GREMLIN Database
SAPB - Peptide transport system permease protein SapB
UniProt: P0AGH3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG20255
Length: 321 (259)
Sequences: 28307 (18194)
Seq/√Len: 1130.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
206_T233_V2.8191.00
28_Y43_A2.6241.00
108_D203_R2.5821.00
49_N53_H2.5621.00
219_A225_R2.4771.00
209_V214_Y2.4681.00
223_L227_T2.4351.00
83_L187_V2.4151.00
45_V49_N2.4051.00
95_V111_I2.4001.00
227_T231_R2.3801.00
76_A265_W2.3461.00
209_V212_Q2.3171.00
270_R274_N2.2841.00
87_F191_S2.2701.00
224_S227_T2.2621.00
226_F230_R2.2501.00
215_V233_V2.0841.00
213_N216_K2.0271.00
246_G302_S2.0181.00
20_T44_W1.9891.00
102_T105_K1.9591.00
97_M206_T1.9541.00
102_T225_R1.9351.00
215_V228_I1.9211.00
65_P68_E1.9121.00
69_Q271_W1.9001.00
41_W45_V1.8991.00
98_I102_T1.8911.00
90_I94_P1.8741.00
198_V248_Q1.8161.00
101_I225_R1.8111.00
42_N45_V1.8101.00
102_T107_Q1.7681.00
100_G206_T1.7391.00
106_W110_L1.7371.00
214_Y236_N1.7291.00
59_S64_Q1.7001.00
33_A36_Q1.6971.00
210_Y233_V1.6881.00
62_N69_Q1.6741.00
209_V237_A1.6481.00
56_F286_A1.6411.00
52_I55_D1.6391.00
67_A71_K1.6311.00
66_I286_A1.6071.00
48_F51_L1.5991.00
21_F44_W1.5991.00
42_N46_F1.5951.00
91_V195_T1.5861.00
79_E83_L1.5861.00
98_I107_Q1.5771.00
107_Q111_I1.5751.00
91_V94_P1.5561.00
101_I229_L1.5481.00
72_E75_P1.5261.00
50_G55_D1.5121.00
89_L245_L1.5051.00
88_A194_P1.5041.00
187_V191_S1.4991.00
54_W65_P1.4811.00
115_A199_I1.4771.00
205_S208_E1.4621.00
272_L287_G1.4611.00
64_Q68_E1.4541.00
111_I199_I1.4531.00
46_F49_N1.4481.00
61_I274_N1.4241.00
275_A283_A1.4021.00
217_A221_R1.4011.00
85_F245_L1.4001.00
96_G100_G1.3911.00
92_G198_V1.3881.00
208_E212_Q1.3801.00
92_G202_M1.3611.00
209_V233_V1.3571.00
25_S28_Y1.3451.00
113_A116_L1.3421.00
45_V48_F1.3381.00
6_L10_L1.3331.00
106_W109_N1.3331.00
17_F21_F1.3261.00
46_F50_G1.3231.00
243_P306_G1.2951.00
95_V199_I1.2881.00
209_V215_V1.2881.00
125_W129_L1.2861.00
56_F67_A1.2851.00
250_S295_V1.2821.00
100_G210_Y1.2811.00
19_L292_G1.2791.00
130_L189_T1.2791.00
76_A79_E1.2761.00
281_Y285_S1.2711.00
201_L244_R1.2661.00
97_M229_L1.2651.00
203_R207_I1.2561.00
39_S42_N1.2541.00
132_L137_T1.2451.00
23_G74_F1.2381.00
61_I278_Q1.2361.00
305_L308_M1.2351.00
191_S195_T1.2261.00
306_G310_N1.2241.00
96_G202_M1.2181.00
104_H108_D1.2081.00
99_A111_I1.2051.00
184_I188_I1.2021.00
10_L14_V1.1951.00
242_I309_A1.1911.00
206_T237_A1.1771.00
51_L56_F1.1731.00
218_A228_I1.1661.00
64_Q69_Q1.1641.00
70_L290_V1.1581.00
118_G196_T1.1491.00
64_Q72_E1.1451.00
218_A223_L1.1231.00
202_M206_T1.1041.00
218_A232_H1.1021.00
97_M234_L1.1011.00
202_M241_V1.1011.00
16_L293_S1.0911.00
114_I118_G1.0721.00
109_N113_A1.0681.00
273_I277_R1.0671.00
24_F28_Y1.0671.00
189_T193_A1.0591.00
80_L260_E1.0591.00
287_G291_C1.0461.00
17_F44_W1.0411.00
221_R232_H1.0411.00
58_V65_P1.0401.00
93_I202_M1.0391.00
94_P97_M1.0361.00
216_K219_A1.0351.00
205_S209_V1.0351.00
56_F70_L1.0341.00
304_I308_M1.0261.00
66_I283_A1.0181.00
121_I126_L1.0141.00
195_T199_I1.0091.00
227_T230_R1.0031.00
66_I271_W1.0001.00
12_L296_I0.9881.00
271_W283_A0.9851.00
18_L22_V0.9821.00
21_F25_S0.9801.00
219_A228_I0.9731.00
68_E72_E0.9691.00
84_A191_S0.9651.00
249_F298_V0.9631.00
79_E183_M0.9601.00
202_M237_A0.9531.00
75_P79_E0.9441.00
12_L15_T0.9431.00
26_L72_E0.9421.00
112_N199_I0.9421.00
69_Q283_A0.9371.00
84_A190_L0.9371.00
218_A221_R0.9311.00
133_F137_T0.9281.00
127_A189_T0.9251.00
275_A284_I0.9241.00
14_V17_F0.9211.00
239_P306_G0.9201.00
110_L114_I0.9161.00
108_D207_I0.9151.00
286_A289_M0.9151.00
84_A88_A0.9111.00
282_A286_A0.9071.00
184_I187_V0.9041.00
73_V271_W0.8981.00
242_I302_S0.8931.00
7_R10_L0.8911.00
79_E82_I0.8891.00
223_L228_I0.8881.00
20_T47_W0.8721.00
70_L286_A0.8711.00
297_I301_I0.8701.00
123_V259_T0.8661.00
93_I241_V0.8601.00
298_V302_S0.8601.00
109_N112_N0.8601.00
225_R228_I0.8581.00
13_I17_F0.8561.00
96_G206_T0.8561.00
107_Q110_L0.8451.00
108_D112_N0.8431.00
69_Q72_E0.8391.00
137_T185_L0.8351.00
123_V127_A0.8331.00
37_G42_N0.8261.00
273_I276_I0.8171.00
244_R248_Q0.8121.00
90_I93_I0.8111.00
89_L198_V0.8091.00
190_L259_T0.8081.00
134_C185_L0.8081.00
71_K75_P0.8041.00
50_G53_H0.8041.00
37_G43_A0.7981.00
58_V63_G0.7981.00
71_K74_F0.7971.00
21_F40_L0.7961.00
89_L93_I0.7951.00
274_N277_R0.7941.00
237_A240_P0.7941.00
94_P98_I0.7891.00
84_A256_A0.7881.00
100_G207_I0.7871.00
115_A196_T0.7811.00
9_I13_I0.7801.00
188_I191_S0.7791.00
216_K220_T0.7761.00
49_N52_I0.7751.00
225_R229_L0.7741.00
230_R233_V0.7721.00
30_T68_E0.7721.00
68_E71_K0.7691.00
183_M187_V0.7681.00
271_W287_G0.7681.00
5_T304_I0.7661.00
89_L94_P0.7641.00
285_S289_M0.7631.00
104_H210_Y0.7611.00
83_L265_W0.7611.00
43_A46_F0.7571.00
95_V195_T0.7491.00
28_Y40_L0.7471.00
223_L232_H0.7431.00
77_T81_C0.7411.00
44_W48_F0.7391.00
87_F187_V0.7381.00
104_H109_N0.7371.00
204_I207_I0.7371.00
83_L86_G0.7341.00
209_V236_N0.7311.00
274_N278_Q0.7311.00
212_Q216_K0.7301.00
26_L29_F0.7281.00
74_F294_L0.7261.00
286_A290_V0.7261.00
20_T289_M0.7261.00
185_L188_I0.7251.00
14_V18_L0.7161.00
291_C295_V0.7141.00
307_A313_K0.7141.00
202_M205_S0.7121.00
119_F196_T0.7111.00
130_L185_L0.7101.00
59_S280_D0.7071.00
12_L300_V0.7041.00
293_S297_I0.7041.00
25_S40_L0.7031.00
55_D67_A0.7031.00
228_I233_V0.7021.00
206_T210_Y0.7011.00
306_G313_K0.7001.00
32_H53_H0.7001.00
82_I86_G0.6971.00
99_A108_D0.6941.00
12_L297_I0.6871.00
285_S288_V0.6861.00
250_S298_V0.6851.00
246_G298_V0.6831.00
226_F229_L0.6821.00
27_S31_P0.6811.00
54_W58_V0.6791.00
25_S29_F0.6771.00
258_I261_M0.6751.00
23_G27_S0.6751.00
205_S237_A0.6741.00
10_L304_I0.6741.00
272_L275_A0.6701.00
45_V50_G0.6691.00
205_S240_P0.6681.00
91_V191_S0.6651.00
19_L294_L0.6651.00
92_G96_G0.6621.00
301_I305_L0.6591.00
88_A191_S0.6571.00
28_Y281_Y0.6511.00
23_G288_V0.6511.00
40_L43_A0.6501.00
16_L296_I0.6411.00
194_P197_E0.6391.00
70_L287_G0.6391.00
135_S185_L0.6331.00
47_W50_G0.6321.00
193_A196_T0.6281.00
9_I300_V0.6211.00
207_I210_Y0.6201.00
110_L113_A0.6201.00
81_C256_A0.6191.00
99_A112_N0.6181.00
51_L289_M0.6181.00
27_S30_T0.6121.00
271_W275_A0.6121.00
111_I115_A0.6101.00
129_L133_F0.6071.00
102_T229_L0.6071.00
85_F249_F0.6041.00
32_H68_E0.6041.00
112_N115_A0.6031.00
198_V244_R0.6001.00
101_I230_R0.5991.00
48_F52_I0.5981.00
32_H54_W0.5971.00
101_I210_Y0.5961.00
295_V299_N0.5941.00
260_E264_S0.5931.00
59_S62_N0.5931.00
284_I288_V0.5931.00
197_E248_Q0.5931.00
123_V126_L0.5921.00
248_Q251_T0.5921.00
223_L226_F0.5881.00
23_G28_Y0.5871.00
92_G199_I0.5861.00
51_L55_D0.5851.00
43_A50_G0.5841.00
55_D65_P0.5831.00
85_F248_Q0.5821.00
10_L13_I0.5791.00
44_W47_W0.5761.00
83_L184_I0.5741.00
7_R11_L0.5731.00
5_T11_L0.5731.00
194_P251_T0.5711.00
115_A195_T0.5691.00
21_F41_W0.5681.00
132_L136_L0.5631.00
12_L18_L0.5621.00
86_G90_I0.5611.00
78_M82_I0.5601.00
91_V95_V0.5561.00
186_P260_E0.5561.00
196_T199_I0.5561.00
307_A314_H0.5521.00
32_H35_L0.5511.00
69_Q73_V0.5491.00
51_L54_W0.5461.00
257_M261_M0.5461.00
22_V26_L0.5451.00
17_F48_F0.5441.00
22_V74_F0.5441.00
24_F27_S0.5441.00
258_I262_V0.5431.00
11_L15_T0.5421.00
194_P248_Q0.5421.00
215_V219_A0.5421.00
47_W51_L0.5401.00
261_M270_R0.5391.00
256_A259_T0.5391.00
80_L187_V0.5391.00
126_L193_A0.5371.00
230_R235_H0.5351.00
99_A203_R0.5351.00
197_E244_R0.5341.00
271_W274_N0.5321.00
201_L205_S0.5271.00
123_V192_V0.5261.00
300_V304_I0.5251.00
49_N54_W0.5251.00
105_K108_D0.5251.00
259_T262_V0.5241.00
22_V71_K0.5191.00
74_F78_M0.5181.00
198_V202_M0.5181.00
191_S194_P0.5171.00
16_L297_I0.5161.00
81_C249_F0.5151.00
113_A117_L0.5151.00
224_S228_I0.5141.00
100_G108_D0.5141.00
89_L241_V0.5131.00
250_S302_S0.5131.00
8_R11_L0.5121.00
31_P67_A0.5111.00
127_A131_T0.5111.00
188_I192_V0.5101.00
31_P68_E0.5091.00
32_H279_Q0.5041.00
134_C137_T0.5031.00
95_V98_I0.5011.00
261_M273_I0.5011.00
20_T24_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tuiA 2 0.6511 99.9 0.662 Contact Map
4tquM 1 0.838 99.9 0.671 Contact Map
3rlfF 1 0.8318 99.9 0.676 Contact Map
3d31C 2 0.7632 99.8 0.692 Contact Map
2onkC 2 0.7757 99.8 0.697 Contact Map
4ymuD 2 0.6542 99.8 0.699 Contact Map
4tquN 1 0.7975 99.8 0.715 Contact Map
3rlfG 1 0.8224 99.8 0.722 Contact Map
2yevC 1 0.1059 7.8 0.963 Contact Map
1q16C 2 0.3863 5.1 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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