GREMLIN Database
RATA - Ribosome association toxin RatA
UniProt: P0AGL5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13193
Length: 158 (143)
Sequences: 1443 (949)
Seq/√Len: 79.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_S42_Q4.4471.00
34_V105_F3.7031.00
36_D39_S3.5491.00
25_Y152_K3.2401.00
150_R154_V3.0411.00
38_Q55_S3.0191.00
150_R153_E2.7401.00
82_T85_Q2.6151.00
97_K122_E2.5521.00
28_E32_Q2.4341.00
41_P50_S2.2821.00
51_R63_A2.2801.00
54_E61_T2.2701.00
26_S29_Q2.2501.00
37_V60_M2.2121.00
89_M101_G2.0711.00
18_S118_H1.9541.00
32_Q83_S1.9501.00
53_L63_A1.8931.00
82_T86_S1.8741.00
106_T116_E1.8481.00
106_T114_R1.8441.00
108_L114_R1.8081.00
28_E83_S1.8041.00
50_S64_V1.6991.00
31_Y83_S1.6231.00
35_N81_L1.5661.00
80_Q88_L1.5631.00
65_D74_T1.5180.99
76_T92_V1.4470.99
56_T59_Q1.4450.99
78_R90_N1.4380.99
88_L102_G1.4230.99
48_T67_S1.4220.99
63_A74_T1.4160.99
104_K116_E1.4060.99
28_E84_N1.3760.99
63_A76_T1.3540.99
42_Q150_R1.3520.99
33_L151_A1.3440.98
23_V30_M1.3440.98
80_Q90_N1.3230.98
22_L114_R1.3160.98
49_G65_D1.3000.98
60_M81_L1.2840.98
29_Q155_Y1.2620.98
77_T91_L1.2450.97
126_K130_L1.2210.97
30_M105_F1.2170.97
149_V153_E1.2060.97
20_T114_R1.1770.96
145_Q149_V1.1630.96
31_Y84_N1.1580.96
18_S116_E1.1580.96
46_G142_N1.1530.96
63_A77_T1.1520.96
22_L112_A1.1000.95
86_S104_K1.0950.95
30_M113_C1.0740.94
48_T72_S1.0660.94
26_S30_M1.0510.93
132_F135_V1.0390.93
117_F143_M1.0390.93
43_F147_F1.0140.92
30_M151_A1.0050.92
46_G139_L0.9990.92
25_Y156_S0.9930.91
25_Y29_Q0.9830.91
59_Q78_R0.9800.91
54_E59_Q0.9650.90
45_P147_F0.9550.90
61_T78_R0.9550.90
37_V62_A0.9320.88
61_T76_T0.9280.88
27_A107_P0.9280.88
79_N89_M0.9260.88
79_N101_G0.9240.88
95_P151_A0.9160.88
127_L131_A0.9100.87
98_K120_D0.9080.87
108_L112_A0.9060.87
68_K121_F0.9000.87
24_P115_I0.8820.86
116_E129_E0.8680.85
26_S113_C0.8680.85
90_N100_I0.8650.84
16_Q118_H0.8640.84
100_I120_D0.8630.84
35_N148_T0.8590.84
138_E142_N0.8580.84
68_K79_N0.8580.84
53_L61_T0.8390.83
115_I148_T0.8340.82
91_L95_P0.8300.82
48_T71_I0.8240.81
149_V152_K0.8230.81
91_L94_G0.8210.81
36_D55_S0.8190.81
73_K132_F0.8180.81
53_L76_T0.8090.80
44_L147_F0.8060.80
21_A148_T0.8000.80
66_V143_M0.7890.79
113_C144_V0.7800.78
79_N91_L0.7700.77
86_S102_G0.7700.77
121_F143_M0.7590.76
46_G68_K0.7580.76
104_K118_H0.7540.75
14_M94_G0.7490.75
121_F131_A0.7490.75
57_P111_E0.7450.75
67_S70_G0.7360.74
75_F91_L0.7320.73
109_S112_A0.7290.73
58_G80_Q0.7280.73
27_A108_L0.7260.73
14_M95_P0.7020.70
145_Q148_T0.7010.70
77_T101_G0.7010.70
43_F150_R0.7010.70
62_A117_F0.6940.69
81_L87_I0.6940.69
91_L101_G0.6910.69
68_K131_A0.6900.69
90_N98_K0.6880.69
37_V52_I0.6820.68
68_K132_F0.6820.68
95_P136_F0.6810.68
38_Q41_P0.6790.68
78_R92_V0.6780.67
126_K129_E0.6760.67
44_L135_V0.6740.67
15_P120_D0.6660.66
137_K141_A0.6660.66
39_S154_V0.6630.66
24_P152_K0.6620.66
55_S60_M0.6620.66
20_T97_K0.6590.65
67_S73_K0.6580.65
35_N68_K0.6530.65
43_F135_V0.6510.64
77_T89_M0.6510.64
33_L155_Y0.6470.64
19_R46_G0.6450.64
133_G150_R0.6380.63
16_Q120_D0.6340.62
28_E58_G0.6330.62
82_T88_L0.6310.62
75_F79_N0.6310.62
99_L143_M0.6280.61
47_C64_V0.6280.61
108_L111_E0.6280.61
64_V75_F0.6210.61
75_F101_G0.6190.60
85_Q106_T0.6140.60
120_D124_T0.6130.60
88_L100_I0.6120.60
41_P49_G0.6120.60
16_Q128_I0.6040.59
22_L108_L0.6040.59
117_F136_F0.6030.58
41_P95_P0.6020.58
68_K73_K0.5950.57
111_E152_K0.5950.57
119_L144_V0.5940.57
66_V132_F0.5910.57
62_A79_N0.5880.56
57_P83_S0.5850.56
127_L130_L0.5850.56
82_T153_E0.5800.55
59_Q80_Q0.5780.55
43_F146_A0.5760.55
135_V139_L0.5740.55
32_Q84_N0.5680.54
70_G135_V0.5670.54
50_S144_V0.5640.53
33_L95_P0.5580.53
29_Q111_E0.5580.53
131_A138_E0.5580.53
140_A143_M0.5540.52
105_F136_F0.5510.52
96_F140_A0.5490.51
50_S139_L0.5430.51
97_K152_K0.5430.51
63_A129_E0.5420.51
97_K124_T0.5380.50
30_M93_D0.5380.50
58_G83_S0.5380.50
74_T93_D0.5340.50
63_A93_D0.5290.49
31_Y74_T0.5290.49
67_S72_S0.5270.49
94_G151_A0.5270.49
70_G144_V0.5250.48
68_K123_F0.5240.48
76_T93_D0.5230.48
151_A155_Y0.5220.48
73_K79_N0.5200.48
28_E107_P0.5190.48
31_Y141_A0.5170.47
57_P80_Q0.5170.47
46_G146_A0.5160.47
21_A131_A0.5140.47
91_L136_F0.5130.47
77_T119_L0.5120.47
125_N148_T0.5110.47
33_L128_I0.5090.46
48_T66_V0.5060.46
101_G119_L0.5060.46
40_Y43_F0.5060.46
19_R144_V0.5050.46
18_S104_K0.5020.45
66_V73_K0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1t17A 1 0.9051 99.9 0.535 Contact Map
2d4rA 4 0.8924 99.9 0.587 Contact Map
3qszA 1 0.9684 99.8 0.629 Contact Map
3p9vA 2 0.9051 99.8 0.64 Contact Map
3tfzA 2 0.9367 99.7 0.653 Contact Map
3tl1A 1 0.9114 99.7 0.662 Contact Map
3tvqA 1 0.9114 99.7 0.668 Contact Map
4n0gC 1 0.8418 99.7 0.674 Contact Map
3ggnA 2 0.8165 99.6 0.679 Contact Map
2pcsA 1 0.8924 99.6 0.685 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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