GREMLIN Database
SAPC - Peptide transport system permease protein SapC
UniProt: P0AGH5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG20256
Length: 296 (253)
Sequences: 28856 (17943)
Seq/√Len: 1128.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
181_V208_V2.8051.00
128_S178_Y2.6861.00
184_E189_Y2.4571.00
198_A202_N2.4481.00
194_R200_T2.4451.00
202_N206_F2.4041.00
104_V162_M2.3651.00
116_L131_L2.3541.00
108_A166_W2.3211.00
184_E187_K2.2941.00
58_F61_Y2.2801.00
97_P236_F2.2581.00
199_S202_N2.2471.00
201_L205_W2.2081.00
188_E191_I2.1161.00
250_A254_D2.1071.00
190_V208_V2.0331.00
190_V203_I2.0251.00
118_T181_V1.9881.00
221_T284_G1.9821.00
90_R251_M1.9571.00
123_T127_R1.9241.00
119_F123_T1.9011.00
123_T200_T1.8951.00
53_G56_Q1.8741.00
111_I115_V1.8691.00
86_D89_S1.8631.00
173_M223_A1.8491.00
81_D85_R1.7661.00
189_Y211_N1.7531.00
64_L67_S1.7491.00
184_E212_I1.7411.00
37_A41_V1.7301.00
121_G181_V1.7291.00
126_L130_V1.7261.00
122_A200_T1.7241.00
43_C95_A1.7101.00
78_L268_L1.6961.00
88_L92_L1.6571.00
112_C170_L1.6411.00
109_A169_L1.6091.00
119_F127_R1.6011.00
185_L208_V1.5961.00
100_G104_V1.5951.00
112_C115_V1.5941.00
76_F86_D1.5911.00
83_L90_R1.5891.00
127_R131_L1.5841.00
162_M166_W1.5651.00
87_V268_L1.5541.00
29_A286_G1.5471.00
131_L174_V1.5461.00
93_S96_A1.5291.00
180_M183_D1.5281.00
135_L174_V1.5061.00
82_D254_D1.5021.00
110_T220_I1.4951.00
255_A265_T1.4891.00
85_R89_S1.4891.00
122_A204_L1.4841.00
72_G77_F1.4641.00
106_T220_I1.4511.00
113_G173_M1.4491.00
117_G121_G1.4401.00
183_D187_K1.4381.00
252_L269_P1.4181.00
133_H136_D1.3951.00
45_F48_W1.3951.00
32_G279_L1.3881.00
117_G177_I1.3671.00
126_L129_A1.3441.00
116_L174_V1.3381.00
192_A196_D1.3221.00
178_Y182_H1.3211.00
113_G177_I1.3211.00
218_T288_R1.3171.00
145_L149_I1.3071.00
120_A131_L1.3021.00
121_G185_L1.2991.00
30_M34_Y1.2951.00
91_L272_A1.2881.00
97_P100_G1.2801.00
159_S163_F1.2601.00
263_P267_M1.2531.00
184_E190_V1.2511.00
118_T204_L1.2511.00
39_L274_M1.2451.00
150_V164_A1.2371.00
184_E208_V1.2321.00
78_L88_L1.2301.00
41_V45_F1.2301.00
166_W170_L1.2281.00
176_S219_E1.2281.00
287_V290_A1.2211.00
61_Y64_L1.2181.00
288_R292_I1.2151.00
217_V291_I1.2131.00
193_A207_A1.2031.00
27_A30_M1.1991.00
101_G231_I1.1691.00
67_S75_S1.1661.00
85_R90_R1.1531.00
64_L68_W1.1441.00
181_V212_I1.1401.00
193_A203_I1.1321.00
286_G290_A1.1291.00
193_A198_A1.1281.00
118_T209_M1.1251.00
85_R93_S1.1201.00
124_H185_L1.1191.00
138_L171_P1.1131.00
191_I194_R1.1031.00
36_C275_I1.1021.00
177_I216_L1.1021.00
129_A133_H1.0981.00
114_L177_I1.0771.00
78_L91_L1.0771.00
269_P273_I1.0761.00
177_I181_V1.0731.00
115_V118_T1.0721.00
164_A168_A1.0681.00
80_T86_D1.0571.00
141_I146_L1.0561.00
202_N205_W1.0541.00
170_L174_V1.0481.00
147_A164_A1.0411.00
180_M184_E1.0381.00
82_D258_L1.0361.00
157_S160_H1.0321.00
255_A266_V1.0261.00
132_N174_V1.0211.00
46_G93_S1.0191.00
134_I138_L1.0161.00
105_V166_W1.0151.00
96_A100_G1.0151.00
251_M265_T1.0111.00
36_C279_L1.0111.00
87_V251_M1.0071.00
32_G286_G1.0061.00
196_D207_A1.0051.00
31_V34_Y1.0021.00
159_S162_M1.0011.00
128_S132_N0.9951.00
34_Y38_G0.9951.00
87_V265_T0.9941.00
39_L276_S0.9921.00
194_R203_I0.9881.00
50_A89_S0.9841.00
264_W268_L0.9801.00
35_G279_L0.9791.00
72_G75_S0.9781.00
76_F80_T0.9721.00
177_I212_I0.9691.00
100_G158_L0.9671.00
193_A196_D0.9641.00
124_H186_E0.9611.00
34_Y37_A0.9601.00
105_V109_A0.9531.00
214_A288_R0.9461.00
32_G278_L0.9461.00
268_L271_A0.9381.00
91_L268_L0.9381.00
127_R130_V0.9351.00
253_G257_E0.9351.00
89_S93_S0.9341.00
52_Y75_S0.9331.00
65_P68_W0.9301.00
90_R265_T0.9301.00
128_S182_H0.9271.00
198_A203_I0.9241.00
33_L37_A0.9231.00
38_G42_L0.9211.00
200_T203_I0.9171.00
154_A160_H0.9141.00
130_V134_I0.9131.00
117_G181_V0.9121.00
100_G103_F0.9111.00
114_L216_L0.9111.00
125_G128_S0.9041.00
32_G282_L0.9031.00
143_S230_D0.9021.00
105_V165_V0.9011.00
94_G251_M0.8971.00
129_A132_N0.8901.00
35_G275_I0.8891.00
279_L283_L0.8771.00
135_L171_P0.8641.00
280_V284_G0.8641.00
165_V230_D0.8641.00
33_L283_L0.8641.00
217_V284_G0.8641.00
68_W75_S0.8631.00
125_G129_A0.8491.00
52_Y76_F0.8481.00
42_L92_L0.8481.00
212_I215_G0.8431.00
90_R93_S0.8411.00
110_T114_L0.8391.00
158_L162_M0.8381.00
92_L96_A0.8381.00
80_T84_G0.8371.00
60_G64_L0.8341.00
205_W208_V0.8331.00
254_D257_E0.8261.00
219_E223_A0.8251.00
179_S182_H0.8211.00
110_T115_V0.8191.00
111_I114_L0.8191.00
163_F166_W0.8141.00
155_G160_H0.8141.00
60_G63_L0.8131.00
143_S147_A0.8131.00
200_T204_L0.8091.00
156_P160_H0.8061.00
52_Y89_S0.8051.00
181_V185_L0.8041.00
29_A282_L0.8031.00
115_V119_F0.8001.00
95_A276_S0.7961.00
187_K191_I0.7951.00
160_H163_F0.7901.00
68_W77_F0.7891.00
51_P89_S0.7881.00
89_S92_L0.7881.00
103_F107_L0.7871.00
29_A33_L0.7851.00
150_V160_H0.7851.00
116_L170_L0.7841.00
105_V227_A0.7831.00
191_I195_L0.7821.00
267_M271_A0.7791.00
48_W263_P0.7771.00
62_Q66_P0.7711.00
184_E211_N0.7701.00
251_M269_P0.7691.00
63_L68_W0.7691.00
273_I277_V0.7641.00
110_T173_M0.7611.00
104_V107_L0.7551.00
45_F49_F0.7551.00
77_F88_L0.7521.00
104_V236_F0.7431.00
253_G256_L0.7431.00
121_G182_H0.7391.00
139_L171_P0.7381.00
198_A207_A0.7371.00
98_T102_A0.7361.00
289_R295_V0.7331.00
203_I208_V0.7321.00
61_Y76_F0.7281.00
42_L95_A0.7191.00
108_A162_M0.7171.00
258_L261_V0.7161.00
120_A128_S0.7161.00
180_M215_G0.7151.00
28_S32_G0.7121.00
177_I180_M0.7111.00
254_D258_L0.7081.00
268_L272_A0.7071.00
40_A271_A0.7051.00
92_L95_A0.7051.00
277_V281_N0.7021.00
63_L66_P0.6981.00
169_L172_R0.6941.00
275_I279_L0.6911.00
201_L204_L0.6901.00
39_L275_I0.6881.00
221_T280_V0.6871.00
112_C166_W0.6851.00
168_A171_P0.6801.00
81_D262_A0.6791.00
59_L62_Q0.6771.00
122_A185_L0.6741.00
31_V35_G0.6741.00
102_A224_L0.6701.00
180_M212_I0.6691.00
109_A166_W0.6681.00
77_F86_D0.6671.00
32_G35_G0.6631.00
161_A231_I0.6631.00
283_L287_V0.6601.00
229_L232_A0.6591.00
267_M270_G0.6561.00
44_I48_W0.6541.00
72_G76_F0.6521.00
266_V270_G0.6521.00
30_M33_L0.6471.00
113_G117_G0.6421.00
47_G96_A0.6411.00
156_P159_S0.6371.00
124_H128_S0.6321.00
27_A31_V0.6311.00
51_P88_L0.6291.00
130_V133_H0.6291.00
143_S146_L0.6261.00
229_L233_A0.6251.00
231_I235_G0.6251.00
36_C280_V0.6251.00
288_R295_V0.6251.00
107_L111_I0.6201.00
173_M177_I0.6191.00
182_H185_L0.6191.00
91_L269_P0.6181.00
112_C116_L0.6161.00
106_T223_A0.6131.00
173_M219_E0.6091.00
146_L168_A0.6031.00
232_A250_A0.6011.00
99_V103_F0.6011.00
230_D233_A0.6001.00
120_A132_N0.6001.00
102_A227_A0.5991.00
123_T204_L0.5981.00
132_N135_L0.5951.00
124_H182_H0.5911.00
135_L170_L0.5901.00
198_A201_L0.5891.00
172_R223_A0.5871.00
131_L135_L0.5861.00
35_G39_L0.5841.00
43_C270_G0.5831.00
251_M254_D0.5831.00
58_F76_F0.5821.00
133_H137_T0.5811.00
96_A99_V0.5801.00
58_F62_Q0.5771.00
138_L170_L0.5751.00
228_I232_A0.5751.00
64_L80_T0.5731.00
52_Y261_V0.5721.00
104_V159_S0.5661.00
95_A99_V0.5661.00
251_M255_A0.5661.00
167_L170_L0.5651.00
42_L46_G0.5641.00
218_T221_T0.5631.00
169_L223_A0.5601.00
232_A253_G0.5581.00
149_I153_F0.5571.00
160_H164_A0.5571.00
143_S167_L0.5561.00
113_G174_V0.5531.00
50_A93_S0.5521.00
227_A230_D0.5501.00
122_A205_W0.5481.00
252_L273_I0.5471.00
282_L286_G0.5471.00
106_T110_T0.5461.00
66_P264_W0.5431.00
110_T216_L0.5421.00
120_A178_Y0.5411.00
190_V194_R0.5401.00
116_L119_F0.5391.00
285_D288_R0.5381.00
224_L280_V0.5351.00
63_L262_A0.5331.00
28_S282_L0.5321.00
163_F167_L0.5311.00
205_W210_P0.5311.00
101_G161_A0.5291.00
54_I93_S0.5291.00
166_W169_L0.5291.00
136_D139_L0.5281.00
47_G93_S0.5281.00
121_G128_S0.5271.00
62_Q65_P0.5271.00
258_L265_T0.5271.00
36_C283_L0.5261.00
90_R94_G0.5251.00
151_V155_G0.5211.00
232_A254_D0.5211.00
171_P174_V0.5141.00
199_S203_I0.5121.00
57_Q83_L0.5091.00
264_W267_M0.5081.00
176_S180_M0.5071.00
213_T217_V0.5041.00
56_Q68_W0.5041.00
40_A43_C0.5011.00
132_N136_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquM 1 0.8547 99.9 0.607 Contact Map
3d31C 2 0.7838 99.9 0.63 Contact Map
3tuiA 2 0.6824 99.9 0.631 Contact Map
2onkC 2 0.8007 99.9 0.644 Contact Map
3rlfF 1 0.8919 99.9 0.655 Contact Map
4tquN 1 0.8986 99.8 0.665 Contact Map
3rlfG 1 0.8581 99.8 0.669 Contact Map
4ymuD 2 0.7061 99.8 0.673 Contact Map
3j9pD 4 0.7635 40.7 0.945 Contact Map
4ry2A 2 0.9662 26.4 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0094 seconds.