GREMLIN Database
YHHT - UPF0118 inner membrane protein YhhT
UniProt: P0AGM0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12220
Length: 349 (316)
Sequences: 11019 (8605)
Seq/√Len: 484.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
212_W227_A5.1621.00
214_G267_L4.9721.00
53_W57_R4.5371.00
85_A90_F3.1281.00
298_S318_T3.0711.00
45_I190_L3.0711.00
86_S90_F2.9541.00
55_I61_R2.6811.00
208_G231_F2.6651.00
60_Q63_V2.4841.00
259_Y263_L2.4351.00
212_W216_E2.3911.00
262_I266_A2.3571.00
53_W56_R2.3281.00
90_F95_P2.2421.00
43_F158_V2.2351.00
249_M265_G2.2321.00
322_K326_E2.2171.00
208_G227_A2.1931.00
93_M96_K2.1711.00
120_S123_R2.1151.00
59_V67_I2.1021.00
215_L220_V1.9741.00
159_V163_F1.9441.00
40_A158_V1.8891.00
199_L283_M1.8821.00
201_T235_Y1.8711.00
249_M261_C1.8581.00
21_V25_A1.8371.00
121_P124_M1.7941.00
95_P99_K1.7841.00
263_L266_A1.7801.00
188_R327_T1.7781.00
266_A270_V1.7651.00
62_P66_T1.7631.00
211_V230_A1.7591.00
154_L158_V1.7291.00
211_V271_V1.7261.00
184_A327_T1.7201.00
164_E291_S1.6871.00
51_V68_V1.6701.00
189_A320_V1.6561.00
213_L216_E1.6501.00
65_I69_V1.6381.00
157_T293_M1.6311.00
28_H31_A1.6211.00
48_N52_T1.6171.00
207_T234_N1.6041.00
117_L120_S1.6011.00
75_A79_L1.6011.00
118_H122_E1.5891.00
229_L233_L1.5801.00
125_L128_M1.5731.00
282_R286_H1.5731.00
37_L297_L1.5711.00
111_M114_F1.5661.00
119_M122_E1.5651.00
123_R126_Q1.5471.00
212_W223_A1.5271.00
303_G311_M1.5251.00
157_T161_M1.5221.00
223_A227_A1.4981.00
65_I159_V1.4981.00
260_E263_L1.4931.00
119_M123_R1.4901.00
203_L275_I1.4861.00
210_I271_V1.4801.00
20_L24_L1.4641.00
216_E223_A1.4491.00
50_L68_V1.4311.00
77_T81_G1.4211.00
48_N61_R1.4201.00
221_Q255_F1.4071.00
99_K102_T1.3821.00
54_F71_V1.3751.00
88_N92_S1.3691.00
233_L244_S1.3551.00
126_Q129_D1.3481.00
51_V65_I1.3471.00
269_L273_M1.3461.00
113_P116_N1.3321.00
100_E103_R1.3271.00
87_F90_F1.3231.00
173_R183_I1.3121.00
47_L162_L1.3081.00
170_Y174_F1.3081.00
62_P163_F1.3001.00
248_P264_V1.2971.00
226_W248_P1.2941.00
122_E126_Q1.2911.00
245_A249_M1.2901.00
121_P125_L1.2891.00
294_V318_T1.2811.00
51_V61_R1.2621.00
274_V279_L1.2521.00
73_L77_T1.2471.00
44_A161_M1.2471.00
207_T271_V1.2451.00
192_G319_S1.2431.00
259_Y262_I1.2391.00
279_L283_M1.2351.00
99_K103_R1.2321.00
299_L311_M1.2321.00
111_M115_L1.2311.00
272_H276_G1.2311.00
252_V264_V1.2271.00
104_K107_K1.2211.00
302_W318_T1.2201.00
256_N260_E1.2171.00
122_E125_L1.2161.00
13_I17_L1.2091.00
17_L21_V1.2061.00
258_V261_C1.2021.00
265_G269_L1.1921.00
107_K111_M1.1911.00
104_K108_L1.1861.00
96_K99_K1.1801.00
302_W306_L1.1801.00
100_E104_K1.1791.00
51_V162_L1.1701.00
97_F101_L1.1701.00
14_L18_A1.1681.00
96_K100_E1.1641.00
214_G263_L1.1541.00
48_N165_V1.1461.00
106_F109_Q1.1441.00
204_S234_N1.1431.00
203_L207_T1.1421.00
59_V63_V1.1401.00
252_V261_C1.1381.00
40_A154_L1.1371.00
298_S302_W1.1321.00
214_G218_M1.1301.00
109_Q113_P1.1261.00
227_A231_F1.1261.00
36_Q40_A1.1251.00
276_G280_E1.1231.00
215_L230_A1.1231.00
107_K110_E1.1191.00
188_R326_E1.1161.00
43_F154_L1.1151.00
123_R127_R1.1061.00
65_I79_L1.0941.00
51_V64_A1.0821.00
24_L28_H1.0801.00
213_L217_L1.0781.00
185_G324_W1.0711.00
203_L279_L1.0701.00
201_T205_L1.0701.00
85_A89_E1.0661.00
61_R166_R1.0621.00
90_F94_L1.0621.00
50_L53_W1.0601.00
294_V322_K1.0591.00
120_S124_M1.0541.00
220_V252_V1.0431.00
118_H125_L1.0401.00
218_M267_L1.0391.00
178_N181_I1.0361.00
120_S125_L1.0321.00
40_A44_A1.0291.00
93_M97_F1.0291.00
261_C265_G1.0241.00
25_A29_A1.0181.00
55_I64_A1.0131.00
207_T211_V1.0101.00
198_A202_L1.0091.00
195_H199_L1.0081.00
200_K280_E1.0061.00
153_L157_T1.0031.00
164_E167_H1.0021.00
171_K174_F0.9991.00
69_V158_V0.9971.00
157_T297_L0.9941.00
208_G212_W0.9941.00
110_E113_P0.9911.00
231_F235_Y0.9891.00
39_L154_L0.9891.00
37_L157_T0.9891.00
47_L72_M0.9891.00
215_L264_V0.9891.00
89_E93_M0.9881.00
167_H170_Y0.9871.00
59_V64_A0.9851.00
275_I280_E0.9831.00
51_V55_I0.9821.00
19_S23_I0.9811.00
203_L234_N0.9791.00
127_R130_S0.9751.00
41_L161_M0.9691.00
17_L20_L0.9661.00
207_T241_A0.9611.00
278_I282_R0.9611.00
137_T141_M0.9611.00
258_V262_I0.9581.00
203_L280_E0.9551.00
214_G271_V0.9541.00
309_V313_L0.9531.00
253_L261_C0.9521.00
218_M260_E0.9521.00
298_S314_S0.9511.00
64_A68_V0.9511.00
126_Q130_S0.9461.00
177_N181_I0.9431.00
124_M128_M0.9431.00
267_L271_V0.9421.00
106_F110_E0.9401.00
147_A151_V0.9371.00
102_T106_F0.9351.00
263_L267_L0.9301.00
66_T70_V0.9301.00
205_L231_F0.9281.00
212_W224_L0.9261.00
243_I247_P0.9231.00
110_E114_F0.9211.00
84_A87_F0.9171.00
222_F225_M0.9131.00
125_L129_D0.9101.00
229_L244_S0.9031.00
85_A95_P0.9011.00
270_V274_V0.9011.00
321_C325_M0.8991.00
165_V169_P0.8981.00
105_L109_Q0.8981.00
211_V215_L0.8901.00
112_L115_L0.8871.00
234_N241_A0.8821.00
53_W58_G0.8801.00
290_M318_T0.8771.00
227_A230_A0.8741.00
167_H171_K0.8721.00
18_A22_V0.8711.00
21_V24_L0.8701.00
206_W210_I0.8641.00
63_V66_T0.8611.00
140_L144_L0.8601.00
52_T55_I0.8581.00
176_L180_Q0.8561.00
94_L97_F0.8541.00
324_W328_T0.8521.00
184_A188_R0.8501.00
234_N280_E0.8501.00
209_V212_W0.8501.00
33_I301_I0.8491.00
40_A157_T0.8451.00
124_M127_R0.8441.00
202_L206_W0.8421.00
203_L284_M0.8391.00
215_L226_W0.8391.00
89_E92_S0.8341.00
273_M277_N0.8331.00
141_M145_S0.8241.00
195_H287_R0.8201.00
250_I254_L0.8201.00
218_M263_L0.8201.00
209_V213_L0.8191.00
101_L104_K0.8171.00
314_S318_T0.8151.00
245_A268_F0.8071.00
173_R181_I0.8071.00
272_H275_I0.8061.00
253_L258_V0.8041.00
216_E219_G0.7981.00
29_A32_D0.7981.00
118_H121_P0.7941.00
92_S95_P0.7911.00
44_A158_V0.7911.00
251_Q255_F0.7901.00
23_I26_G0.7901.00
121_P128_M0.7881.00
171_K175_A0.7881.00
112_L116_N0.7841.00
230_A234_N0.7841.00
15_L19_S0.7831.00
288_L315_V0.7731.00
117_L122_E0.7721.00
86_S89_E0.7711.00
218_M264_V0.7701.00
109_Q116_N0.7661.00
62_P159_V0.7601.00
60_Q64_A0.7561.00
52_T56_R0.7531.00
119_M124_M0.7501.00
177_N180_Q0.7471.00
16_K20_L0.7471.00
207_T280_E0.7461.00
120_S129_D0.7461.00
297_L301_I0.7401.00
226_W251_Q0.7401.00
285_G295_V0.7401.00
36_Q285_G0.7391.00
158_V162_L0.7371.00
83_L86_S0.7341.00
111_M116_N0.7341.00
204_S235_Y0.7321.00
284_M295_V0.7321.00
216_E227_A0.7311.00
52_T166_R0.7291.00
176_L181_I0.7281.00
191_K195_H0.7251.00
90_F97_F0.7241.00
75_A78_A0.7231.00
54_F68_V0.7201.00
280_E284_M0.7181.00
103_R107_K0.7171.00
117_L121_P0.7161.00
249_M253_L0.7161.00
87_F91_I0.7131.00
14_L17_L0.7121.00
204_S207_T0.7081.00
274_V278_I0.6981.00
204_S208_G0.6961.00
206_W279_L0.6961.00
280_E283_M0.6951.00
203_L283_M0.6921.00
26_G30_A0.6891.00
60_Q65_I0.6881.00
205_L209_V0.6871.00
91_I95_P0.6801.00
61_R65_I0.6751.00
185_G327_T0.6741.00
108_L111_M0.6731.00
230_A244_S0.6691.00
169_P173_R0.6681.00
84_A88_N0.6671.00
88_N91_I0.6641.00
173_R176_L0.6621.00
189_A323_I0.6601.00
241_A244_S0.6591.00
36_Q150_S0.6571.00
188_R192_G0.6561.00
188_R323_I0.6541.00
299_L315_V0.6481.00
101_L105_L0.6451.00
234_N275_I0.6451.00
48_N162_L0.6441.00
318_T322_K0.6421.00
98_N102_T0.6411.00
183_I187_H0.6401.00
189_A193_V0.6391.00
234_N272_H0.6391.00
241_A272_H0.6381.00
146_G150_S0.6361.00
202_L283_M0.6351.00
108_L112_L0.6341.00
207_T275_I0.6331.00
74_I77_T0.6291.00
200_K204_S0.6291.00
90_F101_L0.6251.00
302_W317_L0.6241.00
133_V137_T0.6241.00
134_V137_T0.6241.00
194_S198_A0.6241.00
231_F234_N0.6211.00
133_V136_F0.6200.99
98_N101_L0.6200.99
211_V267_L0.6190.99
71_V74_I0.6180.99
244_S248_P0.6170.99
208_G224_L0.6160.99
204_S231_F0.6140.99
59_V68_V0.6130.99
175_A325_M0.6120.99
109_Q112_L0.6080.99
39_L43_F0.6060.99
292_T296_F0.6050.99
234_N276_G0.6050.99
203_L241_A0.6040.99
125_L130_S0.6040.99
143_G146_G0.6020.99
200_K203_L0.6010.99
13_I16_K0.6000.99
244_S275_I0.5990.99
198_A287_R0.5990.99
200_K234_N0.5990.99
97_F104_K0.5970.99
141_M144_L0.5960.99
131_E135_T0.5930.99
170_Y183_I0.5920.99
121_P127_R0.5910.99
193_V196_Y0.5900.99
143_G147_A0.5860.99
192_G195_H0.5850.99
238_N292_T0.5820.99
196_Y316_P0.5820.99
54_F59_V0.5820.99
62_P65_I0.5810.99
87_F95_P0.5800.99
47_L158_V0.5790.99
208_G228_V0.5790.99
308_P311_M0.5780.99
44_A48_N0.5770.99
171_K294_V0.5760.99
230_A268_F0.5740.99
132_K135_T0.5740.99
255_F260_E0.5700.99
160_F164_E0.5700.99
41_L165_V0.5680.99
230_A241_A0.5670.99
117_L124_M0.5670.99
161_M293_M0.5670.99
120_S127_R0.5660.99
211_V231_F0.5650.99
295_V315_V0.5640.99
94_L98_N0.5640.99
47_L68_V0.5620.99
244_S316_P0.5620.99
64_A75_A0.5610.99
76_L80_V0.5600.99
91_I94_L0.5590.99
207_T272_H0.5590.99
136_F140_L0.5580.99
153_L300_L0.5550.99
77_T80_V0.5540.99
291_S322_K0.5530.99
185_G189_A0.5510.99
37_L161_M0.5500.99
47_L50_L0.5500.99
103_R106_F0.5500.99
244_S272_H0.5490.99
200_K235_Y0.5490.99
78_A82_V0.5490.99
157_T296_F0.5470.99
15_L18_A0.5410.99
229_L247_P0.5400.99
60_Q79_L0.5400.99
121_P129_D0.5400.99
168_V171_K0.5390.99
170_Y173_R0.5380.99
169_P187_H0.5370.99
195_H198_A0.5360.99
285_G289_G0.5360.99
306_L310_G0.5360.99
202_L205_L0.5340.98
199_L319_S0.5330.98
54_F67_I0.5320.98
290_M295_V0.5310.98
192_G323_I0.5310.98
200_K284_M0.5310.98
207_T210_I0.5290.98
95_P101_L0.5280.98
255_F258_V0.5270.98
276_G300_L0.5250.98
120_S130_S0.5250.98
272_H303_G0.5240.98
302_W314_S0.5230.98
55_I60_Q0.5220.98
28_H32_D0.5210.98
233_L247_P0.5180.98
277_N300_L0.5180.98
200_K275_I0.5180.98
172_M175_A0.5180.98
279_L282_R0.5180.98
220_V248_P0.5180.98
44_A162_L0.5160.98
324_W329_K0.5160.98
303_G316_P0.5130.98
18_A21_V0.5120.98
244_S315_V0.5110.98
231_F238_N0.5100.98
215_L268_F0.5090.98
25_A28_H0.5070.98
92_S96_K0.5060.98
220_V255_F0.5060.98
323_I327_T0.5060.98
156_M292_T0.5050.98
273_M276_G0.5050.98
151_V155_V0.5050.98
157_T300_L0.5030.98
83_L87_F0.5030.98
85_A99_K0.5020.98
138_T142_T0.5010.98
207_T238_N0.5000.98
207_T231_F0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mktA 1 0.9799 77.1 0.934 Contact Map
4lz6A 1 0.9656 44.3 0.947 Contact Map
4humA 1 0.9799 41.5 0.947 Contact Map
3w4tA 1 0.8625 37.8 0.949 Contact Map
3tx3A 2 0.6275 19.6 0.955 Contact Map
2kluA 1 0.1547 17.7 0.956 Contact Map
4ltoA 3 0.3181 17.6 0.956 Contact Map
4rp9A 2 0.8768 17.2 0.957 Contact Map
2kv5A 1 0.0946 14.4 0.958 Contact Map
3qe7A 2 0.7851 10.7 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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