GREMLIN Database
ISCR - HTH-type transcriptional regulator IscR
UniProt: P0AGK8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG13397
Length: 162 (134)
Sequences: 5916 (4045)
Seq/√Len: 349.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_G122_N3.8701.00
72_S127_G3.0101.00
92_C104_C2.9841.00
16_D34_R2.8031.00
56_S66_L2.7701.00
10_A83_V2.7551.00
127_G131_N2.6061.00
14_M54_L2.5991.00
112_D120_F2.4071.00
52_N82_A2.3991.00
69_K78_E2.3831.00
81_S122_N2.2991.00
14_M126_L2.2841.00
92_C98_C2.1371.00
77_G81_S2.0681.00
13_A46_F2.0571.00
25_P66_L2.0511.00
17_V55_V1.9491.00
18_A130_V1.9101.00
116_R120_F1.8801.00
98_C104_C1.8081.00
29_A39_L1.8031.00
116_R119_G1.7071.00
16_D26_V1.6281.00
70_D73_S1.5811.00
112_D124_I1.5801.00
58_V66_L1.5761.00
50_R57_S1.5501.00
29_A33_E1.5481.00
69_K73_S1.5471.00
113_L117_L1.4951.00
7_G80_I1.4841.00
47_S51_K1.4521.00
75_A125_T1.4521.00
37_I42_L1.4511.00
120_F123_N1.3641.00
13_A42_L1.3431.00
20_N24_G1.3401.00
21_S71_A1.3061.00
28_L46_F1.2821.00
75_A78_E1.2521.00
114_S118_T1.2451.00
69_K74_I1.2311.00
118_T122_N1.2151.00
109_L124_I1.2131.00
81_S118_T1.1961.00
13_A31_I1.1811.00
112_D132_N1.1491.00
7_G84_D1.1331.00
16_D35_Q1.1301.00
16_D20_N1.1281.00
47_S50_R1.1161.00
115_D119_G1.1151.00
27_P30_D1.1101.00
56_S68_G1.0991.00
25_P58_V1.0761.00
6_K44_Q1.0551.00
54_L74_I1.0541.00
33_E39_L1.0431.00
20_N26_V1.0431.00
113_L121_L1.0361.00
119_G123_N1.0281.00
46_F65_Y1.0101.00
108_A132_N1.0101.00
80_I121_L1.0041.00
14_M79_V0.9901.00
9_Y37_I0.9891.00
78_E122_N0.9691.00
54_L82_A0.9641.00
40_S43_E0.9501.00
111_R115_D0.9491.00
11_V76_V0.9431.00
8_R12_T0.9321.00
30_D34_R0.9111.00
14_M49_L0.9091.00
113_L116_R0.9081.00
5_S41_Y0.8971.00
15_L130_V0.8861.00
46_F55_V0.8781.00
28_L43_E0.8741.00
19_L130_V0.8701.00
70_D127_G0.8631.00
89_A114_S0.8611.00
76_V109_L0.8551.00
17_V26_V0.8511.00
6_K48_R0.8501.00
47_S57_S0.8441.00
24_G30_D0.8381.00
47_S65_Y0.8341.00
48_R52_N0.8341.00
30_D33_E0.8301.00
77_G118_T0.8271.00
6_K41_Y0.8241.00
67_L71_A0.8221.00
112_D116_R0.8081.00
107_H111_R0.8001.00
120_F124_I0.8001.00
43_E65_Y0.7991.00
6_K10_A0.7961.00
128_E131_N0.7931.00
41_Y45_L0.7901.00
68_G74_I0.7851.00
50_R55_V0.7851.00
125_T128_E0.7811.00
21_S70_D0.7791.00
78_E81_S0.7771.00
87_V118_T0.7651.00
76_V129_L0.7611.00
96_G101_G0.7611.00
57_S65_Y0.7581.00
54_L78_E0.7571.00
21_S24_G0.7551.00
28_L39_L0.7501.00
111_R114_S0.7421.00
10_A45_L0.7361.00
43_E50_R0.7341.00
7_G83_V0.7270.99
3_L110_W0.7250.99
3_L80_I0.7180.99
78_E82_A0.7170.99
9_Y45_L0.7120.99
112_D123_N0.6970.99
16_D30_D0.6960.99
39_L43_E0.6910.99
16_D31_I0.6880.99
38_S41_Y0.6860.99
131_N134_E0.6820.99
81_S86_S0.6790.99
98_C107_H0.6780.99
9_Y41_Y0.6610.99
40_S44_Q0.6600.99
75_A122_N0.6570.99
53_G68_G0.6540.99
74_I79_V0.6540.99
119_G122_N0.6450.99
109_L112_D0.6450.99
59_R110_W0.6390.99
31_I46_F0.6390.99
80_I84_D0.6380.99
44_Q47_S0.6380.99
32_S37_I0.6330.99
71_A130_V0.6310.99
27_P62_G0.6300.98
100_G103_K0.6300.98
15_L129_L0.6300.98
92_C107_H0.6300.98
75_A123_N0.6270.98
91_R94_G0.6270.98
110_W117_L0.6260.98
54_L69_K0.6250.98
88_D94_G0.6200.98
3_L7_G0.6130.98
71_A126_L0.6120.98
4_T84_D0.6120.98
8_R106_T0.6020.98
79_V126_L0.5990.98
48_R51_K0.5950.98
17_V46_F0.5850.98
71_A74_I0.5840.98
20_N34_R0.5830.98
52_N78_E0.5820.97
41_Y59_R0.5810.97
4_T7_G0.5780.97
19_L34_R0.5780.97
55_V59_R0.5780.97
104_C107_H0.5770.97
79_V82_A0.5760.97
127_G130_V0.5750.97
93_Q96_G0.5750.97
5_S91_R0.5750.97
4_T41_Y0.5740.97
113_L120_F0.5670.97
72_S131_N0.5650.97
68_G71_A0.5640.97
106_T110_W0.5630.97
5_S36_G0.5620.97
50_R65_Y0.5600.97
74_I126_L0.5590.97
52_N69_K0.5590.97
112_D115_D0.5530.97
101_G107_H0.5500.96
19_L105_L0.5500.96
12_T35_Q0.5400.96
72_S128_E0.5400.96
116_R121_L0.5350.96
99_Q102_D0.5310.96
76_V124_I0.5270.96
69_K72_S0.5260.95
53_G56_S0.5220.95
109_L120_F0.5210.95
9_Y117_L0.5190.95
20_N30_D0.5170.95
9_Y35_Q0.5120.95
40_S65_Y0.5100.95
6_K9_Y0.5080.95
27_P59_R0.5060.94
5_S43_E0.5040.94
27_P50_R0.5030.94
8_R89_A0.5010.94
44_Q48_R0.5000.94
108_A111_R0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hf1A 2 0.8765 100 0.205 Contact Map
1xd7A 2 0.7037 100 0.297 Contact Map
4hf0A 3 0.7531 100 0.299 Contact Map
1ylfA 5 0.7407 100 0.342 Contact Map
3k69A 2 0.8704 100 0.343 Contact Map
3lwfA 5 0.8642 100 0.347 Contact Map
4cicA 2 0.8272 100 0.349 Contact Map
3t8rA 2 0.7469 100 0.386 Contact Map
2y75A 5 0.7901 99.9 0.415 Contact Map
2jscA 2 0.5556 98.5 0.766 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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