GREMLIN Database
YICG - UPF0126 inner membrane protein YicG
UniProt: P0AGM2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11683
Length: 205 (195)
Sequences: 2535 (1767)
Seq/√Len: 126.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_S153_S3.9921.00
25_R139_R3.7871.00
35_I137_C3.4701.00
36_A72_A3.3151.00
12_T71_A3.2471.00
159_L180_F3.1761.00
187_L191_L3.0711.00
156_S181_G3.0261.00
38_A136_F2.7921.00
98_V182_F2.6911.00
45_S58_W2.6451.00
95_L182_F2.5641.00
182_F186_L2.4951.00
105_A157_A2.4601.00
109_L118_A2.4031.00
97_L126_G2.3101.00
27_M137_C2.1921.00
90_L189_L2.1371.00
91_V186_L2.0891.00
187_L193_L2.0541.00
123_V154_F2.0301.00
21_A137_C1.9781.00
148_L152_V1.9621.00
175_I179_V1.9171.00
97_L153_S1.8331.00
4_H8_L1.7541.00
162_A166_Y1.6611.00
51_L113_H1.6561.00
41_I68_V1.6541.00
139_R145_Q1.6111.00
40_A68_V1.6091.00
14_E96_G1.6001.00
163_L168_S1.5931.00
52_G55_P1.5631.00
108_A121_A1.5581.00
119_V161_I1.5341.00
62_P66_I1.5341.00
155_A184_A1.5181.00
152_V184_A1.5071.00
105_A118_A1.4871.00
16_M75_T1.4721.00
118_A161_I1.4701.00
105_A161_I1.4681.00
37_T68_V1.4611.00
113_H117_I1.4421.00
7_Y64_Y1.4171.00
136_F144_F1.4151.00
10_G14_E1.4051.00
188_A193_L1.3981.00
107_V111_M1.3921.00
127_V143_V1.3811.00
26_R197_V1.3811.00
119_V158_V1.3691.00
50_L59_V1.3651.00
46_V124_T1.3301.00
33_I69_A1.3281.00
163_L173_V1.3271.00
4_H61_H1.3161.00
66_I70_T1.3081.00
29_T76_T1.3011.00
179_V183_F1.2991.00
51_L111_M1.2901.00
174_I178_L1.2771.00
46_V128_F1.2731.00
30_F150_A1.2701.00
121_A125_T1.2691.00
146_K194_G1.2521.00
42_G132_L1.2441.00
38_A132_L1.2280.99
98_V102_I1.2180.99
173_V177_T1.2090.99
98_V178_L1.1890.99
131_V143_V1.1820.99
101_S105_A1.1760.99
71_A75_T1.1740.99
36_A68_V1.1740.99
94_A186_L1.1730.99
4_H63_E1.1710.99
115_P161_I1.1600.99
12_T67_I1.1560.99
101_S181_G1.1310.99
94_A182_F1.1160.99
69_A73_V1.1070.99
102_I181_G1.0960.99
33_I72_A1.0960.99
32_V76_T1.0800.99
98_V156_S1.0770.99
54_Y107_V1.0760.99
101_S157_A1.0570.98
19_A32_V1.0500.98
34_I150_A1.0380.98
90_L94_A1.0260.98
155_A180_F1.0260.98
169_N172_V1.0250.98
158_V162_A1.0250.98
45_S128_F1.0210.98
23_G32_V0.9990.98
151_G195_L0.9980.98
105_A122_A0.9940.98
184_A193_L0.9940.98
11_I14_E0.9900.98
152_V156_S0.9870.98
115_P119_V0.9860.98
162_A165_H0.9690.97
105_A160_Y0.9670.97
186_L190_R0.9590.97
6_L99_V0.9560.97
58_W117_I0.9510.97
34_I144_F0.9470.97
11_I41_I0.9420.97
102_I177_T0.9390.97
96_G100_F0.9360.97
188_A192_K0.9310.97
16_M92_L0.9290.97
11_I15_A0.9280.96
156_S177_T0.9250.96
180_F184_A0.9210.96
99_V178_L0.9200.96
58_W128_F0.9200.96
141_P144_F0.9170.96
17_T92_L0.9010.96
122_A177_T0.8930.96
68_V76_T0.8920.96
54_Y111_M0.8900.96
46_V132_L0.8900.96
14_E17_T0.8810.95
106_Q110_D0.8810.95
13_A96_G0.8780.95
160_Y177_T0.8740.95
99_V103_I0.8710.95
10_G100_F0.8630.95
159_L163_L0.8620.95
98_V181_G0.8450.94
30_F127_V0.8450.94
194_G197_V0.8400.94
27_M140_I0.8370.94
45_S57_G0.8300.94
126_G181_G0.8260.93
123_V127_V0.8250.93
89_F92_L0.8210.93
12_T16_M0.8160.93
148_L184_A0.8140.93
37_T65_V0.8120.93
74_L162_A0.8090.93
16_M71_A0.8010.92
22_A32_V0.7840.92
95_L99_V0.7810.91
117_I121_A0.7790.91
51_L108_A0.7690.91
23_G79_A0.7610.90
102_I163_L0.7610.90
70_T74_L0.7580.90
118_A122_A0.7500.90
119_V154_F0.7490.90
8_L67_I0.7320.88
28_D141_P0.7250.88
30_F34_I0.7240.88
148_L195_L0.7230.88
6_L178_L0.7230.88
123_V150_A0.7230.88
164_Q173_V0.7220.88
168_S172_V0.7120.87
30_F154_F0.7100.87
159_L177_T0.7080.87
131_V136_F0.6980.86
51_L54_Y0.6970.86
56_L59_V0.6960.86
62_P114_G0.6960.86
76_T198_F0.6960.86
140_I143_V0.6880.85
106_Q160_Y0.6850.85
19_A75_T0.6840.85
68_V72_A0.6810.85
7_Y14_E0.6810.85
7_Y21_A0.6800.85
113_H118_A0.6770.84
45_S50_L0.6750.84
37_T72_A0.6730.84
69_A72_A0.6730.84
25_R105_A0.6710.84
41_I65_V0.6690.84
50_L124_T0.6680.83
114_G121_A0.6670.83
155_A186_L0.6660.83
9_V193_L0.6660.83
105_A181_G0.6650.83
35_I132_L0.6650.83
85_L88_V0.6650.83
14_E18_G0.6640.83
186_L189_L0.6600.83
161_I164_Q0.6550.82
131_V144_F0.6510.82
57_G64_Y0.6480.82
65_V116_I0.6460.81
8_L12_T0.6450.81
131_V142_L0.6400.81
37_T41_I0.6390.81
103_I125_T0.6360.80
21_A25_R0.6340.80
72_A76_T0.6300.80
7_Y16_M0.6290.80
68_V71_A0.6270.79
160_Y164_Q0.6270.79
100_F126_G0.6260.79
103_I177_T0.6200.79
51_L107_V0.6200.79
163_L177_T0.6200.79
140_I145_Q0.6190.79
98_V122_A0.6170.78
172_V176_S0.6140.78
58_W160_Y0.6130.78
19_A72_A0.6080.77
9_V13_A0.6050.77
154_F157_A0.6030.77
131_V172_V0.6020.77
91_V95_L0.5990.76
46_V50_L0.5990.76
66_I116_I0.5980.76
159_L176_S0.5960.76
97_L181_G0.5930.76
18_G143_V0.5900.75
3_L99_V0.5900.75
152_V188_A0.5900.75
31_G35_I0.5890.75
59_V117_I0.5870.75
35_I138_K0.5860.75
65_V120_V0.5850.75
39_T42_G0.5840.74
19_A23_G0.5830.74
27_M144_F0.5820.74
102_I160_Y0.5800.74
23_G198_F0.5780.74
37_T40_A0.5780.74
7_Y11_I0.5670.72
32_V72_A0.5670.72
7_Y120_V0.5660.72
127_V150_A0.5650.72
41_I152_V0.5630.72
5_I9_V0.5610.72
17_T96_G0.5600.71
9_V37_T0.5570.71
56_L77_I0.5560.71
69_A116_I0.5530.70
24_R27_M0.5480.70
28_D149_Y0.5460.70
38_A42_G0.5450.69
165_H179_V0.5440.69
34_I120_V0.5430.69
164_Q170_H0.5410.69
57_G125_T0.5410.69
15_A71_A0.5400.69
112_G115_P0.5380.68
138_K187_L0.5380.68
35_I125_T0.5360.68
12_T36_A0.5340.68
98_V118_A0.5330.68
99_V107_V0.5310.67
109_L164_Q0.5290.67
29_T190_R0.5290.67
172_V175_I0.5270.67
183_F187_L0.5250.67
101_S156_S0.5250.67
52_G56_L0.5240.66
114_G117_I0.5230.66
18_G154_F0.5230.66
146_K188_A0.5220.66
27_M31_G0.5220.66
34_I128_F0.5200.66
122_A152_V0.5200.66
13_A92_L0.5190.66
7_Y89_F0.5180.65
48_D107_V0.5170.65
10_G92_L0.5160.65
13_A67_I0.5160.65
57_G121_A0.5150.65
3_L172_V0.5150.65
173_V181_G0.5150.65
24_R139_R0.5140.65
8_L155_A0.5100.64
62_P126_G0.5090.64
23_G75_T0.5080.64
19_A36_A0.5080.64
168_S173_V0.5070.64
45_S49_I0.5070.64
98_V189_L0.5070.64
135_M180_F0.5060.64
29_T146_K0.5060.64
147_E192_K0.5040.63
26_R124_T0.5040.63
59_V114_G0.5010.63
103_I107_V0.5010.63
70_T77_I0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2f2bA 4 0.4098 6.6 0.962 Contact Map
3llqA 3 0.4049 6 0.963 Contact Map
3gd8A 4 0.4146 3.3 0.967 Contact Map
2o9gA 3 0.4049 2.6 0.969 Contact Map
1s4zC 1 0.1415 1.6 0.972 Contact Map
3cn5A 3 0.4195 1.4 0.973 Contact Map
3wdoA 1 0.8537 1.2 0.974 Contact Map
3i71A 3 0.2 1.2 0.974 Contact Map
4qncA 2 0.361 1.1 0.975 Contact Map
4b19A 1 0.1463 1.1 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0081 seconds.