GREMLIN Database
SYY - Tyrosine--tRNA ligase
UniProt: P0AGJ9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11043
Length: 424 (392)
Sequences: 3955 (2199)
Seq/√Len: 111.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
314_E318_Q4.1781.00
185_C189_Q3.8781.00
309_R314_E3.3981.00
361_Q372_R3.3281.00
305_E321_K3.2401.00
134_N137_T3.2211.00
85_K240_E3.0371.00
124_A128_D3.0061.00
385_T412_R3.0011.00
67_K122_I2.9541.00
269_Y287_E2.8851.00
205_I222_G2.8761.00
212_T220_V2.8071.00
229_T270_R2.6031.00
11_Q22_E2.5611.00
42_P77_G2.5491.00
59_K63_Q2.5321.00
313_G316_G2.5081.00
35_A67_K2.4721.00
102_D105_R2.4471.00
184_A215_L2.4071.00
288_E292_N2.3201.00
316_G319_A2.3011.00
21_D24_A2.2911.00
358_D361_Q2.2261.00
188_K216_H2.2111.00
27_E31_Q2.1471.00
158_K162_N2.1241.00
382_N390_K2.1041.00
269_Y273_K2.0831.00
309_R317_L2.0441.00
184_A188_K2.0151.00
38_C54_P1.9641.00
55_L108_V1.9601.00
187_N218_N1.9591.00
93_T96_T1.9481.00
285_A289_E1.9441.00
282_E285_A1.9371.00
385_T390_K1.9241.00
98_Q102_D1.9211.00
369_Q375_A1.9171.00
99_E103_K1.9091.00
105_R109_A1.8991.00
36_L61_F1.8971.00
114_F121_A1.8851.00
380_A394_P1.8681.00
370_P374_Q1.8561.00
28_R34_I1.8421.00
75_A130_F1.8201.00
99_E102_D1.8171.00
301_Y325_E1.8081.00
362_A421_I1.7891.00
94_E98_Q1.7881.00
273_K287_E1.7851.00
363_L384_I1.7431.00
305_E317_L1.7241.00
145_H214_R1.7241.00
35_A69_V1.7181.00
364_V372_R1.7171.00
36_L58_L1.7111.00
71_L186_L1.7031.00
230_K234_T1.6801.00
78_L94_E1.6681.00
284_N287_E1.6621.00
12_E280_I1.6561.00
321_K325_E1.6461.00
130_F133_M1.6241.00
287_E291_K1.6211.00
280_I284_N1.6181.00
187_N216_H1.6181.00
305_E318_Q1.6161.00
285_A288_E1.6121.00
368_L419_C1.6111.00
146_F207_S1.6081.00
279_S282_E1.6051.00
378_T383_A1.5911.00
374_Q378_T1.5871.00
101_V125_N1.5821.00
96_T99_E1.5821.00
180_G207_S1.5741.00
293_S296_A1.5591.00
69_V124_A1.5541.00
373_G377_K1.5481.00
92_N96_T1.5461.00
362_A398_F1.5391.00
127_Y131_G1.5341.00
20_T222_G1.5261.00
356_G397_F1.5231.00
54_P225_V1.5221.00
40_F55_L1.5151.00
87_A90_K1.5061.00
267_D270_R1.5051.00
302_V306_Q1.4971.00
210_D213_R1.4851.00
38_C196_I1.4611.00
256_F307_V1.4571.00
318_Q322_R1.4501.00
234_T240_E1.4451.00
359_L391_Q1.4441.00
378_T381_S1.4391.00
369_Q378_T1.4331.00
113_D120_S1.4331.00
257_Y321_K1.4311.00
74_G125_N1.4281.00
378_T413_R1.4271.00
124_A186_L1.4261.00
24_A28_R1.4251.00
298_R301_Y1.4201.00
40_F47_L1.4081.00
256_F308_T1.4061.00
9_Q12_E1.4051.00
412_R418_Y1.4041.00
377_K381_S1.4001.00
315_E319_A1.3951.00
24_A29_L1.3931.00
264_A267_D1.3761.00
92_N100_W1.3611.00
40_F54_P1.3601.00
278_M302_V1.3441.00
278_M306_Q1.3331.00
147_S167_G1.3171.00
49_L260_W1.2970.99
61_F194_L1.2970.99
364_V369_Q1.2880.99
374_Q377_K1.2790.99
358_D372_R1.2750.99
22_E26_A1.2710.99
297_P301_Y1.2700.99
115_D120_S1.2660.99
316_G320_A1.2650.99
269_Y290_D1.2630.99
282_E302_V1.2620.99
74_G127_Y1.2520.99
248_P253_P1.2480.99
244_V260_W1.2480.99
184_A212_T1.2420.99
317_L324_T1.2340.99
102_D106_K1.2330.99
289_E293_S1.2300.99
135_V138_F1.2290.99
289_E298_R1.2210.99
18_Q21_D1.2130.99
69_V122_I1.1990.99
359_L396_Y1.1990.99
288_E291_K1.1950.99
23_E27_E1.1930.99
70_A108_V1.1930.99
58_L61_F1.1850.99
384_I413_R1.1740.99
187_N217_Q1.1680.99
45_D99_E1.1590.99
278_M282_E1.1580.99
301_Y321_K1.1510.99
18_Q202_W1.1480.99
150_Q153_N1.1440.99
184_A216_H1.1430.99
322_R325_E1.1360.99
154_K206_T1.1290.98
360_M379_I1.1230.98
306_Q309_R1.1160.98
155_E159_Q1.1150.98
256_F260_W1.1150.98
386_I409_T1.1140.98
269_Y284_N1.1140.98
361_Q365_D1.1070.98
281_E284_N1.0990.98
318_Q321_K1.0980.98
305_E309_R1.0980.98
382_N392_S1.0940.98
230_K242_G1.0900.98
398_F409_T1.0890.98
106_K247_D1.0870.98
18_Q224_T1.0850.98
28_R31_Q1.0770.98
130_F178_L1.0770.98
29_L34_I1.0720.98
11_Q26_A1.0710.98
273_K280_I1.0700.98
253_P312_H1.0680.98
130_F181_Y1.0660.98
366_S419_C1.0660.98
25_L28_R1.0640.98
125_N128_D1.0640.98
360_M372_R1.0620.98
284_N288_E1.0540.98
352_E365_D1.0530.98
135_V178_L1.0470.97
393_D396_Y1.0380.97
56_L310_L1.0360.97
254_Y323_I1.0330.97
57_C225_V1.0330.97
357_A362_A1.0290.97
301_Y305_E1.0280.97
159_Q163_R1.0240.97
69_V186_L1.0240.97
317_L321_K1.0230.97
28_R32_G1.0210.97
151_M173_F1.0200.97
163_R166_Q1.0060.97
377_K383_A1.0010.97
51_H54_P0.9960.97
56_L277_F0.9950.97
359_L379_I0.9950.97
283_I287_E0.9900.96
17_A199_S0.9840.96
258_Q262_N0.9830.96
357_A365_D0.9790.96
185_C188_K0.9790.96
135_V174_S0.9760.96
272_L303_L0.9740.96
16_V19_V0.9730.96
9_Q60_R0.9720.96
236_F259_F0.9630.96
315_E318_Q0.9560.96
248_P316_G0.9460.95
184_A211_L0.9450.95
194_L223_L0.9430.95
256_F311_V0.9420.95
323_I326_C0.9400.95
413_R417_N0.9400.95
343_L410_L0.9340.95
53_V228_I0.9340.95
319_A322_R0.9320.95
35_A122_I0.9300.95
272_L286_L0.9260.95
273_K283_I0.9260.95
67_K120_S0.9260.95
403_R409_T0.9250.95
133_M181_Y0.9240.95
94_E131_G0.9230.95
83_S168_I0.9180.95
359_L384_I0.9180.95
59_K277_F0.9160.95
139_L178_L0.9120.94
363_L411_L0.9030.94
391_Q396_Y0.9000.94
138_F177_L0.8930.94
298_R302_V0.8930.94
19_V22_E0.8910.94
60_R64_A0.8900.94
15_L60_R0.8890.94
55_L111_F0.8860.93
369_Q384_I0.8850.93
302_V305_E0.8850.93
15_L274_F0.8810.93
145_H215_L0.8790.93
142_I181_Y0.8780.93
276_T306_Q0.8770.93
268_V295_K0.8760.93
228_I275_F0.8740.93
38_C51_H0.8730.93
370_P417_N0.8720.93
322_R326_C0.8710.93
286_L302_V0.8710.93
296_A300_Q0.8710.93
252_S255_K0.8710.93
255_K258_Q0.8700.93
45_D51_H0.8680.93
109_A121_A0.8660.93
205_I224_T0.8650.93
244_V259_F0.8640.93
410_L420_L0.8630.93
34_I66_H0.8620.93
305_E314_E0.8590.92
15_L223_L0.8580.92
71_L124_A0.8550.92
139_L174_S0.8540.92
28_R218_N0.8460.92
44_A51_H0.8460.92
12_E284_N0.8440.92
272_L302_V0.8380.91
27_E30_A0.8370.91
286_L290_D0.8370.91
102_D109_A0.8350.91
62_Q121_A0.8350.91
25_L194_L0.8330.91
287_E290_D0.8290.91
257_Y301_Y0.8260.91
276_T307_V0.8220.91
369_Q374_Q0.8220.91
60_R63_Q0.8190.91
398_F421_I0.8190.91
260_W275_F0.8160.90
289_E294_G0.8140.90
323_I327_L0.8130.90
108_V123_A0.8120.90
105_R123_A0.8110.90
316_G324_T0.8100.90
386_I411_L0.8060.90
360_M376_R0.8060.90
407_R422_C0.8030.90
184_A220_V0.8030.90
258_Q328_F0.8030.90
83_S87_A0.8010.90
106_K109_A0.7990.89
85_K239_T0.7960.89
188_K215_L0.7960.89
147_S169_S0.7940.89
262_N416_K0.7940.89
230_K241_G0.7930.89
57_C196_I0.7870.89
388_G412_R0.7870.89
33_P66_H0.7870.89
364_V375_A0.7860.89
40_F51_H0.7850.89
34_I194_L0.7850.89
40_F70_A0.7810.88
360_M394_P0.7810.88
341_E344_A0.7800.88
133_M142_I0.7790.88
42_P101_V0.7790.88
289_E292_N0.7790.88
24_A27_E0.7780.88
261_I297_P0.7730.88
258_Q324_T0.7730.88
349_P352_E0.7720.88
152_I161_L0.7710.88
113_D121_A0.7700.88
45_D103_K0.7680.87
341_E407_R0.7670.87
25_L29_L0.7600.87
352_E422_C0.7590.87
382_N385_T0.7560.87
257_Y305_E0.7550.87
109_A114_F0.7530.86
98_Q101_V0.7520.86
150_Q154_K0.7520.86
326_C330_G0.7510.86
19_V25_L0.7510.86
358_D395_E0.7470.86
289_E295_K0.7470.86
55_L112_L0.7460.86
277_F306_Q0.7450.86
44_A241_G0.7450.86
231_A266_A0.7440.86
294_G297_P0.7430.86
21_D28_R0.7430.86
245_W248_P0.7320.85
257_Y261_I0.7320.85
286_L289_E0.7300.85
140_R145_H0.7270.84
181_Y185_C0.7260.84
273_K284_N0.7220.84
51_H239_T0.7220.84
78_L97_V0.7210.84
157_V176_N0.7190.84
331_S334_A0.7180.84
329_S332_L0.7170.84
155_E158_K0.7170.84
187_N212_T0.7160.84
36_L194_L0.7160.84
90_K96_T0.7150.83
143_G174_S0.7150.83
62_Q113_D0.7130.83
15_L56_L0.7130.83
58_L70_A0.7120.83
144_K171_T0.7100.83
230_K259_F0.7080.83
111_F256_F0.7050.83
381_S413_R0.7050.83
53_V274_F0.7040.83
51_H55_L0.7030.82
309_R315_E0.7020.82
107_Q247_D0.6980.82
280_I283_I0.6940.82
289_E302_V0.6930.82
91_L171_T0.6920.81
91_L140_R0.6910.81
38_C47_L0.6910.81
257_Y324_T0.6910.81
367_E370_P0.6900.81
297_P300_Q0.6900.81
387_N409_T0.6890.81
240_E243_A0.6880.81
321_K324_T0.6880.81
136_L140_R0.6870.81
276_T302_V0.6870.81
130_F135_V0.6860.81
17_A21_D0.6850.81
49_L259_F0.6820.81
146_F177_L0.6810.80
109_A123_A0.6790.80
286_L299_A0.6790.80
146_F180_G0.6780.80
40_F44_A0.6780.80
232_D264_A0.6750.80
24_A219_Q0.6740.80
325_E329_S0.6730.80
408_F422_C0.6710.79
147_S150_Q0.6710.79
268_V299_A0.6710.79
301_Y329_S0.6700.79
85_K159_Q0.6690.79
52_L275_F0.6680.79
207_S210_D0.6680.79
330_G333_S0.6670.79
359_L363_L0.6660.79
148_V168_I0.6650.79
52_L310_L0.6630.79
148_V173_F0.6600.78
392_S396_Y0.6580.78
386_I398_F0.6570.78
210_D214_R0.6570.78
295_K299_A0.6560.78
347_G350_M0.6550.78
105_R114_F0.6540.78
54_P196_I0.6530.78
295_K298_R0.6510.77
272_L299_A0.6500.77
372_R376_R0.6500.77
181_Y215_L0.6480.77
230_K271_F0.6480.77
133_M137_T0.6460.77
256_F312_H0.6460.77
97_V100_W0.6460.77
234_T239_T0.6450.77
93_T97_V0.6430.77
227_L240_E0.6430.77
231_A263_T0.6420.76
68_P120_S0.6410.76
227_L247_D0.6380.76
138_F142_I0.6370.76
170_F174_S0.6360.76
42_P48_H0.6350.76
49_L307_V0.6340.76
49_L230_K0.6340.76
358_D379_I0.6330.75
347_G351_V0.6320.75
262_N328_F0.6310.75
373_G376_R0.6300.75
88_E144_K0.6280.75
87_A240_E0.6280.75
239_T242_G0.6280.75
36_L196_I0.6280.75
83_S156_A0.6270.75
267_D271_F0.6260.75
30_A33_P0.6250.74
202_W224_T0.6220.74
376_R394_P0.6210.74
60_R277_F0.6210.74
348_V390_K0.6190.74
379_I394_P0.6190.74
379_I384_I0.6170.74
350_M422_C0.6170.74
206_T209_I0.6160.73
138_F178_L0.6160.73
18_Q24_A0.6150.73
176_N180_G0.6140.73
231_A264_A0.6130.73
361_Q364_V0.6120.73
51_H103_K0.6120.73
151_M176_N0.6110.73
33_P67_K0.6110.73
358_D397_F0.6090.73
59_K108_V0.6080.72
272_L283_I0.6060.72
28_R221_F0.6050.72
263_T271_F0.6050.72
373_G380_A0.6000.71
59_K62_Q0.6000.71
333_S389_E0.5990.71
151_M170_F0.5990.71
110_P247_D0.5990.71
232_D242_G0.5990.71
326_C329_S0.5980.71
268_V287_E0.5970.71
326_C332_L0.5970.71
20_T28_R0.5960.71
324_T416_K0.5960.71
77_G97_V0.5960.71
24_A221_F0.5950.71
255_K345_Q0.5950.71
151_M157_V0.5930.71
389_E396_Y0.5930.71
353_M421_I0.5930.71
248_P252_S0.5920.70
156_A176_N0.5920.70
106_K110_P0.5920.70
258_Q416_K0.5910.70
49_L274_F0.5910.70
260_W308_T0.5910.70
278_M286_L0.5900.70
78_L92_N0.5890.70
51_H225_V0.5880.70
378_T384_I0.5870.70
49_L111_F0.5860.70
291_K354_E0.5850.70
86_A90_K0.5810.69
356_G399_K0.5810.69
85_K90_K0.5790.69
9_Q64_A0.5790.69
363_L375_A0.5780.69
153_N244_V0.5780.69
258_Q261_I0.5780.69
56_L60_R0.5750.68
110_P248_P0.5750.68
260_W271_F0.5740.68
78_L131_G0.5730.68
49_L275_F0.5730.68
369_Q411_L0.5730.68
127_Y130_F0.5730.68
234_T241_G0.5720.68
355_K400_E0.5720.68
290_D298_R0.5700.68
170_F173_F0.5690.67
20_T209_I0.5690.67
203_G206_T0.5690.67
148_V151_M0.5680.67
53_V57_C0.5680.67
347_G422_C0.5670.67
54_P83_S0.5670.67
276_T310_L0.5660.67
368_L413_R0.5660.67
180_G211_L0.5650.67
342_Q345_Q0.5650.67
49_L256_F0.5650.67
320_A324_T0.5640.67
13_R280_I0.5630.67
228_I259_F0.5620.66
40_F108_V0.5620.66
309_R318_Q0.5610.66
150_Q210_D0.5600.66
362_A409_T0.5590.66
341_E345_Q0.5590.66
70_A112_L0.5570.66
23_E26_A0.5540.65
349_P353_M0.5530.65
254_Y328_F0.5510.65
18_Q28_R0.5470.64
196_I225_V0.5470.64
290_D293_S0.5460.64
77_G101_V0.5460.64
170_F177_L0.5460.64
48_H77_G0.5450.64
51_H59_K0.5440.64
55_L70_A0.5430.64
51_H271_F0.5430.64
328_F333_S0.5430.64
72_V101_V0.5410.64
375_A379_I0.5410.64
51_H104_I0.5390.63
307_V311_V0.5380.63
288_E293_S0.5370.63
354_E357_A0.5360.63
389_E392_S0.5350.63
18_Q29_L0.5340.63
293_S300_Q0.5340.63
343_L347_G0.5340.63
47_L70_A0.5300.62
36_L54_P0.5300.62
90_K240_E0.5290.62
92_N97_V0.5290.62
404_L407_R0.5280.62
370_P373_G0.5280.62
9_Q280_I0.5280.62
356_G400_E0.5270.62
409_T421_I0.5260.61
275_F310_L0.5230.61
209_I220_V0.5230.61
378_T417_N0.5220.61
88_E171_T0.5220.61
259_F263_T0.5220.61
103_K106_K0.5210.61
383_A403_R0.5200.61
61_F196_I0.5180.60
239_T256_F0.5180.60
98_Q125_N0.5170.60
361_Q395_E0.5130.60
173_F386_I0.5120.59
18_Q199_S0.5120.59
108_V125_N0.5100.59
133_M178_L0.5100.59
132_N137_T0.5100.59
212_T216_H0.5100.59
35_A187_N0.5090.59
330_G334_A0.5080.59
33_P120_S0.5080.59
254_Y324_T0.5070.59
269_Y283_I0.5070.59
40_F146_F0.5060.58
19_V222_G0.5050.58
149_N205_I0.5050.58
400_E403_R0.5040.58
156_A159_Q0.5030.58
275_F307_V0.5020.58
29_L66_H0.5010.58
38_C55_L0.5010.58
254_Y258_Q0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4oudA 2 0.967 100 0.241 Contact Map
2ts1A 2 0.7476 100 0.248 Contact Map
1jilA 2 0.7594 100 0.248 Contact Map
2janA 2 0.9788 100 0.254 Contact Map
1h3fA 2 0.8892 100 0.349 Contact Map
1y42X 2 0.75 100 0.386 Contact Map
2pidA 2 0.7288 100 0.436 Contact Map
2yxnA 2 0.7594 100 0.442 Contact Map
3p0jA 1 0.9175 100 0.564 Contact Map
3hv0A 2 0.7193 100 0.581 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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