GREMLIN Database
UBIA - 4-hydroxybenzoate octaprenyltransferase
UniProt: P0AGK1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11370
Length: 290 (274)
Sequences: 6353 (4280)
Seq/√Len: 258.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_R93_E4.6211.00
69_Y93_E4.3031.00
15_R90_A3.6471.00
69_Y97_R3.4471.00
62_A104_V3.1551.00
79_K82_A3.0901.00
92_T95_E3.0041.00
115_N118_T2.7131.00
230_G239_Y2.6871.00
74_F200_I2.6861.00
116_T120_L2.4941.00
118_T159_A2.4791.00
65_V103_L2.3861.00
76_G87_P2.3741.00
210_Y214_I2.3361.00
242_S282_G2.2941.00
25_A57_W2.2631.00
193_D196_V2.2291.00
252_Y256_L2.2041.00
51_V113_T2.1761.00
51_V110_L2.1191.00
192_R196_V2.0331.00
94_K98_A2.0311.00
59_M107_S2.0111.00
236_G286_S1.9891.00
33_L53_V1.9731.00
16_L95_E1.9091.00
223_L247_G1.8581.00
69_Y96_A1.8241.00
196_V205_I1.7481.00
65_V99_L1.7451.00
70_A134_F1.7421.00
77_H198_I1.7321.00
178_L221_G1.7071.00
117_M159_A1.6991.00
112_L119_I1.6711.00
148_A173_F1.6691.00
91_V96_A1.6471.00
135_M145_V1.6301.00
98_A102_V1.6081.00
261_E264_A1.6041.00
104_V126_L1.5971.00
131_V145_V1.5951.00
135_M138_Y1.5881.00
192_R209_Q1.5681.00
86_L96_A1.5351.00
58_L106_I1.5321.00
248_A252_Y1.5301.00
72_R76_G1.5161.00
211_D215_I1.5111.00
71_D137_R1.5061.00
273_N277_L1.5051.00
61_A103_L1.4911.00
142_P202_S1.4621.00
65_V100_F1.4581.00
267_K270_M1.4541.00
189_M211_D1.4471.00
214_I218_L1.4271.00
175_A226_M1.4261.00
128_L149_A1.4221.00
192_R205_I1.4211.00
166_P169_C1.4141.00
222_V226_M1.3871.00
120_L124_A1.3771.00
245_V249_L1.3691.00
91_V99_L1.3641.00
65_V91_V1.3541.00
50_A54_A1.3431.00
127_A131_V1.3421.00
282_G286_S1.3331.00
264_A268_A1.3291.00
59_M122_S1.3281.00
29_L33_L1.3211.00
165_V169_C1.3211.00
14_H19_T1.3201.00
246_A279_L1.3131.00
182_A219_Q1.3101.00
253_Q256_L1.2971.00
249_L271_N1.2911.00
71_D74_F1.2881.00
17_M99_L1.2831.00
230_G240_Y1.2711.00
45_Q48_I1.2611.00
155_P173_F1.2521.00
86_L91_V1.2481.00
272_N276_G1.2431.00
74_F137_R1.2391.00
274_Y278_V1.2381.00
14_H18_R1.2241.00
36_L49_L1.2211.00
165_V170_W1.2201.00
249_L252_Y1.2141.00
266_F270_M1.1991.00
29_L53_V1.1991.00
47_W51_V1.1911.00
170_W174_L1.1861.00
58_L107_S1.1731.00
227_A230_G1.1701.00
93_E97_R1.1581.00
111_V122_S1.1501.00
91_V95_E1.1481.00
167_L170_W1.1421.00
221_G225_L1.1371.00
108_F123_I1.1371.00
262_R265_C1.1371.00
271_N275_V1.1341.00
251_V255_K1.1291.00
20_D61_A1.1221.00
66_V100_F1.1201.00
223_L227_A1.1181.00
55_G111_V1.1181.00
231_E240_Y1.1171.00
109_L113_T1.1161.00
270_M273_N1.1161.00
274_Y277_L1.1151.00
151_G180_A1.1131.00
72_R86_L1.1041.00
32_T56_V1.0991.00
151_G176_N1.0971.00
39_A161_V1.0971.00
97_R101_V1.0961.00
51_V114_L1.0911.00
32_T52_F1.0911.00
151_G177_I1.0871.00
58_L103_L1.0781.00
101_V105_L1.0781.00
211_D214_I1.0771.00
118_T156_M1.0741.00
246_A275_V1.0721.00
71_D133_P1.0701.00
69_Y86_L1.0671.00
39_A158_F1.0641.00
188_A204_A1.0521.00
115_N121_L1.0511.00
190_V266_F1.0431.00
203_T207_F1.0341.00
272_N277_L1.0341.00
36_L52_F1.0211.00
69_Y100_F1.0181.00
253_Q271_N1.0001.00
220_I224_A0.9981.00
78_V194_D0.9951.00
128_L148_A0.9891.00
189_M209_Q0.9861.00
176_N180_A0.9791.00
178_L218_L0.9741.00
140_H201_K0.9721.00
256_L264_A0.9701.00
171_L232_L0.9691.00
263_E267_K0.9671.00
227_A243_I0.9611.00
79_K193_D0.9591.00
70_A133_P0.9561.00
210_Y213_L0.9541.00
125_A152_W0.9521.00
17_M22_P0.9481.00
99_L103_L0.9481.00
237_W241_W0.9431.00
135_M139_T0.9421.00
216_G254_Q0.9411.00
38_V158_F0.9401.00
65_V96_A0.9401.00
227_A231_E0.9391.00
252_Y255_K0.9341.00
269_F273_N0.9331.00
123_I127_A0.9331.00
193_D197_K0.9321.00
155_P169_C0.9291.00
125_A156_M0.9241.00
41_P44_P0.9221.00
164_S168_S0.9201.00
117_M163_E0.9191.00
108_F119_I0.9181.00
87_P96_A0.9071.00
73_K77_H0.9051.00
260_R264_A0.9021.00
150_F180_A0.8981.00
244_L248_A0.8951.00
47_W50_A0.8931.00
18_R90_A0.8901.00
269_F272_N0.8881.00
201_K206_L0.8841.00
158_F169_C0.8841.00
122_S156_M0.8831.00
109_L112_L0.8821.00
151_G157_A0.8811.00
152_W156_M0.8801.00
236_G239_Y0.8781.00
18_R85_P0.8751.00
250_F253_Q0.8731.00
213_L216_G0.8691.00
42_G45_Q0.8671.00
26_L273_N0.8671.00
74_F198_I0.8651.00
54_A110_L0.8641.00
117_M121_L0.8561.00
117_M120_L0.8561.00
207_F211_D0.8551.00
40_T161_V0.8540.99
228_I232_L0.8540.99
66_V101_V0.8470.99
32_T153_S0.8390.99
112_L116_T0.8360.99
108_F112_L0.8330.99
113_T116_T0.8330.99
174_L178_L0.8290.99
220_I223_L0.8270.99
158_F166_P0.8270.99
45_Q161_V0.8220.99
184_D187_Y0.8180.99
139_T145_V0.8150.99
73_K76_G0.8140.99
238_G242_S0.8140.99
95_E98_A0.8120.99
68_D71_D0.8070.99
270_M274_Y0.8050.99
36_L161_V0.8040.99
191_D195_D0.7990.99
37_W284_A0.7990.99
40_T44_P0.7880.99
23_I27_L0.7870.99
105_L109_L0.7860.99
147_G181_V0.7850.99
36_L40_T0.7850.99
271_N274_Y0.7830.99
20_D103_L0.7820.99
13_F17_M0.7800.99
224_A228_I0.7800.99
164_S167_L0.7760.99
131_V135_M0.7760.99
71_D200_I0.7730.99
35_A39_A0.7720.99
154_I176_N0.7700.99
143_Q185_T0.7690.99
239_Y243_I0.7670.99
230_G233_N0.7650.99
21_K266_F0.7640.99
34_W284_A0.7630.99
175_A225_L0.7610.99
227_A240_Y0.7590.99
186_Q257_I0.7580.99
143_Q184_D0.7560.99
146_L183_Y0.7530.99
66_V70_A0.7510.99
256_L267_K0.7470.99
154_I160_A0.7430.99
111_V119_I0.7430.99
260_R265_C0.7420.99
114_L118_T0.7400.99
17_M20_D0.7370.99
225_L228_I0.7370.99
224_A227_A0.7330.98
240_Y244_L0.7310.98
275_V279_L0.7310.98
166_P170_W0.7280.98
175_A222_V0.7270.98
143_Q180_A0.7250.98
79_K194_D0.7240.98
242_S278_V0.7200.98
168_S233_N0.7200.98
242_S246_A0.7160.98
256_L268_A0.7160.98
163_E166_P0.7140.98
114_L119_I0.7120.98
212_K254_Q0.7120.98
48_I114_L0.7080.98
158_F162_S0.7070.98
139_T203_T0.7060.98
250_F254_Q0.7050.98
144_V181_V0.7040.98
249_L253_Q0.7040.98
182_A222_V0.7030.98
116_T119_I0.7030.98
61_A99_L0.7020.98
37_W280_F0.7020.98
238_G285_M0.7010.98
69_Y72_R0.6970.98
280_F284_A0.6970.98
48_I161_V0.6940.98
183_Y187_Y0.6940.98
64_C68_D0.6930.98
194_D197_K0.6910.98
14_H17_M0.6880.98
85_P90_A0.6860.98
95_E99_L0.6850.98
16_L91_V0.6830.98
279_L282_G0.6830.98
281_L285_M0.6810.98
235_L286_S0.6810.98
115_N160_A0.6760.97
86_L89_G0.6750.97
222_V227_A0.6720.97
33_L49_L0.6710.97
195_D202_S0.6700.97
121_L159_A0.6670.97
111_V114_L0.6660.97
102_V106_I0.6630.97
85_P89_G0.6600.97
16_L99_L0.6580.97
230_G235_L0.6580.97
277_L281_L0.6570.97
171_L228_I0.6550.97
59_M126_L0.6550.97
47_W54_A0.6540.97
154_I157_A0.6540.97
243_I247_G0.6530.97
35_A38_V0.6520.97
178_L225_L0.6490.97
141_L144_V0.6470.97
140_H206_L0.6470.97
272_N275_V0.6450.97
79_K83_N0.6430.96
102_V109_L0.6420.96
268_A273_N0.6410.96
22_P25_A0.6400.96
150_F183_Y0.6390.96
251_V254_Q0.6370.96
185_T203_T0.6360.96
128_L145_V0.6350.96
118_T122_S0.6310.96
78_V195_D0.6300.96
243_I246_A0.6300.96
229_I233_N0.6290.96
146_L187_Y0.6190.96
27_L276_G0.6170.96
237_W240_Y0.6160.96
100_F104_V0.6140.95
212_K216_G0.6130.95
242_S247_G0.6130.95
243_I282_G0.6120.95
252_Y271_N0.6110.95
189_M192_R0.6080.95
19_T25_A0.6070.95
283_L286_S0.6050.95
35_A157_A0.6050.95
66_V130_W0.6020.95
223_L226_M0.6010.95
37_W40_T0.6000.95
255_K259_N0.6000.95
117_M162_S0.5990.95
133_P184_D0.5990.95
146_L180_A0.5980.95
104_V108_F0.5930.95
60_R187_Y0.5900.94
217_I221_G0.5900.94
73_K93_E0.5880.94
207_F214_I0.5840.94
60_R64_C0.5840.94
255_K258_A0.5830.94
55_G110_L0.5810.94
110_L113_T0.5800.94
74_F77_H0.5800.94
279_L283_L0.5760.94
171_L225_L0.5750.94
185_T212_K0.5750.94
184_D188_A0.5740.94
241_W245_V0.5730.93
249_L275_V0.5730.93
214_I258_A0.5720.93
254_Q258_A0.5720.93
208_G212_K0.5690.93
143_Q181_V0.5640.93
52_F160_A0.5620.93
193_D262_R0.5610.93
111_V156_M0.5580.93
146_L184_D0.5580.93
231_E234_G0.5580.93
249_L256_L0.5570.93
236_G240_Y0.5560.92
152_W155_P0.5540.92
43_V47_W0.5530.92
256_L259_N0.5530.92
24_G64_C0.5490.92
78_V133_P0.5480.92
97_R130_W0.5470.92
280_F283_L0.5460.92
248_A255_K0.5440.92
215_I219_Q0.5410.91
97_R100_F0.5410.91
245_V248_A0.5350.91
19_T57_W0.5330.91
38_V229_I0.5330.91
203_T218_L0.5310.91
141_L206_L0.5310.91
24_G184_D0.5290.90
258_A261_E0.5290.90
78_V183_Y0.5290.90
39_A157_A0.5280.90
273_N276_G0.5240.90
167_L171_L0.5210.90
145_V178_L0.5200.90
244_L247_G0.5190.90
174_L225_L0.5180.90
264_A267_K0.5160.89
24_G71_D0.5140.89
179_W183_Y0.5130.89
187_Y190_V0.5120.89
28_L32_T0.5120.89
213_L258_A0.5120.89
57_W61_A0.5110.89
58_L110_L0.5100.89
209_Q213_L0.5100.89
242_S286_S0.5090.89
154_I158_F0.5070.89
263_E270_M0.5050.88
216_G268_A0.5040.88
210_Y258_A0.5040.88
254_Q257_I0.5030.88
32_T36_L0.5020.88
115_N163_E0.5020.88
127_A148_A0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4od4A 1 0.9172 100 0.239 Contact Map
4tq3A 1 0.9414 100 0.317 Contact Map
2xq2A 2 0.7724 32.7 0.946 Contact Map
1fftA 1 0 11.1 0.957 Contact Map
3ze3A 4 0.369 8.7 0.959 Contact Map
4xnjA 1 0.5862 7.6 0.96 Contact Map
3ixzA 1 0.6724 4.2 0.964 Contact Map
4uc1A 3 0.5241 3.4 0.966 Contact Map
2cfqA 1 0.8931 3 0.967 Contact Map
1a87A 1 0.2724 2.8 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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