PSTC - ECOLI - GREMLIN Contacts

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PSTC - Phosphate transport system permease protein PstC

UniProt:	P0AGH8	Sequences: MAATKPAFNPPGKKGDIIFSVLVKLAALIVLLMLGGIIVSLIISSWPSIQKFGLAFLWTKEWDAPNDIYGALVPIYGTLVTSFIALLIAVPVSFGIALFLTELAPGWLKRPLGIAIELLAAIPSIVYGMWGLFIFAPLFAVYFQEPVGNIMSNIPIVGALFSGPAFGIGILAAGVILAIMIIPYIAAVMRDVFEQTPVMMKESAYGIGCTTWEVIWRIVLPFTKNGVIGGIMLGLGRALGETMAVTFIIGNTYQLDSASLYMPGNSITSALANEFAEAESGLHVAALMELGLILFVITFIVLAASKFMIMRLAKNEGAR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10784
Length:	319 (258)
Sequences:	68737 (45610)
Seq/√Len:	2839.6

ECOLI - PSTC POTH UGPA YCJO CYSW YDCU PSTA THIP CYST POTB MALF YCJP MALG YDCV POTI UGPE YNJC POTC MODB TAUC YEHY SSUC PHNE YEHW METI PROW YECS
BACSU - GANP AMYD MDXF ARAP YESP YTEP LPLB YQGH YURN YQGI YESQ GANQ MDXG YURM LPLC AMYC YTCP ARAQ SSUC YVGM YTLD OPUAB METP TCYB TCYL YXEN OPUBD OPUCB OPUBB OPUCD
HALSA - Q9HML6 Q9HP01 Q9HMT4 Q9HHQ7 Q9HP02 Q9HS11 Q9HR05 Q9HPK3 Q9HHQ6 Q9HNI9 Q9HS12 Q9HML7
SULSO - Q97YY2 Q97UF3 Q97UZ0 Q97ZT7 Q97YY3 Q97ZT6 Q97VC0 Q97ZC2 Q97UY9 Q97UF4 Q97ZC1 Q97Z98

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
213_E	217_R	3.960	1.00
76_Y	80_V	3.231	1.00
205_Y	214_V	3.102	1.00
190_R	194_E	3.056	1.00
73_V	76_Y	2.684	1.00
33_M	37_I	2.510	1.00
102_E	201_K	2.508	1.00
74_P	270_A	2.479	1.00
192_V	226_G	2.477	1.00
210_T	213_E	2.469	1.00
84_I	174_G	2.458	1.00
201_K	219_V	2.416	1.00
72_L	76_Y	2.412	1.00
204_A	214_V	2.405	1.00
265_N	273_N	2.319	1.00
211_T	214_V	2.292	1.00
86_L	231_I	2.288	1.00
43_I	47_P	2.262	1.00
283_H	286_A	2.248	1.00
59_T	62_W	2.191	1.00
88_I	178_A	2.169	1.00
189_M	227_V	2.153	1.00
212_W	216_W	2.151	1.00
209_C	213_E	2.044	1.00
94_F	215_I	1.987	1.00
185_I	230_G	1.985	1.00
80_V	170_I	1.981	1.00
60_K	63_D	1.974	1.00
213_E	216_W	1.972	1.00
106_G	109_K	1.956	1.00
193_F	223_T	1.897	1.00
59_T	63_D	1.893	1.00
200_M	222_F	1.888	1.00
101_T	194_E	1.861	1.00
204_A	209_C	1.856	1.00
60_K	64_A	1.846	1.00
94_F	223_T	1.809	1.00
113_G	190_R	1.774	1.00
73_V	77_G	1.747	1.00
85_A	238_A	1.731	1.00
303_A	307_F	1.731	1.00
205_Y	211_T	1.728	1.00
58_W	62_W	1.697	1.00
80_V	84_I	1.687	1.00
82_S	235_L	1.669	1.00
90_V	231_I	1.660	1.00
63_D	67_D	1.644	1.00
93_S	185_I	1.618	1.00
96_I	186_A	1.607	1.00
201_K	214_V	1.606	1.00
39_V	43_I	1.605	1.00
94_F	189_M	1.602	1.00
58_W	61_E	1.596	1.00
201_K	205_Y	1.596	1.00
40_S	44_S	1.585	1.00
270_A	274_E	1.579	1.00
198_V	201_K	1.572	1.00
57_L	60_K	1.551	1.00
100_L	186_A	1.544	1.00
36_G	40_S	1.495	1.00
40_S	43_I	1.451	1.00
108_L	111_P	1.428	1.00
242_T	246_T	1.419	1.00
70_G	73_V	1.405	1.00
56_F	59_T	1.376	1.00
185_I	234_G	1.365	1.00
103_L	106_G	1.343	1.00
89_A	234_G	1.337	1.00
45_S	62_W	1.333	1.00
244_A	248_I	1.327	1.00
229_G	233_L	1.325	1.00
20_S	24_K	1.325	1.00
17_I	21_V	1.325	1.00
193_F	219_V	1.321	1.00
101_T	190_R	1.312	1.00
220_L	227_V	1.308	1.00
97_A	189_M	1.299	1.00
189_M	230_G	1.291	1.00
274_E	278_A	1.287	1.00
24_K	28_L	1.286	1.00
19_F	23_V	1.285	1.00
102_E	198_V	1.283	1.00
198_V	202_E	1.265	1.00
91_P	95_G	1.262	1.00
94_F	227_V	1.243	1.00
111_P	114_I	1.222	1.00
266_S	269_S	1.219	1.00
274_E	283_H	1.215	1.00
199_M	202_E	1.207	1.00
204_A	218_I	1.202	1.00
98_L	193_F	1.199	1.00
166_F	171_L	1.198	1.00
176_I	248_I	1.190	1.00
104_A	109_K	1.176	1.00
265_N	270_A	1.175	1.00
90_V	227_V	1.174	1.00
42_I	292_L	1.173	1.00
135_F	172_A	1.157	1.00
81_T	266_S	1.154	1.00
57_L	61_E	1.153	1.00
87_L	91_P	1.149	1.00
170_I	264_G	1.148	1.00
78_T	267_I	1.145	1.00
47_P	51_K	1.138	1.00
242_T	272_A	1.137	1.00
84_I	87_L	1.136	1.00
77_G	80_V	1.128	1.00
210_T	214_V	1.126	1.00
196_T	222_F	1.123	1.00
169_G	264_G	1.121	1.00
37_I	41_L	1.115	1.00
173_A	245_V	1.107	1.00
201_K	211_T	1.105	1.00
168_I	171_L	1.105	1.00
133_F	137_P	1.103	1.00
64_A	286_A	1.103	1.00
273_N	277_E	1.095	1.00
189_M	226_G	1.089	1.00
307_F	310_M	1.088	1.00
270_A	273_N	1.085	1.00
224_K	228_I	1.070	1.00
44_S	47_P	1.068	1.00
111_P	115_A	1.060	1.00
27_A	31_L	1.047	1.00
265_N	269_S	1.041	1.00
88_I	174_G	1.037	1.00
35_G	39_V	1.017	1.00
18_I	21_V	1.015	1.00
182_I	186_A	1.011	1.00
64_A	67_D	1.006	1.00
222_F	225_N	1.003	1.00
85_A	89_A	1.001	1.00
84_I	88_I	0.997	1.00
98_L	211_T	0.992	1.00
167_G	171_L	0.987	1.00
241_E	244_A	0.981	1.00
37_I	45_S	0.978	1.00
41_L	292_L	0.977	1.00
31_L	35_G	0.974	1.00
79_L	83_F	0.971	1.00
209_C	214_V	0.962	1.00
28_L	32_L	0.958	1.00
95_G	99_F	0.958	1.00
57_L	62_W	0.956	1.00
188_V	230_G	0.954	1.00
171_L	175_V	0.947	1.00
98_L	215_I	0.945	1.00
48_S	51_K	0.943	1.00
16_D	19_F	0.935	1.00
85_A	177_L	0.929	1.00
18_I	22_L	0.929	1.00
101_T	193_F	0.927	1.00
26_A	30_V	0.919	1.00
80_V	83_F	0.916	1.00
174_G	178_A	0.915	1.00
167_G	170_I	0.914	1.00
21_V	25_L	0.914	1.00
87_L	231_I	0.913	1.00
270_A	290_L	0.911	1.00
214_V	217_R	0.911	1.00
56_F	61_E	0.909	1.00
37_I	46_W	0.905	1.00
23_V	27_A	0.905	1.00
304_A	307_F	0.905	1.00
275_F	287_L	0.898	1.00
33_M	41_L	0.897	1.00
85_A	174_G	0.897	1.00
68_I	72_L	0.893	1.00
89_A	93_S	0.889	1.00
80_V	171_L	0.888	1.00
81_T	170_I	0.888	1.00
170_I	174_G	0.880	1.00
44_S	48_S	0.871	1.00
131_G	248_I	0.866	1.00
109_K	194_E	0.866	1.00
77_G	170_I	0.862	1.00
50_Q	53_G	0.860	1.00
166_F	169_G	0.860	1.00
97_A	101_T	0.859	1.00
296_V	301_V	0.856	1.00
284_V	287_L	0.854	1.00
246_T	269_S	0.852	1.00
56_F	62_W	0.851	1.00
83_F	87_L	0.849	1.00
110_R	113_G	0.845	1.00
241_E	245_V	0.838	1.00
99_F	106_G	0.837	1.00
75_I	79_L	0.833	1.00
100_L	113_G	0.833	1.00
88_I	91_P	0.832	1.00
75_I	267_I	0.828	1.00
192_V	223_T	0.827	1.00
223_T	226_G	0.826	1.00
245_V	266_S	0.825	1.00
272_A	276_A	0.823	1.00
177_L	238_A	0.822	1.00
224_K	227_V	0.819	1.00
71_A	290_L	0.818	1.00
76_Y	79_L	0.818	1.00
169_G	172_A	0.817	1.00
234_G	238_A	0.817	1.00
66_N	72_L	0.816	1.00
48_S	55_A	0.811	1.00
93_S	186_A	0.805	1.00
288_M	292_L	0.799	1.00
81_T	177_L	0.796	1.00
214_V	219_V	0.791	1.00
131_G	176_I	0.788	1.00
124_S	180_M	0.788	1.00
97_A	193_F	0.785	1.00
107_W	110_R	0.783	1.00
185_I	189_M	0.778	1.00
176_I	244_A	0.776	1.00
62_W	67_D	0.769	1.00
189_M	223_T	0.767	1.00
216_W	220_L	0.764	1.00
296_V	300_I	0.763	1.00
298_T	302_L	0.763	1.00
97_A	186_A	0.762	1.00
215_I	220_L	0.755	1.00
168_I	251_N	0.749	1.00
42_I	46_W	0.748	1.00
274_E	286_A	0.748	1.00
171_L	174_G	0.744	1.00
89_A	185_I	0.734	1.00
17_I	20_S	0.731	1.00
45_S	61_E	0.727	1.00
117_E	187_A	0.723	1.00
136_A	140_A	0.723	1.00
69_Y	73_V	0.723	1.00
211_T	215_I	0.720	1.00
284_V	288_M	0.719	1.00
89_A	238_A	0.718	1.00
286_A	290_L	0.717	1.00
33_M	46_W	0.715	1.00
132_L	136_A	0.714	1.00
203_S	207_I	0.711	1.00
172_A	176_I	0.707	1.00
274_E	290_L	0.706	1.00
297_I	301_V	0.702	1.00
117_E	120_A	0.699	1.00
89_A	181_I	0.696	1.00
30_V	34_L	0.695	1.00
136_A	139_F	0.690	1.00
128_G	247_F	0.687	1.00
136_A	167_G	0.681	1.00
32_L	36_G	0.680	1.00
82_S	86_L	0.679	1.00
168_I	172_A	0.679	1.00
16_D	20_S	0.676	1.00
131_G	134_I	0.675	1.00
63_D	68_I	0.674	1.00
86_L	235_L	0.674	1.00
128_G	243_M	0.672	1.00
215_I	219_V	0.671	1.00
90_V	189_M	0.671	1.00
249_I	264_G	0.671	1.00
103_L	109_K	0.670	1.00
137_P	140_A	0.669	1.00
209_C	217_R	0.669	1.00
285_A	288_M	0.669	1.00
196_T	223_T	0.668	1.00
100_L	190_R	0.666	1.00
124_S	243_M	0.664	1.00
189_M	193_F	0.663	1.00
128_G	132_L	0.662	1.00
227_V	230_G	0.662	1.00
100_L	112_L	0.662	1.00
74_P	77_G	0.660	1.00
86_L	90_V	0.653	1.00
61_E	64_A	0.652	1.00
299_F	303_A	0.651	1.00
25_L	28_L	0.651	1.00
200_M	218_I	0.651	1.00
288_M	291_G	0.650	1.00
269_S	273_N	0.648	1.00
198_V	205_Y	0.645	1.00
252_T	265_N	0.644	1.00
66_N	69_Y	0.643	1.00
133_F	136_A	0.642	1.00
47_P	55_A	0.640	1.00
24_K	27_A	0.639	1.00
93_S	189_M	0.637	1.00
81_T	173_A	0.637	1.00
226_G	230_G	0.637	1.00
21_V	24_K	0.636	1.00
269_S	272_A	0.633	1.00
296_V	302_L	0.629	1.00
37_I	49_I	0.628	1.00
96_I	182_I	0.627	1.00
74_P	267_I	0.626	1.00
300_I	304_A	0.624	1.00
241_E	266_S	0.622	1.00
283_H	287_L	0.620	1.00
181_I	237_R	0.619	1.00
41_L	45_S	0.619	1.00
81_T	174_G	0.616	1.00
72_L	75_I	0.612	1.00
173_A	249_I	0.612	1.00
36_G	39_V	0.611	1.00
298_T	305_S	0.611	1.00
29_I	33_M	0.609	1.00
113_G	187_A	0.609	1.00
116_I	183_P	0.608	1.00
69_Y	72_L	0.608	1.00
106_G	112_L	0.608	1.00
64_A	283_H	0.605	1.00
96_I	116_I	0.604	1.00
173_A	177_L	0.603	1.00
115_A	119_L	0.602	1.00
219_V	222_F	0.600	1.00
108_L	112_L	0.598	1.00
307_F	311_R	0.595	1.00
15_G	19_F	0.594	1.00
65_P	68_I	0.592	1.00
203_S	206_G	0.592	1.00
33_M	44_S	0.586	1.00
188_V	226_G	0.582	1.00
302_L	306_K	0.582	1.00
227_V	231_I	0.582	1.00
84_I	178_A	0.581	1.00
64_A	68_I	0.579	1.00
231_I	234_G	0.578	1.00
92_V	178_A	0.577	1.00
99_F	103_L	0.576	1.00
82_S	238_A	0.576	1.00
181_I	234_G	0.570	1.00
110_R	114_I	0.569	1.00
55_A	59_T	0.569	1.00
81_T	85_A	0.569	1.00
58_W	63_D	0.568	1.00
89_A	178_A	0.568	1.00
37_I	43_I	0.566	1.00
37_I	48_S	0.566	1.00
216_W	219_V	0.563	1.00
55_A	58_W	0.562	1.00
51_K	54_L	0.559	1.00
271_L	290_L	0.555	1.00
224_K	307_F	0.555	1.00
59_T	64_A	0.554	1.00
47_P	50_Q	0.554	1.00
56_F	60_K	0.554	1.00
20_S	23_V	0.552	1.00
82_S	239_L	0.552	1.00
127_Y	179_I	0.552	1.00
78_T	239_L	0.551	1.00
296_V	299_F	0.550	1.00
228_I	231_I	0.549	1.00
278_A	283_H	0.548	1.00
98_L	219_V	0.548	1.00
65_P	286_A	0.548	1.00
107_W	111_P	0.548	1.00
236_G	240_G	0.546	1.00
125_I	247_F	0.544	1.00
90_V	94_F	0.543	1.00
78_T	268_T	0.543	1.00
22_L	26_A	0.541	1.00
65_P	293_I	0.537	1.00
243_M	246_T	0.537	1.00
274_E	277_E	0.536	1.00
114_I	118_L	0.535	1.00
92_V	182_I	0.535	1.00
214_V	218_I	0.534	1.00
31_L	34_L	0.533	1.00
70_G	270_A	0.533	1.00
76_Y	170_I	0.531	1.00
268_T	272_A	0.526	1.00
120_A	184_Y	0.525	1.00
55_A	60_K	0.525	1.00
85_A	178_A	0.523	1.00
304_A	308_M	0.523	1.00
243_M	247_F	0.523	1.00
253_Y	264_G	0.523	1.00
177_L	241_E	0.518	1.00
73_V	80_V	0.518	1.00
245_V	269_S	0.517	1.00
47_P	56_F	0.517	1.00
37_I	44_S	0.516	1.00
104_A	198_V	0.516	1.00
113_G	194_E	0.511	1.00
25_L	29_I	0.510	1.00
303_A	306_K	0.508	1.00
97_A	190_R	0.508	1.00
196_T	201_K	0.507	1.00
41_L	61_E	0.506	1.00
41_L	288_M	0.500	1.00
51_K	55_A	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2onkC	2	0.7868	100	0.324	Contact Map
4tquM	1	0.8871	100	0.349	Contact Map
3d31C	2	0.7774	100	0.35	Contact Map
3rlfF	1	0.9154	100	0.394	Contact Map
3rlfG	1	0.8401	100	0.4	Contact Map
4tquN	1	0.8245	100	0.411	Contact Map
4ymuD	2	0.6708	100	0.506	Contact Map
3tuiA	2	0.6583	99.9	0.53	Contact Map
2kogA	1	0.1285	18	0.946	Contact Map
2m8rA	1	0.1285	16	0.948	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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