GREMLIN Database
TRMH - tRNA (guanosine(18)-2'-O)-methyltransferase
UniProt: P0AGJ2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10967
Length: 229 (178)
Sequences: 1896 (1265)
Seq/√Len: 94.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
78_T81_D5.2161.00
47_E74_K4.2611.00
80_G132_L4.0541.00
49_H76_H3.6201.00
137_I157_I3.5611.00
41_D69_S3.3581.00
35_A63_A3.2791.00
95_A133_A3.0571.00
23_C115_C2.8681.00
86_L115_C2.6521.00
116_I157_I2.6451.00
22_V158_L2.5881.00
26_Q52_W2.4151.00
77_R81_D2.3161.00
26_Q120_Q2.3081.00
49_H74_K2.1991.00
47_E113_P2.1441.00
118_M154_S2.1171.00
22_V40_A2.0681.00
94_L135_Q2.0411.00
24_M150_V1.9681.00
83_V93_I1.9321.00
21_T49_H1.9021.00
64_A68_N1.8701.00
118_M150_V1.7851.00
183_Q186_L1.7841.00
120_Q129_A1.7601.00
40_A45_V1.7031.00
92_Q135_Q1.6871.00
150_V154_S1.6791.00
39_T155_A1.6741.00
36_I154_S1.6501.00
79_I117_L1.5901.00
45_V158_L1.5391.00
162_Q166_Q1.5151.00
52_W77_R1.4271.00
187_L191_G1.3850.99
94_L137_I1.3620.99
87_K113_P1.3620.99
24_M154_S1.3550.99
37_I48_V1.3450.99
103_V106_R1.3370.99
105_F108_I1.3170.99
31_H59_T1.3090.99
93_I117_L1.3050.99
22_V116_I1.2990.99
79_I83_V1.2930.99
21_T47_E1.2930.99
43_V155_A1.2850.99
160_E163_R1.2790.99
36_I150_V1.2680.99
19_D113_P1.2340.99
120_Q126_T1.2030.98
128_E131_A1.1970.98
189_E193_P1.1800.98
31_H155_A1.1730.98
97_H136_D1.1710.98
107_E110_Y1.1710.98
46_H72_Q1.1650.98
134_D181_A1.1600.98
103_V107_E1.1280.97
51_V82_A1.1220.97
106_R110_Y1.1190.97
30_P56_R1.1170.97
117_L133_A1.1070.97
35_A42_A1.1030.97
126_T129_A1.0950.97
180_E183_Q1.0920.97
25_E125_I1.0910.97
98_L146_Q1.0830.97
179_P182_E1.0650.96
21_T76_H1.0580.96
182_E186_L1.0580.96
63_A152_V1.0530.96
20_L45_V1.0390.96
106_R109_D1.0370.96
134_D184_Q1.0360.96
23_C86_L1.0350.96
188_F195_L1.0350.96
96_T157_I1.0340.96
58_R61_A1.0320.96
61_A68_N1.0150.95
92_Q112_R1.0080.95
28_H122_K1.0070.95
85_H182_E1.0060.95
186_L190_G1.0030.95
79_I129_A1.0000.95
104_D109_D0.9860.94
35_A151_S0.9850.94
22_V45_V0.9700.94
28_H147_S0.9580.93
47_E72_Q0.9460.93
64_A67_S0.9460.93
92_Q114_T0.9370.93
186_L189_E0.9340.93
25_E129_A0.9310.92
195_L198_V0.9270.92
87_K112_R0.9240.92
83_V86_L0.9200.92
141_M145_V0.9150.92
23_C82_A0.9140.92
26_Q53_P0.9130.92
185_R189_E0.9080.91
62_S65_A0.8950.91
20_L161_A0.8850.90
21_T86_L0.8790.90
104_D107_E0.8760.90
130_L136_D0.8740.90
30_P57_M0.8730.90
25_E120_Q0.8670.89
52_W75_T0.8640.89
142_I145_V0.8570.89
60_M71_V0.8510.89
42_A145_V0.8450.88
56_R61_A0.8440.88
95_A125_I0.8440.88
43_V148_L0.8400.88
192_Y196_A0.8370.88
37_I127_Q0.8330.87
165_R171_Y0.8290.87
86_L93_I0.8230.87
57_M60_M0.8190.87
105_F110_Y0.8150.86
41_D67_S0.8100.86
41_D70_W0.8070.86
30_P33_V0.7900.85
95_A130_L0.7890.84
141_M146_Q0.7870.84
116_I161_A0.7840.84
160_E164_Q0.7820.84
49_H85_H0.7820.84
179_P184_Q0.7800.84
37_I71_V0.7730.83
123_T126_T0.7720.83
66_G145_V0.7710.83
59_T63_A0.7700.83
29_K155_A0.7680.83
195_L199_A0.7560.82
148_L156_L0.7490.81
20_L114_T0.7480.81
50_A53_P0.7470.81
49_H86_L0.7470.81
190_G194_V0.7420.81
29_K63_A0.7420.81
100_D138_I0.7400.80
25_E86_L0.7350.80
95_A134_D0.7260.79
22_V118_M0.7250.79
100_D104_D0.7230.79
126_T178_L0.7230.79
52_W78_T0.7180.78
34_S125_I0.7170.78
41_D145_V0.7160.78
33_V53_P0.7140.78
93_I96_T0.7130.78
42_A63_A0.7100.78
117_L129_A0.7080.77
98_L101_N0.7040.77
25_E122_K0.6980.76
43_V141_M0.6920.76
103_V110_Y0.6920.76
25_E51_V0.6900.76
145_V152_V0.6800.75
65_A68_N0.6770.74
95_A98_L0.6730.74
36_I66_G0.6720.74
170_M177_M0.6720.74
53_P75_T0.6690.73
35_A155_A0.6660.73
35_A152_V0.6590.72
70_W143_G0.6570.72
179_P187_L0.6570.72
37_I125_I0.6550.72
174_E178_L0.6460.71
170_M174_E0.6450.71
98_L127_Q0.6430.70
180_E186_L0.6420.70
43_V162_Q0.6410.70
23_C76_H0.6360.70
40_A158_L0.6350.70
33_V36_I0.6340.69
112_R176_S0.6340.69
36_I151_S0.6330.69
29_K66_G0.6320.69
191_G194_V0.6300.69
181_A185_R0.6280.69
102_A131_A0.6270.69
67_S145_V0.6190.68
93_I181_A0.6180.67
32_N38_R0.6170.67
139_I156_L0.6130.67
95_A117_L0.6130.67
19_D109_D0.6110.67
57_M65_A0.6110.67
39_T152_V0.6050.66
168_A171_Y0.6020.65
169_G174_E0.6020.65
96_T156_L0.6010.65
51_V79_I0.6000.65
121_E124_G0.5980.65
127_Q131_A0.5970.65
141_M162_Q0.5900.64
37_I73_V0.5880.64
184_Q188_F0.5870.63
117_L153_A0.5830.63
174_E177_M0.5800.63
48_V71_V0.5790.62
24_M36_I0.5780.62
60_M67_S0.5770.62
77_R80_G0.5760.62
110_Y137_I0.5760.62
28_H120_Q0.5740.62
165_R177_M0.5720.61
28_H43_V0.5710.61
194_V198_V0.5700.61
188_F191_G0.5680.61
51_V129_A0.5670.61
42_A141_M0.5650.61
29_K35_A0.5650.61
47_E86_L0.5650.61
92_Q134_D0.5600.60
42_A155_A0.5560.59
31_H63_A0.5560.59
29_K56_R0.5560.59
113_P180_E0.5560.59
48_V53_P0.5540.59
25_E126_T0.5530.59
28_H54_G0.5520.59
93_I134_D0.5520.59
197_K200_K0.5490.58
60_M63_A0.5470.58
85_H127_Q0.5470.58
60_M73_V0.5470.58
100_D136_D0.5470.58
179_P186_L0.5460.58
40_A48_V0.5440.58
22_V154_S0.5420.57
40_A73_V0.5410.57
110_Y165_R0.5410.57
84_A182_E0.5410.57
194_V197_K0.5400.57
97_H102_A0.5340.56
92_Q95_A0.5330.56
76_H81_D0.5320.56
130_L138_I0.5300.56
100_D107_E0.5290.56
184_Q195_L0.5290.56
40_A70_W0.5270.55
96_T159_Y0.5250.55
86_L134_D0.5240.55
31_H152_V0.5210.54
131_A136_D0.5200.54
159_Y163_R0.5190.54
41_D139_I0.5170.54
31_H43_V0.5170.54
41_D46_H0.5160.54
94_L114_T0.5110.53
132_L185_R0.5100.53
23_C83_V0.5090.53
74_K77_R0.5080.53
96_T150_V0.5050.52
173_R177_M0.5050.52
185_R188_F0.5040.52
189_E192_Y0.5040.52
169_G172_L0.5030.52
103_V198_V0.5020.52
151_S164_Q0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1v2xA 2 0.821 100 0.32 Contact Map
1zjrA 2 0.8515 100 0.331 Contact Map
4cndA 2 0.6769 100 0.347 Contact Map
3onpA 2 0.6245 100 0.355 Contact Map
3ilkA 2 0.9127 100 0.358 Contact Map
4cngA 2 0.6245 100 0.379 Contact Map
3ic6A 2 0.7817 100 0.4 Contact Map
1gz0A 2 0.7205 100 0.42 Contact Map
1x7oA 2 0.7336 100 0.421 Contact Map
2ha8A 2 0.6856 100 0.426 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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