GREMLIN Database
TDCF - Putative reactive intermediate deaminase TdcF
UniProt: P0AGL2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12757
Length: 129 (115)
Sequences: 6896 (4455)
Seq/√Len: 415.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_R93_Q3.2711.00
58_K68_V2.9941.00
66_L70_D2.6631.00
45_D48_D2.5741.00
73_K122_E2.5351.00
47_Q86_T2.3661.00
76_V87_I2.0641.00
51_R55_E2.0631.00
77_F108_V2.0541.00
109_Q112_R2.0241.00
47_Q89_E2.0211.00
55_E94_F1.9491.00
57_V123_A1.8711.00
33_I117_V1.8231.00
49_Q118_K1.8171.00
58_K62_V1.7481.00
61_V125_A1.6961.00
52_L56_N1.6411.00
83_D118_K1.6351.00
51_R94_F1.5801.00
112_R116_D1.5781.00
74_M123_A1.5591.00
27_V66_L1.5461.00
81_L109_Q1.5381.00
23_L72_I1.5211.00
55_E58_K1.4661.00
67_S70_D1.4361.00
78_I87_I1.4351.00
46_V50_A1.4271.00
97_E101_T1.3801.00
34_P117_V1.3751.00
23_L126_V1.3321.00
22_D25_S1.3241.00
28_F124_I1.3161.00
52_L55_E1.3101.00
36_C40_G1.3081.00
36_C39_T1.3021.00
42_I117_V1.2901.00
71_I123_A1.2831.00
78_I107_C1.2821.00
106_S122_E1.2591.00
86_T89_E1.2421.00
88_N105_R1.2371.00
31_G120_E1.2281.00
90_V93_Q1.2171.00
43_P48_D1.2161.00
79_T83_D1.1551.00
41_E115_K1.1481.00
83_D86_T1.1481.00
22_D27_V1.1321.00
27_V64_A1.1191.00
61_V66_L1.1101.00
91_Y105_R1.1001.00
26_M126_V1.0881.00
29_T60_I1.0841.00
77_F110_V1.0581.00
79_T112_R1.0411.00
75_T122_E1.0411.00
22_D66_L1.0381.00
29_T123_A1.0351.00
96_D102_Y1.0341.00
96_D101_T1.0291.00
9_R62_V1.0251.00
51_R90_V1.0241.00
34_P53_S1.0211.00
71_I95_F1.0091.00
10_A19_Q0.9941.00
77_F106_S0.9921.00
50_A87_I0.9881.00
46_V87_I0.9751.00
26_M72_I0.9701.00
62_V67_S0.9681.00
79_T118_K0.9241.00
47_Q90_V0.9171.00
89_E92_K0.9161.00
58_K94_F0.9121.00
79_T116_D0.9111.00
61_V71_I0.9081.00
32_Q60_I0.9041.00
20_G60_I0.8871.00
80_D83_D0.8711.00
97_E102_Y0.8651.00
74_M91_Y0.8651.00
68_V71_I0.8521.00
82_N112_R0.8431.00
34_P49_Q0.8311.00
54_L94_F0.8221.00
84_F107_C0.8191.00
43_P49_Q0.8071.00
54_L68_V0.8071.00
44_A49_Q0.8041.00
79_T111_A0.8001.00
89_E93_Q0.7991.00
46_V83_D0.7961.00
90_V94_F0.7951.00
92_K102_Y0.7941.00
47_Q51_R0.7891.00
59_A62_V0.7871.00
54_L121_I0.7801.00
44_A48_D0.7621.00
37_P52_L0.7581.00
68_V94_F0.7541.00
74_M95_F0.7421.00
79_T110_V0.7331.00
71_I125_A0.7171.00
25_S126_V0.7141.00
69_G96_D0.7011.00
47_Q93_Q0.6981.00
16_P88_N0.6901.00
45_D118_K0.6841.00
54_L91_Y0.6791.00
50_A119_L0.6781.00
46_V90_V0.6751.00
29_T57_V0.6710.99
20_G27_V0.6690.99
53_S121_I0.6650.99
46_V119_L0.6640.99
84_F114_P0.6570.99
76_V105_R0.6560.99
20_G64_A0.6450.99
43_P118_K0.6440.99
48_D51_R0.6400.99
9_R59_A0.6380.99
85_A89_E0.6340.99
35_V40_G0.6330.99
14_I115_K0.6210.99
46_V86_T0.6210.99
76_V121_I0.6200.99
27_V125_A0.6190.99
88_N91_Y0.6190.99
23_L28_F0.6180.99
77_F122_E0.6170.99
19_Q60_I0.6110.99
30_S104_T0.6110.99
24_G126_V0.6070.99
45_D86_T0.6030.99
75_T106_S0.5880.99
66_L126_V0.5850.99
81_L112_R0.5780.99
32_Q57_V0.5760.98
37_P59_A0.5740.98
73_K106_S0.5690.98
69_G97_E0.5680.98
23_L26_M0.5680.98
26_M124_I0.5670.98
21_V72_I0.5660.98
78_I81_L0.5640.98
78_I83_D0.5600.98
61_V68_V0.5540.98
80_D118_K0.5520.98
60_I63_A0.5490.98
66_L125_A0.5470.98
39_T42_I0.5460.98
55_E59_A0.5460.98
22_D64_A0.5430.98
61_V123_A0.5400.98
79_T109_Q0.5340.98
18_V21_V0.5300.97
14_I17_Y0.5280.97
29_T106_S0.5240.97
83_D109_Q0.5230.97
33_I115_K0.5210.97
53_S119_L0.5210.97
84_F88_N0.5190.97
71_I74_M0.5170.97
76_V119_L0.5130.97
34_P44_A0.5080.97
53_S57_V0.5070.97
73_K104_T0.5070.97
74_M121_I0.5070.97
36_C41_E0.5040.96
34_P42_I0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vczA 5 0.9535 100 0.134 Contact Map
2b33A 3 0.969 100 0.137 Contact Map
2dyyA 3 0.969 100 0.139 Contact Map
1xrgA 3 0.9612 100 0.144 Contact Map
1qu9A 3 0.9845 100 0.147 Contact Map
2cvlA 3 0.9612 100 0.151 Contact Map
3k0tA 3 0.9612 100 0.153 Contact Map
1x25A 3 0.969 100 0.157 Contact Map
3l7qA 3 0.9535 100 0.158 Contact Map
3r0pA 5 0.9612 100 0.163 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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