GREMLIN Database
SIRB1 - Protein sirB1
UniProt: P0AGM5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11251
Length: 269 (251)
Sequences: 928 (648)
Seq/√Len: 40.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
221_R237_D5.1611.00
118_P125_L4.8071.00
230_C233_V4.5971.00
34_V92_K3.3491.00
196_Q199_L3.2321.00
205_E221_R2.9191.00
63_I105_L2.8581.00
103_A179_V2.5051.00
19_I34_V2.3831.00
225_Y230_C2.3781.00
83_D89_Q2.3011.00
188_K204_S2.2631.00
74_A142_F2.1991.00
106_L116_L2.1931.00
79_Y84_A2.1700.99
64_A69_D2.1000.99
45_A112_L2.0750.99
38_L104_V2.0190.99
225_Y233_V2.0180.99
15_C38_L2.0090.99
8_E11_K1.9950.99
30_P33_D1.9760.99
201_L221_R1.9700.99
75_S84_A1.9610.99
41_L65_L1.9380.99
249_P257_Q1.9330.99
188_K220_D1.8530.98
72_F91_L1.8440.98
79_Y142_F1.8400.98
42_V111_R1.8390.98
26_R88_D1.8220.98
9_F12_A1.8130.98
63_I67_Y1.7790.98
191_L199_L1.7640.98
54_P57_E1.7610.98
109_A116_L1.7540.98
40_R44_L1.7510.97
121_F152_L1.7410.97
254_I259_N1.7030.97
98_A182_K1.6640.97
37_E41_L1.6480.96
79_Y97_S1.6140.96
67_Y141_P1.6080.96
188_K217_E1.6020.96
119_V122_P1.5820.95
79_Y186_T1.5760.95
39_E111_R1.5720.95
22_C88_D1.5640.95
222_G238_L1.5620.95
245_C254_I1.5550.95
37_E40_R1.5280.94
118_P179_V1.5220.94
45_A65_L1.5080.94
39_E43_S1.4850.94
110_N176_N1.4840.94
240_Y244_Q1.4820.93
109_A113_D1.4710.93
252_E255_R1.4670.93
175_D178_E1.4430.93
238_L254_I1.4320.92
219_R241_F1.4280.92
80_R84_A1.4250.92
219_R222_G1.4110.92
29_F88_D1.4090.92
140_N182_K1.3990.91
256_A259_N1.3980.91
100_S183_L1.3900.91
245_C248_D1.3890.91
16_E35_Y1.3850.91
107_W111_R1.3750.91
222_G241_F1.3640.90
78_V81_L1.3580.90
90_V144_G1.3460.90
74_A79_Y1.3440.90
201_L228_L1.3360.89
188_K222_G1.3120.88
188_K219_R1.3090.88
34_V37_E1.2870.87
21_A24_A1.2750.87
187_L191_L1.2580.86
84_A142_F1.2560.86
125_L179_V1.2470.86
84_A97_S1.2300.85
10_N16_E1.2290.85
12_A176_N1.2230.85
252_E259_N1.2220.85
122_P182_K1.2180.84
105_L116_L1.2180.84
65_L70_W1.2120.84
203_T226_A1.2070.84
121_F126_I1.2050.84
96_G112_L1.2040.84
106_L127_L1.1930.83
75_S80_R1.1900.83
251_S255_R1.1780.82
241_F250_I1.1710.82
43_S46_K1.1650.82
196_Q200_A1.1610.81
62_L109_A1.1550.81
75_S97_S1.1330.80
119_V128_R1.1260.79
17_G176_N1.1230.79
246_P249_P1.1220.79
217_E220_D1.1170.79
181_R211_N1.1050.78
119_V138_L1.1050.78
106_L179_V1.0860.77
99_V186_T1.0790.76
140_N155_W1.0680.76
31_S35_Y1.0580.75
200_A204_S1.0490.74
124_Q140_N1.0470.74
82_S187_L1.0450.74
98_A186_T1.0380.73
12_A17_G1.0350.73
35_Y45_A1.0290.73
39_E42_V1.0250.73
215_P245_C1.0250.73
89_Q92_K1.0170.72
9_F177_I1.0160.72
257_Q260_N1.0080.71
38_L42_V1.0030.71
36_D50_S0.9990.71
95_Q109_A0.9990.71
41_L44_L0.9930.70
8_E12_A0.9920.70
246_P260_N0.9920.70
166_L170_D0.9910.70
50_S53_L0.9910.70
33_D60_E0.9780.69
87_L90_V0.9720.68
96_G124_Q0.9630.68
223_L238_L0.9580.67
44_L70_W0.9560.67
42_V87_L0.9560.67
182_K186_T0.9490.67
16_E27_R0.9380.66
37_E91_L0.9330.65
219_R223_L0.9240.64
27_R229_D0.9240.64
252_E260_N0.9230.64
188_K207_L0.9210.64
60_E103_A0.9210.64
238_L241_F0.9190.64
157_K162_P0.9140.64
245_C260_N0.9130.64
140_N144_G0.9130.64
49_I52_L0.9100.63
99_V102_G0.9090.63
252_E256_A0.9080.63
175_D224_I0.9070.63
41_L108_V0.9030.63
9_F176_N0.9020.63
205_E208_L0.9010.62
97_S100_S0.8950.62
21_A34_V0.8870.61
37_E47_E0.8790.61
189_A192_M0.8760.60
79_Y182_K0.8720.60
140_N152_L0.8660.59
8_E15_C0.8660.59
67_Y144_G0.8550.58
38_L111_R0.8540.58
141_P152_L0.8530.58
233_V238_L0.8520.58
145_E151_M0.8520.58
185_D189_A0.8510.58
67_Y102_G0.8500.58
8_E100_S0.8490.58
101_L122_P0.8490.58
234_A245_C0.8480.58
103_A183_L0.8460.58
98_A140_N0.8450.57
10_N36_D0.8420.57
26_R86_W0.8390.57
102_G186_T0.8370.57
118_P123_T0.8360.57
181_R207_L0.8340.56
50_S61_K0.8320.56
85_L190_S0.8320.56
140_N151_M0.8290.56
106_L118_P0.8280.56
171_L227_Q0.8220.55
122_P144_G0.8190.55
22_C29_F0.8180.55
166_L169_E0.8160.55
20_L24_A0.8150.55
234_A241_F0.8140.55
138_L152_L0.8130.55
16_E20_L0.8110.54
94_R100_S0.8110.54
83_D108_V0.8110.54
21_A31_S0.8070.54
249_P254_I0.8070.54
96_G123_T0.8050.54
192_M200_A0.8030.54
51_Q68_G0.8020.54
183_L254_I0.8000.53
118_P186_T0.7980.53
90_V98_A0.7980.53
225_Y237_D0.7940.53
103_A107_W0.7920.53
85_L184_L0.7900.52
121_F141_P0.7890.52
225_Y231_E0.7860.52
154_V158_G0.7820.52
47_E130_E0.7780.51
24_A206_A0.7700.51
251_S259_N0.7690.51
156_L183_L0.7670.50
28_D68_G0.7650.50
234_A238_L0.7620.50
208_L218_I0.7610.50
131_C135_E0.7590.50
223_L227_Q0.7550.49
62_L114_L0.7540.49
237_D241_F0.7520.49
200_A224_I0.7500.49
116_L159_N0.7480.49
235_L239_S0.7410.48
106_L125_L0.7390.48
26_R29_F0.7390.48
43_S50_S0.7380.48
188_K241_F0.7380.48
63_I70_W0.7370.48
85_L183_L0.7330.47
253_M260_N0.7310.47
91_L108_V0.7230.46
253_M257_Q0.7220.46
11_K195_N0.7200.46
74_A98_A0.7200.46
220_D241_F0.7190.46
109_A186_T0.7180.46
51_Q143_N0.7150.46
84_A182_K0.7150.46
221_R228_L0.7150.46
247_E252_E0.7140.45
160_I168_Y0.7120.45
150_H227_Q0.7080.45
97_S182_K0.7000.44
83_D120_I0.7000.44
98_A120_I0.7000.44
101_L182_K0.6980.44
208_L228_L0.6980.44
13_P19_I0.6980.44
253_M259_N0.6960.44
157_K165_E0.6890.43
20_L23_E0.6880.43
44_L69_D0.6850.43
58_Q65_L0.6820.42
39_E49_I0.6800.42
75_S85_L0.6800.42
99_V142_F0.6780.42
116_L127_L0.6760.42
248_D257_Q0.6740.42
123_T140_N0.6700.41
188_K191_L0.6690.41
85_L93_N0.6550.40
239_S258_I0.6520.40
166_L200_A0.6500.40
13_P16_E0.6490.40
19_I24_A0.6470.39
30_P57_E0.6460.39
119_V173_E0.6420.39
79_Y100_S0.6390.39
110_N171_L0.6360.38
184_L203_T0.6360.38
104_V176_N0.6330.38
150_H154_V0.6330.38
90_V97_S0.6330.38
105_L111_R0.6300.38
58_Q62_L0.6290.38
33_D43_S0.6280.38
43_S167_F0.6270.38
47_E92_K0.6250.37
75_S183_L0.6240.37
48_E51_Q0.6230.37
98_A107_W0.6220.37
102_G187_L0.6190.37
244_Q248_D0.6180.37
43_S149_E0.6170.37
74_A140_N0.6170.37
11_K18_M0.6150.37
223_L234_A0.6150.37
85_L98_A0.6120.36
106_L110_N0.6110.36
22_C25_I0.6090.36
32_Q35_Y0.6080.36
142_F182_K0.6070.36
218_I237_D0.6050.36
139_I144_G0.6040.36
33_D52_L0.6020.35
18_M97_S0.6000.35
28_D243_E0.5990.35
75_S190_S0.5980.35
146_S149_E0.5980.35
248_D254_I0.5960.35
94_R229_D0.5950.35
246_P252_E0.5940.35
17_G20_L0.5910.35
11_K20_L0.5900.34
23_E235_L0.5890.34
66_F133_D0.5880.34
245_C253_M0.5870.34
66_F101_L0.5870.34
102_G121_F0.5860.34
188_K223_L0.5850.34
62_L66_F0.5830.34
122_P140_N0.5800.34
13_P34_V0.5790.34
204_S217_E0.5790.34
15_C107_W0.5770.33
20_L139_I0.5760.33
120_I140_N0.5740.33
162_P165_E0.5730.33
249_P260_N0.5730.33
21_A103_A0.5730.33
34_V40_R0.5730.33
8_E47_E0.5720.33
56_E65_L0.5700.33
245_C251_S0.5700.33
98_A138_L0.5660.32
58_Q61_K0.5650.32
109_A122_P0.5630.32
54_P58_Q0.5630.32
10_N213_E0.5630.32
248_D260_N0.5620.32
99_V183_L0.5610.32
47_E54_P0.5600.32
121_F156_L0.5600.32
234_A237_D0.5580.32
60_E148_S0.5570.32
203_T207_L0.5570.32
220_D234_A0.5560.32
145_E155_W0.5550.32
125_L186_T0.5550.32
10_N43_S0.5530.31
62_L112_L0.5510.31
247_E253_M0.5490.31
48_E69_D0.5450.31
74_A182_K0.5450.31
96_G141_P0.5450.31
25_I229_D0.5450.31
32_Q178_E0.5450.31
32_Q36_D0.5440.31
99_V109_A0.5430.31
99_V103_A0.5430.31
230_C240_Y0.5420.31
135_E153_D0.5390.30
123_T182_K0.5380.30
36_D169_E0.5370.30
254_I257_Q0.5360.30
93_N111_R0.5360.30
195_N212_P0.5350.30
99_V107_W0.5350.30
31_S119_V0.5340.30
106_L109_A0.5330.30
222_G234_A0.5290.30
114_L226_A0.5280.29
124_Q128_R0.5280.29
102_G184_L0.5270.29
56_E238_L0.5260.29
197_M228_L0.5240.29
64_A235_L0.5220.29
104_V159_N0.5220.29
32_Q37_E0.5200.29
79_Y99_V0.5190.29
63_I85_L0.5140.28
51_Q133_D0.5140.28
100_S108_V0.5120.28
41_L141_P0.5090.28
218_I225_Y0.5080.28
91_L97_S0.5050.28
200_A212_P0.5030.28
215_P249_P0.5010.27
97_S184_L0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u04A 2 0.3346 99.5 0.729 Contact Map
4l9pA 1 0.4684 99.4 0.749 Contact Map
2pziA 1 0.8662 99.4 0.751 Contact Map
2vsyA 1 0.4647 99.3 0.753 Contact Map
3urzA 1 0.4647 99.3 0.756 Contact Map
4ja7A 1 0.3494 99.3 0.758 Contact Map
4i2zA 1 0.4684 99.3 0.758 Contact Map
2c2lA 1 0.342 99.3 0.759 Contact Map
1dceA 1 0.5465 99.3 0.759 Contact Map
4gywA 2 0.4684 99.3 0.762 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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