GREMLIN Database
TRKA - Trk system potassium uptake protein TrkA
UniProt: P0AGI8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11019
Length: 458 (442)
Sequences: 1498 (1034)
Seq/√Len: 49.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
282_G289_L6.5041.00
252_E277_T5.9411.00
236_M298_V5.8011.00
6_L52_G5.1851.00
315_A328_V5.1481.00
160_A203_V5.0891.00
240_G270_L4.9581.00
264_Q281_F4.7641.00
385_A428_I4.5591.00
59_R64_D3.9831.00
238_V301_F3.7131.00
2_K25_D3.7021.00
259_L277_T3.6661.00
36_L47_V3.6561.00
168_G204_E3.6131.00
238_V284_A3.5131.00
400_D425_N3.4871.00
167_I205_A3.4041.00
16_A43_F3.3271.00
153_V412_A3.2901.00
171_L185_V3.2761.00
398_V401_E3.1941.00
188_I201_T3.0631.00
88_S116_A2.9961.00
199_G424_D2.9531.00
160_A167_I2.8711.00
170_A173_T2.8491.00
137_I300_L2.8151.00
4_I63_A2.7871.00
162_Y205_A2.7861.00
248_A259_L2.7781.00
248_A274_L2.7011.00
188_I203_V2.6651.00
30_D36_L2.5741.00
396_G429_E2.5211.00
190_R207_D2.5141.00
129_V348_I2.4391.00
266_R269_E2.3291.00
390_S430_Q2.3211.00
63_A92_T2.3151.00
80_M119_I2.1971.00
261_E267_A2.1821.00
5_I16_A2.1301.00
172_S200_S2.1141.00
319_K345_D2.0501.00
147_N151_G2.0141.00
413_V426_L2.0011.00
400_D424_D1.9920.99
170_A202_I1.9820.99
290_L295_I1.9300.99
196_R199_G1.8870.99
152_K417_N1.8750.99
69_L82_A1.8710.99
20_V45_L1.8680.99
87_Y95_R1.8480.99
160_A164_G1.8430.99
13_G43_F1.8380.99
83_C95_R1.8100.99
236_M293_E1.7860.99
295_I323_A1.7620.99
415_R432_D1.7530.99
399_I410_I1.7500.99
167_I203_V1.7460.99
168_G205_A1.7230.99
301_F318_A1.6740.98
33_G49_Q1.6730.98
4_I66_A1.6640.98
29_V57_V1.6120.98
415_R420_M1.6020.98
62_G65_D1.6010.98
396_G427_R1.5960.98
84_Q88_S1.5840.97
410_I436_M1.5830.97
289_L293_E1.5800.97
169_N173_T1.5760.97
32_N35_R1.5620.97
245_A266_R1.5620.97
404_L408_T1.5540.97
363_R379_E1.5530.97
237_L248_A1.5440.97
134_Y250_R1.5410.97
260_I289_L1.5320.97
5_I15_L1.5140.97
236_M301_F1.5130.97
252_E275_Q1.5100.97
258_K293_E1.5100.97
385_A395_V1.5090.97
83_C97_A1.5060.96
152_K251_L1.5040.96
158_V211_F1.5020.96
370_V381_I1.4890.96
137_I302_I1.4700.96
235_I300_L1.4560.96
280_F289_L1.4470.96
13_G39_L1.4430.95
69_L92_T1.4400.95
39_L43_F1.4390.95
264_Q268_A1.4160.95
186_A411_G1.4080.95
36_L89_L1.4060.95
241_G283_D1.4050.95
32_N327_M1.3980.95
151_G283_D1.3670.94
84_Q118_P1.3660.94
85_V111_L1.3570.94
304_V329_L1.3530.94
241_G244_G1.3500.94
244_G248_A1.3490.94
235_I254_D1.3330.93
56_R60_E1.3280.93
9_G12_G1.3250.93
220_A271_A1.3230.93
241_G332_R1.3210.93
184_R409_I1.3200.93
9_G98_R1.3060.92
128_L353_A1.3060.92
423_N426_L1.2930.92
398_V427_R1.2860.92
245_A249_R1.2720.91
28_V45_L1.2720.91
39_L45_L1.2600.91
367_I381_I1.2600.91
413_V422_A1.2510.91
69_L86_A1.2450.90
27_T46_R1.2410.90
235_I255_Y1.2280.90
83_C123_I1.2160.89
288_E291_A1.2120.89
76_D308_D1.2100.89
15_L72_V1.2070.89
378_A437_F1.2020.89
157_V210_F1.1990.89
7_G12_G1.1950.89
51_H77_E1.1900.88
366_D386_H1.1900.88
16_A28_V1.1900.88
197_P424_D1.1870.88
89_L92_T1.1850.88
10_Q329_L1.1800.88
99_I292_E1.1770.88
235_I302_I1.1760.88
87_Y118_P1.1750.88
187_A194_P1.1680.87
188_I195_I1.1540.87
420_M426_L1.1520.87
245_A269_E1.1510.87
29_V48_V1.1470.86
244_G304_V1.1440.86
269_E273_K1.1430.86
274_L277_T1.1330.86
309_E335_Y1.1330.86
405_P437_F1.1100.85
3_I26_I1.1080.84
2_K65_D1.1050.84
265_Q268_A1.1040.84
252_E276_N1.1000.84
240_G261_E1.0920.84
11_V98_R1.0770.83
167_I204_E1.0730.82
154_S215_S1.0650.82
33_G37_R1.0630.82
103_D119_I1.0610.82
313_M437_F1.0610.82
410_I413_V1.0590.82
3_I42_K1.0580.82
5_I26_I1.0550.81
328_V344_I1.0490.81
129_V329_L1.0460.81
236_M260_I1.0410.80
37_R41_D1.0380.80
248_A277_T1.0360.80
169_N174_M1.0250.79
259_L274_L1.0160.79
286_D319_K1.0160.79
134_Y247_L1.0120.79
168_G337_D1.0070.78
131_D250_R1.0060.78
203_V225_L1.0050.78
291_A321_M1.0050.78
247_L339_V1.0040.78
184_R424_D1.0030.78
54_H103_D1.0000.78
213_A217_H0.9960.77
6_L82_A0.9880.77
10_Q80_M0.9870.77
257_V277_T0.9840.77
395_V430_Q0.9820.76
81_V84_Q0.9780.76
30_D47_V0.9730.76
245_A270_L0.9710.76
283_D332_R0.9680.75
185_V217_H0.9670.75
157_V340_Q0.9610.75
313_M340_Q0.9600.75
186_A212_I0.9550.74
61_A66_A0.9520.74
38_T41_D0.9510.74
157_V208_E0.9490.74
160_A224_E0.9450.74
148_F380_A0.9440.74
173_T176_E0.9440.74
245_A273_K0.9430.73
10_Q14_T0.9390.73
268_A272_E0.9370.73
142_A145_V0.9360.73
309_E312_I0.9320.73
348_I353_A0.9290.72
10_Q306_N0.9250.72
34_E262_R0.9240.72
95_R146_V0.9230.72
8_A39_L0.9220.72
384_V433_H0.9180.71
188_I197_P0.9170.71
237_L313_M0.9150.71
184_R422_A0.9150.71
397_R401_E0.9060.70
251_L257_V0.9060.70
409_I424_D0.9050.70
59_R348_I0.9050.70
80_M84_Q0.9030.70
237_L355_I0.8990.70
66_A92_T0.8990.70
381_I436_M0.8960.70
40_Q47_V0.8910.69
410_I422_A0.8890.69
10_Q331_Q0.8870.69
415_R426_L0.8860.69
214_A348_I0.8860.69
14_T18_N0.8850.69
197_P409_I0.8820.68
301_F314_S0.8770.68
422_A426_L0.8730.68
22_E363_R0.8720.67
168_G171_L0.8720.67
42_K48_V0.8660.67
121_H124_A0.8650.67
54_H101_S0.8630.67
259_L340_Q0.8620.67
26_I39_L0.8570.66
241_G399_I0.8550.66
415_R429_E0.8530.66
234_R256_S0.8520.66
265_Q269_E0.8520.66
295_I448_E0.8510.66
187_A378_A0.8490.65
162_Y206_G0.8480.65
245_A315_A0.8480.65
28_V31_T0.8470.65
50_G57_V0.8470.65
133_I302_I0.8450.65
164_G167_I0.8420.65
2_K131_D0.8380.64
188_I336_V0.8370.64
100_R126_E0.8360.64
174_M203_V0.8350.64
4_I27_T0.8320.64
408_T420_M0.8320.64
339_V357_A0.8310.64
348_I368_V0.8300.64
85_V413_V0.8300.64
196_R424_D0.8290.64
414_V419_V0.8290.64
117_V411_G0.8280.63
273_K431_G0.8280.63
40_Q422_A0.8260.63
409_I422_A0.8250.63
308_D350_P0.8240.63
14_T308_D0.8240.63
4_I292_E0.8230.63
213_A218_I0.8200.63
26_I211_F0.8180.62
273_K279_V0.8170.62
287_Q330_I0.8170.62
349_S421_I0.8130.62
119_I122_L0.8110.62
285_S310_A0.8090.62
161_Y164_G0.8070.61
223_S228_L0.8060.61
241_G284_A0.8050.61
235_I253_K0.8020.61
169_N177_H0.8020.61
336_V340_Q0.8020.61
301_F436_M0.7980.61
245_A274_L0.7970.60
46_R199_G0.7970.60
94_N120_D0.7950.60
15_L109_D0.7930.60
192_D211_F0.7930.60
267_A281_F0.7930.60
249_R401_E0.7870.59
185_V221_V0.7860.59
80_M118_P0.7860.59
213_A221_V0.7860.59
11_V354_T0.7810.59
206_G401_E0.7790.59
327_M348_I0.7770.58
428_I447_V0.7760.58
276_N404_L0.7720.58
127_Q131_D0.7720.58
82_A188_I0.7710.58
149_A414_V0.7710.58
72_V123_I0.7690.58
203_V397_R0.7680.58
291_A296_D0.7650.57
30_D382_E0.7650.57
99_I118_P0.7650.57
173_T256_S0.7630.57
179_P279_V0.7620.57
13_G38_T0.7620.57
216_Q418_D0.7610.57
76_D359_L0.7600.57
167_I200_S0.7600.57
57_V327_M0.7590.57
153_V435_I0.7580.57
294_H298_V0.7560.56
25_D425_N0.7540.56
347_A408_T0.7530.56
295_I397_R0.7530.56
70_V362_V0.7500.56
366_D431_G0.7480.56
411_G437_F0.7460.55
232_Y300_L0.7430.55
132_N196_R0.7420.55
64_D165_P0.7410.55
133_I247_L0.7410.55
82_A210_F0.7400.55
395_V431_G0.7400.55
330_I374_R0.7390.55
314_S344_I0.7390.55
80_M440_D0.7330.54
303_A315_A0.7320.54
270_L316_M0.7320.54
235_I251_L0.7310.54
124_A329_L0.7300.54
174_M217_H0.7270.53
368_V384_V0.7270.53
182_D217_H0.7270.53
362_V434_V0.7260.53
153_V414_V0.7260.53
385_A431_G0.7240.53
100_R363_R0.7210.53
249_R273_K0.7200.53
93_P396_G0.7190.53
149_A153_V0.7150.52
53_S77_E0.7150.52
107_D185_V0.7130.52
263_N354_T0.7100.52
200_S263_N0.7100.52
56_R103_D0.7100.52
59_R107_D0.7080.52
63_A323_A0.7070.51
313_M351_Q0.7060.51
123_I305_T0.7060.51
92_T323_A0.7060.51
256_S416_G0.7050.51
394_V447_V0.7050.51
58_L303_A0.7040.51
60_E413_V0.7040.51
273_K401_E0.7030.51
196_R304_V0.7000.51
199_G283_D0.7000.51
282_G290_L0.7000.51
180_H373_L0.7000.51
29_V249_R0.6980.51
171_L197_P0.6980.51
27_T330_I0.6970.50
170_A177_H0.6970.50
279_V413_V0.6960.50
129_V351_Q0.6950.50
263_N344_I0.6940.50
394_V428_I0.6940.50
128_L357_A0.6890.50
2_K24_N0.6840.49
214_A217_H0.6840.49
244_G259_L0.6820.49
206_G447_V0.6810.49
45_L73_T0.6790.49
56_R235_I0.6780.49
185_V347_A0.6780.49
381_I438_L0.6770.48
342_S433_H0.6770.48
24_N308_D0.6770.48
4_I62_G0.6760.48
216_Q392_S0.6750.48
285_S332_R0.6750.48
262_R281_F0.6750.48
163_G167_I0.6740.48
29_V247_L0.6730.48
328_V429_E0.6730.48
57_V61_A0.6720.48
123_I354_T0.6710.48
287_Q291_A0.6700.48
332_R349_S0.6680.47
248_A312_I0.6670.47
81_V146_V0.6670.47
173_T253_K0.6660.47
6_L69_L0.6660.47
2_K309_E0.6660.47
146_V213_A0.6650.47
253_K276_N0.6630.47
81_V104_Y0.6620.47
304_V312_I0.6610.47
85_V213_A0.6610.47
333_R351_Q0.6600.47
100_R185_V0.6600.47
377_V417_N0.6600.47
51_H124_A0.6590.47
126_E258_K0.6590.47
407_G437_F0.6580.46
66_A286_D0.6560.46
118_P243_I0.6560.46
385_A430_Q0.6550.46
223_S447_V0.6550.46
172_S243_I0.6530.46
28_V428_I0.6520.46
97_A358_L0.6510.46
262_R306_N0.6500.46
261_E283_D0.6490.46
68_M362_V0.6490.46
147_N154_S0.6470.45
8_A405_P0.6470.45
398_V424_D0.6470.45
392_S451_F0.6440.45
365_A448_E0.6400.45
199_G409_I0.6390.45
29_V406_P0.6330.44
103_D410_I0.6320.44
36_L45_L0.6290.44
52_G124_A0.6280.43
136_L244_G0.6280.43
219_R423_N0.6270.43
36_L351_Q0.6260.43
233_K416_G0.6260.43
77_E81_V0.6260.43
71_A379_E0.6260.43
159_K208_E0.6250.43
20_V104_Y0.6250.43
267_A293_E0.6240.43
259_L361_H0.6240.43
4_I269_E0.6240.43
17_E288_E0.6230.43
301_F323_A0.6220.43
103_D143_L0.6210.43
213_A250_R0.6210.43
2_K62_G0.6200.43
348_I351_Q0.6200.43
330_I425_N0.6200.43
151_G261_E0.6180.42
162_Y214_A0.6180.42
199_G428_I0.6180.42
72_V394_V0.6180.42
195_I437_F0.6160.42
287_Q328_V0.6140.42
10_Q100_R0.6130.42
144_Q213_A0.6130.42
139_Y211_F0.6130.42
259_L368_V0.6120.42
64_D281_F0.6100.42
284_A412_A0.6100.42
33_G64_D0.6100.42
218_I349_S0.6090.42
53_S308_D0.6080.41
240_G245_A0.6070.41
343_V391_T0.6070.41
146_V422_A0.6060.41
166_L251_L0.6060.41
54_H107_D0.6060.41
49_Q165_P0.6060.41
51_H54_H0.6050.41
284_A310_A0.6040.41
287_Q332_R0.6040.41
105_V140_P0.6030.41
303_A318_A0.6030.41
49_Q160_A0.6020.41
285_S316_M0.6010.41
2_K395_V0.6010.41
263_N446_D0.6010.41
91_N355_I0.6010.41
185_V361_H0.5990.41
353_A357_A0.5990.41
386_H391_T0.5980.40
84_Q354_T0.5970.40
83_C382_E0.5960.40
33_G281_F0.5950.40
145_V349_S0.5940.40
125_P282_G0.5920.40
69_L230_K0.5900.40
212_I421_I0.5900.40
116_A119_I0.5890.40
156_A218_I0.5890.40
14_T328_V0.5880.40
36_L40_Q0.5870.39
153_V250_R0.5860.39
196_R430_Q0.5860.39
75_S104_Y0.5860.39
181_I217_H0.5850.39
160_A354_T0.5820.39
299_D324_K0.5820.39
28_V138_E0.5810.39
194_P377_V0.5810.39
68_M229_E0.5800.39
283_D426_L0.5800.39
39_L415_R0.5800.39
278_I293_E0.5800.39
137_I327_M0.5800.39
80_M100_R0.5790.39
399_I402_I0.5790.39
88_S118_P0.5780.39
63_A91_N0.5780.39
195_I228_L0.5770.38
313_M335_Y0.5760.38
80_M229_E0.5750.38
80_M258_K0.5750.38
9_G45_L0.5750.38
42_K401_E0.5720.38
16_A55_P0.5710.38
145_V303_A0.5710.38
84_Q122_L0.5710.38
75_S195_I0.5710.38
330_I340_Q0.5700.38
237_L260_I0.5690.38
30_D148_F0.5690.38
241_G282_G0.5690.38
402_I428_I0.5690.38
192_D396_G0.5690.38
304_V315_A0.5690.38
160_A221_V0.5680.38
123_I448_E0.5680.38
88_S243_I0.5680.38
287_Q360_S0.5670.37
307_D310_A0.5670.37
153_V419_V0.5670.37
27_T206_G0.5660.37
378_A382_E0.5660.37
54_H89_L0.5650.37
237_L302_I0.5640.37
330_I359_L0.5640.37
180_H192_D0.5640.37
345_D451_F0.5630.37
264_Q267_A0.5630.37
55_P89_L0.5620.37
212_I265_Q0.5620.37
1_M7_G0.5620.37
208_E312_I0.5620.37
190_R195_I0.5610.37
120_D248_A0.5610.37
24_N350_P0.5610.37
131_D236_M0.5610.37
131_D134_Y0.5600.37
45_L52_G0.5600.37
192_D320_R0.5600.37
156_A279_V0.5600.37
206_G223_S0.5590.37
243_I335_Y0.5590.37
36_L236_M0.5580.37
204_E220_A0.5570.37
241_G266_R0.5570.37
320_R341_G0.5560.36
376_G451_F0.5560.36
70_V357_A0.5560.36
412_A435_I0.5550.36
361_H367_I0.5550.36
128_L312_I0.5550.36
394_V401_E0.5540.36
39_L123_I0.5530.36
69_L95_R0.5530.36
173_T177_H0.5530.36
153_V350_P0.5530.36
17_E31_T0.5520.36
394_V442_K0.5510.36
84_Q87_Y0.5500.36
268_A338_L0.5500.36
76_D100_R0.5490.36
301_F339_V0.5490.36
24_N345_D0.5480.36
78_T92_T0.5470.36
100_R125_P0.5460.36
28_V39_L0.5450.35
187_A429_E0.5450.35
75_S99_I0.5450.35
210_F437_F0.5440.35
161_Y227_R0.5440.35
314_S370_V0.5430.35
228_L280_F0.5420.35
187_A316_M0.5410.35
109_D114_S0.5390.35
284_A325_K0.5390.35
283_D333_R0.5380.35
184_R199_G0.5380.35
286_D327_M0.5380.35
157_V409_I0.5380.35
434_V443_F0.5370.35
6_L285_S0.5370.35
129_V323_A0.5360.35
221_V286_D0.5360.35
39_L253_K0.5340.34
155_L414_V0.5340.34
50_G308_D0.5340.34
4_I58_L0.5340.34
80_M256_S0.5330.34
232_Y325_K0.5330.34
18_N351_Q0.5330.34
394_V402_I0.5310.34
245_A267_A0.5310.34
17_E337_D0.5300.34
302_I343_V0.5290.34
150_E416_G0.5280.34
236_M294_H0.5280.34
180_H399_I0.5280.34
63_A89_L0.5270.34
355_I383_A0.5270.34
109_D273_K0.5260.34
133_I348_I0.5260.34
95_R364_K0.5250.34
267_A289_L0.5250.34
214_A330_I0.5250.34
111_L428_I0.5250.34
111_L118_P0.5250.34
65_D276_N0.5240.33
81_V119_I0.5230.33
274_L280_F0.5220.33
70_V78_T0.5210.33
238_V314_S0.5200.33
249_R392_S0.5200.33
121_H361_H0.5200.33
274_L306_N0.5200.33
133_I363_R0.5190.33
263_N442_K0.5180.33
162_Y429_E0.5180.33
42_K416_G0.5180.33
142_A221_V0.5170.33
307_D359_L0.5160.33
32_N295_I0.5160.33
176_E410_I0.5150.33
28_V392_S0.5150.33
8_A12_G0.5150.33
380_A437_F0.5150.33
16_A344_I0.5140.33
186_A437_F0.5140.33
348_I427_R0.5110.32
415_R435_I0.5110.32
34_E37_R0.5100.32
204_E330_I0.5090.32
132_N300_L0.5080.32
187_A225_L0.5080.32
122_L331_Q0.5070.32
208_E374_R0.5060.32
228_L373_L0.5060.32
195_I316_M0.5060.32
405_P411_G0.5050.32
385_A413_V0.5050.32
3_I19_L0.5050.32
136_L145_V0.5050.32
33_G96_I0.5040.32
320_R357_A0.5040.32
128_L347_A0.5040.32
38_T430_Q0.5040.32
383_A436_M0.5040.32
169_N202_I0.5030.32
303_A407_G0.5030.32
115_D255_Y0.5020.32
326_V344_I0.5010.31
262_R348_I0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g65A 2 0.9934 100 0.429 Contact Map
4gx0A 3 0.9323 100 0.477 Contact Map
3mt5A 5 0.9432 100 0.534 Contact Map
4hpfA 3 0.9258 100 0.535 Contact Map
3nafA 3 0.9585 100 0.536 Contact Map
2aefA 2 0.4782 100 0.734 Contact Map
3l4bC 2 0.4716 100 0.737 Contact Map
1lnqA 6 0.4716 100 0.743 Contact Map
4j91A 3 0.4651 100 0.777 Contact Map
1vctA 3 0.4127 99.9 0.84 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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