GREMLIN Database
XYLH - Xylose transport system permease protein XylH
UniProt: P0AGI4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12276
Length: 393 (367)
Sequences: 1516 (885)
Seq/√Len: 46.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
69_I306_I6.9571.00
42_F46_T5.9481.00
144_A380_L5.3191.00
97_V119_L4.2631.00
70_L326_A4.0691.00
117_L298_L4.0231.00
190_L225_A3.7971.00
101_C105_L3.7351.00
218_V222_A3.7041.00
268_I292_V3.5981.00
107_W115_V3.5911.00
82_E289_K3.3281.00
195_G199_R3.1131.00
264_F291_A3.1101.00
107_W111_L2.8951.00
121_L298_L2.8801.00
214_S218_V2.8091.00
187_A229_L2.7891.00
108_P111_L2.7181.00
255_G295_I2.6911.00
90_M123_L2.6831.00
40_M356_S2.6691.00
331_V337_L2.6441.00
98_A116_T2.6361.00
101_C115_V2.6261.00
254_G258_M2.6031.00
126_W130_W2.4801.00
76_F259_A2.4661.00
199_R202_M2.4211.00
304_G308_S2.3571.00
103_V164_P2.3201.00
186_G232_I2.2051.00
135_K275_L2.1971.00
130_W136_V2.1851.00
114_I118_V2.1301.00
34_A38_A2.1211.00
68_G351_A2.1211.00
68_G248_L2.0971.00
205_Q211_S2.0841.00
93_L123_L2.0811.00
41_L45_W2.0570.99
72_V251_L2.0440.99
97_V115_V1.9840.99
133_Y287_R1.9410.99
191_M195_G1.9350.99
230_G234_L1.9350.99
202_M205_Q1.9170.99
258_M264_F1.9120.99
70_L303_A1.9090.99
127_N145_G1.8880.99
361_M374_V1.8730.99
301_A305_L1.8580.99
251_L302_I1.8190.99
111_L115_V1.8050.99
202_M206_A1.7840.99
203_R206_A1.7230.98
180_S184_I1.7170.98
116_T305_L1.7150.98
93_L152_I1.7120.98
284_N287_R1.6820.98
122_L125_A1.6800.98
133_Y286_E1.6560.98
186_G228_V1.6500.98
68_G348_V1.6420.97
185_I192_A1.6270.97
55_R238_Y1.6240.97
276_E279_R1.6090.97
40_M52_L1.6000.97
152_I155_G1.5820.97
74_M87_V1.5710.97
290_L294_A1.5670.97
152_I373_I1.5580.97
138_S293_F1.5320.96
101_C112_T1.5260.96
307_L367_P1.4980.96
170_S312_G1.4910.96
65_A312_G1.4680.95
189_G253_L1.4630.95
135_K286_E1.4550.95
88_G319_G1.4500.95
121_L294_A1.4390.95
95_G318_A1.4360.94
61_L245_V1.4330.94
215_T219_G1.4230.94
193_F224_T1.4200.94
82_E138_S1.4130.94
201_R211_S1.4110.94
201_R205_Q1.4080.94
41_L44_T1.3980.94
79_I259_A1.3930.94
244_P306_I1.3890.93
33_I227_I1.3810.93
94_L116_T1.3730.93
110_P114_I1.3620.93
298_L301_A1.3570.93
177_L241_V1.3470.92
287_R291_A1.3410.92
81_A275_L1.3280.92
243_T246_L1.3200.92
134_R384_W1.3120.91
126_W377_A1.3110.91
107_W114_I1.2970.91
194_V225_A1.2710.90
39_I353_I1.2660.90
362_S371_Q1.2570.89
256_M260_T1.1970.87
78_I83_I1.1940.87
155_G373_I1.1930.87
161_T313_A1.1930.87
351_A355_A1.1740.86
118_V122_L1.1740.86
107_W112_T1.1620.85
274_N283_I1.1600.85
26_N30_F1.1590.85
138_S337_L1.1580.85
279_R286_E1.1550.85
64_T358_D1.1480.85
194_V198_W1.1460.85
300_V304_G1.1390.84
129_W134_R1.1340.84
120_G301_A1.1280.84
101_C107_W1.1260.83
63_Q310_R1.1260.83
31_V35_A1.1240.83
250_L254_G1.1230.83
109_L264_F1.1140.83
127_N149_F1.1110.83
75_V79_I1.1090.82
205_Q214_S1.1060.82
177_L180_S1.1050.82
75_V335_T1.1030.82
303_A316_P1.0930.82
312_G361_M1.0860.81
122_L250_L1.0800.81
66_I307_L1.0730.80
97_V118_V1.0720.80
190_L229_L1.0670.80
186_G229_L1.0620.80
130_W390_K1.0610.80
198_W202_M1.0560.79
161_T164_P1.0550.79
194_V221_Q1.0530.79
179_A182_G1.0510.79
222_A226_I1.0490.79
120_G297_G1.0400.78
95_G308_S1.0310.78
64_T355_A1.0290.77
46_T366_V1.0280.77
268_I288_T1.0200.77
41_L287_R1.0170.77
155_G370_W1.0170.77
359_N363_M1.0140.76
201_R217_V1.0110.76
219_G222_A1.0080.76
373_I377_A1.0080.76
185_I241_V1.0030.76
164_P361_M1.0010.75
190_L228_V0.9950.75
163_S313_A0.9910.75
192_A196_W0.9900.75
89_S146_M0.9880.75
358_D375_K0.9860.74
235_L245_V0.9830.74
183_F229_L0.9790.74
327_I383_V0.9770.74
125_A290_L0.9740.73
203_R225_A0.9740.73
257_F262_T0.9690.73
336_S353_I0.9680.73
192_A253_L0.9680.73
138_S324_L0.9650.73
188_L192_A0.9640.73
184_I214_S0.9610.72
219_G226_I0.9590.72
82_E293_F0.9530.72
334_G342_G0.9500.72
325_D375_K0.9450.71
188_L222_A0.9430.71
106_G368_T0.9410.71
203_R224_T0.9360.70
275_L285_V0.9310.70
223_L227_I0.9310.70
46_T294_A0.9280.70
348_V352_F0.9250.70
358_D369_F0.9230.69
149_F152_I0.9220.69
195_G198_W0.9170.69
191_M233_W0.9110.68
115_V225_A0.9090.68
185_I200_G0.9080.68
151_G272_G0.9080.68
75_V347_A0.9060.68
307_L322_A0.8990.67
118_V121_L0.8980.67
58_S62_R0.8980.67
27_L188_L0.8950.67
187_A206_A0.8940.67
74_M280_L0.8930.67
96_G157_T0.8860.66
164_P311_L0.8850.66
109_L113_I0.8820.66
249_T306_I0.8820.66
77_V293_F0.8820.66
218_V253_L0.8770.65
28_Q31_V0.8770.65
164_P170_S0.8750.65
74_M325_D0.8740.65
193_F197_Q0.8700.65
64_T68_G0.8660.64
127_N141_V0.8630.64
75_V330_C0.8610.64
29_V343_S0.8550.63
103_V162_V0.8540.63
66_I331_V0.8540.63
70_L91_M0.8500.63
162_V165_T0.8500.63
162_V313_A0.8490.63
164_P168_A0.8470.63
53_S118_V0.8460.63
78_I335_T0.8420.62
122_L177_L0.8420.62
80_S292_V0.8330.61
110_P168_A0.8320.61
145_G383_V0.8290.61
332_I335_T0.8290.61
225_A229_L0.8230.60
122_L126_W0.8210.60
188_L227_I0.8200.60
100_I156_I0.8180.60
169_M172_I0.8150.60
130_W380_L0.8140.60
76_F292_V0.8140.60
337_L387_S0.8120.59
94_L119_L0.8120.59
94_L300_V0.8110.59
188_L196_W0.8100.59
26_N33_I0.8080.59
156_I202_M0.8070.59
222_A227_I0.8050.59
351_A354_M0.8050.59
253_L345_A0.8020.58
174_Q365_D0.7970.58
49_G296_N0.7950.58
34_A37_I0.7920.57
56_N63_Q0.7920.57
57_V254_G0.7910.57
370_W374_V0.7900.57
90_M352_F0.7890.57
173_G179_A0.7880.57
188_L250_L0.7880.57
330_C337_L0.7860.57
305_L391_R0.7860.57
33_I37_I0.7850.57
57_V235_L0.7840.57
119_L184_I0.7840.57
125_A305_L0.7820.56
188_L374_V0.7810.56
265_G282_G0.7810.56
197_Q221_Q0.7790.56
76_F268_I0.7780.56
32_M36_I0.7750.56
275_L337_L0.7720.56
264_F295_I0.7720.56
154_I348_V0.7720.56
370_W373_I0.7710.55
39_I314_G0.7690.55
165_T173_G0.7660.55
109_L168_A0.7650.55
79_I354_M0.7640.55
74_M146_M0.7640.55
77_V131_V0.7640.55
60_L309_S0.7610.54
44_T52_L0.7600.54
357_L375_K0.7600.54
66_I322_A0.7590.54
167_A172_I0.7580.54
77_V292_V0.7570.54
42_F45_W0.7510.53
112_T121_L0.7490.53
90_M149_F0.7480.53
188_L205_Q0.7440.53
77_V83_I0.7430.53
87_V146_M0.7430.53
64_T356_S0.7420.53
200_G203_R0.7410.52
73_G120_G0.7360.52
280_L323_E0.7350.52
194_V247_L0.7350.52
102_D112_T0.7340.52
150_R323_E0.7270.51
114_I156_I0.7230.51
187_A202_M0.7220.51
209_L303_A0.7210.51
189_G216_A0.7210.51
28_Q79_I0.7200.50
65_A244_P0.7190.50
105_L226_I0.7180.50
164_P312_G0.7180.50
272_G327_I0.7170.50
218_V381_L0.7160.50
184_I198_W0.7160.50
188_L223_L0.7120.50
126_W286_E0.7120.50
37_I40_M0.7100.49
74_M327_I0.7090.49
128_G142_T0.7080.49
358_D378_I0.7070.49
197_Q212_P0.7060.49
212_P217_V0.7050.49
267_R351_A0.7050.49
58_S361_M0.7050.49
198_W221_Q0.7050.49
100_I104_W0.7030.49
274_N324_L0.7020.49
87_V383_V0.7010.49
89_S150_R0.7000.48
54_A349_M0.6970.48
69_I251_L0.6960.48
246_L388_A0.6950.48
55_R374_V0.6940.48
106_G115_V0.6930.48
35_A150_R0.6900.47
34_A228_V0.6890.47
123_L368_T0.6880.47
126_W149_F0.6870.47
84_D143_L0.6850.47
38_A227_I0.6840.47
177_L181_T0.6830.47
92_G150_R0.6830.47
125_A294_A0.6820.47
77_V92_G0.6810.47
58_S238_Y0.6800.46
68_G79_I0.6800.46
56_N359_N0.6800.46
113_I305_L0.6780.46
302_I377_A0.6770.46
82_E131_V0.6760.46
161_T357_L0.6750.46
27_L192_A0.6750.46
27_L110_P0.6740.46
202_M261_R0.6740.46
117_L302_I0.6720.46
235_L353_I0.6710.46
151_G240_G0.6690.45
138_S289_K0.6670.45
297_G300_V0.6660.45
262_T271_I0.6650.45
276_E335_T0.6630.45
143_L151_G0.6630.45
147_L347_A0.6630.45
60_L63_Q0.6610.45
148_A301_A0.6610.45
78_I331_V0.6600.45
133_Y290_L0.6590.44
122_L260_T0.6580.44
230_G233_W0.6580.44
173_G178_P0.6560.44
133_Y284_N0.6540.44
171_Q243_T0.6530.44
60_L89_S0.6530.44
54_A190_L0.6510.44
240_G361_M0.6510.44
219_G223_L0.6500.44
213_A227_I0.6490.43
44_T94_L0.6480.43
169_M173_G0.6480.43
74_M145_G0.6450.43
233_W237_D0.6450.43
369_F372_Y0.6420.43
289_K293_F0.6410.43
142_T342_G0.6410.43
75_V292_V0.6400.43
203_R210_Q0.6400.43
26_N29_V0.6390.42
136_V212_P0.6390.42
96_G330_C0.6360.42
74_M323_E0.6340.42
126_W156_I0.6340.42
212_P215_T0.6340.42
121_L254_G0.6330.42
116_T135_K0.6330.42
113_I366_V0.6330.42
29_V33_I0.6320.42
80_S289_K0.6320.42
251_L301_A0.6310.42
228_V249_T0.6290.42
276_E336_S0.6280.41
238_Y297_G0.6280.41
103_V163_S0.6270.41
29_V34_A0.6270.41
189_G192_A0.6260.41
89_S145_G0.6200.41
79_I82_E0.6200.41
90_M94_L0.6190.41
115_V122_L0.6190.41
126_W129_W0.6180.40
135_K337_L0.6180.40
104_W162_V0.6150.40
157_T365_D0.6140.40
26_N39_I0.6120.40
275_L289_K0.6110.40
151_G313_A0.6110.40
85_L88_G0.6110.40
294_A298_L0.6090.40
292_V347_A0.6080.40
99_A332_I0.6080.40
59_N63_Q0.6050.39
339_G342_G0.6050.39
42_F258_M0.6030.39
202_M219_G0.6010.39
334_G350_G0.5990.39
122_L202_M0.5950.38
157_T355_A0.5950.38
161_T315_S0.5940.38
196_W213_A0.5940.38
286_E385_M0.5930.38
97_V101_C0.5910.38
50_A312_G0.5900.38
131_V144_A0.5880.38
131_V293_F0.5880.38
60_L156_I0.5860.37
166_S176_Y0.5860.37
337_L341_V0.5850.37
195_G226_I0.5850.37
33_I129_W0.5840.37
195_G202_M0.5830.37
40_M61_L0.5830.37
188_L220_R0.5820.37
46_T364_M0.5810.37
253_L287_R0.5800.37
113_I188_L0.5790.37
173_G238_Y0.5790.37
269_Y343_S0.5780.37
200_G208_G0.5770.37
207_L271_I0.5740.36
355_A359_N0.5710.36
195_G219_G0.5710.36
92_G153_L0.5700.36
223_L229_L0.5690.36
59_N239_R0.5670.36
265_G333_G0.5670.36
125_A192_A0.5660.36
267_R288_T0.5650.36
93_L302_I0.5650.36
151_G336_S0.5640.35
280_L330_C0.5630.35
263_A267_R0.5630.35
117_L301_A0.5610.35
58_S176_Y0.5610.35
240_G293_F0.5610.35
268_I317_S0.5610.35
96_G147_L0.5610.35
325_D355_A0.5600.35
159_G238_Y0.5590.35
99_A220_R0.5580.35
73_G83_I0.5580.35
293_F342_G0.5570.35
188_L221_Q0.5560.35
107_W365_D0.5540.35
200_G210_Q0.5530.34
148_A380_L0.5530.34
56_N59_N0.5520.34
54_A237_D0.5510.34
50_A377_A0.5510.34
187_A191_M0.5500.34
125_A297_G0.5500.34
111_L187_A0.5500.34
33_I114_I0.5480.34
72_V252_L0.5470.34
34_A202_M0.5470.34
37_I115_V0.5460.34
153_L209_L0.5460.34
159_G371_Q0.5460.34
137_P272_G0.5460.34
108_P198_W0.5450.34
167_A171_Q0.5440.34
345_A349_M0.5430.34
269_Y316_P0.5400.33
32_M353_I0.5400.33
174_Q187_A0.5390.33
30_F36_I0.5390.33
47_T364_M0.5390.33
84_D360_G0.5390.33
33_I191_M0.5380.33
282_G333_G0.5370.33
35_A351_A0.5350.33
128_G272_G0.5350.33
181_T184_I0.5350.33
312_G316_P0.5340.33
190_L198_W0.5340.33
314_G319_G0.5330.33
203_R258_M0.5320.33
209_L357_L0.5320.33
184_I218_V0.5320.33
92_G278_A0.5300.32
183_F206_A0.5300.32
214_S253_L0.5300.32
41_L214_S0.5300.32
47_T50_A0.5300.32
330_C388_A0.5300.32
108_P192_A0.5300.32
174_Q343_S0.5290.32
77_V88_G0.5280.32
109_L243_T0.5280.32
197_Q217_V0.5270.32
145_G327_I0.5270.32
172_I177_L0.5270.32
153_L157_T0.5270.32
58_S311_L0.5260.32
273_G277_A0.5260.32
184_I200_G0.5250.32
129_W298_L0.5250.32
198_W206_A0.5250.32
191_M218_V0.5250.32
240_G371_Q0.5240.32
137_P273_G0.5240.32
65_A104_W0.5240.32
161_T165_T0.5230.32
33_I226_I0.5220.32
351_A356_S0.5220.32
168_A171_Q0.5210.32
41_L212_P0.5210.32
204_R209_L0.5200.32
267_R284_N0.5200.32
295_I299_M0.5170.31
88_G342_G0.5170.31
145_G149_F0.5170.31
266_R273_G0.5160.31
152_I341_V0.5160.31
167_A388_A0.5160.31
134_R284_N0.5150.31
24_S30_F0.5140.31
57_V185_I0.5130.31
135_K391_R0.5100.31
90_M300_V0.5100.31
243_T247_L0.5100.31
78_I323_E0.5100.31
206_A219_G0.5090.31
311_L315_S0.5080.31
251_L324_L0.5070.30
59_N316_P0.5060.30
338_A341_V0.5050.30
27_L34_A0.5050.30
111_L211_S0.5040.30
46_T387_S0.5020.30
255_G299_M0.5010.30
182_G236_N0.5000.30
84_D273_G0.5000.30
68_G337_L0.5000.30
185_I249_T0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g1uA 2 0.6641 94.6 0.938 Contact Map
2nq2A 2 0.7405 93.3 0.942 Contact Map
2qi9A 2 0.7303 92.6 0.943 Contact Map
3dh4A 3 0.1221 22.5 0.969 Contact Map
4tkrA 2 0.43 22 0.969 Contact Map
4z7fA 2 0.4046 16.6 0.97 Contact Map
2zy9A 2 0.3817 15.1 0.971 Contact Map
4ytpC 1 0.2824 14.5 0.971 Contact Map
1zoyC 1 0.2748 14.4 0.971 Contact Map
2kogA 1 0.1298 13.4 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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