GREMLIN Database
TLDD - Metalloprotease TldD
UniProt: P0AGG8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG12826
Length: 481 (433)
Sequences: 4534 (2904)
Seq/√Len: 139.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
325_E330_K4.2681.00
322_V325_E4.1021.00
384_Y414_E3.9411.00
299_D320_Y3.7201.00
386_I422_V3.5641.00
383_E415_N3.3431.00
288_L292_E3.3401.00
439_S471_K3.3061.00
439_S473_D3.2521.00
247_T474_N3.2151.00
374_T377_E3.1221.00
140_R224_D3.1131.00
382_V413_I3.0721.00
414_E419_T3.0701.00
284_Q287_E3.0221.00
130_S133_E2.9651.00
412_L420_K2.9071.00
241_V420_K2.8711.00
414_E420_K2.7651.00
384_Y412_L2.5821.00
136_D140_R2.4871.00
178_D310_A2.4481.00
42_S165_L2.4351.00
151_R193_E2.3881.00
192_E195_G2.3741.00
77_G96_A2.3211.00
378_I469_T2.3051.00
23_A86_L2.2291.00
412_L419_T2.2291.00
295_T322_V2.2041.00
374_T443_N2.1571.00
229_E232_R2.1331.00
297_V369_L2.1311.00
22_F26_G2.1211.00
143_K147_E2.0771.00
297_V320_Y2.0411.00
27_Q90_E2.0231.00
380_E417_K2.0121.00
379_I413_I1.9901.00
293_L326_N1.9791.00
293_L441_V1.9781.00
228_K232_R1.9641.00
288_L436_Q1.9421.00
444_D469_T1.9251.00
373_S377_E1.9191.00
292_E326_N1.9111.00
295_T326_N1.8711.00
152_V191_V1.8561.00
90_E94_Q1.8221.00
167_L175_L1.8221.00
290_A435_M1.8201.00
191_V234_A1.8081.00
222_R225_A1.8071.00
83_Q88_A1.7851.00
434_T472_V1.7811.00
148_A228_K1.7751.00
309_V318_G1.7671.00
248_M477_V1.7641.00
251_V382_V1.7641.00
134_K159_L1.7581.00
319_Q345_T1.7561.00
36_G171_T1.7411.00
209_G212_F1.7331.00
375_P469_T1.7321.00
334_Q344_M1.7161.00
144_V224_D1.7031.00
94_Q98_T1.6981.00
232_R236_V1.6951.00
27_Q30_E1.6931.00
28_L36_G1.6721.00
75_K105_D1.6681.00
378_I440_M1.6651.00
381_S440_M1.6351.00
382_V471_K1.6261.00
402_K430_S1.6101.00
148_A231_V1.5991.00
413_I419_T1.5841.00
191_V235_L1.5811.00
176_A311_I1.5781.00
72_S101_R1.5761.00
202_S229_E1.5751.00
193_E239_S1.5701.00
321_N349_N1.5671.00
339_A345_T1.5661.00
381_S471_K1.5601.00
334_Q338_N1.5331.00
136_D139_R1.5291.00
85_S88_A1.5241.00
433_E437_Q1.5211.00
321_N331_G1.5201.00
288_L328_I1.5201.00
70_A96_A1.5191.00
277_G282_S1.5131.00
320_Y367_Y1.5041.00
437_Q474_N1.5031.00
144_V227_A1.5021.00
375_P379_I1.4821.00
42_S64_Q1.4801.00
191_V238_L1.4791.00
387_Y413_I1.4781.00
133_E136_D1.4781.00
139_R143_K1.4691.00
249_P471_K1.4681.00
269_L323_L1.4671.00
50_L55_I1.4501.00
91_Q94_Q1.4481.00
152_V235_L1.4441.00
411_Y418_V1.4371.00
193_E196_K1.4351.00
249_P473_D1.4351.00
437_Q473_D1.4311.00
385_G413_I1.4191.00
251_V378_I1.4171.00
430_S433_E1.4151.00
169_A175_L1.4061.00
373_S440_M1.3841.00
66_V81_A1.3811.00
165_L177_A1.3771.00
23_A26_G1.3741.00
370_P445_L1.3641.00
253_G387_Y1.3621.00
309_V364_T1.3601.00
316_T346_P1.3541.00
87_L91_Q1.3521.00
323_L333_M1.3521.00
19_Q22_F1.3481.00
290_A294_C1.3441.00
334_Q342_M1.3421.00
27_Q31_R1.3381.00
274_N332_Y1.3361.00
142_D146_R1.3351.00
145_A227_A1.3291.00
134_K161_G1.3251.00
165_L179_V1.2961.00
52_D154_E1.2931.00
28_L32_R1.2931.00
135_L139_R1.2901.00
297_V322_V1.2901.00
275_R342_M1.2871.00
198_E423_K1.2801.00
72_S100_V1.2741.00
138_L157_A1.2711.00
153_Q192_E1.2631.00
27_Q94_Q1.2551.00
284_Q432_I1.2541.00
263_E266_G1.2541.00
204_G226_W1.2481.00
301_T318_G1.2371.00
251_V471_K1.2351.00
326_N330_K1.2291.00
286_G330_K1.2291.00
72_S97_R1.2251.00
373_S381_S1.2231.00
227_A231_V1.2181.00
79_A92_S1.2181.00
271_G334_Q1.2141.00
257_P470_L1.2101.00
37_D170_A1.2101.00
386_I425_A1.2081.00
376_Q380_E1.2021.00
375_P378_I1.1991.00
295_T369_L1.1861.00
212_F304_D1.1861.00
294_C441_V1.1841.00
145_A189_V1.1781.00
224_D228_K1.1771.00
308_S365_N1.1771.00
25_L36_G1.1771.00
397_D402_K1.1620.99
316_T348_G1.1570.99
48_W55_I1.1550.99
251_V413_I1.1530.99
46_E134_K1.1420.99
88_A92_S1.1410.99
316_T336_K1.1400.99
31_R94_Q1.1380.99
73_G105_D1.1340.99
87_L90_E1.1290.99
322_V326_N1.1290.99
53_R142_D1.1280.99
152_V231_V1.1240.99
367_Y466_G1.1220.99
387_Y418_V1.1220.99
225_A229_E1.1210.99
367_Y445_L1.1210.99
132_E136_D1.1200.99
163_Y179_V1.1120.99
320_Y369_L1.1120.99
261_L368_M1.1100.99
351_R362_R1.1090.99
322_V330_K1.1050.99
407_T410_A1.1030.99
21_L169_A1.1030.99
295_T325_E1.1020.99
39_Y352_R1.1010.99
433_E436_Q1.1010.99
251_V375_P1.1000.99
144_V228_K1.0990.99
376_Q417_K1.0950.99
23_A27_Q1.0860.99
379_I382_V1.0780.99
442_G469_T1.0750.99
243_A248_M1.0700.99
379_I387_Y1.0690.99
37_D69_R1.0650.99
441_V470_L1.0650.99
42_S62_I1.0600.99
209_G304_D1.0570.99
189_V231_V1.0510.99
375_P443_N1.0440.99
25_L171_T1.0440.99
26_G30_E1.0420.99
447_L466_G1.0410.99
161_G210_Y1.0370.99
285_V344_M1.0370.99
198_E237_N1.0310.99
191_V231_V1.0290.99
202_S226_W1.0210.99
74_E105_D1.0180.99
141_V223_A1.0170.99
339_A346_P1.0170.99
68_V92_S1.0170.99
252_L388_A1.0140.99
422_V425_A1.0120.99
294_C438_I1.0110.99
159_L185_L1.0070.98
81_A92_S1.0060.98
186_S201_A1.0020.98
382_V385_G1.0010.98
291_S441_V0.9980.98
249_P474_N0.9980.98
331_G347_T0.9980.98
264_A267_H0.9960.98
241_V412_L0.9940.98
403_F434_T0.9940.98
35_Y172_D0.9940.98
231_V235_L0.9860.98
170_A174_T0.9800.98
296_V366_T0.9800.98
440_M471_K0.9750.98
300_G309_V0.9740.98
46_E161_G0.9700.98
50_L139_R0.9670.98
192_E197_R0.9660.98
140_R143_K0.9650.98
296_V324_I0.9650.98
334_Q346_P0.9590.98
265_V435_M0.9580.98
397_D400_S0.9560.98
377_E380_E0.9540.98
230_A234_A0.9530.98
434_T475_L0.9490.98
88_A91_Q0.9490.98
189_V234_A0.9460.98
248_M412_L0.9460.98
277_G283_G0.9400.98
378_I442_G0.9320.97
294_C368_M0.9290.97
300_G318_G0.9130.97
321_N347_T0.9130.97
140_R144_V0.9120.97
19_Q23_A0.9120.97
280_V432_I0.9080.97
93_A97_R0.9070.97
293_L373_S0.9000.97
71_I76_T0.8950.97
22_F175_L0.8950.97
35_Y168_V0.8930.97
44_Y62_I0.8900.97
40_F66_V0.8890.97
25_L29_A0.8860.97
121_T124_D0.8840.97
91_Q95_A0.8810.96
200_G230_A0.8790.96
77_G100_V0.8780.96
38_L66_V0.8770.96
65_G78_F0.8770.96
23_A90_E0.8760.96
28_L33_L0.8730.96
119_L123_V0.8730.96
335_D361_P0.8710.96
290_A324_I0.8700.96
375_P444_D0.8690.96
79_A96_A0.8670.96
375_P387_Y0.8660.96
300_G364_T0.8660.96
223_A227_A0.8640.96
78_F358_L0.8630.96
145_A230_A0.8600.96
411_Y421_P0.8520.96
41_Q164_E0.8480.96
257_P467_Q0.8470.96
167_L177_A0.8460.96
349_N364_T0.8460.96
121_T304_D0.8450.96
67_G352_R0.8380.95
141_V185_L0.8380.95
246_G384_Y0.8370.95
376_Q379_I0.8300.95
251_V387_Y0.8280.95
49_V57_D0.8200.95
249_P384_Y0.8170.95
300_G321_N0.8170.95
283_G287_E0.8090.94
302_M367_Y0.8080.94
415_N419_T0.8070.94
314_E336_K0.8070.94
271_G342_M0.8040.94
261_L296_V0.8030.94
373_S378_I0.7970.94
275_R334_Q0.7960.94
266_G366_T0.7960.94
144_V147_E0.7960.94
151_R235_L0.7960.94
168_V176_A0.7940.94
247_T476_T0.7940.94
396_V405_F0.7930.94
24_I89_L0.7910.94
51_E56_K0.7910.94
243_A386_I0.7900.94
363_M366_T0.7880.94
417_K420_K0.7870.93
387_Y469_T0.7850.93
81_A88_A0.7850.93
263_E267_H0.7830.93
44_Y163_Y0.7830.93
200_G234_A0.7810.93
137_I210_Y0.7810.93
64_Q84_I0.7810.93
49_V158_S0.7780.93
307_G464_G0.7780.93
382_V439_S0.7750.93
394_G405_F0.7740.93
403_F429_G0.7740.93
55_I135_L0.7670.93
123_V163_Y0.7660.93
110_T340_R0.7630.92
137_I140_R0.7630.92
35_Y171_T0.7620.92
302_M308_S0.7570.92
172_D336_K0.7560.92
389_P411_Y0.7550.92
262_H267_H0.7540.92
388_A427_L0.7530.92
335_D338_N0.7520.92
333_M363_M0.7510.92
244_P384_Y0.7500.92
373_S443_N0.7490.92
367_Y447_L0.7470.92
40_F64_Q0.7470.92
144_V148_A0.7470.92
413_I418_V0.7450.91
110_T113_A0.7420.91
228_K231_V0.7410.91
225_A228_K0.7410.91
256_W259_V0.7410.91
299_D367_Y0.7400.91
248_M386_I0.7390.91
129_M210_Y0.7370.91
261_L294_C0.7360.91
298_D321_N0.7340.91
33_L72_S0.7330.91
269_L281_F0.7320.91
240_A423_K0.7320.91
379_I384_Y0.7310.91
66_V89_L0.7310.91
257_P368_M0.7300.91
269_L329_L0.7300.91
91_Q98_T0.7300.91
256_W391_F0.7260.90
24_I86_L0.7260.90
189_V230_A0.7250.90
241_V414_E0.7250.90
300_G308_S0.7250.90
145_A231_V0.7240.90
410_A422_V0.7240.90
266_G362_R0.7210.90
69_R314_E0.7200.90
318_G364_T0.7200.90
242_A424_G0.7170.90
438_I470_L0.7150.90
29_A171_T0.7150.90
166_I178_D0.7150.90
205_G306_R0.7150.90
338_N361_P0.7130.90
334_Q339_A0.7110.89
326_N345_T0.7110.89
140_R223_A0.7100.89
249_P382_V0.7090.89
302_M305_R0.7070.89
379_I418_V0.7060.89
290_A438_I0.7050.89
136_D143_K0.7040.89
350_G361_P0.7030.89
392_G408_S0.7010.89
275_R338_N0.6970.89
21_L38_L0.6940.88
144_V231_V0.6930.88
141_V187_V0.6920.88
378_I382_V0.6920.88
119_L122_S0.6920.88
250_V475_L0.6880.88
445_L466_G0.6870.88
281_F329_L0.6850.88
97_R101_R0.6850.88
52_D155_V0.6840.88
267_H270_E0.6830.88
151_R238_L0.6800.87
148_A235_L0.6800.87
202_S230_A0.6770.87
248_M422_V0.6760.87
252_L391_F0.6760.87
33_L97_R0.6760.87
437_Q475_L0.6750.87
235_L238_L0.6740.87
129_M133_E0.6740.87
22_F29_A0.6710.87
158_S186_S0.6700.87
148_A151_R0.6700.87
206_G212_F0.6690.86
287_E328_I0.6680.86
391_F395_Q0.6670.86
271_G275_R0.6670.86
43_S164_E0.6660.86
396_V431_G0.6640.86
109_Q113_A0.6620.86
291_S294_C0.6620.86
233_M253_G0.6600.86
391_F394_G0.6590.86
279_S332_Y0.6580.86
386_I412_L0.6580.86
33_L70_A0.6570.85
52_D146_R0.6560.85
393_G404_V0.6560.85
47_S59_S0.6560.85
20_D23_A0.6560.85
161_G183_V0.6540.85
274_N279_S0.6540.85
25_L38_L0.6530.85
39_Y166_I0.6520.85
29_A33_L0.6510.85
380_E384_Y0.6500.85
335_D360_M0.6470.85
112_G115_E0.6420.84
368_M470_L0.6420.84
43_S162_V0.6410.84
253_G389_P0.6410.84
243_A246_G0.6400.84
48_W131_R0.6400.84
123_V181_P0.6380.84
70_A77_G0.6360.84
379_I383_E0.6360.84
21_L40_F0.6340.83
47_S158_S0.6330.83
260_L391_F0.6320.83
31_R90_E0.6310.83
164_E180_R0.6300.83
338_N342_M0.6290.83
129_M134_K0.6280.83
319_Q331_G0.6270.83
261_L470_L0.6260.83
289_V436_Q0.6250.83
254_A469_T0.6250.83
31_R97_R0.6240.82
336_K340_R0.6230.82
262_H362_R0.6210.82
265_V289_V0.6210.82
121_T125_P0.6200.82
77_G99_I0.6190.82
86_L90_E0.6160.82
73_G101_R0.6160.82
406_S424_G0.6150.82
382_V387_Y0.6150.82
149_D235_L0.6130.81
262_H266_G0.6120.81
385_G418_V0.6120.81
285_V332_Y0.6110.81
380_E383_E0.6110.81
45_H160_S0.6100.81
325_E328_I0.6090.81
413_I471_K0.6070.81
117_S310_A0.6070.81
285_V330_K0.6070.81
82_D85_S0.6050.80
37_D67_G0.6050.80
393_G429_G0.6050.80
239_S421_P0.6050.80
383_E419_T0.6040.80
301_T320_Y0.6020.80
395_Q405_F0.6020.80
133_E137_I0.6010.80
28_L70_A0.6010.80
256_W388_A0.6010.80
290_A296_V0.6000.80
391_F405_F0.5980.80
407_T425_A0.5970.80
58_G139_R0.5950.79
33_L36_G0.5950.79
27_Q86_L0.5930.79
235_L239_S0.5920.79
442_G445_L0.5910.79
296_V368_M0.5910.79
111_L114_V0.5900.79
288_L326_N0.5900.79
272_D276_R0.5880.79
371_G443_N0.5870.78
25_L28_L0.5850.78
120_Y124_D0.5840.78
275_R341_L0.5840.78
268_G280_V0.5830.78
264_A405_F0.5820.78
61_N287_E0.5820.78
285_V331_G0.5820.78
144_V223_A0.5820.78
262_H363_M0.5800.78
109_Q112_G0.5800.78
145_A155_V0.5790.77
270_E363_M0.5790.77
24_I31_R0.5790.77
337_L341_L0.5780.77
152_V234_A0.5780.77
147_E228_K0.5770.77
262_H270_E0.5740.77
120_Y125_P0.5740.77
142_D157_A0.5730.77
395_Q404_V0.5730.77
244_P248_M0.5720.77
147_E150_K0.5710.77
366_T467_Q0.5710.77
267_H362_R0.5710.77
196_K239_S0.5710.77
404_V428_I0.5690.76
26_G29_A0.5680.76
236_V411_Y0.5680.76
438_I442_G0.5670.76
45_H63_D0.5670.76
384_Y415_N0.5670.76
432_I436_Q0.5660.76
251_V379_I0.5650.76
372_K443_N0.5630.76
39_Y164_E0.5620.75
232_R235_L0.5600.75
122_S179_V0.5580.75
392_G426_T0.5580.75
269_L333_M0.5560.75
94_Q228_K0.5560.75
138_L159_L0.5550.74
305_R308_S0.5530.74
34_D72_S0.5530.74
114_V172_D0.5530.74
313_D351_R0.5510.74
374_T442_G0.5510.74
333_M366_T0.5510.74
377_E381_S0.5500.74
283_G332_Y0.5500.74
265_V324_I0.5470.73
404_V426_T0.5470.73
122_S125_P0.5470.73
326_N369_L0.5460.73
410_A425_A0.5450.73
29_A101_R0.5450.73
335_D350_G0.5440.73
253_G257_P0.5440.73
134_K210_Y0.5430.73
45_H162_V0.5430.73
401_G430_S0.5420.73
334_Q361_P0.5410.73
362_R463_V0.5410.73
44_Y60_Y0.5400.72
246_G386_I0.5390.72
86_L89_L0.5390.72
274_N342_M0.5390.72
270_E362_R0.5380.72
27_Q93_A0.5380.72
147_E224_D0.5380.72
119_L303_V0.5360.72
467_Q470_L0.5360.72
393_G426_T0.5350.72
155_V189_V0.5350.72
378_I418_V0.5340.72
381_S439_S0.5340.72
104_G107_K0.5340.72
272_D360_M0.5330.72
80_Y352_R0.5330.72
241_V419_T0.5320.71
48_W134_K0.5310.71
323_L366_T0.5310.71
291_S295_T0.5300.71
44_Y165_L0.5300.71
50_L138_L0.5290.71
260_L431_G0.5280.71
384_Y419_T0.5270.71
108_V111_L0.5270.71
66_V88_A0.5260.71
268_G432_I0.5260.71
262_H463_V0.5260.71
123_V126_L0.5250.70
37_D78_F0.5250.70
407_T427_L0.5250.70
241_V421_P0.5250.70
445_L467_Q0.5240.70
276_R400_S0.5230.70
126_L210_Y0.5230.70
260_L472_V0.5220.70
442_G468_P0.5220.70
108_V113_A0.5210.70
312_D348_G0.5190.70
224_D227_A0.5190.70
297_V367_Y0.5180.69
121_T209_G0.5180.69
363_M394_G0.5170.69
160_S184_R0.5160.69
258_G446_K0.5160.69
120_Y123_V0.5160.69
274_N329_L0.5150.69
406_S426_T0.5150.69
145_A187_V0.5150.69
128_S133_E0.5150.69
143_K437_Q0.5140.69
96_A100_V0.5140.69
390_N408_S0.5130.69
49_V156_T0.5130.69
84_I88_A0.5120.69
264_A396_V0.5120.69
270_E335_D0.5120.69
377_E443_N0.5110.68
249_P383_E0.5110.68
116_H120_Y0.5110.68
126_L161_G0.5110.68
39_Y65_G0.5100.68
70_A93_A0.5100.68
370_P443_N0.5090.68
265_V294_C0.5080.68
229_E233_M0.5080.68
32_R97_R0.5080.68
55_I58_G0.5080.68
380_E415_N0.5080.68
256_W406_S0.5070.68
277_G284_Q0.5060.68
265_V366_T0.5060.68
266_G363_M0.5050.67
339_A344_M0.5030.67
19_Q26_G0.5030.67
291_S326_N0.5030.67
252_L257_P0.5020.67
298_D323_L0.5020.67
240_A421_P0.5010.67
124_D128_S0.5010.67
150_K228_K0.5000.67
381_S413_I0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qtdA 2 0.9064 100 0.164 Contact Map
1vl4A 2 0.8794 100 0.181 Contact Map
1vpbA 2 0.894 100 0.181 Contact Map
3tv9A 2 0.894 100 0.184 Contact Map
2plgA 4 0.2931 12.2 0.974 Contact Map
4hvzA 5 0.3846 7.8 0.977 Contact Map
4htiA 1 0.1788 6.8 0.977 Contact Map
2zcwA 2 0.1164 6.3 0.978 Contact Map
3e97A 2 0.1102 6.2 0.978 Contact Map
3b02A 2 0.1247 5 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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