GREMLIN Database
PSTC - Phosphate transport system permease protein PstC
UniProt: P0AGH8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10784
Length: 319 (258)
Sequences: 68737 (45610)
Seq/√Len: 2839.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
213_E217_R3.9601.00
76_Y80_V3.2311.00
205_Y214_V3.1021.00
190_R194_E3.0561.00
73_V76_Y2.6841.00
33_M37_I2.5101.00
102_E201_K2.5081.00
74_P270_A2.4791.00
192_V226_G2.4771.00
210_T213_E2.4691.00
84_I174_G2.4581.00
201_K219_V2.4161.00
72_L76_Y2.4121.00
204_A214_V2.4051.00
265_N273_N2.3191.00
211_T214_V2.2921.00
86_L231_I2.2881.00
43_I47_P2.2621.00
283_H286_A2.2481.00
59_T62_W2.1911.00
88_I178_A2.1691.00
189_M227_V2.1531.00
212_W216_W2.1511.00
209_C213_E2.0441.00
94_F215_I1.9871.00
185_I230_G1.9851.00
80_V170_I1.9811.00
60_K63_D1.9741.00
213_E216_W1.9721.00
106_G109_K1.9561.00
193_F223_T1.8971.00
59_T63_D1.8931.00
200_M222_F1.8881.00
101_T194_E1.8611.00
204_A209_C1.8561.00
60_K64_A1.8461.00
94_F223_T1.8091.00
113_G190_R1.7741.00
73_V77_G1.7471.00
85_A238_A1.7311.00
303_A307_F1.7311.00
205_Y211_T1.7281.00
58_W62_W1.6971.00
80_V84_I1.6871.00
82_S235_L1.6691.00
90_V231_I1.6601.00
63_D67_D1.6441.00
93_S185_I1.6181.00
96_I186_A1.6071.00
201_K214_V1.6061.00
39_V43_I1.6051.00
94_F189_M1.6021.00
58_W61_E1.5961.00
201_K205_Y1.5961.00
40_S44_S1.5851.00
270_A274_E1.5791.00
198_V201_K1.5721.00
57_L60_K1.5511.00
100_L186_A1.5441.00
36_G40_S1.4951.00
40_S43_I1.4511.00
108_L111_P1.4281.00
242_T246_T1.4191.00
70_G73_V1.4051.00
56_F59_T1.3761.00
185_I234_G1.3651.00
103_L106_G1.3431.00
89_A234_G1.3371.00
45_S62_W1.3331.00
244_A248_I1.3271.00
229_G233_L1.3251.00
20_S24_K1.3251.00
17_I21_V1.3251.00
193_F219_V1.3211.00
101_T190_R1.3121.00
220_L227_V1.3081.00
97_A189_M1.2991.00
189_M230_G1.2911.00
274_E278_A1.2871.00
24_K28_L1.2861.00
19_F23_V1.2851.00
102_E198_V1.2831.00
198_V202_E1.2651.00
91_P95_G1.2621.00
94_F227_V1.2431.00
111_P114_I1.2221.00
266_S269_S1.2191.00
274_E283_H1.2151.00
199_M202_E1.2071.00
204_A218_I1.2021.00
98_L193_F1.1991.00
166_F171_L1.1981.00
176_I248_I1.1901.00
104_A109_K1.1761.00
265_N270_A1.1751.00
90_V227_V1.1741.00
42_I292_L1.1731.00
135_F172_A1.1571.00
81_T266_S1.1541.00
57_L61_E1.1531.00
87_L91_P1.1491.00
170_I264_G1.1481.00
78_T267_I1.1451.00
47_P51_K1.1381.00
242_T272_A1.1371.00
84_I87_L1.1361.00
77_G80_V1.1281.00
210_T214_V1.1261.00
196_T222_F1.1231.00
169_G264_G1.1211.00
37_I41_L1.1151.00
173_A245_V1.1071.00
201_K211_T1.1051.00
168_I171_L1.1051.00
133_F137_P1.1031.00
64_A286_A1.1031.00
273_N277_E1.0951.00
189_M226_G1.0891.00
307_F310_M1.0881.00
270_A273_N1.0851.00
224_K228_I1.0701.00
44_S47_P1.0681.00
111_P115_A1.0601.00
27_A31_L1.0471.00
265_N269_S1.0411.00
88_I174_G1.0371.00
35_G39_V1.0171.00
18_I21_V1.0151.00
182_I186_A1.0111.00
64_A67_D1.0061.00
222_F225_N1.0031.00
85_A89_A1.0011.00
84_I88_I0.9971.00
98_L211_T0.9921.00
167_G171_L0.9871.00
241_E244_A0.9811.00
37_I45_S0.9781.00
41_L292_L0.9771.00
31_L35_G0.9741.00
79_L83_F0.9711.00
209_C214_V0.9621.00
28_L32_L0.9581.00
95_G99_F0.9581.00
57_L62_W0.9561.00
188_V230_G0.9541.00
171_L175_V0.9471.00
98_L215_I0.9451.00
48_S51_K0.9431.00
16_D19_F0.9351.00
85_A177_L0.9291.00
18_I22_L0.9291.00
101_T193_F0.9271.00
26_A30_V0.9191.00
80_V83_F0.9161.00
174_G178_A0.9151.00
167_G170_I0.9141.00
21_V25_L0.9141.00
87_L231_I0.9131.00
270_A290_L0.9111.00
214_V217_R0.9111.00
56_F61_E0.9091.00
37_I46_W0.9051.00
23_V27_A0.9051.00
304_A307_F0.9051.00
275_F287_L0.8981.00
33_M41_L0.8971.00
85_A174_G0.8971.00
68_I72_L0.8931.00
89_A93_S0.8891.00
80_V171_L0.8881.00
81_T170_I0.8881.00
170_I174_G0.8801.00
44_S48_S0.8711.00
131_G248_I0.8661.00
109_K194_E0.8661.00
77_G170_I0.8621.00
50_Q53_G0.8601.00
166_F169_G0.8601.00
97_A101_T0.8591.00
296_V301_V0.8561.00
284_V287_L0.8541.00
246_T269_S0.8521.00
56_F62_W0.8511.00
83_F87_L0.8491.00
110_R113_G0.8451.00
241_E245_V0.8381.00
99_F106_G0.8371.00
75_I79_L0.8331.00
100_L113_G0.8331.00
88_I91_P0.8321.00
75_I267_I0.8281.00
192_V223_T0.8271.00
223_T226_G0.8261.00
245_V266_S0.8251.00
272_A276_A0.8231.00
177_L238_A0.8221.00
224_K227_V0.8191.00
71_A290_L0.8181.00
76_Y79_L0.8181.00
169_G172_A0.8171.00
234_G238_A0.8171.00
66_N72_L0.8161.00
48_S55_A0.8111.00
93_S186_A0.8051.00
288_M292_L0.7991.00
81_T177_L0.7961.00
214_V219_V0.7911.00
131_G176_I0.7881.00
124_S180_M0.7881.00
97_A193_F0.7851.00
107_W110_R0.7831.00
185_I189_M0.7781.00
176_I244_A0.7761.00
62_W67_D0.7691.00
189_M223_T0.7671.00
216_W220_L0.7641.00
296_V300_I0.7631.00
298_T302_L0.7631.00
97_A186_A0.7621.00
215_I220_L0.7551.00
168_I251_N0.7491.00
42_I46_W0.7481.00
274_E286_A0.7481.00
171_L174_G0.7441.00
89_A185_I0.7341.00
17_I20_S0.7311.00
45_S61_E0.7271.00
117_E187_A0.7231.00
136_A140_A0.7231.00
69_Y73_V0.7231.00
211_T215_I0.7201.00
284_V288_M0.7191.00
89_A238_A0.7181.00
286_A290_L0.7171.00
33_M46_W0.7151.00
132_L136_A0.7141.00
203_S207_I0.7111.00
172_A176_I0.7071.00
274_E290_L0.7061.00
297_I301_V0.7021.00
117_E120_A0.6991.00
89_A181_I0.6961.00
30_V34_L0.6951.00
136_A139_F0.6901.00
128_G247_F0.6871.00
136_A167_G0.6811.00
32_L36_G0.6801.00
82_S86_L0.6791.00
168_I172_A0.6791.00
16_D20_S0.6761.00
131_G134_I0.6751.00
63_D68_I0.6741.00
86_L235_L0.6741.00
128_G243_M0.6721.00
215_I219_V0.6711.00
90_V189_M0.6711.00
249_I264_G0.6711.00
103_L109_K0.6701.00
137_P140_A0.6691.00
209_C217_R0.6691.00
285_A288_M0.6691.00
196_T223_T0.6681.00
100_L190_R0.6661.00
124_S243_M0.6641.00
189_M193_F0.6631.00
128_G132_L0.6621.00
227_V230_G0.6621.00
100_L112_L0.6621.00
74_P77_G0.6601.00
86_L90_V0.6531.00
61_E64_A0.6521.00
299_F303_A0.6511.00
25_L28_L0.6511.00
200_M218_I0.6511.00
288_M291_G0.6501.00
269_S273_N0.6481.00
198_V205_Y0.6451.00
252_T265_N0.6441.00
66_N69_Y0.6431.00
133_F136_A0.6421.00
47_P55_A0.6401.00
24_K27_A0.6391.00
93_S189_M0.6371.00
81_T173_A0.6371.00
226_G230_G0.6371.00
21_V24_K0.6361.00
269_S272_A0.6331.00
296_V302_L0.6291.00
37_I49_I0.6281.00
96_I182_I0.6271.00
74_P267_I0.6261.00
300_I304_A0.6241.00
241_E266_S0.6221.00
283_H287_L0.6201.00
181_I237_R0.6191.00
41_L45_S0.6191.00
81_T174_G0.6161.00
72_L75_I0.6121.00
173_A249_I0.6121.00
36_G39_V0.6111.00
298_T305_S0.6111.00
29_I33_M0.6091.00
113_G187_A0.6091.00
116_I183_P0.6081.00
69_Y72_L0.6081.00
106_G112_L0.6081.00
64_A283_H0.6051.00
96_I116_I0.6041.00
173_A177_L0.6031.00
115_A119_L0.6021.00
219_V222_F0.6001.00
108_L112_L0.5981.00
307_F311_R0.5951.00
15_G19_F0.5941.00
65_P68_I0.5921.00
203_S206_G0.5921.00
33_M44_S0.5861.00
188_V226_G0.5821.00
302_L306_K0.5821.00
227_V231_I0.5821.00
84_I178_A0.5811.00
64_A68_I0.5791.00
231_I234_G0.5781.00
92_V178_A0.5771.00
99_F103_L0.5761.00
82_S238_A0.5761.00
181_I234_G0.5701.00
110_R114_I0.5691.00
55_A59_T0.5691.00
81_T85_A0.5691.00
58_W63_D0.5681.00
89_A178_A0.5681.00
37_I43_I0.5661.00
37_I48_S0.5661.00
216_W219_V0.5631.00
55_A58_W0.5621.00
51_K54_L0.5591.00
271_L290_L0.5551.00
224_K307_F0.5551.00
59_T64_A0.5541.00
47_P50_Q0.5541.00
56_F60_K0.5541.00
20_S23_V0.5521.00
82_S239_L0.5521.00
127_Y179_I0.5521.00
78_T239_L0.5511.00
296_V299_F0.5501.00
228_I231_I0.5491.00
278_A283_H0.5481.00
98_L219_V0.5481.00
65_P286_A0.5481.00
107_W111_P0.5481.00
236_G240_G0.5461.00
125_I247_F0.5441.00
90_V94_F0.5431.00
78_T268_T0.5431.00
22_L26_A0.5411.00
65_P293_I0.5371.00
243_M246_T0.5371.00
274_E277_E0.5361.00
114_I118_L0.5351.00
92_V182_I0.5351.00
214_V218_I0.5341.00
31_L34_L0.5331.00
70_G270_A0.5331.00
76_Y170_I0.5311.00
268_T272_A0.5261.00
120_A184_Y0.5251.00
55_A60_K0.5251.00
85_A178_A0.5231.00
304_A308_M0.5231.00
243_M247_F0.5231.00
253_Y264_G0.5231.00
177_L241_E0.5181.00
73_V80_V0.5181.00
245_V269_S0.5171.00
47_P56_F0.5171.00
37_I44_S0.5161.00
104_A198_V0.5161.00
113_G194_E0.5111.00
25_L29_I0.5101.00
303_A306_K0.5081.00
97_A190_R0.5081.00
196_T201_K0.5071.00
41_L61_E0.5061.00
41_L288_M0.5001.00
51_K55_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2onkC 2 0.7868 100 0.324 Contact Map
4tquM 1 0.8871 100 0.349 Contact Map
3d31C 2 0.7774 100 0.35 Contact Map
3rlfF 1 0.9154 100 0.394 Contact Map
3rlfG 1 0.8401 100 0.4 Contact Map
4tquN 1 0.8245 100 0.411 Contact Map
4ymuD 2 0.6708 100 0.506 Contact Map
3tuiA 2 0.6583 99.9 0.53 Contact Map
2kogA 1 0.1285 18 0.946 Contact Map
2m8rA 1 0.1285 16 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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