390_K0.6010.72
151_G156_S0.6010.72
167_A170_V0.6000.72
150_E158_T0.6000.72
169_T340_L0.5990.72
39_F189_V0.5990.72
85_L222_R0.5990.72
65_I266_S0.5990.72
43_P327_Q0.5980.72
151_G400_I0.5970.72
40_H43_P0.5950.71
245_H348_S0.5930.71
360_Y365_N0.5930.71
189_V240_A0.5930.71
266_S270_N0.5920.71
53_G269_A0.5920.71
103_L167_A0.5910.71
20_L289_G0.5910.71
174_V345_I0.5910.71
189_V334_M0.5900.71
77_S81_L0.5900.71
374_I377_V0.5900.71
96_M232_L0.5880.70
120_F178_G0.5850.70
199_M322_L0.5840.70
143_M338_S0.5830.70
63_G262_G0.5830.70
14_L312_F0.5820.70
169_T172_G0.5800.69
40_H324_A0.5800.69
210_A320_G0.5800.69
192_G200_G0.5790.69
34_L37_V0.5780.69
102_C106_F0.5780.69
66_P98_G0.5780.69
369_T373_L0.5770.69
30_G290_E0.5760.69
290_E342_Y0.5750.69
121_P293_G0.5750.69
128_I166_L0.5740.69
14_L17_T0.5740.69
115_W120_F0.5730.69
154_P158_T0.5730.69
395_A399_G0.5710.68
49_F273_S0.5710.68
66_P253_V0.5700.68
205_T210_A0.5680.68
248_V348_S0.5680.68
60_I261_P0.5670.68
206_P280_F0.5670.68
406_F409_I0.5670.68
66_P93_G0.5660.68
224_E231_I0.5650.67
130_A346_G0.5650.67
235_A274_T0.5650.67
139_V143_M0.5640.67
137_A370_S0.5630.67
145_G149_A0.5610.67
364_Q402_L0.5610.67
87_Y91_L0.5600.67
78_P391_G0.5590.67
245_H287_T0.5590.67
103_L163_I0.5580.66
93_G232_L0.5580.66
91_L97_C0.5580.66
33_V43_P0.5580.66
132_I288_Y0.5570.66
243_V247_V0.5570.66
54_T286_T0.5570.66
274_T277_S0.5560.66
126_G349_G0.5540.66
85_L299_R0.5520.66
334_M337_V0.5520.66
213_F319_V0.5500.65
127_A399_G0.5500.65
161_I189_V0.5500.65
168_V187_I0.5500.65
8_V302_S0.5500.65
79_V83_L0.5500.65
79_V231_I0.5500.65
149_A154_P0.5490.65
57_Y303_T0.5490.65
364_Q408_L0.5480.65
317_S323_A0.5480.65
137_A339_L0.5470.65
360_Y366_L0.5470.65
315_L387_A0.5470.65
300_V334_M0.5460.65
171_L401_G0.5450.65
270_N286_T0.5440.65
158_T201_I0.5430.64
291_N294_V0.5430.64
108_V121_P0.5420.64
257_L262_G0.5420.64
272_L275_V0.5420.64
69_L274_T0.5400.64
351_R357_K0.5390.64
38_L80_L0.5390.64
247_V299_R0.5380.64
84_P224_E0.5380.64
173_S184_P0.5370.64
74_A286_T0.5370.64
303_T307_G0.5370.64
48_L389_L0.5370.64
167_A214_A0.5360.63
21_S129_V0.5360.63
244_G376_G0.5340.63
242_H287_T0.5330.63
158_T161_I0.5310.63
90_A93_G0.5300.63
391_G395_A0.5300.63
198_A215_L0.5300.63
178_G188_G0.5300.63
289_G393_A0.5280.62
55_L59_F0.5280.62
250_A254_K0.5270.62
145_G331_L0.5260.62
130_A169_T0.5260.62
35_V46_V0.5250.62
238_V246_L0.5250.62
220_T279_F0.5240.62
199_M203_D0.5230.62
180_L184_P0.5220.61
159_I162_S0.5210.61
119_L403_S0.5200.61
197_F200_G0.5190.61
142_G190_L0.5190.61
64_K167_A0.5190.61
375_I380_A0.5180.61
159_I380_A0.5180.61
202_V206_P0.5170.61
289_G292_I0.5170.61
121_P126_G0.5160.61
371_V377_V0.5160.61
45_T281_G0.5150.60
69_L246_L0.5150.60
73_F134_L0.5150.60
368_L378_S0.5140.60
32_T313_A0.5140.60
200_G333_V0.5140.60
20_L344_V0.5140.60
351_R360_Y0.5140.60
178_G181_A0.5130.60
181_A360_Y0.5130.60
102_C376_G0.5120.60
32_T71_S0.5110.60
194_A208_I0.5100.60
135_E391_G0.5090.59
383_N386_A0.5090.59
18_I315_L0.5090.59
118_V404_L0.5090.59
101_F105_S0.5090.59
71_S140_A0.5080.59
115_W260_D0.5080.59
353_L366_L0.5070.59
199_M398_V0.5070.59
368_L404_L0.5050.59
57_Y62_K0.5050.59
81_L86_G0.5050.59
193_Y197_F0.5040.59
270_N370_S0.5040.59
194_A213_F0.5030.59
217_T278_G0.5030.59
272_L307_G0.5020.58
250_A255_K0.5020.58
11_R14_L0.5010.58
100_L235_A0.5010.58
8_V35_V0.5010.58
86_G222_R0.5000.58
348_S351_R0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qe7A 2 0.9487 100 0.336 Contact Map
3o7qA 1 0.4499 75.8 0.961 Contact Map
2jlnA 1 0.8741 74.9 0.961 Contact Map
3wdoA 1 0.8695 69.9 0.963 Contact Map
1pw4A 1 0.4709 62.9 0.964 Contact Map
2cfqA 1 0.4476 42 0.969 Contact Map
4j05A 3 0.8368 40.6 0.969 Contact Map
4ltoA 3 0.2611 34.1 0.97 Contact Map
3mktA 1 0.9627 32.5 0.97 Contact Map
4f35D 2 0.5361 30.5 0.971 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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